Pharmaron Beijing Co., Ltd. 康龙化成（北京）新药技术股份有限公司 2025 H Share Award and Trust Scheme 2025年H股奖励信托计划 1 Table of Contents 目录 | 1. | Definitions and Interpretation 定义和解释 | 1 | | --- | --- | --- | | 2. | General Introduction and Purpose of the Scheme 本计划概览与目的 | 5 | | 3. | Conditions 条件 | 7 | | 4. | Duration 期限 | 7 | | 5. | Administration 管理 | 7 | | 6. | Selection of Selected Participant 选定参与者的选择 | 10 | | 7. | Award Letter regarding Grant of Awards 奖励授予的奖励函 | 15 | | 8. | Receipt of Treasury H Shares by the Trustee ...

证券代码：300759 证券简称：康龙化成 公告编号：2025-028 康龙化成（北京）新药技术股份有限公司 关于召开 2024 年年度股东大会、2025 年第一次 A 股类别股 2、股东大会的召集人：公司董事会。 3、会议召开的合法、合规性：本次股东大会的召集、召开程序符合有关法 律、行政法规、部门规章、规范性文件和《公司章程》的规定。 4、会议召开的时间： （1）现场会议召开时间：2025 年 6 月 20 日（星期五）13:30； （2）网络投票时间：通过深圳证券交易所交易系统进行网络投票的具体时 间为 2025 年 6 月 20 日的交易时间，即 9:15-9:25，9:30-11:30 和 13:00-15:00；通 过深圳证券交易所互联网投票系统进行网络投票的具体时间为 2025 年 6 月 20 日 9:15-15:00。 5、会议的召开方式： 东大会及 2025 年第一次 H 股类别股东大会的通知 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假记 载、误导性陈述或重大遗漏。 经康龙化成（北京）新药技术股份有限公司（以下简称"公司"）于 2025 年 3 月 26 日召开的第 ...

Group 1 - The National Vaccine and Biotechnology Index (980015) has seen a strong increase of 2.39% as of May 29, 2025, with notable gains in constituent stocks such as Zhaoyan New Drug (603127) up 9.99%, Yifan Pharmaceutical (002019) up 9.17%, and Dizhe Pharmaceutical (688192) up 8.73% [1] - The Biovaccine ETF (159657) rose by 2.28%, with the latest price reported at 0.63 yuan [2] - The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting will take place from May 30 to June 3, 2025, in Chicago, showcasing the development of oncology research in China, with over 70 studies from Chinese scholars selected for presentation [2] Group 2 - The top ten weighted stocks in the National Vaccine and Biotechnology Index (980015) as of April 30, 2025, include Fosun Pharma (600196), Changchun High-tech (000661), and others, collectively accounting for 63.18% of the index [3] - The Biovaccine ETF closely tracks the National Vaccine and Biotechnology Index, which consists of 50 companies involved in the biotechnology industry, reflecting the overall performance of quality listed companies in the sector [2]

Group 1 - The innovative drug sector is experiencing significant growth, with the biopharmaceutical ETF (159508) rising by 1.90% and attracting over 10 million yuan in net inflows yesterday [1] - Notable stocks in the sector include Junshi Biosciences-U and Dizal Pharmaceuticals-U, both rising over 6%, along with other companies like Kelun Pharmaceutical, Hangzhou Tigermed Consulting, and WuXi AppTec also seeing gains [1] - Year-to-date, ETFs focused on Hong Kong innovative drugs and biotechnology have shown strong performance, with gains exceeding 32%, while 90% of pharmaceutical-themed funds have reported positive growth this year [1] Group 2 - The innovative drug sector is one of the few growth areas within the overall pharmaceutical industry, with a favorable environment for commercialization and increasing self-sustainability among domestic innovative drugs [2] - Future trends in medical insurance spending are expected to support the payment growth for innovative drugs, with collaboration between commercial insurance and medical insurance entering a rapid development phase [2] - The outlook for the pharmaceutical industry is becoming increasingly positive, indicating a potential for significant advancements in the sector [2]

Group 1 - The core viewpoint is that the pharmaceutical industry is expected to experience stable growth driven by innovation, policy optimization, and increasing clinical demand due to aging demographics [3] - The National Biopharmaceutical Index (399441) has shown a strong increase of 1.83%, with key stocks like Kylin Pharmaceutical (002821) rising by 5.51% and Zhaoyan New Drug (603127) by 4.66% [1] - The Biopharmaceutical ETF (159839) has seen a cumulative increase of 1.54% over the past two weeks, indicating positive market sentiment [1] Group 2 - Open Source Securities emphasizes that the pharmaceutical sector will benefit from improved drug procurement policies and a favorable external environment, leading to a recovery in the healthcare industry [3] - Citic Securities notes that the pharmaceutical sector achieved its best market returns in the first half of 2025, driven by policy trends and the maturation of pharmaceutical innovation [3] - The current PEG levels for most growth-oriented pharmaceutical companies are below 1, suggesting potential for performance and valuation recovery [3]

Group 1 - The core viewpoint of the news is the performance and holdings of the China Europe Medical Health Mixed Fund C, which has shown a recent net value increase and varying returns over different time frames [1] - As of May 27, 2025, the fund's latest net value is 1.5582 yuan, reflecting a growth of 0.85% [1] - The fund's one-month return is 3.03%, ranking 1106 out of 4652 in its category, while its six-month return is 0.23%, ranking 3299 out of 4496 [1] - Year-to-date, the fund has achieved a return of 2.43%, ranking 2140 out of 4544 [1] Group 2 - The top ten stock holdings of the fund account for a total of 55.30%, with significant positions in companies such as Heng Rui Pharmaceutical (10.60%), WuXi AppTec (9.95%), and Kanglong Chemical (6.24%) [1] - The fund was established on September 29, 2016, and as of March 31, 2025, it has a total scale of 15.566 billion yuan [1] - The fund manager, Ge Lan, has a background in biomedical engineering and has held various positions in research and fund management since joining China Europe Fund Management in 2014 [2]

Core Insights - The CRO (Contract Research Organization) and CDMO (Contract Development and Manufacturing Organization) sectors are crucial in advancing innovative drugs from laboratory to clinical application and large-scale production, with Chinese companies gaining significant market share due to enhanced technical capabilities and cost advantages [1][2]. Group 1: Strategic Opportunities in CXO - The CXO sector in China has experienced rapid growth over the past decade, evolving through four development stages, with a significant acceleration post-2015 due to increased demand for innovative drug development and the transfer of overseas industrial chains [2][3]. - The COVID-19 pandemic in 2020 catalyzed the upgrade of China's CXO industry, leading to a surge in participation in the global innovative drug supply chain [3]. Group 2: Growing Demand for Outsourcing in the Pharmaceutical Industry - The number of new drug registration clinical trials in China has been increasing annually, with a compound annual growth rate (CAGR) of 15% from 2019 to 2024, rising from 2,385 trials in 2019 to 4,884 in 2024 [4]. - The number of first-class new drugs listed in China has grown from 18 in 2020 to 49 in 2024, reflecting a CAGR of 28.4%, indicating a sustained upward trend in innovation capabilities [6]. Group 3: MAH System and Business Opportunities - The implementation of the MAH (Marketing Authorization Holder) system has separated drug production and marketing licenses, significantly boosting the CDMO market, with the number of B certificate enterprises increasing from 140 in 2021 to 1,349 by the end of 2024, a growth rate of 23% [10]. Group 4: Market Growth Rates - China's CRO market is projected to grow at a CAGR of 20.4%, increasing from 388 billion RMB in 2018 to 1,183 billion RMB in 2024, with expectations to reach 1,923 billion RMB by 2027 [12][14]. - The CDMO market in China is expected to grow at a CAGR of 37.8%, from 132 billion RMB in 2017 to 1,246 billion RMB in 2024, with projections to reach 3,559 billion RMB by 2030 [16][18]. Group 5: Rankings of CRO and CDMO Companies - The 2024 rankings of Chinese CRO companies include top-tier firms such as WuXi Biologics, Kanglong Chemical, and Tigermed, while the second tier features companies like Yino Science and Kingsray Biotech [22]. - The leading CDMO companies in 2024 include WuXi AppTec, Kelun Pharmaceutical, and WuXi Biologics, with a second tier comprising companies like Notch Biotech and Haier Pharmaceutical [24]. Group 6: Conclusion - Chinese CRO and CDMO companies have established comprehensive service capabilities across the pharmaceutical industry chain, transitioning from "Chinese service providers" to "global innovation partners," with a focus on technological innovation and compliance [26][27].

Group 1 - The core viewpoint of the news is the performance and holdings of the China Europe Medical Health Mixed A Fund, which has seen a recent decline in net value and varying returns over different time frames [1] - As of May 26, 2025, the latest net value of the fund is 1.6119 yuan, reflecting a decrease of 1.60%. The fund's one-month return is 3.10%, six-month return is 0.62%, and year-to-date return is 2.75, with respective rankings of 937 out of 3909, 2718 out of 3796, and 1764 out of 3832 [1] - The top ten stock holdings of the fund account for a total of 55.30%, with significant positions in companies such as Heng Rui Pharmaceutical (10.60%), WuXi AppTec (9.95%), and Mindray Medical (5.21%) [1] Group 2 - The China Europe Medical Health Mixed A Fund was established on September 29, 2016, and as of March 31, 2025, it has a total scale of 15.613 billion yuan. The fund manager is Ms. Ge Lan [1] - Ms. Ge Lan has a background in biomedical engineering with a Ph.D. from Northwestern University and has held various research and fund management positions since joining China Europe Fund Management in October 2014 [2]

Core Viewpoint - The CRO (Contract Research Organization) sector has shown a positive performance with a 1.51% increase, ranking second among concept sectors, driven by significant gains in specific stocks like New Tian Di, which hit a 20% limit up [1][2]. Sector Performance - The CRO concept sector saw 42 stocks rise, with New Tian Di leading at a 20% increase, followed by Yang Guang Nuo He at 12.55%, Rui Zhi Yi Yao at 8.05%, and Hong Bo Yi Yao at 7.73% [1][2]. - Conversely, stocks like *ST Shuang Cheng, Si Chuan Shuang Ma, and Jin An Dan Bai experienced declines of 5.01%, 3.73%, and 3.19% respectively [1][2]. Capital Flow - The CRO sector experienced a net outflow of 507,500 yuan, with 29 stocks receiving net inflows. New Tian Di topped the list with a net inflow of 86,619,800 yuan, followed by Kang Long Hua Cheng with 58,064,600 yuan and Tai Ge Yi Yao with 49,707,000 yuan [2][3]. - The net inflow ratios for leading stocks included New Tian Di at 10.25%, Nuo Si Ge at 9.53%, and Kang Long Hua Cheng at 6.78% [3]. Stock Highlights - Key stocks in the CRO sector included: - New Tian Di: 20.02% increase, 57.74% turnover rate, net inflow of 86,619,800 yuan, net inflow ratio of 10.25% [3][4]. - Kang Long Hua Cheng: 2.38% increase, 2.58% turnover rate, net inflow of 58,064,600 yuan, net inflow ratio of 6.78% [3][4]. - Tai Ge Yi Yao: 5.64% increase, 4.82% turnover rate, net inflow of 49,707,000 yuan, net inflow ratio of 3.80% [3][4]. Declining Stocks - Notable declines included: - *ST Shuang Cheng: 5.01% decrease, with a significant net outflow of 1,391,440 yuan [5][6]. - Si Chuan Shuang Ma: 3.73% decrease, with a net outflow of 500,800 yuan [5][6]. - Jin An Dan Bai: 3.19% decrease, with a net outflow of 233,620 yuan [5][6].

Group 1 - The overall market experienced a decline in the afternoon, but the pharmaceutical and medical sectors showed resilience, with only three out of 31 industries reporting gains [1] - The representative medical ETF (512170) saw a daily increase of 0.62%, with a significant trading volume of 9.82 billion, marking a 128% increase from the previous day and the highest single-day trading volume in over a month and a half [2] - The CXO-related stocks were the main contributors to the sector's performance, with notable gains from companies like Tigermed, which rose by 5.64%, while major player WuXi AppTec experienced a decline [2] Group 2 - For the week of May 19-23, the medical ETF (512170) accumulated a gain of 1.24%, outperforming major indices such as the Shanghai Composite Index, which fell by 0.57% [4] - The market for medical stocks is gradually recovering, with increased trading activity and positive catalysts such as domestic pharmaceutical companies securing overseas contracts [4] - A new "Pharmaceutical ETF" is set to launch on May 26, which will track the CSI Pharmaceutical Index, focusing on chemical drugs, biological drugs, and traditional Chinese medicine, complementing the existing medical ETF [4] Group 3 - The medical and pharmaceutical sectors have been in a prolonged adjustment period since 2021, with current valuations potentially offering high cost-effectiveness for investors [4]