Financial Performance - The company's audited net profit for 2019 was -58.3992 million RMB, resulting in a cumulative undistributed profit of -233 million RMB as of December 31, 2019, leading to no profit distribution to shareholders [6]. - The total operating revenue for 2019 was approximately 1.387 billion RMB, representing a year-on-year increase of 5.02% compared to 2018 [22]. - The net profit attributable to shareholders of the listed company for 2019 was approximately 49.695 million RMB, a decrease of 16.13% from 2018 [22]. - The net cash flow generated from operating activities for 2019 was approximately 241.49 million RMB, an increase of 85.64% compared to 2018 [25]. - The total assets as of the end of 2019 were approximately 4.889 billion RMB, reflecting a year-on-year increase of 10.02% [25]. - The net assets attributable to shareholders of the listed company at the end of 2019 were approximately 3.354 billion RMB, a 20.96% increase from the end of 2018 [25]. - Basic earnings per share decreased by 26.67% to CNY 0.11 in 2019 compared to CNY 0.15 in 2018 [26]. - The company reported a net profit of approximately 28.438 million RMB after deducting non-recurring gains and losses, a significant improvement compared to a loss of approximately 262.48 million RMB in 2018 [22]. - The company reported a net profit of CNY 30,843,567.35 in Q1 2019, with a decline to -CNY 43,807,553.58 in Q4 2019 [29]. Revenue and Growth - The company achieved a revenue of 1.387 billion, representing a year-on-year growth of 5.02% [61]. - The company reported a total revenue of 109,648,855.89 CNY in R&D investments, accounting for 7.91% of total operating income [76]. - The company reported a significant increase in investment activities cash flow, with a net outflow of RMB 555,140,139.32, a change of -12,968.55% year-over-year [62]. - The company achieved a 66.96% increase in asset disposal income, amounting to 9,997,983.62 CNY, attributed to gains from patent technology disposals [75]. - The company reported a total guarantee amount of 2.17 billion RMB, which accounts for 6.47% of the company's net assets [199]. Research and Development - R&D investment accounted for 7.91% of the company's total revenue in 2019, with 180 R&D personnel [54]. - The company has established a comprehensive industry chain in precision medicine, covering cell storage, gene testing, and in vitro diagnostic reagents [48]. - The company has initiated 28 research projects in Shanghai Zhi Cheng Company, indicating a strong focus on expanding its research capabilities [77]. - The company has established a robust pipeline of diagnostic products, with a focus on immunohistochemistry and related methodologies [99]. - The company’s commitment to research and development is evident in its continuous introduction of new diagnostic reagents throughout the year [100]. Market and Industry Position - The company operates in the fields of cell detection, preparation, storage, and in vitro diagnostic reagents and instruments [35]. - The company aims to expand through both organic growth and strategic acquisitions globally [36]. - The domestic stem cell storage rate is currently below 1%, indicating significant growth potential, with the market size expected to exceed 30 billion RMB [39]. - The sales revenue of in vitro diagnostic reagents in China ranks among the top three in the medical device market, with immunodiagnostics and biochemical diagnostics dominating the market share since 2019 [43]. - The company has established a nationwide stem cell storage network with over 300,000 stored units, covering more than 2/3 of regions and 3/4 of the population in China [38]. Compliance and Governance - The company has established a quality safety management system to prevent potential incidents that could harm its reputation and financial performance [141]. - The company has made commitments to avoid engaging in competitive businesses and to adhere to share lock-up agreements related to major asset restructuring [155]. - The company will ensure compliance with relevant laws and regulations in all transactions to protect the interests of Zhongyuan Hehe and its minority shareholders [161]. - The company has not faced any penalties or corrective actions against its directors, supervisors, or senior management during the reporting period [187]. - The company has not engaged in any undisclosed major related party transactions during the reporting period [191]. Future Plans and Commitments - The company aims to achieve a revenue of 1.482 billion in 2020, focusing on cell storage and in vitro diagnostics as core businesses [137]. - The company plans to enhance its product line by expanding the types of stem cells stored, including hematopoietic stem cells and adipose-derived stem cells [134]. - The company intends to strengthen its online platform for the "life bank," improving user experience and service capabilities [137]. - The company will optimize its management system and organizational structure to improve operational efficiency and reduce costs [137]. - The company is committed to upgrading production processes, including the development of serum-free cell culture systems and automated diagnostic instruments [140].

2019 年第三季度报告 公司代码：600645 公司简称：中源协和 中源协和细胞基因工程股份有限公司 2019 年第三季度报告 1 / 23 2019 年第三季度报告 一、 重要提示 二、 公司基本情况. 11[ 重要事项 四、 附录 目录 2 / 23 2019 年第三季度报告 单位：元 币种：人民币 一、 重要提示 1.1 公司董事会、监事会及董事、监事、高级管理人员保证季度报告内容的真实、准确、完整， 不存在虚假记载、误导性陈述或者重大遗漏，并承担个别和连带的法律责任。 1.2 公司全体董事出席董事会审议季度报告。 1.3 公司负责人李德福、主管会计工作负责人王鹏及会计机构负责人（会计主管人员）王鹏保证 季度报告中财务报表的真实、准确、完整。 1.4 本公司第三季度报告未经审计。 二、 公司基本情况 2.1 主要财务数据 | --- | --- | --- | --- | |-----------------------------------------------|------------------------------|------------------------------------ ...

公司代码：600645 公司简称：中源协和 2019 年半年度报告 中源协和细胞基因工程股份有限公司 2019 年半年度报告 1 / 174 2019 年半年度报告 重要提示 一、本公司董事会、监事会及董事、监事、高级管理人员保证半年度报告内容的真实、 准确、完整，不存在虚假记载、误导性陈述或重大遗漏，并承担个别和连带的法 律责任。 二、 公司全体董事出席董事会会议。 三、 本半年度报告未经审计。 四、 公司负责人李德福、主管会计工作负责人王鹏及会计机构负责人（会计主管人员） 王鹏声明：保证半年度报告中财务报告的真实、准确、完整。 五、 经董事会审议的报告期利润分配预案或公积金转增股本预案 无 六、 前瞻性陈述的风险声明 √适用 □不适用 本报告所涉及的未来计划等前瞻性陈述，不构成公司对投资者的实质承诺，请投资者 注意投资风险。 七、 是否存在被控股股东及其关联方非经营性占用资金情况 否 八、 是否存在违反规定决策程序对外提供担保的情况？ 否 九、 重大风险提示 公司已经在本报告中详细描述了公司存在的风险因素，敬请查阅第四节"经营情况的 讨论与分析"中其他披露事项可能面对的风险。 十、 其他 □适用 √不适用 ...

证券代码：600645 证券简称：中源协和 公告编号：2019-038 中源协和细胞基因工程股份有限公司 关于举行"投资者网上集体接待日"活动公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重大 遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 重要内容提示： ●召开时间：2019年5月9日（星期四）15：00-16:30 ●召开方式：网络方式召开 一、说明会类型 中源协和细胞基因工程股份有限公司（以下简称"公司"）于2019年4月30 日发布了2018年年度报告。为便于广大投资者更深入全面地了解公司情况，公司 将在全景网以网络方式举行"投资者网上集体接待日"活动。 二、召开时间和方式 时间：2019年5月9日（星期四）15：00-16:30 方式：网络方式召开 三、公司出席人员 公司出席本次"投资者网上集体接待日"活动的人员有：公司副董事长、总 经理李德福先生，董事、常务副总经理李旭先生，副总经理、董事会秘书杨新喆 先生，财务总监王鹏先生（如有特殊情况，出席人员会有调整）。 四、投资者参加方式 投资者可以登录" 全景·路演天下"（http://rs.p5w.net）参 ...

2019 年第一季度报告 公司代码：600645 公司简称：中源协和 中源协和细胞基因工程股份有限公司 2019 年第一季度报告 1 / 25 2019 年第一季度报告 í 二、 11Í 四、 目录 | --- | |----------------| | | | 重要提示 . | | 公司基本情况 . | | 重要事项 . | | 附录 . | 2 / 25 2019 年第一季度报告 单位：元 币种：人民币 一、 重要提示 1.1 公司董事会、监事会及董事、监事、高级管理人员保证季度报告内容的真实、准确、完整， 不存在虚假记载、误导性陈述或者重大遗漏，并承担个别和连带的法律责任。 1.2 公司全体董事出席董事会审议季度报告。 1.3 公司负责人李德福、主管会计工作负责人王鹏及会计机构负责人（会计主管人员）王鹏保证 季度报告中财务报表的真实、准确、完整。 1.4 本公司第一季度报告未经审计。 二、 公司基本情况 2.1 主要财务数据 | --- | --- | --- | --- | --- | |-------------------------------------------------|------ ...

Financial Performance - The audited net profit for the parent company in 2018 was RMB 33.93 million, with accumulated undistributed profits as of December 31, 2018, amounting to -RMB 175 million[4]. - The company's operating revenue for 2018 was approximately ¥1.32 billion, a slight decrease of 0.02% compared to 2017[22]. - Net profit attributable to shareholders for 2018 was approximately ¥59.25 million, representing a significant increase of 471.58% year-over-year[22]. - The net profit attributable to shareholders after deducting non-recurring gains and losses decreased by 1,296.39% compared to the previous year, primarily due to goodwill impairment losses[24]. - Basic earnings per share for 2018 were ¥0.15, a 400% increase from ¥0.03 in 2017[24]. - The weighted average return on equity for 2018 was 2.18%, an increase of 1.79 percentage points compared to 2017[24]. - The company generated a net cash flow from operating activities of approximately ¥130.08 million in 2018, an increase of 24.60% from the previous year[22]. - Non-recurring gains for 2018 totaled approximately ¥321.73 million, significantly higher than the previous year's gains[32]. - The company reported a net profit of approximately ¥133.48 million in Q1 2018, with a notable decline in Q4 resulting in a net loss of approximately ¥275.30 million[30]. - The company achieved a revenue of RMB 1.32 billion in the reporting period, a slight decrease of 0.02% compared to the previous year[60]. - Net profit attributable to shareholders reached RMB 59.25 million, representing a significant increase of 471.58% year-on-year, primarily due to a gain of RMB 260 million from the disposal of equity stakes in Beijing Pan Genomics and Beijing San You Li He Ze Biotechnology[60]. Asset and Investment Overview - The company's total assets at the end of 2018 were approximately ¥4.44 billion, reflecting a 0.64% increase from the previous year[22]. - The company's available-for-sale financial assets increased by 36.35% compared to the previous period, amounting to ¥307,866,380.71, which represents 6.93% of total assets[47]. - Investment properties rose by 68.78% from the previous period, totaling ¥157,750,673.03, accounting for 3.55% of total assets[47]. - The overseas assets of the company amounted to ¥481,628,032.08, representing 10.84% of total assets[47]. - The company has a total of 163,337,005.68 yuan in assets under restriction due to mortgage loans[95]. - The company has provided guarantees with joint liability for various projects, indicating a commitment to support its subsidiaries[198]. Research and Development - The company invested approximately RMB 103.3 million in research and development during the reporting period, focusing on innovation and product line expansion[37]. - R&D investment accounted for 7.82% of the company's total revenue in 2018, with over 157 R&D personnel, including 56 with master's degrees or higher[51]. - The company completed 48 stem cell research and product development projects, with 3 completed and 4 halted[82]. - The company launched the "Yuanwei Kang Disease Full Item Genetic Susceptibility Gene Detection" product, utilizing a chip developed in collaboration with Illumina, specifically designed for the East Asian population[51]. Market and Business Expansion - The company has established cell resource banks in 18 provinces, covering over 2/3 of the regions and 3/4 of the population in China, with more than 300,000 stored units accumulated over 18 years[35]. - The company has developed a national marketing network for cell detection and storage services, as well as a distributor-based network for in vitro diagnostic reagents, enhancing its sales capabilities[37]. - The company aims to leverage synergies between its business segments to mitigate risks associated with fluctuations in specific industries, ensuring sustainable growth[35]. - The company is expanding its cell storage offerings, including adult cell storage for immune and adipose stem cells, while maintaining its leadership in the newborn stem cell storage market[41]. - The company plans to enhance market penetration through new media marketing and e-commerce, leveraging its "life bank" resources[123]. Regulatory and Compliance - The company has not reported any non-operating fund occupation by controlling shareholders or related parties[4]. - The company has not proposed any profit distribution plan or capital reserve transfer plan for the 2018 fiscal year, pending approval at the annual shareholders' meeting[4]. - The company has commitments regarding share lock-up periods, with certain shareholders restricted from trading their shares for 36 months post-issuance[140]. - The company has a plan for share repurchase that is not applicable for cash dividends[137]. - The company has established a commitment to avoid and minimize related party transactions post-restructuring, ensuring fair operations at market prices[156]. Risks and Challenges - The company has detailed the risk factors it faces in the report, which can be found in the section discussing operational conditions[4]. - The company faces risks related to industry policies, technology, talent retention, quality management, and exchange rate fluctuations[130]. - In 2018, the national newborn birth rate dropped to 15.16 million, a 12% decrease from 17.23 million in 2017, impacting storage business negatively; however, the overall stem cell storage rate in China remains below 1%, indicating significant growth potential[41]. Shareholder Commitments - The company has committed to achieving a net profit of no less than 65 million yuan, 79 million yuan, and 96 million yuan for the years 2018, 2019, and 2020 respectively[145]. - The company guarantees that there will be no direct or indirect competition with Zhongyuan Xiehe and its subsidiaries in the future[145]. - The company will ensure compliance with all relevant regulations and will not exploit its shareholder position for undue benefits[148]. Legal and Audit Matters - The company is involved in significant litigation, including a case against Singapore Huide Investment Holdings for a land use rights dispute, with a judgment requiring repayment of 71.21 million yuan[171]. - The company has not faced any significant accounting errors or non-standard audit opinions during the reporting period[164]. - The audit fee for the company in 2018 was adjusted to 2.2 million yuan, including 500,000 yuan for internal control audit[168].

2018 年第三季度报告 公司代码：600645 公司简称：中源协和 中源协和细胞基因工程股份有限公司 2018 年第三季度报告 1 / 21 | 目录 | | --- | | 一、 | 重要提示 | 3 | | --- | --- | --- | | 二、 | 公司基本情况 | 3 | | 三、 | 重要事项 | 6 | | 四、 | 附录 | 10 | 2018 年第三季度报告 一、 重要提示 1.1 公司董事会、监事会及董事、监事、高级管理人员保证季度报告内容的真实、准确、完整， 不存在虚假记载、误导性陈述或者重大遗漏，并承担个别和连带的法律责任。 1.2 公司全体董事出席董事会审议季度报告。 1.3 公司负责人李德福、主管会计工作负责人王鹏及会计机构负责人（会计主管人员）王鹏保证 季度报告中财务报表的真实、准确、完整。 1.4 本公司第三季度报告未经审计。 二、 公司基本情况 2.1 主要财务数据 3 / 21 单位：元 币种：人民币 本报告期末 上年度末 本报告期末 比上年度末 增减(%) 调整后 调整前 总资产 4,659,152,934.87 4,376,659,493.92 2,999,979 ...

2018 年半年度报告 五、 经董事会审议的报告期利润分配预案或公积金转增股本预案 公司代码：600645 公司简称：中源协和 中源协和细胞基因工程股份有限公司 2018 年半年度报告 1 / 155 2018 年半年度报告 重要提示 一、本公司董事会、监事会及董事、监事、高级管理人员保证半年度报告内容的真实、准确、完 整，不存在虚假记载、误导性陈述或重大遗漏，并承担个别和连带的法律责任。 二、 公司全体董事出席董事会会议。 三、 本半年度报告未经审计。 四、 公司负责人李德福、主管会计工作负责人王鹏及会计机构负责人（会计主管人员）王鹏声明： 保证半年度报告中财务报告的真实、准确、完整。 无 六、 前瞻性陈述的风险声明 √适用 □不适用 本报告所涉及的未来计划等前瞻性陈述，不构成公司对投资者的实质承诺，请投资者注意投资风 险。 七、 是否存在被控股股东及其关联方非经营性占用资金情况 否 八、是否存在违反规定决策程序对外提供担保的情况？ 否 九、 重大风险提示 公司已经在本报告中详细描述了公司存在的风险因素，敬请查阅第四节"经营情况的讨论与分析" 中其他披露事项可能面对的风险。 十、 其他 □适用 √不适用 2 ...

2018 年第一季度报告 公司代码：600645 公司简称：中源协和 中源协和细胞基因工程股份有限公司 2018 年第一季度报告 1 / 20 | 一、 | 重要提示 3 | | --- | --- | | 二、 | 公司基本情况 3 | | 三、 | 重要事项 5 | | 四、 | 附录 10 | 2018 年第一季度报告 一、 重要提示 二、 公司基本情况 2.1 主要财务数据 单位：元 币种：人民币 | | 本报告期末 | 上年度末 | 本报告期末比上 年度末增减(%) | | | | --- | --- | --- | --- | --- | --- | | 总资产 | 3,032,917,089.85 | 2,999,979,976.43 | 1.10 | | | | 归属于上市公司股东的 | 1,576,278,763.77 | 1,509,015,295.94 | 4.46 | | | | 净资产 | | | | | | | | 年初至报告期末 | 上年初至上年报告期末 | 比上年同期增减 | | | | | | | (%) | | | | 经营活动产生的现金流 | -27,471,358.58 ...

Financial Performance - The company's audited net profit for 2017 was -38.14 million RMB, resulting in a cumulative undistributed profit of -209 million RMB as of December 31, 2017, leading to no profit distribution to shareholders[5]. - Operating revenue for 2017 was 870.91 million RMB, representing a 3.94% increase compared to 837.90 million RMB in 2016[21]. - The net loss attributable to shareholders for 2017 was -18.46 million RMB, a decrease of 148.76% from a profit of 37.86 million RMB in 2016[22]. - The net cash flow from operating activities was 70.27 million RMB, down 51.09% from 143.67 million RMB in 2016[22]. - Total assets as of the end of 2017 were 2.99 billion RMB, a slight decrease of 0.12% from 3.00 billion RMB in 2016[22]. - The net assets attributable to shareholders decreased by 4.96% to 1.51 billion RMB from 1.59 billion RMB in 2016[22]. - Basic earnings per share decreased by 150% compared to the previous year, from 0.10 to -0.05 RMB[23]. - The weighted average return on equity dropped by 3.64 percentage points to -1.23%[23]. - The company reported a net profit of -64.43 million RMB for 2016 and -38.14 million RMB for 2017, with cumulative undistributed profits of -209 million RMB as of December 31, 2017, resulting in no profit distribution to shareholders[112]. Business Operations - The company’s main business includes cell preparation and storage services, gene testing, and sales of in vitro diagnostic reagents[32]. - The company operates under a division + direct management model, promoting independent accounting and resource integration across business units[33]. - The company achieved operating revenue of 871 million RMB, a year-on-year increase of 3.94%[47]. - The company plans to acquire 100% equity of Shanghai Aoyuan Medical Supplies Co., enhancing industry integration and core competitiveness[43]. - The company is in the process of responding to feedback from the China Securities Regulatory Commission regarding its major asset restructuring application[44]. - The company is focusing on enhancing brand awareness through various media channels and hosting events like the "Zhongyuan Xiehe Life Medicine Award" ceremony[45]. - The company plans to expand its market presence and enhance its product offerings in the coming year[55]. - The establishment of Wuhan Guanggu Zhongyuan Co. contributed to the overall revenue growth, marking a strategic expansion[56]. Research and Development - Research and development expenses rose by 43.11% to 67.11 million RMB[50]. - The company completed 16 out of 44 stem cell research and product development projects during the reporting period[63]. - The company has established a key expert group for "Stem Cell and Translational Research" to ensure the successful implementation of national key R&D projects[88]. - The company is committed to developing a wide range of testing projects and strengthening collaborations with internationally renowned institutions to provide competitive testing services[103]. - The company will continue to push forward with research and development projects and actively pursue drug approvals in both domestic and international markets[105]. Market Trends and Strategy - The global stem cell storage market is projected to reach $18.16 billion by 2018, with a compound annual growth rate (CAGR) of 21% from 2015 to 2018[92]. - The domestic stem cell storage rate is currently below 1%, indicating significant growth potential, with an estimated market size exceeding $30 billion[93]. - The approval of the first CAR-T cell therapy, Kymriah, priced at $475,000, marks a significant milestone in the commercialization of CAR-T products[96]. - The immune cell therapy sector is recognized as a key area for development, with policies supporting its growth across multiple regions in China[90]. - The company aims to secure its leading position in the immune cell field by actively applying for CAR-T drug approvals, leveraging proprietary technology and clinical application advantages[97]. Corporate Governance and Compliance - The company has established a commitment to fair and transparent dealings in any necessary related transactions with controlling shareholders[116]. - The company has confirmed that it will not require any illegal guarantees from its controlling shareholders[116]. - The company has maintained a governance structure that complies with relevant laws and regulations, ensuring the protection of shareholder rights[189]. - The company has no recent penalties from securities regulatory agencies, indicating compliance with regulations[183]. - The board of directors consists of 9 members, including 3 independent directors, complying with legal regulations and the company's articles of association[190]. Shareholder and Equity Management - The company has not distributed any dividends in the last three years, with a net profit of -18.46 million RMB in 2017[112]. - The total number of ordinary shares decreased from 386,091,314 to 386,081,314 due to the repurchase and cancellation of 10,000 restricted shares[152]. - The number of shareholders increased from 41,885 to 44,607 during the reporting period[159]. - The company has a commitment to maintain a 30-month lock-up period for newly issued shares, ensuring stability in shareholding[165]. - The total remuneration for all directors, supervisors, and senior management during the reporting period amounted to 7.0953 million yuan[181]. Employee Management and Development - The total number of employees in the parent company and major subsidiaries is 1,981, with 931 in sales, 420 in production, and 281 in technical roles[184]. - The company has implemented a performance evaluation and compensation system for senior management, which was approved by the board of directors[181]. - A training program has been established to improve employee skills, including a special training project for mid-to-senior management called the "Blackstone Plan"[186]. - The company is focusing on enhancing its compensation and benefits system to attract and retain talent, particularly for core business personnel[185]. Financial Management and Investments - The company has made a significant equity investment of ¥12,834.40 million (100%) in Concord East China Stem Cell Gene Engineering Co., Ltd. for a 20-year term[75]. - The company holds a total of 172 authorized patents, ensuring its competitive edge in research and clinical transformation[40]. - The company has received approval for 172 patents, with 17 new patents granted in 2017[45]. - The company has implemented an employee stock ownership plan, purchasing 2,540,100 shares for a total of RMB 87,002,663.34, with an average price of approximately RMB 34.25 per share[127]. - The total investment amount during the reporting period was 263.14 million, reflecting a decrease of 37.38% compared to the previous year[74].