Core Viewpoint - The article discusses the performance and holdings of the Industrial and Commercial Bank of China Medical Healthcare Stock Fund, highlighting its recent net value, returns, and top holdings [1]. Fund Performance - The latest net value of the ICBC Medical Healthcare Stock Fund is 2.5580 yuan, reflecting a decrease of 1.16% - The fund's return over the past month is 3.52%, ranking 172 out of 940 in its category - Over the last six months, the return is 9.79%, with a ranking of 202 out of 914 - Year-to-date, the return stands at 12.24%, ranking 98 out of 926 [1]. Fund Holdings - The top ten holdings of the ICBC Medical Healthcare Stock Fund account for a total of 39.79%, with the following key positions: - Heng Rui Medicine: 8.90% - WuXi AppTec: 5.12% - Aier Eye Hospital: 4.94% - BeiGene: 3.77% - Zai Lab: 3.52% - New Horizon Health: 3.27% - Mindray Medical: 2.80% - Yuwell Medical: 2.76% - United Imaging Healthcare: 2.47% - Innovent Biologics: 2.24% [1]. Fund Management - The ICBC Medical Healthcare Stock Fund was established on November 18, 2014, and as of March 31, 2025, it has a total scale of 2.724 billion yuan - The fund is managed by Zhao Bei and Ding Yang, both of whom have extensive experience in the healthcare sector [1][2].

Core Viewpoint - The approval of the injection drug Velaglucerase beta (brand name: Gorynin) by the National Medical Products Administration (NMPA) marks a significant milestone as it is the first domestically developed enzyme replacement therapy for Gaucher disease in China, targeting adolescents and adults aged 12 and above with Type I and III Gaucher disease [1][2]. Group 1: Product Approval and Significance - Velaglucerase beta is the only locally developed enzyme replacement therapy for Gaucher disease in China, making it a unique addition to the treatment options available [1]. - The drug is noted for having the broadest range of indications among Gaucher disease treatments currently available [1]. Group 2: Disease Background and Treatment - Gaucher disease is a rare genetic lysosomal storage disorder, with clinical manifestations including hepatosplenomegaly, anemia, bone pain, and neurological complications, potentially leading to life-threatening conditions [2]. - The global prevalence of Gaucher disease is estimated at 0.7 to 1.75 cases per 100,000 people [2]. - Enzyme replacement therapy (ERT) has been the standard treatment for Gaucher disease for 30 years, showing significant efficacy in improving non-neurological symptoms and enhancing the quality of life for patients [2]. Group 3: Development and Technology - The development of Gorynin was facilitated by collaborative efforts with partners like WuXi Biologics, which helped reduce development costs and ensure the drug is safe and effective for patients [2]. - The drug's development utilized second-generation innovative technology, resulting in over a 110-fold increase in production yield and more than a 50% enhancement in enzyme activity, significantly lowering production costs [2]. - WuXi Biologics also developed a cell-based activity assay for quality control, addressing the unique challenges of testing enzyme-based drugs [2].

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeiGene, Ltd. 百濟神州有限公司 （於開曼群島註冊成立的有限公司） （股份代號：06160） 授出購股權及受限制股份單位 本公告乃根據上市規則第17.06A、17.06B以及17.06C條作出。於2025年5月21 日，董事會根據2016期權及激勵計劃的條款向九名獨立非執行董事授出可認購合 共15,750股美國存託股份的購股權及合共7,605股美國存託股份的受限制股份單 位。 2016期權及激勵計劃項下的購股權 於2025年5月21日，董事會授權根據2016期權及激勵計劃的條款向九名獨立非執 行董事授出可認購合共15,750股美國存託股份的購股權。 授出購股權詳情 購股權詳情如下： 1 授出日期： 2025年5月21日 已授出購股權涉及的 相關股份數目： 204,750 購股權總數（美國存託股份）: 15,750 因已授出購股權獲行使而 可予認購的新美國存託 股份總數： 15,750 授出的代 ...

Core Viewpoint - The article discusses the promising results of Mazdutide, a dual agonist of GLP-1 and GCG receptors, in weight management and its potential impact on obesity treatment guidelines globally [2][3]. Group 1: Drug Mechanism and Development - Mazdutide activates GLP-1 receptors to suppress appetite and delay gastric emptying, while also activating GCG receptors to promote liver fat breakdown and enhance energy expenditure, addressing both weight loss and fatty liver issues [2]. - The clinical trial results of Mazdutide were published in the prestigious New England Journal of Medicine, marking a significant milestone for Chinese drug development in the field of metabolic and endocrine diseases [3][6]. Group 2: Clinical Trial Results - In a Phase 3, double-blind, placebo-controlled trial involving 610 participants, the average weight loss at 32 weeks for the 6 mg group was 12.55% (approximately 11 kg), and at 48 weeks, it was 14.01% (approximately 12 kg) [6][9]. - The trial showed that 49.5% of participants in the 6 mg group lost over 15% of their body weight, indicating significant efficacy in weight management [9]. Group 3: Safety and Side Effects - The most commonly reported adverse events were gastrointestinal-related, primarily mild to moderate, with a low incidence of treatment discontinuation due to side effects: 0.5% in the 6 mg group compared to higher rates in similar drugs [8][9]. - The study confirmed the high safety profile of Mazdutide, with side effects concentrated in the initial treatment phase [8].

Core Viewpoint - The recent developments in the innovative drug sector, particularly the record-breaking licensing deal and the upcoming ASCO conference, highlight the growing competitiveness and potential of Chinese pharmaceutical companies in the global market [4][5]. Group 1: Market Performance - The Hong Kong Innovative Drug ETF (159570) opened high but closed lower, experiencing a 1% pullback after four days of gains last week, with trading volume reaching 300 million, indicating strong liquidity [1]. - Major component stocks of the ETF mostly declined, with notable drops including a more than 4% decrease for 3SBio and over 3% for both WuXi AppTec and Rongchang Biopharmaceutical [2]. Group 2: Licensing Deal - A historic licensing agreement was reached where Pfizer will pay a $1.25 billion upfront fee to Chinese companies for the PD-1/VEGF dual antibody SSGJ-707, with potential total payments reaching $4.8 billion [4]. - This deal sets a new record for Chinese innovative drugs entering the international market and is expected to enhance market valuation expectations for the innovative drug sector [4]. Group 3: ASCO Conference Insights - The upcoming ASCO conference is anticipated to showcase the global competitiveness of Chinese pharmaceutical companies, with numerous clinical studies being presented [5]. - Key highlights include the performance of domestic drugs that have shown potential to outperform established treatments, such as the combination of Bemarituzumab and Anlotinib against Keytruda in NSCLC [5]. - CAR-T therapies are also making significant strides, with Kintor Pharmaceuticals presenting promising data for their CLDN18.2 CAR-T therapy [5]. Group 4: Innovative Drug ETF Characteristics - The Hong Kong Innovative Drug ETF (159570) has a high concentration in innovative drugs, with over 85% of its weight in this category, making it the highest among all pharmaceutical indices [6]. - The ETF features a low valuation, with a five-year price-to-sales ratio at the 48.5th percentile, indicating potential undervaluation in the innovative drug sector [6].

Investment Rating - The report indicates a positive investment outlook for the pharmaceutical and biotechnology industry, particularly focusing on innovative drugs and their potential in the market [1]. Core Insights - The report highlights the significant achievements of domestic innovative drugs showcased at the upcoming ASCO 2025 conference, emphasizing the growing innovation capabilities of Chinese pharmaceutical companies [6][7]. - A strategic collaboration between 3SBio and Pfizer regarding the PD-1/VEGF dual antibody has been established, which includes a global licensing agreement with potential payments up to $4.8 billion based on development milestones and sales performance [2][6]. - Three domestic Class 1 innovative drugs have been approved for market launch, targeting prevalent diseases such as influenza, cancer, and diabetes, marking a critical step in the innovation and internationalization of domestic original drugs [2][6]. Market Performance Review - During the period from May 17 to May 24, the Shanghai Composite Index closed at 3348.37, down 0.57%, while the pharmaceutical industry index rose by 1.78%, ranking first among 31 primary industry indices [1][12]. - The weekly performance of various sectors within the pharmaceutical industry showed positive growth, with notable increases in chemical preparations (3.49%), biological products (1.74%), and medical services (1.42%) [1][12]. Upcoming Events - The ASCO annual meeting, a major international conference in oncology, is scheduled to take place from May 30 to June 3, 2025, in Chicago, where numerous innovative research results from domestic companies are expected to be presented [6][7]. Key Companies to Watch - The report suggests focusing on companies with strong innovation capabilities, including Heng Rui Medicine, Innovent Biologics, BeiGene, and 3SBio, as they are expected to showcase significant advancements at ASCO 2025 [7][19]. - It also recommends monitoring companies involved in high-end medical devices and those benefiting from market concentration in chain pharmacies and comprehensive medical services [8][19].

证券研究报告 | 金融工程 2025 年 05 月 24 日 刚需+出海+历史低位，多重因素凸显制药价值 ——华宝中证制药 ETF 投资价值分析 随着保健意识的提升及国内人口老龄化趋势的发展，药品作为人们生活中的刚 性需求，其市场需求量日益增长。从供给端来看，原研药专利集中到期，创新 药频获出海订单，中药受政策大力扶持，各细分领域药企均迎来发展机遇。时 逢相关标的位于历史的价格低位，药品制造业显示出一定的投资机会。华宝中 证制药 ETF（认购代码：562053.OF）通过紧密跟踪中证制药指数，一键式配 置制药行业优质上市企业，值得投资者关注。 任瞳 S1090519080004 rentong@cmschina.com.cn ❑ 风险提示：本报告仅作为投资参考，基金产品过往业绩并不预示其未来表 现，亦不构成投资收益的保证或投资建议，新发基金无历史业绩可参考。 敬请阅读末页的重要说明 专题报告 ❑ 在新兴市场经济快速发展和各国医疗保障制度的逐渐完整之下，全球医药 市场规模仍旧维持着稳定增长态势。而据统计，我国的人均药品用量仍远 低于世界发达国家水平，国内药品用量的需求增长仍然具有较大的空间。 ❑ 在供给端，各细 ...

2025.05. 24 本文字数：2099，阅读时长大约3分钟 Wind数据显示，在已经披露2024年年报的药企中，高管年薪在千万以上绝非个例。在俞德超之前， 还有多家药企的高管薪酬过亿。 作者 | 第一财经 陈敏之 近日，理想汽车（02015.HK/LI.US）创始人、董事长兼CEO李想2024年领取6.39亿元"天价年薪"冲 上热搜引发热议。 事实上，创新药企业里，也不乏上亿年薪的创始人和CEO，但有所不同的是，这些创新药公司多数 还没有走完商业化历程，公司处于连年亏损状态。比如刚刚敲钟上市的映恩生物（9606.HK），创 始人朱忠远去年薪酬8556万元，公司同期亏损超过10亿元。近期三次递表港交所的英矽智能，执行 董事任峰2024年薪酬总计307.3万美元，公司当年净亏损1709.6万美元。 这样例子在创新药企业里比比皆是。Wind数据显示，思路迪医药股份（1244.HK）董事长龚兆龙 2024年的薪酬为2067万元，六年的薪酬总额则超过5亿元，而公司六年亏损超40亿元。 高薪背后，是创新药行业整体尚未步出资本寒冬。高管的收入与公司业绩形成的强烈反差，引发市场 对行业价值导向的深度思考。 年薪千万比比皆 ...

Group 1 - The article highlights the stark contrast between high executive salaries and the financial performance of companies in the innovative drug sector, where many firms are still unprofitable [2][10][11] - Li Xiang, the founder and CEO of Li Auto, received a salary of 639 million RMB in 2024, sparking discussions about excessive executive compensation in the context of ongoing company losses [2][3] - Companies like InnoCare Pharma and Sihuan Pharmaceutical have reported significant executive salaries while simultaneously posting substantial losses, raising questions about the sustainability of such compensation structures [5][10] Group 2 - The article provides examples of high executive salaries in the innovative drug industry, including Zhu Zhongyuan of InnoCare Pharma with a salary of 85.56 million RMB in 2024, despite the company losing over 1 billion RMB [3][10] - Other notable salaries include Yu Dechao of Innovent Biologics, who earned approximately 136 million RMB, and Gong Zhaolong of Sihuan Pharmaceutical, whose total compensation exceeded 500 million RMB over six years [5][10] - The trend of high salaries persists even among companies that have not yet commercialized their products, such as Yingxi Intelligent and Weili Zhibo, which have reported significant losses [11]

Group 1 - The core viewpoint of the news is the performance and holdings of the Wanjiay Economic New Momentum Mixed C Fund, which has shown a decline in recent value but positive returns over longer periods [1] - As of May 23, 2025, the latest net value of the fund is 1.6007 yuan, reflecting a decrease of 1.79% [1] - The fund's one-month return is -4.46%, ranking 4362 out of 4480 in its category, while its six-month return is 22.90%, ranking 161 out of 4322, and its year-to-date return is 28.00%, ranking 90 out of 4372 [1] Group 2 - The top ten stock holdings of the Wanjiay Economic New Momentum Mixed C Fund account for a total of 75.95%, with significant positions in companies such as Ruixin Micro (9.12%), BeiGene-U (8.80%), and Deepin Technology (8.64%) [1] - The fund was established on February 7, 2018, and as of March 31, 2025, it has a total scale of 1.223 billion yuan [1] - The fund manager, Huang Xingliang, has a strong academic background with a Ph.D. from Tsinghua University and extensive experience in the investment management industry [2]