中国国际金融股份有限公司 根据《关于在上海证券交易所设立科创板并试点注册制的实施意见》《科创板上 市公司持续监管办法（试行）》《上海证券交易所科创板股票上市规则》《上海证券 交易所科创板上市公司自律监管指引第 4 号——询价转让和配售》（以下简称"《询 价转让和配售指引》"）等相关规定，中金公司对参与本次询价出让方的相关资格进 行了核查。 本次询价转让的委托情况、出让方相关资格的核查情况及核查意见如下： 一、本次询价转让的委托 中金公司已收到出让方关于本次询价转让的委托，委托中金公司组织实施本次询 价转让。 二、关于参与本次询价转让股东相关资格的核查情况 （一）核查过程 关于科兴生物制药股份有限公司 股东向特定机构投资者询价转让股份 相关资格的核查意见 中国国际金融股份有限公司（以下简称"中金公司"）受科兴生物制药股份有限 公司（以下简称"科兴制药"）股东深圳科益医药控股有限公司（以下简称"科益医 药""出让方"）委托，组织实施本次科兴制药股东向特定机构投资者询价转让（以 下简称"本次询价转让"）。 4、出让方不存在《上市公司股东减持股份管理暂行办法》《上海证券交易所上市 公司自律监管指引第 15 号——股东 ...

格隆汇11月14日丨科兴制药(688136.SH)公布，本次拟参与科兴制药首发前股东询价转让（简称"本次询 价转让"）的股东为科益医药；出让方拟转让股份的总数为10,062,800股，占公司总股本的比例为 5.00%。 ...

Core Viewpoint - The Hong Kong stock market is experiencing a surge in IPO applications from biotech companies, but the recent delay in the IPO of Baile Tianheng highlights potential risks and challenges in the market [1][7][11]. Group 1: IPO Activity - Six biotech companies, including Mindray Medical and Insilico Medicine, submitted IPO applications to the Hong Kong Stock Exchange within six days, marking a record high for the year [1][2]. - The Hong Kong Stock Exchange's support for the biotech sector, particularly the 18A listing rule allowing unprofitable biotech firms to go public, has attracted these companies [2][3]. Group 2: Company Profiles - Mindray Medical, a leading medical device company, aims to enhance its international strategy and brand influence through its IPO, with a projected international revenue share exceeding 50% by Q3 2025 [3]. - Other companies like Kexing Pharmaceutical and Real Bio are also seeking to expand their international presence and fund R&D through their IPOs [4]. Group 3: Market Environment - The influx of southbound capital into the Hong Kong market has reached a historic high, with net inflows exceeding HKD 5 trillion, boosting investor confidence [5][6]. - Despite the positive fundraising environment, there is a shift in investment strategies towards high-dividend stocks, which may impact the biotech sector's attractiveness [5][11]. Group 4: Challenges and Risks - Baile Tianheng's delayed IPO raises concerns about high entry barriers and insufficient valuation discounts, which may deter retail investors [8][9]. - The company's volatile financial performance and reliance on a significant one-time transaction for revenue have led to skepticism about its long-term profitability [9][10]. - The market's increasing focus on stable cash flows and product commercialization capabilities may pose challenges for companies lacking clear market positioning [11].

Core Viewpoint - Baili Tianheng has decided to delay its H-share global offering and listing due to current market conditions, which has been in preparation for over a year [1][4] Company Overview - Baili Tianheng, originally established as Baili Pharmaceutical in 1996, shifted its R&D focus to innovative cancer treatments around 2011, including ADCs and bispecific antibodies [5] - The company has faced significant challenges in drug development, adhering to the "double ten rule," which states that new drug development takes an average of ten years and costs around $1 billion [5] Financial Performance - R&D expenses increased from 181 million yuan in 2019 to 375 million yuan in 2022, with the proportion of R&D expenses to revenue rising from 15.03% to 53.32% [5] - In 2023, R&D expenses reached 746 million yuan, accounting for 132.82% of revenue, leading to cash flow issues with only 404 million yuan remaining by year-end [6] - A significant turnaround occurred in 2024, with revenue soaring by 936.31% to 5.823 billion yuan and net profit turning positive at 3.708 billion yuan, following a licensing agreement with Bristol-Myers Squibb worth up to $8.4 billion [6] Market Context - The delay in H-share listing is seen as a strategic adjustment, with expectations of revising pricing and offering scales to enhance market reception [4][7] - The trend of dual listings ("A+H") is gaining traction among innovative pharmaceutical companies, with 22 biopharmaceutical firms having listed in Hong Kong this year [8] - The market for innovative drug companies remains volatile, with some newly listed firms experiencing significant price fluctuations shortly after their IPOs [9] Future Outlook - Baili Tianheng aims to become a leading multinational company focused on oncology within ten years, with ongoing assessments of its global offering timeline [7] - The company is actively managing its R&D pipeline, with 90 clinical trials underway, and has plans to raise up to 3.764 billion yuan for further innovation projects [6][7]

Core Viewpoint - The Hong Kong stock market is experiencing a surge in biotech IPO applications, with companies eager to capitalize on the favorable listing environment, despite some unexpected delays in the process [1][2]. Group 1: IPO Activity - Six biotech companies, including major players like Mindray Medical and innovative firms like Insilico Medicine and Anxuyuan Technology, have submitted IPO applications to the Hong Kong Stock Exchange within a short span, indicating a strong demand for capital [2][3]. - The Hong Kong Stock Exchange's 18A listing rule, introduced in 2018, allows unprofitable biotech companies to raise funds, which has attracted many innovative firms to the market [2]. Group 2: Company Strategies - Mindray Medical, a leader in the medical device sector, aims to enhance its international strategy through its IPO, with plans to increase its global revenue share and invest in R&D and sales networks [3]. - Smaller biotech firms like Sinovac Biotech and Real Bio are also seeking to expand internationally through their IPOs, with specific plans to fund product development and market expansion [4]. Group 3: Market Environment - The influx of southbound capital into the Hong Kong market has reached a historic high, with net inflows exceeding HKD 5 trillion, providing a solid foundation for biotech IPOs [5][6]. - Recent market dynamics show a shift in investor strategy from aggressive tech investments to defensive high-dividend stocks, impacting the appetite for biotech IPOs [5]. Group 4: Valuation Concerns - The delay in the IPO of Baillie Gifford is notable, as it highlights valuation challenges in the biotech sector, with concerns over high entry barriers and insufficient valuation discounts compared to A-shares [7][8]. - Baillie Gifford's fluctuating performance raises questions about its long-term profitability, as its recent revenue surge is tied to a one-time transaction rather than sustainable growth [9][10]. Group 5: Industry Outlook - The case of Baillie Gifford serves as a warning for other biotech firms, emphasizing the importance of clear market positioning, valuation strategies, and stable performance to succeed in the Hong Kong IPO landscape [10][11]. - The market is becoming more discerning, favoring companies with genuine technological advantages and commercialization potential, signaling a return to rationality in the biotech sector [11].

Group 1 - The company has established a special settlement account for managing temporarily idle raised funds through financial products at China Bank Qianhai Shekou Branch [1] - All financial products purchased through the special settlement account have matured and been redeemed, leading to the account's cancellation [1] - The cancellation of the account has been completed in accordance with relevant regulations, including the "Regulations on the Supervision of Raised Funds by Listed Companies" and the "Self-Regulatory Guidelines for Listed Companies on the Science and Technology Innovation Board" [1]

Group 1 - A-share companies are increasingly seeking listings on the Hong Kong Stock Exchange, with over 80 companies having submitted applications this year alone [1][3] - The number of A+H listed companies has reached 160, with 16 companies successfully listing in Hong Kong this year, surpassing the total from the previous five years [2][3] - Major A-share companies that have recently listed include Ningde Times, which raised nearly 40 billion HKD, and others like Sails and Sany Heavy Industry, each raising over 10 billion HKD [2] Group 2 - The sectors attracting A-share companies to Hong Kong include biomedicine, technology, and consumer goods, reflecting investor interest in these areas [3][4] - The Hong Kong Stock Exchange has optimized its listing mechanisms, making it easier for companies to access capital, which is crucial for their growth [4] - The trend of A+H listings is driven by the desire of mainland companies to enter international markets, leveraging Hong Kong's unique position and regulatory environment [5] Group 3 - The Hong Kong Stock Exchange has seen record revenue and net profit in the first three quarters of the year, driven by high trading activity and a surge in new listings [6] - There are currently around 300 listing applications being processed, with half from new economy sectors such as electric vehicles and biotechnology [6] - Despite the overall positive trend, some new listings have faced challenges, with instances of stocks dropping below their issue price on debut, leading to delays in some IPOs [6][7]

科兴生物制药股份有限公司 关于注销部分募集资金理财产品专用结算账户的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 一、募集资金理财产品结算账户的开立情况 科兴生物制药股份有限公司（以下简称"公司"）为满足部分暂时闲置募集 资金现金管理的需要，在中国银行前海蛇口分行营业部开立了募集资金理财产品 专用结算账户，具体内容详见公司于2024年6月7日在上海证券交易所网站 （www.see.com.cn）披露的《关于开立理财产品专用结算账户的公告》（公告编 号：2024-042）。 证券代码：688136 证券简称：科兴制药 公告编号：2025-093 截至本公告披露日，公司在中国银行前海蛇口分行营业部账户（账号： 777078668780）购买的理财产品均已全部到期赎回，且不再使用该账户。根据《上 市公司募集资金监管规则》及《上海证券交易所科创板上市公司自律监管指引第 1号——规范运作》的相关规定，公司于近日办理完毕上述理财产品专用结算账 户的注销手续。具体账户信息如下： | 开户机构 | 开户名称 | 账号 | | -- ...

Market Overview - The biopharmaceutical sector experienced a slight decline of 0.08% on November 11, with He Yuan Bio leading the drop [1] - The Shanghai Composite Index closed at 4002.76, down 0.39%, while the Shenzhen Component Index closed at 13289.0, down 1.03% [1] Stock Performance - Notable gainers included: - Jin Ke (688670) with a closing price of 24.97, up 19.99% on a trading volume of 134,300 shares and a transaction value of 310 million [1] - Kanghua Bio (300841) closed at 83.21, up 6.04% with a trading volume of 57,100 shares [1] - Watson Bio (300142) closed at 12.82, up 2.64% with a trading volume of 942,000 shares [1] - Significant losers included: - Bu Yuan Bio (688765) closed at 86.00, down 8.02% with a trading volume of 107,600 shares [2] - Ao Pu Mai (688293) closed at 59.18, down 3.65% with a trading volume of 17,900 shares [2] - Rongchang Bio (688331) closed at 86.00, down 2.55% with a trading volume of 45,900 shares [2] Capital Flow - The biopharmaceutical sector saw a net outflow of 671 million from institutional investors, while retail investors contributed a net inflow of 335 million [2] - The capital flow for key stocks showed: - Jin Ke had a net inflow of 48.11 million from institutional investors, but a net outflow of 24.49 million from speculative funds [3] - Zhifei Bio (300122) experienced a net inflow of 15.25 million from institutional investors, with a net outflow of 23.20 million from retail investors [3] - Kanghua Bio had a net inflow of 14.35 million from institutional investors, but a net outflow of 23.26 million from speculative funds [3]

Market Performance - A-shares saw a rise with the Shanghai Composite Index closing up 0.53% at 4018.6 points, while the Shenzhen Component Index increased by 0.18%[1] - The Hang Seng Index in Hong Kong closed up 1.55% at 26649.06 points, with the Hang Seng Tech Index rising 1.34% and the Hang Seng China Enterprises Index up 1.90%[1] - The total market turnover in Hong Kong decreased to 2147.878 million HKD[1] Economic Indicators - The U.S. government shutdown is expected to end soon, with the Senate likely to vote on a temporary funding bill[1] - China's passenger car sales fell for the first time in over a year, with a 0.8% year-on-year decline in October due to the withdrawal of trade-in subsidies[1][12] International Trade - Switzerland is reportedly close to reaching an agreement with the U.S. to reduce export tax rates from 39% to 15%, with a potential deal expected in the next two weeks[12] - The U.S. trade representative is optimistic about reaching a trade agreement with India, which may involve lowering tariffs on Indian goods[12]