Group 1 - The Shanghai Stock Exchange has released the "Self-Regulatory Supervision Guidelines for Companies Listed on the Sci-Tech Innovation Board No. 5 - Sci-Tech Growth Tier" [1] - The reform does not impose additional listing thresholds for unprofitable companies entering the Sci-Tech Growth Tier, allowing 32 existing unprofitable companies to enter immediately upon the guideline's implementation [1] - Newly registered unprofitable companies will enter the Sci-Tech Growth Tier from the date of their listing [1] Group 2 - Investors participating in the subscription and trading of newly registered stocks in the Sci-Tech Growth Tier must sign a "Risk Disclosure Statement for the Sci-Tech Growth Tier" [2] - The 32 existing companies that have not yet removed the "U" designation include: Zejing Pharmaceutical, Junshi Biosciences, Frontier Biotech, Qingyun Technology, Hehui Optoelectronics, Jingjin Electric, BeiGene, Dize Pharmaceutical, Maiwei Biotech, Aojie Technology, Yuhong Pharmaceutical, Shouyao Holdings, Haichuang Pharmaceutical, CloudWalk Technology, Yifang Biotech, Obsidian Optics, Mengke Pharmaceutical, Nuo Cheng Jianhua, Xinke Mobile, Xinghuan Technology, Yutai Micro, Yuntian Lifa, Tianzhihang, Qi Anxin, Hanwujin, Yihua Tong, Aifute, Huizhiwei, Xinlian Integrated, Zhixiang Jintai, Shengke Communication, and Zhongjuxin [2]

Group 1 - The core viewpoint highlights the significant growth and performance of the Kexin Pharmaceutical ETF managed by Jiashi, with a notable increase in trading volume and fund size [2] - As of July 9, the Kexin Pharmaceutical ETF achieved a daily average trading volume of 34.95 million yuan over the past month, ranking first among comparable funds [2] - The fund's size increased by 16.76 million yuan in the past two weeks, also ranking first among comparable funds [2] - The ETF saw a total inflow of 12.84 million yuan over the last ten trading days, indicating strong investor interest [2] - The net value of the Kexin Pharmaceutical ETF rose by 36.83% over the past year, showcasing its strong performance [2] Group 2 - The top ten weighted stocks in the Shanghai Stock Exchange Science and Technology Innovation Board Biopharmaceutical Index account for 50.3% of the index, with leading companies including United Imaging Healthcare and BeiGene [2][4] - On July 9, Shanghai Pharmaceuticals announced an expected net profit of 4.45 billion yuan for the first half of 2025, representing a year-on-year increase of approximately 52% [4] Group 3 - Short-term market expectations for overseas transactions in innovative drugs are high, leading to a continuous rise in valuations [5] - China's innovative drug research and development capabilities are competitive globally, and the trend of innovative drugs going overseas is expected to persist [5] - The commercial health insurance sector in China is anticipated to see significant growth in premium income and payout rates, becoming an important source of funding for innovative drugs [5]

Group 1 - Shengde Xintai won a bid for a thermal power steel pipe project worth approximately 217 million yuan, accounting for 8.15% of its audited revenue for 2024 [1] - High-speed Electric's subsidiary won a project for the Shanghai-Nanjing-Hefei high-speed railway, with a bid amount of 71.76 million yuan [1] - Cangge Mining's subsidiary received a construction permit for a lithium-boron mining project, with a construction area of 106,900 square meters [2] Group 2 - China Electric Power Construction signed a mining transportation project contract in Guinea worth approximately 5.063 billion yuan, with a total duration of about 72 months [3] - Guobang Pharmaceutical's subsidiary completed the registration of an equity investment fund focusing on strategic emerging industries [4] - Deshi Co. obtained two invention patents related to oil and gas field development [5][26] Group 3 - Xue Tian Salt Industry expects a significant decrease in net profit for the first half of 2025, projecting a decline of 76.34% to 80.29% [6] - Rundu Co. received a drug registration certificate for moxifloxacin hydrochloride tablets, used for treating various bacterial infections [7] - China Nuclear Power reported a 15.65% increase in power generation in the first half of the year, with nuclear power generation up by 12.01% [8] Group 4 - Suqian Liansheng obtained two invention patents related to wastewater treatment methods [9] - Boshi Co. signed a 109 million yuan operation and maintenance service contract for solid product packaging [11] - *ST Sailong's subsidiary received a drug registration certificate for torasemide injection, used for various medical conditions [13] Group 5 - North Bay Port reported a 10.95% increase in cargo throughput for the first half of 2025, with container throughput also showing growth [14] - Kaiwei Te expects a revenue increase of 56.17% to 90.87% for the first half of 2025 [15] - Wankai New Materials plans to reduce production and conduct maintenance on 60,000 tons of PET capacity, affecting overall performance [16] Group 6 - Haiwang Bio's HW130 injection successfully completed Phase I clinical trials, showing good safety and tolerability [19] - Zhenai Meijia received a total of 22.8 million yuan in compensation for land acquisition, which will significantly impact its 2025 performance [20] - Changyuan Electric reported a 23.58% decrease in power generation in June, with a notable decline in thermal power generation [21] Group 7 - Shouxiangu's subsidiary completed the registration of two health food products [22] - Kailun Co. announced the resignation of its deputy general manager and board secretary [23] - Xibu Muye reported a 2.15% year-on-year increase in fresh milk production in June [24] Group 8 - Deshi Co. obtained two invention patents related to oil and gas field development [26] - Jingwei Huikai plans to acquire a 12.44% stake in Nuo Si Micro for 149 million yuan [27] - Electric Alloy completed the registration of its subsidiary in Mexico [29] Group 9 - Meinuohua expects a net profit increase of 142.84% to 174.52% for the first half of 2025 [30] - Guizhou Moutai repurchased approximately 3.38 million shares, accounting for 0.2692% of its total share capital [31][32] - Warner Pharmaceutical received approval for the listing application of a raw material drug for treating respiratory diseases [34] Group 10 - Yuan Dong Bio's independent director is under investigation for serious violations [35] - Dash Intelligent signed a contract for a smart project worth 11.88 million yuan [36] - Dayou Energy plans to transfer 586,500 tons of coal production capacity replacement indicators [37] Group 11 - Foton Motor reported a 150.96% increase in new energy vehicle sales in the first half of 2025 [39] - Renfu Pharmaceutical's shareholder plans to increase its stake by 1% to 2% [40] - Zongshen Power expects a net profit increase of 70% to 100% for the first half of 2025 [42] Group 12 - Yingboer plans to sell its wholly-owned subsidiary for 239 million yuan [44] - Changan Automobile reported a 1.59% increase in total vehicle sales in the first half of 2025 [46] - Fulian Precision signed a cooperation framework agreement with Sichuan Development Longmang [48] Group 13 - Nengte Technology plans to repurchase shares worth 300 million to 500 million yuan [50] - Longsoft Technology's controlling shareholder donated 3.43% of the company's shares [51] - Data Port's shareholders plan to reduce their holdings by up to 2% [52]

Group 1 - Guizhou Moutai has repurchased a total of 3.3821 million shares as of June 30, 2025, accounting for 0.2692% of the total share capital, with a total expenditure of 5.202 billion yuan [2] - Luxshare Precision is planning to issue H-shares and list on the Hong Kong Stock Exchange to enhance its global financing capabilities and governance transparency [2] - Huazhong Xinchuang has received a project notification from a leading domestic eVTOL manufacturer for the development and supply of an intelligent cockpit multimedia display system [3] Group 2 - Meinohua expects a net profit of 46 million to 52 million yuan for the first half of 2025, representing a year-on-year increase of 142.84% to 174.52% [4] - Jiangnan Water has received a report from shareholder Lianan Life Insurance indicating an increase in shareholding by 46.99 million shares, representing 5.03% of the total share capital [5] - Huasen Pharmaceutical has received approval for clinical trials of its CX001 sustained-release tablets, marking a milestone for its innovative drug development platform [6] Group 3 - Zongshen Power anticipates a net profit growth of 70% to 100% for the first half of the year [7] - Yutong Bus reported a sales volume of 5,919 units in June, a year-on-year increase of 24.79% [7] - Guangzhou Port expects a 7.0% year-on-year increase in container throughput for June 2025 [7] Group 4 - Data Port's shareholders plan to reduce their holdings by up to 1.74% and 0.26% of the company's shares [9] - Humanwell Healthcare's shareholder plans to increase its stake by 1% to 2% [9] - Nengte Technology plans to repurchase shares worth between 300 million to 500 million yuan [10]

证券代码：688443 证券简称：智翔金泰 公告编号：2025-028 药品名称：GR1803 注射液 申请事项：境内生产药品注册临床试验 申请人：重庆智翔金泰生物制药股份有限公司 受理号：CXSL2500325 适应症：复发/难治性多发性骨髓瘤成人患者 审批结论：根据《中华人民共和国药品管理法》及有关规定，经审查，GR1803 注射液临床试验申请符合药品注册的有关要求，同意本品开展联合抗 CD38 单克 隆抗体在复发/难治性多发性骨髓瘤成人患者的临床试验。 二、药品其他相关情况 重庆智翔金泰生物制药股份有限公司 自愿披露关于GR1803注射液联合抗CD38单克隆抗体 治疗复发/难治性多发性骨髓瘤成人患者适应症获得 药物临床试验批准通知书的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 近日，重庆智翔金泰生物制药股份有限公司（以下简称"公司"）收到国家 药品监督管理局核准签发的《药物临床试验批准通知书》，公司在研产品 GR1803 注射液联合抗 CD38 单克隆抗体在复发/难治性多发性骨髓瘤成人患者中开展临 床试验的临床 ...

证券代码：688443 证券简称：智翔金泰 公告编号：2025-027 重庆智翔金泰生物制药股份有限公司 本次回购股份符合法律法规的规定及公司回购股份方案。 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： | 回购方案首次披露日 | 2024/10/16 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 回购方案实施期限 | 2024 年 15 日~2025 10 | 10 | 月 | 年 | 月 | 14 | 日 | | 预计回购金额 | 2,000万元~4,000万元 | | | | | | | | 回购用途 | □减少注册资本 √用于员工持股计划或股权激励 □用于转换公司可转债 | | | | | | | | | □为维护公司价值及股东权益 | | | | | | | | 累计已回购股数 | 796,100股 | | | | | | | | 累计已回购股数占总股本比例 | 0.2171% | | | | | | | | 累计 ...

Investment Rating - The report maintains a "Buy" rating for the company [5] Core Insights - The company has successfully entered the global market with its product GR1803 through a licensing agreement with Cullinan Therapeutics, which includes a total milestone payment of up to $712 million [1] - The company is rapidly expanding its domestic and international business lines, with significant clinical trial progress and new drug applications [2] - The leading product, Celeric monoclonal antibody, is expected to launch in August 2024 and participate in medical insurance negotiations in 2025 [2] Financial Projections - Revenue projections for 2025-2027 are estimated at 206 million, 500 million, and 1.078 billion yuan respectively, with net losses expected to decrease from 622 million to 275 million yuan over the same period [2][4] - The company anticipates a significant year-on-year revenue growth rate of 2,384.1% in 2024 and 584.5% in 2025 [4] - The latest diluted EPS is projected to improve from -2.19 yuan in 2023 to -0.75 yuan in 2027 [4] Business Development - The company has submitted a new drug application for GR2001, which has reached the primary efficacy endpoint in its Phase III clinical trial for tetanus passive immunity [2] - The collaboration with Cullinan Therapeutics focuses on the CD3/BCMA target, indicating a strategic enhancement in the company's autoimmune TCE dual antibody layout [1]

智翔金泰首次公开发行股票募集资金总额347,283.84万元；扣除发行费用后，募集资金净额为329,140.14 万元。智翔金泰实际募资净额比原拟募集资金金额少68,859.86万元。智翔金泰于2023年6月15日披露的 招股说明书显示，该公司拟募集资金398,000.00万元，用于抗体产业化基地项目一期改扩建、抗体产业 化基地项目二期、抗体药物研发项目、补充流动资金。 智翔金泰首次公开发行股票的发行费用合计18,143.70万元(不含税)，其中，保荐承销费16,495.98万元。 2020年至2024年，公司营业收入分别为108.77万元、3,919.02万元、47.52万元、121.15万元、3,009.50万 元，归属于上市公司股东的净利润分别为-37,261.56万元、-32,213.27万元、-57,636.57万元、-80,131.93 万元、-79,727.36万元，归属于上市公司股东的扣除非经常性损益的净利润分别为-14,155.53万 元、-33,387.33万元、-64,536.25万元、-81,292.85万元、-80,432.96万元，经营活动产生的现金流量净额 分别为-14,039. ...

Core Viewpoint - The company has made significant changes in its fundamentals since its listing two years ago, highlighted by a licensing agreement with Cullinan Therapeutics for the GR1803 dual antibody, which could yield over $712 million in total payments and revenue sharing [1][2][3]. Group 1: Licensing Agreement and Financial Implications - The licensing agreement with Cullinan Therapeutics grants them global rights for GR1803 outside of China, while the company retains rights within China [2][3]. - The agreement includes an upfront payment of $20 million and potential milestone payments of up to $692 million, along with revenue sharing, totaling over $712 million [1][3]. - The GR1803 injection is currently in Phase II clinical trials and is aimed at treating relapsed/refractory multiple myeloma, with promising early clinical data showing an overall response rate of 85% [3]. Group 2: Product Commercialization and Market Challenges - The company’s first commercialized product, Selecitinib (IL-17A monoclonal antibody), achieved sales of 30 million yuan after receiving approval for psoriasis treatment, but missed the opportunity for insurance reimbursement negotiations [1][6]. - The company reported a significant revenue increase of 2384.1% year-on-year, reaching 30.09 million yuan, but still faced a net loss of 797 million yuan [6]. - The company is actively working to negotiate for Selecitinib's inclusion in the insurance reimbursement list to enhance market penetration and sales volume [6][7]. Group 3: Future Strategies and Market Environment - The company plans to adopt a dual strategy for future growth, utilizing a sales outsourcing model domestically while pursuing early licensing agreements internationally [4]. - The innovative drug market is experiencing favorable conditions, with a surge in business development activities, as evidenced by a total of $45.5 billion in domestic innovative drug business development in the first five months of 2025 [4][7]. - The company anticipates that profitability may not be achieved until 2027, despite plans for two additional product launches in the future [7].

北京市万商天勤律师事务所 关于重庆智翔金泰生物制药股份有限公司 2024 年年度股东大会的 法律意见书 1 北京市万商天勤律师事务所 关于重庆智翔金泰生物制药股份有限公司 2024 年年度股东大会的 法律意见书 致：重庆智翔金泰生物制药股份有限公司 北京市万商天勤律师事务所（以下简称"本所"）接受重庆智翔金泰生物制 药股份有限公司（以下简称"公司"）的委托，指派律师出席了公司召开的2024 年年度股东大会。根据《中华人民共和国公司法》、《中华人民共和国证券法》、 《上市公司股东会规则》（下称"《股东会规则》"）等法律、法规和规范性文件 以及《重庆智翔金泰生物制药股份有限公司章程》（下称"《公司章程》"）的要 求，就公司 2024 年年度股东大会（下称"本次股东大会"）的相关事宜出具本 法律意见书。 公司已向本所律师提供了本所律师认为出具本法律意见书必要的文件资料， 本所律师对该等文件和资料进行了核查、验证，并据此出具法律意见。 本所律师仅就本次股东大会的召集、召开程序、出席会议人员资格、召集 人资格及会议表决程序、表决结果是否符合《公司法》、《股东会规则》以及 《公司章程》发表意见。 本所律师同意公司将本法律 ...