Group 1 - The Hang Seng Biotechnology Index (HSHKBIO) has seen a strong increase of 4.10%, with notable gains in constituent stocks such as Xintai Medical (02291) up 46.88%, Lepu Biopharma-B (02157) up 11.87%, and Innovent Biologics (09969) up 11.10% [1] - The Hang Seng Biotechnology ETF (513280) has risen by 2.80%, marking its third consecutive increase, with the latest price at 0.84 HKD. Over the past two weeks, the ETF has accumulated a rise of 3.27% [1] - The trading activity for the Hang Seng Biotechnology ETF has been active, with a turnover rate of 18.69% and a transaction volume of 46.885 million HKD, indicating robust market participation [1] Group 2 - The Hang Seng Biotechnology ETF has experienced a significant increase in shares, with a growth of 14 million shares over the past month, ranking it in the top third among comparable funds [3] - In terms of capital inflow, the ETF has seen net inflows on 15 out of the last 21 trading days, totaling 16.1235 million HKD [3] Group 3 - The pharmaceutical sector is showing a continuous upward recovery, with a focus on key innovative drug clinical data and milestone progress. Notable developments include the initiation of a Phase III clinical trial by Innovent Biologics for a drug targeting obstructive sleep apnea and the approval of a monoclonal antibody by CanSino Biologics [6] - The National Medical Products Administration has approved CanSino's monoclonal antibody injection for treating moderate to severe plaque psoriasis in adults [6] Group 4 - Hainan University has announced the release of its self-developed brain-computer interface (BCI) technology, marking a significant advancement in the field and enhancing China's capabilities in brain science research and medical applications [7] - The increase in tariffs on imports from the U.S. is expected to benefit domestic companies in the blood products and high-end medical device sectors, as well as in innovative drug development, promoting domestic substitutes [7] Group 5 - The Hang Seng Biotechnology ETF (513280) is noted for its low fee structure, with a management fee of only 0.15% per year, significantly lower than similar products, which could lead to better long-term returns for investors [8] - The ETF's composition includes a high proportion of innovative drugs at 66.4%, with a balanced distribution across various sectors, enhancing its investment potential [8]

Investment Rating - The industry investment rating is "Outperform the Market" [1][50]. Core Insights - Eli Lilly's first oral small molecule GLP-1 drug, Orforglipron, has successfully completed Phase 3 clinical trials, which is expected to change the landscape of weight loss medications [3][4]. - The ACHIEVE-1 trial showed that Orforglipron significantly reduced HbA1c levels by 1.3% to 1.6% from a baseline of 8.0% after 40 weeks, with over 65% of patients achieving HbA1c levels ≤6.5% [3][4]. - Patients receiving the highest dose of Orforglipron lost an average of 7.3 kg, indicating potential for further weight loss [4]. - Eli Lilly plans to submit a global application for Orforglipron for weight management by the end of this year and for type 2 diabetes treatment in 2026 [4][5]. Summary by Sections Industry Overview - The successful Phase 3 trial of Orforglipron positions it as a potential second oral GLP-1 drug in the U.S., following Novo Nordisk's Rybelsus [5]. Investment Strategy - Focus on "innovation," "overseas expansion," "equipment upgrades," and "consumer recovery" as key investment themes [7]. - Recommended companies include innovative drug developers and those with strong overseas market potential [7]. Key Companies to Watch - **Nocera Health**: Expected to achieve over 1 billion yuan in revenue from its core product, with a projected 49% year-on-year growth [8]. - **Sihuan Pharmaceutical**: Strong fundamentals with a stable growth outlook, particularly in the ADC market [11]. - **China Biopharmaceutical**: Rapid revenue growth with a focus on innovative products [13]. - **Aier Eye Hospital**: Benefiting from increasing demand in ophthalmology and ongoing overseas expansion [22]. Market Performance - The pharmaceutical sector saw a decline of 0.36% last week, while the broader market index rose by 0.59% [25][36].

Investment Rating - The report maintains an optimistic outlook for the pharmaceutical industry, projecting growth opportunities across various segments by 2025 [10][12]. Core Insights - The current valuation of the pharmaceutical sector is low, with public funds under-allocating to this sector. Positive macroeconomic factors are expected to drive growth [10]. - The report emphasizes a shift from quantity to quality in the domestic innovative drug sector, highlighting the importance of differentiated and internationalized pipelines [10]. - The medical device market is showing signs of recovery, particularly in imaging equipment and home medical devices, with significant growth potential [10]. - The report identifies a favorable environment for the CXO and life sciences services sectors, anticipating a rebound in domestic investment and a return to high growth by 2025 [10]. - The traditional Chinese medicine sector is expected to benefit from policy changes and market dynamics, with specific companies recommended for investment [12]. - The report highlights the potential for the blood products industry to grow, particularly in the context of domestic production capabilities and the impact of U.S. tariffs on imported products [30][43]. Market Overview - The report notes that the Chinese albumin market is heavily reliant on imports, with 2024 projections indicating a market size of approximately 235 billion yuan, reflecting an 8.4% decline from the previous year [15][30]. - The domestic albumin market is expected to see a shift towards increased local production due to changing tariff structures and supply chain dynamics [30][43]. - The report outlines the competitive landscape for albumin, indicating that domestic products are poised to capture market share as U.S. imports decline [30][39]. Specific Company Insights - The report identifies several key companies in the innovative drug space, including 恒瑞, 百济, and 贝达, which are expected to lead in product development and profitability [10]. - In the medical device sector, companies like 迈瑞 and 联影 are highlighted for their growth potential due to ongoing equipment upgrades and international expansion [10]. - The report also discusses the emerging opportunities for companies involved in recombinant human albumin production, particularly those utilizing innovative production methods [50][55].

证券研究报告 | 医药生物 | 2025年4月19日 www.hczq.com 华创医药投资观点&研究专题周周谈·第122期 对美关税反制，国产白蛋白市场展望 本周周专题联系人：朱珂琛 | 华创医药团队： | | | --- | --- | | 首席分析师 郑辰 | 执业编号: S0360520110002 邮箱: zhengchen@hcyjs.com | | 联席首席分析师 刘浩 | 执业编号: S0360520120002 邮箱: liuhao@hcyjs.com | | 医疗器械组组长 李婵娟 | 执业编号: S0360520110004 邮箱: lichanjuan@hcyjs.com | | 中药和流通组组长 高初蕾 | 执业编号：S0360524070002 邮箱：gaochulei@hcyjs.com | | 分析师 万梦蝶 | 执业编号：S0360523080008 邮箱：wanmengdie@hcyjs.com | | 分析师 王宏雨 | 执业编号：S0360523080006 邮箱：wanghongyu@hcyjs.com | | 分析师 朱珂琛 | 执业编号: S03605240700 ...

Investment Rating - The report maintains a "Buy" rating for the company with a target price of 23.29 RMB, compared to the last closing price of 17.86 RMB [1][6]. Core Insights - The company's revenue for 2024 reached 1.009 billion RMB, representing a year-on-year growth of 36.7%. The core product, Aobutini, achieved sales exceeding 1 billion RMB, with a year-on-year increase of 49.1% due to the expansion of MZL indications and improved commercialization capabilities [4]. - The gross margin increased to 86.3% in 2024, up 3.7 percentage points from 2023, primarily driven by changes in revenue structure and enhanced production efficiency of Aobutini [4]. - The company reported a loss of 453 million RMB for the period, a reduction of 193 million RMB or 29.9% year-on-year, attributed to increased drug sales, improved cost efficiency, and reduced unrealized exchange losses [4]. - As of December 31, 2024, the company had approximately 7.8 billion RMB in cash and cash equivalents [4]. Summary by Sections Financial Performance - Revenue for 2024 is projected at 1.009 billion RMB, with growth rates of 36.68% for 2024, 29.87% for 2025, 41.80% for 2026, and 32.16% for 2027 [9]. - The company expects to continue narrowing losses, with projected net losses of 441 million RMB in 2024 and 461 million RMB in 2025 [9]. Product Pipeline and Clinical Progress - In the hematological malignancies sector, Aobutini's NDA for first-line CLL/SLL has been accepted by NMPA, with approval expected in 2025. Additionally, Aobutini in combination with BCL2 inhibitor ICP-248 is entering Phase 3 clinical trials [5]. - In the autoimmune sector, Aobutini's Phase 3 clinical trial for ITP is accelerating, and the 2b phase for SLE has completed patient enrollment [5]. Future Catalysts - The company has a rich pipeline of catalysts expected within the next 12 months, including potential approvals for Aobutini and other products in various indications [6].

公司具备证券投资咨询业务资格 证券研究报告 医药生物 [Table_Title] 全国各地出台创新药械支持政策 [Table_ReportDate] 2025 年 04 月 14 日 [Table_ReportType] 医药生物行业周报（4 月第 2 周） [Table_S 行业ummary 观点：] 请务必阅读文后重要声明及免责条款 [Table_Industry] [Table_BaseData] 1) 周度市场回顾。上周（4 月 7 日-4 月 11 日）医药生物 收跌-5.61%，跑输 Wind 全 A（-4.31%）和沪深 300（- 2.87%）。从板块来看，血液制品（4.06%）和线下药店 （1.81%）为避险板块，领涨其他子板块，医疗研发外 包（-16.04%）、体外诊断（-8.28%）和医药流通（-6.4%） 跌幅居前。从个股来看，涨幅前三的个股为奕瑞科技 （20.5%）、一品红（17.0%）和永安药业（13.9%），跌 幅前三的个股为润都股份（-27.8%）、多瑞医药（- 27.2%）和博腾股份（-22.2%）。 2) 全国各地出台创新药械支持政策。本周北京和深圳都 出台了关于创新药械的 ...

Investment Rating - The industry investment rating is "Outperform the Market" [52] Core Views - The report emphasizes the ongoing disruptions caused by the US-China tariff policies and suggests focusing on opportunities in non-US markets and import substitution [4][9] - The report highlights that the adjustment of tariffs is expected to impact the trade of pharmaceutical products between China and the US, while companies primarily exporting to markets outside the US will be less affected [4][9] Summary by Sections Tariff Policy Overview - Since April 2, 2025, the US government has imposed a 34% "reciprocal tariff" on Chinese goods, with frequent adjustments to tariff rates and exemptions for certain pharmaceutical products [4][5] - As of April 11, 2025, the tariff rates for bilateral trade between China and the US have been adjusted to 125%, with China indicating it will not respond to further tariff increases from the US [5] Opportunities in the Biopharmaceutical Sector - The report identifies potential for domestic products to increase market share in the blood products sector due to tariff impacts, particularly for albumin, where US imports are significant [9] - It suggests monitoring companies such as Palin Bio, Tiantan Bio, and Huashan Bio for potential growth in market share as import costs rise [9] Medical Devices - The report notes that the tariff policies and anti-dumping investigations are likely to accelerate the domestic substitution process in medical devices, particularly in electrophysiology and imaging fields [10] - Companies like Yirui Technology and United Imaging are highlighted as making progress in domestic production capabilities [10] Investment Strategies - The report recommends focusing on "innovation," "overseas expansion," "equipment upgrades," and "consumption recovery" as key investment themes [12] - Specific companies to watch include BeiGene, Mindray, and Xiamen Innovax for their innovative products and overseas market potential [12] Key Companies to Watch - Notable companies include: - **Nocera Biopharma**: Expected to achieve significant revenue growth with its core product, demonstrating strong cash flow and reduced losses [13][14] - **Sino Biopharmaceutical**: Rapid revenue growth with a focus on innovative products and a strong pipeline [18] - **Kexing Biopharma**: Stable domestic business with promising overseas expansion [18] - **Wuxi Biologics**: Recognized for its strong technical capabilities and expanding overseas operations [22] Market Performance - The report notes a decline in the pharmaceutical sector, with a 5.61% drop in the past week, while the overall market saw a smaller decline [31][42] - The biopharmaceutical sector is highlighted as having the smallest decline among sub-sectors, indicating relative resilience [44]

Core Viewpoint - The article emphasizes the importance of investing in Hong Kong's innovative pharmaceuticals, highlighting the sector's competitive advantages and favorable market conditions amid changing geopolitical dynamics and regulatory environments [2][7]. Group 1: Competitive Advantages of Chinese Innovative Pharmaceuticals - Chinese pharmaceutical companies are increasingly demonstrating global competitiveness in innovative drug development, particularly through License-out transactions, which have seen significant growth from approximately $11 billion in 2020 to over $51 billion in 2024 [7][8]. - The emergence of the NewCo model allows original drug companies to address challenges such as financing difficulties and high R&D risks by forming joint ventures with investors, enhancing their ability to monetize innovations [8][11]. Group 2: Impact of Tariff Policies - Current tariff policies have a minimal impact on innovative pharmaceuticals compared to other growth sectors, as the License-out model primarily involves intellectual property transactions that are not subject to tariffs [11][12]. - The innovative drug sector is expected to benefit from a correction in market mispricing, as it has been less affected by recent market volatility compared to other sectors [11][12]. Group 3: Favorable Policy and Regulatory Environment - Recent policy shifts indicate a more supportive regulatory environment for innovative drugs, including optimization of centralized procurement rules and increased support for innovative drug development in government reports [12][13]. - The introduction of new drugs into the medical insurance catalog and local government initiatives to support the biopharmaceutical industry further enhance the sector's growth prospects [13][14]. Group 4: Financial Performance and Valuation - Leading Hong Kong innovative pharmaceutical companies are experiencing steady revenue and profit growth due to increased License-out activities, with significant revenue growth rates reported for several companies [14][15]. - The pharmaceutical sector's valuation remains relatively safe compared to other growth industries, with a current price-to-earnings ratio of 27.1, placing it in a favorable percentile range historically [16][17]. Group 5: Market Dynamics and Trading Activity - Despite improvements in trading conditions in the Hong Kong market, the pharmaceutical sector has not garnered significant attention, with trading volumes remaining low compared to other sectors [18]. - Southbound capital has shifted focus from dividend-paying stocks to growth sectors, indicating a potential for increased investment in pharmaceuticals as market conditions stabilize [18].

Investment Rating - The industry investment rating is "Outperform the Market" [52] Core Viewpoints - The ongoing US-China tariff policies are causing disruptions, suggesting a focus on non-US market expansion and import substitution opportunities in the biopharmaceutical sector [4][9] - The report highlights that the adjustment of tariffs is expected to impact the trade of pharmaceutical products between China and the US, with companies primarily exporting to markets outside the US being less affected [4][9] - The report emphasizes the potential for domestic products to gain market share in the biopharmaceutical sector due to increased tariffs on US imports [9][10] Summary by Sections Tariff Policy Overview - As of April 11, 2025, the tariff rates for bilateral trade between China and the US have been adjusted to 125%, with China indicating it will not respond to further tariff increases from the US [4][5] Biopharmaceutical Sector Insights - The blood products sector is expected to stabilize prices and increase the market share of domestic products due to tariff impacts on imports, particularly for albumin [9] - The medical device sector is anticipated to accelerate domestic substitution due to reliance on North American production, with specific focus on electrophysiology and imaging products [10] - The report suggests monitoring companies such as Palin Bio, Tian Tan Bio, and Huashan Bio for potential growth opportunities in the blood products market [9][10] Investment Strategies - The report recommends focusing on "innovation," "overseas expansion," "equipment upgrades," and "consumer recovery" as key investment themes [12] - Specific companies highlighted for innovation include BeiGene, Dongcheng Pharmaceutical, and others with strong global competitiveness [12] - Companies like Mindray Medical and United Imaging are noted for their potential in overseas markets [12] Key Companies to Watch - Notable companies include: - **Nocera Biopharma**: Expected to achieve significant revenue growth with its core product, showing a 49% year-on-year increase in sales [13] - **Sino Biopharmaceutical**: Rapid revenue growth with a focus on innovative products [18] - **Kexing Biopharma**: Stable domestic business with promising overseas expansion [18] - The report also highlights the potential of companies like East China Pharmaceutical and others in the nuclear medicine sector [17] Market Performance - The biopharmaceutical sector has seen a decline of 5.61% recently, with specific sub-sectors experiencing varying levels of impact [31][44]

Investment Rating - The industry investment rating is "Positive" [6] Core Viewpoints - The escalation of tariffs between China and the US is accelerating domestic substitution in the research service sector, with a focus on opportunities in this area [3][15] - The increase in tariffs on US imports is expected to raise prices of certain research service products, enhancing the price advantage of domestic brands [3][15] - The overall market for scientific services in China is currently dominated by foreign brands, indicating a low domestic market penetration [15] Summary by Sections Tariff Escalation and Trade Conflict - The US has increased tariffs on all imports from China to 145% as of April 10, 2025, while China has raised tariffs on US imports to 84% [3][11] - The ongoing trade conflict is expected to lead to price increases for US-made research service products, which may benefit domestic alternatives [3][11] Market Performance - In the second week of April 2025, the pharmaceutical and biological sector declined by 5.61%, underperforming the CSI 300 index by 2.73 percentage points, ranking 22nd among 31 sub-industries [4][17] - The blood products sector saw the highest increase, rising by 4.06%, while the medical research outsourcing sector experienced the largest decline at 16.04% [4][21] Recommended and Benefiting Stocks - Recommended stocks include: - Pharmaceuticals and Biologics: Zai Lab, Innovent Biologics, Kelun-Biotech, and others [5] - Traditional Chinese Medicine: Dong-E E-Jiao, Zhaoke Pharmaceutical, and others [5] - Research Services: Aopumai, Aladdin, and others [5] - Raw Materials: Pro Pharma, Jianyou, and others [5] - Medical Devices: Aotai Bio, Anjiesi, and others [5] - CXO: WuXi AppTec, and others [5] - Medical Services: Aier Eye Hospital, and others [5] - Retail Pharmacies: Yifeng Pharmacy [5]