Investment Rating - The report indicates a positive investment outlook for the pharmaceutical and biotechnology industry, particularly focusing on innovative drugs and their potential in the market [1]. Core Insights - The report highlights the significant achievements of domestic innovative drugs showcased at the upcoming ASCO 2025 conference, emphasizing the growing innovation capabilities of Chinese pharmaceutical companies [6][7]. - A strategic collaboration between 3SBio and Pfizer regarding the PD-1/VEGF dual antibody has been established, which includes a global licensing agreement with potential payments up to $4.8 billion based on development milestones and sales performance [2][6]. - Three domestic Class 1 innovative drugs have been approved for market launch, targeting prevalent diseases such as influenza, cancer, and diabetes, marking a critical step in the innovation and internationalization of domestic original drugs [2][6]. Market Performance Review - During the period from May 17 to May 24, the Shanghai Composite Index closed at 3348.37, down 0.57%, while the pharmaceutical industry index rose by 1.78%, ranking first among 31 primary industry indices [1][12]. - The weekly performance of various sectors within the pharmaceutical industry showed positive growth, with notable increases in chemical preparations (3.49%), biological products (1.74%), and medical services (1.42%) [1][12]. Upcoming Events - The ASCO annual meeting, a major international conference in oncology, is scheduled to take place from May 30 to June 3, 2025, in Chicago, where numerous innovative research results from domestic companies are expected to be presented [6][7]. Key Companies to Watch - The report suggests focusing on companies with strong innovation capabilities, including Heng Rui Medicine, Innovent Biologics, BeiGene, and 3SBio, as they are expected to showcase significant advancements at ASCO 2025 [7][19]. - It also recommends monitoring companies involved in high-end medical devices and those benefiting from market concentration in chain pharmacies and comprehensive medical services [8][19].

Group 1 - The core viewpoint of the articles highlights the rapid development of China's innovative drug industry, supported by government policies, leading to a significant increase in the number of approved innovative drugs [1][2] - Guangdong Zhongsheng Pharmaceutical Co., Ltd. announced the approval of its innovative drug, Anladiwei Tablets, marking a major breakthrough in respiratory system treatment and enhancing the company's market competitiveness [2][3] - The approval of Anladiwei Tablets is expected to contribute positively to the company's future performance, as it expands the product line and strengthens its leading position in the respiratory drug market [2][3] Group 2 - Health元药业集团 announced the approval of its long-acting injectable Aripiprazole Microspheres, which is the first of its kind globally, targeting adult schizophrenia [3] - Sichuan Kelun Pharmaceutical Co., Ltd. made progress in international collaboration by entering into an exclusive licensing agreement for the development of SKB378/HBM9378/WIN378, indicating a strategic move in the innovative drug sector [3] - The overall demand for innovative drugs is expected to grow due to aging populations, changing disease patterns, and increased health awareness, suggesting a significant market opportunity for domestic companies [3]

Investment Rating - The report maintains a "Buy" rating for the company, with a target price of 42.24 CNY based on a reasonable valuation level of 24 times the earnings per share for 2025 [2][5]. Core Views - The company is entering a harvest period for innovative drugs, although its main business faces short-term pressure due to the impact of centralized procurement on the infusion and generic drug segments [1]. - The company achieved a revenue of 21.81 billion CNY in 2024, reflecting a growth of 1.67%, and a net profit attributable to the parent company of 2.94 billion CNY, up 19.53% [9]. - The first quarter of 2025 saw a revenue decline to 4.39 billion CNY, down 29.42%, and a net profit of 584 million CNY, down 43.07%, primarily due to high base effects from the previous year [9]. - The ADC platform is expected to yield significant commercial results, with key products like SKB264 receiving regulatory approval for multiple indications [9]. - The antibiotic supply-demand structure remains stable, with synthetic biology products contributing to revenue growth [9]. Financial Summary - The company’s projected financials indicate a revenue increase from 21.45 billion CNY in 2023 to 29.19 billion CNY by 2027, with a compound annual growth rate of approximately 13% [4]. - The net profit attributable to the parent company is expected to grow from 2.46 billion CNY in 2023 to 3.62 billion CNY in 2027, with a notable increase in 2024 [4]. - Earnings per share are projected to be 1.76 CNY in 2025, with a gradual increase to 2.27 CNY by 2027 [4][2]. - The gross margin is expected to stabilize around 50% to 52.7% over the forecast period, indicating a solid profitability outlook [4].

证券研究报告 | 金融工程 2025 年 05 月 24 日 刚需+出海+历史低位，多重因素凸显制药价值 ——华宝中证制药 ETF 投资价值分析 随着保健意识的提升及国内人口老龄化趋势的发展，药品作为人们生活中的刚 性需求，其市场需求量日益增长。从供给端来看，原研药专利集中到期，创新 药频获出海订单，中药受政策大力扶持，各细分领域药企均迎来发展机遇。时 逢相关标的位于历史的价格低位，药品制造业显示出一定的投资机会。华宝中 证制药 ETF（认购代码：562053.OF）通过紧密跟踪中证制药指数，一键式配 置制药行业优质上市企业，值得投资者关注。 任瞳 S1090519080004 rentong@cmschina.com.cn ❑ 风险提示：本报告仅作为投资参考，基金产品过往业绩并不预示其未来表 现，亦不构成投资收益的保证或投资建议，新发基金无历史业绩可参考。 敬请阅读末页的重要说明 专题报告 ❑ 在新兴市场经济快速发展和各国医疗保障制度的逐渐完整之下，全球医药 市场规模仍旧维持着稳定增长态势。而据统计，我国的人均药品用量仍远 低于世界发达国家水平，国内药品用量的需求增长仍然具有较大的空间。 ❑ 在供给端，各细 ...

Market Performance - On May 23, major market indices experienced fluctuations and closed lower, with A-shares trading volume reaching 1.18 trillion yuan, and over 1,100 stocks closing higher, including 52 stocks hitting the daily limit [1] - For the week, the Shanghai Composite Index fell by 0.57%, the ChiNext Index dropped by 0.88%, and the STAR Market 50 Index decreased by 1.47% [1] Individual Stock Performance - Over 1,600 stocks rose this week, with 22 stocks gaining over 30%. Notably, six stocks surged over 50%, with the largest increase being 99.96% for Sanofi [1][2] - Other significant gainers included Huibo Yuntong (301316) and Binhai Energy (000695), both of which saw weekly increases exceeding 60% [1][2] Sector Analysis - Among the stocks that rose over 30%, the pharmaceutical and biological sector had six representatives, followed by light industry manufacturing with three stocks [1] Historical Highs - On May 23, 17 stocks reached historical closing highs, with the pharmaceutical and biological, mechanical equipment, and automotive sectors showing a concentration of high performers [3][4] - The average increase for stocks reaching historical highs was 8.20%, with notable gainers including Xintiandi (301277) and Zhongzhou Special Materials (300963) [3] Institutional Activity - On May 23, ten stocks saw net purchases from institutions, with Yixin Tang (002727) leading at a net buy of 102 million yuan [5][6] - Conversely, institutions sold off stocks such as Hongchuang Holdings (002379) and Tianqimo (002510), each experiencing net sales exceeding 50 million yuan [5][6] Northbound Capital Flow - Northbound capital was present in nine stocks on the trading board, with net purchases in three stocks: Xue Ren Shares (002639), Huibo Yuntong, and Jinlongyu (002882) [7] - Yixin Tang faced the highest net sell-off from northbound capital, totaling 68.98 million yuan [7] Company Announcements - Zhongjin Gold (600489) plans to inject four companies, including Inner Mongolia Jintao, into the company to resolve competition issues [8] - Huakang Clean (301235) won a bid for a healthcare project with a contract value of 60.24 million yuan and a duration of 120 days [8] - Weier Shares (603501) intends to issue H-shares and list on the Hong Kong Stock Exchange [9] - Yunchongma (603130) plans to raise no more than 640 million yuan for a project to produce DTY silk and high-performance leather base fabric [9]

Investment Rating - The industry view is rated as Attractive [7] Core Insights - The report highlights over 70 oral presentations from Chinese scholars at the 2025 ASCO, including 11 late-breaking abstracts, showcasing advancements in various pharmaceutical developments [1] - Sino Biopharma's combination of Benmelstobart (PD-L1) with anlotinib showed superior efficacy in first-line squamous non-small cell lung cancer (sq-NSCLC) with a median progression-free survival (mPFS) of 10.12 months compared to 7.79 months for tislelizumab [2] - CSPC's SYS6010 (EGFR ADC) demonstrated preliminary efficacy in advanced gastrointestinal cancers with mPFS of 5.8 months in gastric cancer patients [3] - Kelun Pharma's sac-TMT (TROP2 ADC) achieved a confirmed overall response rate (ORR) of 59.3% in first-line non-squamous NSCLC [4] - Fosun Pharma's HLX43 (PD-L1 ADC) showed an ORR of 31.3% in late-line solid tumors, with competitive results in NSCLC patients [5] Company Summaries Sino Biopharma - The combination therapy of Benmelstobart and anlotinib is expected to release Phase 3 data for first-line NSCLC and maintenance treatment after radiochemotherapy soon [2] - TQB2102 (HER2 bsAbADC) achieved an ORR of 53.4% in late-line HER2 low-expressing breast cancer [2] CSPC - SYS6010 in combination with SYH2051 showed preliminary efficacy for second-line advanced gastrointestinal cancers, with a G3+ treatment-related adverse event (TRAE) rate of 48% [3] - ALMB-0168 (Cx43 agonist) for relapsed/refractory osteosarcoma showed an ORR of 20% and a disease control rate (DCR) of 90% [10] Kelun Pharma - Sac-TMT demonstrated a 70.7% ORR and a mPFS of 13.4 months in first-line triple-negative breast cancer (TNBC) [11] - In the third-line EGFR-mutant NSCLC setting, sac-TMT achieved a PFS of 6.9 months compared to 2.8 months for docetaxel [11] Fosun Pharma - HLX43's competitive ORR of 38.1% in NSCLC patients during the dose-expansion phase indicates potential for further development [5]

关于子公司根据 SKB378/HBM9378/WIN378 的独占性许可协议 证券代码：002422 证券简称：科伦药业 公告编号：2025-045 四川科伦药业股份有限公司 二、风险提示 收到现金及股权支付的首付款的公告 创新药物研发过程周期长、环节多、能否开发成功及商业化具有一定的不确 定性，敬请广大投资者谨慎决策，注意防范投资风险。公司将根据后续进展情况 及时履行信息披露义务。 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假记载、误 导性陈述或重大遗漏。 特此公告。 四川科伦药业股份有限公司（以下简称"公司"）近日获悉，公司控股子公 司四川科伦博泰生物医药股份有限公司（以下简称"科伦博泰"）已根据科伦博 泰及和铂医药控股有限公司（以下简称"和铂医药"）与 Windward Bio AG （"Windward Bio"）关于 SKB378/HBM9378/WIN3781订立的独占性许可协议， 收到 Windward Bio 支付的首付款，包括：（1）现金付款，该款项于 2025 年 2 月 收到，及（2）Windward Bio 母公司的股权，该股权于获得中国境内相关监管批 准并满足其 ...

一、行情回顾 市场全天冲高回落，三大指数午后集体跳水。可控核聚变概念表现活跃，王子新材、尚纬股份、融发核电等多股涨停。创新药概念股再度大涨，海辰药业、 众生药业等封板，信立泰、科伦药业创历史新高。下跌方面，航运港口板块延续跌势，南京港、连云港跌停；电力股集体调整，西昌电力、乐山电力跌停。 个股跌多涨少，沪深京三市下跌个股超4200只，今日成交1.18万亿。 二、当日热点 1.核聚变 核聚变板块今日继续大涨，王子新材、中洲特材等继续涨停，尚纬股份2连板，融发核电涨停。 5月23日，行情数据显示，美核电股盘后集体大涨。Altman持股的Oklo涨幅从15.63%收窄至12.54%，Centrus能源涨12.4%，Nuscale涨10.15%，Uranium能源 涨8.14%等。 新浪财经消息称，称特朗普将签署核能命令，这些行政命令将试图简化新反应堆审批的监管流程，并加强燃料供应链。 国内方面核电领域近期也迎来重大催化。国家能源局近日发布关于促进能源领域民营经济发展若干举措的通知。其中提到，支持民营企业参股投资核电项 目，建立健全长效工作机制。国家今年新核准浙江三门、福建霞浦、山东海阳、广东台山、广西防城港等5个核 ...

Core Viewpoint - The innovative pharmaceutical concept stocks are experiencing significant growth, with notable companies reaching historical highs [1] Group 1: Stock Performance - Xinlitai and Kelun Pharmaceutical both achieved historical highs in stock prices [1] - Yangguang Nuohe is approaching a 20% daily limit increase [1] - Zhongsheng Pharmaceutical previously hit a daily limit increase [1] - Haichen Pharmaceutical, Beida Pharmaceutical, and Hongbo Pharmaceutical saw stock prices rise over 10% [1] - Shutaishen, Haixiang Pharmaceutical, Tigermed, and Huahai Pharmaceutical experienced stock price increases of over 5% [1]

Investment Rating - The investment rating for the company is "Buy" (maintained) [2][13]. Core Views - The company reported strong performance in 2024, with total revenue reaching 21.81 billion yuan (up 1.7% year-on-year) and net profit attributable to shareholders of 2.94 billion yuan (up 19.5% year-on-year) [4][5]. - The innovative drug segment is accelerating, with significant contributions from various product lines, including raw material intermediates and innovative drugs [5][6]. Financial Performance Summary - In 2024, the company achieved a total revenue of 21.81 billion yuan, with a net profit of 2.94 billion yuan and a non-recurring net profit of 2.90 billion yuan [4]. - For Q1 2025, the company reported a revenue of 4.39 billion yuan (down 29.4% year-on-year) and a net profit of 580 million yuan (down 43.1% year-on-year) [4]. - The company’s major segments, including large-volume infusion, raw material intermediates, and generic drugs, showed stable performance, with notable growth in certain product lines [6]. Segment Performance - The large-volume infusion segment generated sales of 8.91 billion yuan in 2024, despite a decline of 11.85% year-on-year, with a total volume of 4.35 billion bottles/bags [6]. - The non-infusion formulations segment saw a revenue increase of 5.41% year-on-year, reaching 4.17 billion yuan, with significant growth in specific generic products [6]. - The antibiotic intermediates and raw materials segment reported a revenue of 5.86 billion yuan, up 20.9% year-on-year, driven by increased market demand and production efficiency [6]. Innovation and Future Outlook - The successful launch of the innovative drug Jiatailai (Lukangshatuo) is expected to contribute significantly to future revenues, with multiple clinical studies ongoing for various indications [6][13]. - The company anticipates steady performance in its core business and accelerated growth in the innovative drug segment in 2025 [5][13].