Core Viewpoint - The collaboration between Borui Pharmaceutical and China Resources Sanjiu focuses on the development, registration, production, and commercialization of BGM0504 injection in mainland China, highlighting the potential of this innovative drug in treating various metabolic diseases [1] Group 1: Collaboration Details - Borui Pharmaceutical and its subsidiaries have signed a cooperation research agreement with China Resources Sanjiu for the exclusive development and commercialization of BGM0504 injection [1] - The agreement grants China Resources Sanjiu a non-transferable exclusive license for development and commercialization, specifically for collaboration with Borui Pharmaceutical and its affiliates [1] Group 2: Product Information - BGM0504 injection is a dual agonist of GLP-1 and GIP, classified as a first-class innovative chemical drug that has not yet been marketed domestically or internationally [1] - The drug aims to activate downstream pathways of GIP and GLP-1, demonstrating potential biological effects such as blood sugar control, weight loss, and treatment of non-alcoholic steatohepatitis (NASH) [1] Group 3: Development Status - Currently, BGM0504 injection is still in the research and development phase, requiring the completion of Phase III clinical trials and approval from the National Medical Products Administration before it can be produced and marketed [1]

Core Viewpoint - The company, Borui Pharmaceutical, has signed a collaboration research agreement with China Resources Sanjiu for the development, registration, production, and commercialization of BGM0504 injection in mainland China [1] Group 1: Collaboration Agreement - Borui Pharmaceutical and its subsidiaries have granted China Resources Sanjiu exclusive collaboration development and commercialization licenses for BGM0504 injection [1] - The agreement allows for a sublicensable exclusive collaboration development implementation license and a sublicensable exclusive commercialization implementation license [1] Group 2: Product Details - BGM0504 injection is a dual agonist of GLP-1 and GIP, classified as a first-class innovative chemical drug that has not yet been marketed domestically or internationally [1] - The injection aims to control blood sugar, promote weight loss, and treat non-alcoholic steatohepatitis (NASH), showcasing potential for various metabolic disease treatments [1] Group 3: Development Status - BGM0504 injection is currently in the research phase and requires completion of Phase III clinical trials before it can be reviewed and approved by the National Medical Products Administration for production and market launch [1]

格隆汇8月1日丨博瑞医药（维权）(688166.SH)公布，公司及全资子公司博瑞制药(苏州)有限公司(以下 简称"博瑞制药")、博瑞新创生物医药科技(无锡)有限公司(该三家许可方统称为"博瑞医药及关联公司") 与华润三九医药股份有限公司(以下简称"华润三九")签署了《合作研发协议》，就BGM0504注射液在中 国大陆地区(不包含香港、澳门及台湾地区)的研发、注册、生产及商业化达成合作，博瑞医药及关联公 司授予华润三九一项仅与博瑞医药及关联公司合作的可分许可的排他性合作开发实施许可及一项可分许 可的独占性商业化实施许可。 ...

Group 1 - The total salary of A-share listed company secretaries in 2024 reached 4.086 billion yuan, with an average annual salary of 754,300 yuan [1] - Among the A-share listed companies, 1,144 secretaries earned over 1 million yuan annually, accounting for over 21% [1] - The age distribution of secretaries shows that those aged 40-50 constitute 42%, while those over 50 account for 29%, and those under 40 make up 26% [1] Group 2 - The educational background of secretaries indicates that 5% have an associate degree, 42% hold a bachelor's degree, 49% possess a master's degree, and 4% have a doctoral degree, with over half holding a master's degree or higher [3] - Only three secretaries hold a doctoral degree, specifically from Yiling Pharmaceutical, Kunming Pharmaceutical Group, and Jinhua Co., Ltd. [3] Group 3 - The average annual salary of secretaries in A-share listed Chinese medicine companies is 742,400 yuan, with 39% earning below 500,000 yuan, 42% earning between 500,000 and 1 million yuan, and 15% earning between 1 million and 2 million yuan [5] - The top five highest-paid secretaries are from China Resources Sanjiu, Jichuan Pharmaceutical, Tianjin Pharmaceutical, Yiling Pharmaceutical, and Yibai Pharmaceutical, with salaries ranging from 1.3935 million to 2.5587 million yuan [7] Group 4 - There is significant variation in the number of investor receptions among listed companies, with 59% receiving fewer than 10 times a year, while 3% received between 300 and 1,000 times [9] - The five companies with the highest number of investor receptions are Zoli Pharmaceutical, Qizheng Pharmaceutical, Yunnan Baiyao, Jinghua Pharmaceutical, and Pianzihuang, with receptions ranging from 207 to 410 times [9]

Core Insights - The report highlights that the total salary for A-share listed company secretaries in 2024 reached 4.086 billion yuan, with an average annual salary of 754,300 yuan [1] - A total of 1,144 company secretaries earn over 1 million yuan annually, accounting for more than 21% of the total [1] Salary Distribution - The average annual salary for company secretaries in the A-share traditional Chinese medicine sector is 742,400 yuan [5] - The distribution of salaries is as follows: below 500,000 yuan (27 individuals, 39%), between 500,000-1,000,000 yuan (29 individuals, 42%), between 1,000,000-2,000,000 yuan (10 individuals, 15%), between 2,000,000-3,000,000 yuan (2 individuals, 3%), and above 3,000,000 yuan (1 individual, 1%) [5] Age and Educational Background - The age distribution of company secretaries shows that those aged 40-50 constitute 42%, while those over 50 account for 29%, and those under 40 make up 26% [1] - In terms of educational qualifications, 5% have an associate degree, 42% hold a bachelor's degree, 49% possess a master's degree, and 4% have a doctoral degree, with over half of the secretaries holding a master's degree or higher [3] Top Earners and Investor Relations - The top five highest-paid company secretaries are: - Xing Jian from China Resources Sanjiu (2.5587 million yuan) - Cao Wei from Jichuan Pharmaceutical (2.4107 million yuan) - Yu Jie from Tian Shi Li (2.525 million yuan) - Wu Rui from Yiling Pharmaceutical (1.89 million yuan) - Jiang Xianhong from Yibai Pharmaceutical (1.3935 million yuan) [7] - The frequency of investor meetings varies significantly among companies, with 41 companies hosting fewer than 10 meetings annually (59%), 17 companies holding 10-100 meetings (25%), 9 companies conducting 100-300 meetings (13%), and 2 companies having 300-1000 meetings (3%) [7] Most Active Companies in Investor Relations - The five companies with the highest number of investor meetings are: - Zoli Pharmaceutical (410 meetings) - Qizheng Tibetan Medicine (404 meetings) - Yunnan Baiyao (298 meetings) - Jinghua Pharmaceutical (221 meetings) - Pian Zai Huang (207 meetings) [9]

Group 1 - The total salary of A-share listed company secretaries in 2024 reached 4.086 billion yuan, with an average annual salary of 754,300 yuan [1] - Among the A-share listed companies, 1,144 secretaries earned over 1 million yuan annually, accounting for over 21% [1] - The age distribution of secretaries shows that those aged 40-50 constitute 42%, while those over 50 account for 29%, and those under 40 make up 26% [1] Group 2 - The educational background of secretaries indicates that 5% have an associate degree, 42% hold a bachelor's degree, 49% possess a master's degree, and 4% have a doctoral degree, with over half holding a master's or higher [3] - Only three secretaries hold a doctoral degree, specifically from Yiling Pharmaceutical, Kunming Pharmaceutical Group, and Jinhua Co., Ltd. [3] Group 3 - The average annual salary of secretaries in A-share listed Chinese medicine companies is 742,400 yuan, with 39% earning below 500,000 yuan, 42% earning between 500,000-1 million yuan, 15% between 1-2 million yuan, 3% between 2-3 million yuan, and 1% above 3 million yuan [5] - The top five highest-paid secretaries are from China Resources Sanjiu, Jichuan Pharmaceutical, Tianjin Tasly, Yiling Pharmaceutical, and Yibai Pharmaceutical, with salaries of 2.5587 million yuan, 2.4107 million yuan, 2.525 million yuan, 1.89 million yuan, and 1.3935 million yuan respectively [7] Group 4 - There is significant variation in the number of investor receptions among listed companies, with 59% receiving fewer than 10 times a year, 25% between 10-100 times, 13% between 100-300 times, and 3% between 300-1000 times [9] - The five companies with the highest number of investor receptions are Zoli Pharmaceutical, Qizheng Tibetan Medicine, Yunnan Baiyao, Jinghua Pharmaceutical, and Pianzihuang, with receptions of 410, 404, 298, 221, and 207 respectively [9]

Core Insights - The report highlights that the total salary for A-share listed company secretaries in 2024 reached 4.086 billion yuan, with an average annual salary of 754,300 yuan [1] - A total of 1,144 company secretaries earn over 1 million yuan annually, accounting for more than 21% of the total [1] Salary Distribution - The average annual salary for company secretaries in the A-share traditional Chinese medicine sector is 742,400 yuan [5] - The distribution of salaries is as follows: - Below 500,000 yuan: 27 individuals (39%) - 500,000-1,000,000 yuan: 29 individuals (42%) - 1,000,000-2,000,000 yuan: 10 individuals (15%) - 2,000,000-3,000,000 yuan: 2 individuals (3%) - Above 3,000,000 yuan: 1 individual (1%) [5] Age and Educational Background - The age distribution of company secretaries shows that those aged 40-50 constitute 42%, while those over 50 account for 29%, and those under 40 make up 26% [1] - The educational background indicates that 5% have an associate degree, 42% hold a bachelor's degree, 49% possess a master's degree, and 4% have a doctoral degree, with over half of the secretaries holding a master's degree or higher [3] Top Earning Company Secretaries - The top five highest-paid company secretaries are: - Xing Jian from China Resources Sanjiu: 2.5587 million yuan - Cao Wei from Jichuan Pharmaceutical: 2.4107 million yuan - Yu Jie from Tianjin Tasly: 2.525 million yuan - Wu Rui from Yiling Pharmaceutical: 1.89 million yuan - Jiang Xianhong from Yibai Pharmaceutical: 1.3935 million yuan - Their tenure at the companies ranges from less than 1 year to 15 years [7] Investor Engagement - There is significant variation in the number of investor meetings held by companies: - Less than 10 meetings: 41 companies (59%) - 10-100 meetings: 17 companies (25%) - 100-300 meetings: 9 companies (13%) - 300-1000 meetings: 2 companies (3%) [7] - The five companies with the highest number of investor meetings are: - Zoli Pharmaceutical: 410 meetings - Qizheng Pharmaceutical: 404 meetings - Yunnan Baiyao: 298 meetings - Jinghua Pharmaceutical: 221 meetings - Pianzihuang: 207 meetings [9]

Core Insights - The report highlights that in 2024, the total salary for A-share listed company secretaries reached 4.086 billion yuan, with an average annual salary of 754,300 yuan [1] - The data indicates that over 21% of company secretaries earn more than 1 million yuan annually [1] Group 1: Salary Distribution - The average annual salary for company secretaries in the A-share traditional Chinese medicine sector is 742,400 yuan [7] - The distribution of salaries shows that 39% earn below 500,000 yuan, 42% earn between 500,000 and 1 million yuan, 15% earn between 1 million and 2 million yuan, 3% earn between 2 million and 3 million yuan, and 1% earn above 3 million yuan [7] - The top five highest-paid company secretaries are from Huaren Sanjiu, Jichuan Pharmaceutical, Tianshili, Yiling Pharmaceutical, and Yibai Pharmaceutical, with salaries of 2.5587 million yuan, 2.4107 million yuan, 2.525 million yuan, 1.89 million yuan, and 1.3935 million yuan respectively [7] Group 2: Age Distribution - Company secretaries aged between 40 and 50 constitute 42% of the market, while those over 50 account for 29%, and those under 40 make up 26% [3] - The youngest company secretary is 32 years old, representing Te Yi Pharmaceutical [3] Group 3: Educational Background - The educational background of company secretaries shows that 5% have an associate degree, 42% hold a bachelor's degree, 49% have a master's degree, and 4% possess a doctoral degree [5] - More than half of the company secretaries hold a master's degree or higher, with only three having a doctoral degree [5] Group 4: Investor Engagement - There is significant variation in the number of investor meetings held by listed companies, with 59% of companies hosting fewer than 10 meetings annually [9] - The top five companies with the most investor meetings are Zoli Pharmaceutical, Qizheng Tibetan Medicine, Yunnan Baiyao, Jinghua Pharmaceutical, and Pianzihuang, with 410, 404, 298, 221, and 207 meetings respectively [9]

Group 1 - The core viewpoint of the news is that the Shanghai Stock Exchange 300 Pharmaceutical Index has shown significant growth, with a 12.60% increase over the past month, 13.11% over the past three months, and 19.34% year-to-date [1] - The Shanghai Stock Exchange 300 Pharmaceutical Index is composed of listed companies in the pharmaceutical sector selected from the Shanghai and Shenzhen 300 Index, reflecting the overall performance of these companies [1] - The index was established on December 31, 2004, with a base point of 1000.0 [1] Group 2 - The top ten weighted companies in the Shanghai Stock Exchange 300 Pharmaceutical Index include: Heng Rui Medicine (44.25%), Pian Zai Huang (9.6%), Yunnan Baiyao (7.98%), Kelun Pharmaceutical (6.66%), East China Pharmaceutical (6.13%), Fosun Pharmaceutical (5.62%), New Harmony (5.46%), Baillie Tianheng (4.07%), Tong Ren Tang (3.93%), and China Resources Sanjiu (3.33%) [1] - The market share of the index's holdings is 70.43% from the Shanghai Stock Exchange and 29.57% from the Shenzhen Stock Exchange [1] - The composition of the index by industry shows that drug formulations account for 66.73%, traditional Chinese medicine for 27.81%, and raw materials for 5.46% [1] Group 3 - The index sample is adjusted every six months, with adjustments implemented on the next trading day following the second Friday of June and December each year [2] - Weight factors are adjusted in accordance with the sample adjustments, which occur at the same time [2] - In special circumstances, the index may undergo temporary adjustments, such as when a sample company is delisted or undergoes mergers, acquisitions, or splits [2]

Core Insights - The Chinese healthcare investment market has experienced significant fluctuations over the past decade, with a peak in financing reaching over 380 billion yuan in 2021, followed by a period of stagnation [1] - Many healthcare unicorns emerged during the investment boom, but high valuations and slow commercialization have led to persistent losses and survival challenges for many companies [1][2] - The current market environment is shifting, with nearly 40 healthcare companies filing for IPOs in the first half of the year, indicating potential recovery [2][3] Group 1: Market Dynamics - Since 2021, several companies, including Yuanxin Technology and Yingsi Intelligent, have struggled to enter the secondary market despite multiple IPO attempts [2] - The withdrawal of dollar funds and the cautious approach of domestic RMB funds have changed the funding landscape, leading to difficulties in financing and exits for many unicorns [2][4] - The healthcare sector is undergoing a profound reshaping, with a collective recalibration of expectations among industry participants [4][5] Group 2: Business Strategies - Many unicorns are shifting focus from IPO aspirations to mergers and acquisitions as a means of exit, with notable transactions occurring in the sector [2][10] - Companies are adopting survival strategies such as layoffs, product line cuts, and focusing on more profitable business areas to navigate the current challenges [12][11] - The emphasis has shifted from high valuations to sustainable business models and cash flow, with investors now prioritizing immediate returns over long-term visions [18][23] Group 3: Investment Landscape - The investment criteria have evolved, with a greater focus on clear profitability paths and customer retention, while technological innovation has become a secondary consideration [18][14] - The previous era of high valuations driven by ambitious narratives has given way to a more cautious investment approach, emphasizing realistic financial performance [21][22] - The market is no longer celebrating valuations but is instead focused on cash returns, reflecting a significant shift in investor sentiment [23][29] Group 4: Future Outlook - IPOs remain a preferred exit strategy for many companies, but not all are equipped to pursue this path, leading to a reliance on mergers as an alternative [24][26] - The potential for recovery in the secondary market may provide new opportunities for companies to secure funding and navigate the current landscape [28] - Companies that can adapt to the changing environment and demonstrate sustainable business practices are more likely to succeed in the long term [29]