Group 1 - The core point of the news is that TEBIO conducted a block trade on October 14, with a transaction volume of 46,500 shares and a total transaction amount of 3.76 million yuan, at a price of 80.92 yuan per share [1][2] - The buyer of the block trade was Guotai Junan Securities Co., Ltd. headquarters, while the seller was GF Securities Co., Ltd. Xiamen Hubin South Road Securities Business Department [1][2] - In the last three months, TEBIO has had a total of 11 block trades, with a cumulative transaction amount of 80.79 million yuan [1][2] Group 2 - As of October 14, TEBIO's closing price was 80.92 yuan, reflecting a decrease of 3.54%, with a daily turnover rate of 0.83% and a total trading volume of 276 million yuan [1][2] - The net inflow of main funds for the day was 4.21 million yuan, and over the past five days, the stock has seen a cumulative decline of 3.41% with a total net inflow of 1.33 million yuan [1][2] - The latest margin financing balance for TEBIO is 1.477 billion yuan, which has increased by 5.19 million yuan over the past five days, representing a growth of 0.35% [2]

10月14日，特宝生物大宗交易成交4.65万股，成交额376.04万元，占当日总成交额的1.35%，成交价 80.92元，较市场收盘价80.92元持平。 ...

Investment Rating - The industry investment rating is "Overweight (Maintain)" [1] Core Viewpoints - The report highlights significant advancements in the hepatitis B treatment sector, with innovative drugs like GST-HG131 and Peginterferon being recognized for their clinical efficacy and market potential [6][4] - The global hepatitis B infection rate is concerning, with 254 million chronic infections reported in 2022, indicating a substantial market opportunity for effective treatments [4] - The Chinese government's action plan aims to enhance diagnosis and treatment rates for hepatitis B, which is expected to further drive market growth [5] Summary by Sections Industry Overview - The pharmaceutical and biotechnology industry is currently focused on hepatitis B treatments, with a notable increase in research and development efforts [1][6] Recent Developments - Guangsheng Tang's innovative drug GST-HG131 has been accepted for presentation at the American Association for the Study of Liver Diseases, marking a significant recognition in the field [3][4] - The approval of new indications for Peginterferon by TEBIO enhances its competitive position in the market [3][6] Market Potential - The report emphasizes the vast market potential for hepatitis B treatments, with current diagnosis and treatment rates in China at only 22% and 15% respectively, suggesting significant room for improvement [4][5] - The government's action plan sets ambitious targets for reducing hepatitis B prevalence and increasing treatment rates by 2030, which could lead to a more favorable market environment for pharmaceutical companies [5]

Core Viewpoint - The stock of TEBIO experienced a decline of 2.00% on October 14, with a current price of 82.21 CNY per share and a market capitalization of 33.443 billion CNY. The company has seen a year-to-date stock price increase of 13.00% but has faced a slight decline in the recent trading periods [1]. Financial Performance - For the first half of 2025, TEBIO reported a revenue of 1.511 billion CNY, representing a year-on-year growth of 26.96%. The net profit attributable to shareholders was 428 million CNY, showing a year-on-year increase of 40.60% [2]. - Since its A-share listing, TEBIO has distributed a total of 577 million CNY in dividends, with 506 million CNY distributed over the past three years [3]. Shareholder and Market Activity - As of June 30, 2025, TEBIO had 8,439 shareholders, an increase of 13.00% from the previous period. The average number of circulating shares per shareholder decreased by 11.51% to 48,204 shares [2]. - The major shareholders include ETFs such as 华夏上证科创板50成份ETF and 易方达上证科创板50ETF, which have increased their holdings [3]. Company Overview - TEBIO, established on August 7, 1996, and listed on January 17, 2020, is based in Xiamen, Fujian Province. The company specializes in the research, production, and sales of recombinant proteins and long-acting modified drugs, with a revenue composition of 86.85% from antiviral drugs and 12.87% from blood/cancer drugs [1]. - The company operates within the pharmaceutical and biotechnology sector, specifically in the biopharmaceuticals category [1].

每经AI快讯，10月13日，特宝生物(688278.SZ)公告，公司产品派格宾联合核苷(酸)类似物用于成人慢性 乙型肝炎患者HBsAg持续清除的增加适应症已获国家药监局批准。此次获批基于临床试验结果，显示 31.4%患者在停药24周后实现HBsAg转阴且HBVDNA持续抑制。该适应症拓展显著提升派格宾市场潜 力，强化其在慢乙肝临床治愈领域的地位。 ...

受理号：CXSS2400023、CXSS2400024、CXSS2400025、CXSS2400026 证书编号：2025S03097、2025S03098、2025S03099、2025S03100 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或者重大遗漏，并对其内容的 真实性、准确性和完整性依法承担法律责任。 近日，厦门特宝生物工程股份有限公司（以下简称"公司"）收到国家药品监督管理局核准签发的《药品 注册证书》，公司产品派格宾联合核苷（酸）类似物用于成人慢性乙型肝炎患者的HBsAg持续清除的增 加适应症（以下简称"增加适应症"）上市许可申请获得批准。现将有关情况公告如下： 一、药品基本情况 药品名称：派格宾? 通用名称：聚乙二醇干扰素α-2b注射液 申请事项：药品注册（境内生产） 我国2022版《慢性乙型肝炎防治指南》中指出："对于部分适合条件的患者，应追求临床治愈（又称功 能性治愈）"，即停止所有治疗药物6个月或更长时间HBsAg持续清除伴HBV DNA持续抑制。HBsAg持 续清除是一个重要的临床治疗目标，目前被认为是获得HBV功能性治愈的标志。本次派格宾获批增加 适应症是基于一 ...

证券代码：688278 证券简称：特宝生物 公告编号：2025-038 厦门特宝生物工程股份有限公司 上市许可持有人：厦门特宝生物工程股份有限公司 审批结论：根据《中华人民共和国药品管理法》及有关规定，经审查，本品符合药品注册的有关要求， 批准增加适应症，具体为："本品联合核苷（酸）类似物用于成人慢性乙型肝炎患者的HBsAg持续清 除。适用于以下患者：核苷（酸）经治、HBsAg 1500 IU/mL以下、持续病毒学抑制、HBeAg阴性或 HBeAg 10 COI以下的慢性乙型肝炎患者"。 关于派格宾增加适应症上市许可申请获得批准的公告 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或者重大遗漏，并对其内容的 真实性、准确性和完整性依法承担法律责任。 近日，厦门特宝生物工程股份有限公司（以下简称"公司"）收到国家药品监督管理局核准签发的《药品 注册证书》，公司产品派格宾联合核苷（酸）类似物用于成人慢性乙型肝炎患者的HBsAg持续清除的增 加适应症（以下简称"增加适应症"）上市许可申请获得批准。现将有关情况公告如下： 一、药品基本情况 药品名称：派格宾? 通用名称：聚乙二醇干扰素α-2b注射液 ...

派格宾是公司目前的核心产品，是公司自主研发的全球首个40kD聚乙二醇长效干扰素α-2b注射液，是 治疗用生物制品国家1类新药，是我国第一个国产上市的聚乙二醇(PEG)修饰干扰素品种。派格宾于 2016年10月获批上市，获批适应症为治疗成人慢性丙型肝炎;2017年9月获批成人慢性乙型肝炎适应症。 特宝生物(688278.SH)发布公告，近日，公司收到国家药品监督管理局核准签发的《药品注册证书》， 公司产品派格宾联合核苷(酸)类似物用于成人慢性乙型肝炎患者的HBsAg持续清除的增加适应症(简 称"增加适应症")上市许可申请获得批准。 ...

智通财经APP讯，特宝生物(688278.SH)发布公告，近日，公司收到国家药品监督管理局核准签发的 《药品注册证书》，公司产品派格宾联合核苷(酸)类似物用于成人慢性乙型肝炎患者的HBsAg持续清除 的增加适应症(简称"增加适应症")上市许可申请获得批准。 派格宾是公司目前的核心产品，是公司自主研发的全球首个40kD聚乙二醇长效干扰素α-2b注射液，是 治疗用生物制品国家1类新药，是我国第一个国产上市的聚乙二醇(PEG)修饰干扰素品种。派格宾于 2016年10月获批上市，获批适应症为治疗成人慢性丙型肝炎;2017年9月获批成人慢性乙型肝炎适应症。 ...

北京商报讯（记者 丁宁）10月12日晚间，特宝生物（688278）发布公告称，公司收到国家药品监督管 理局核准签发的《药品注册证书》，公司产品派格宾联合核苷（酸）类似物用于成人慢性乙型肝炎患者 的HBsAg持续清除的增加适应症上市许可申请获得批准。 公告显示，派格宾是公司目前的核心产品，是公司自主研发的全球首个40kD聚乙二醇长效干扰素α-2b 注射液，是治疗用生物制品国家1类新药，是我国第一个国产上市的聚乙二醇（PEG）修饰干扰素品 种。派格宾于2016年10月获批上市，获批适应症为治疗成人慢性丙型肝炎；2017年9月获批成人慢性乙 型肝炎适应症。 ...