记者丨季媛媛 编辑丨张星 中国创新药交易额现已超越美国，本土创新成果正逐步获得全球主流市场认可。 医药魔方NextPharma数据库显示，截至2025年12月31日，中国创新药商务拓展（BD）出海授权全年交易总金额达到1356.55亿美元（约9483亿元人民 币），首付款70亿美元，交易总数量达到157笔，远超2024年全年519亿美元和94笔，各个维度的数据统计均达到了历史新高。 国家药监局药品注册管理司副司长蓝恭涛也指出，2025年我国创新药对外授权交易总额较上一年翻了大约一倍，创新药审批数量也创新高，这是我国持续 深化药品审评审批制度改革，一系列鼓励创新政策落地实施的重大成果。"在创新药数量增长的同时，我们坚持标准不降低、标准国际化，对外授权的大 幅增长也反映出国际社会对我国创新药价值的认可。" 盘点2025年的授权交易情况，有不少业内人士预计，跨国药企面临"专利悬崖"和降成本压力，对中国创新资产的需求将持续。同时，出海模式正从单一 的"License-out"（授权出海）向联合开发、自主出海等更深度合作模式演进。 这意味着中国药企有望在全球价值链中分享更多收益。 中国创新药BD交易的火热背后，是多层次 ...

国家药监局药品注册管理司副司长蓝恭涛也指出，2025年我国创新药对外授权交易总额较上一 年翻了大约一倍，创新药审批数量也创新高，这是我国持续深化药品审评审批制度改革，一系 列鼓励创新政策落地实施的重大成果。"在创新药数量增长的同时，我们坚持标准不降低、标 准国际化，对外授权的大幅增长也反映出国际社会对我国创新药价值的认可。" 盘点2025年的授权交易情况，有不少业内人士预计，跨国药企面临"专利悬崖"和降成本压力， 对中国创新资产的需求将持续。同时，出海模式正从单一的"License-out"（授权出海）向联合 开发、自主出海等更深度合作模式演进。 这意味着中国药企有望在全球价值链中分享更多收益。 记者丨 季媛媛 编辑丨张星 中国创新药交易额现已超越美国，本土创新成果正逐步获得全球主流市场认可。 医药魔方NextPharma数据库显示， 截至2025年12月31日，中国创新药商务拓展（BD）出海 授权全年交易总金额达到1356.55亿美元（约9483亿元人民币），首付款70亿美元，交易总数 量达到157笔，远超2024年全年519亿美元和94笔，各个维度的数据统计均达到了历史新高。 热潮 从已披露的数据可见，2 ...

Core Viewpoint - The article highlights the unprecedented surge in business development (BD) activities in China's biotech sector, with the total amount of domestic innovative drug licensing exceeding $100 billion by November 18, 2025, marking a doubling compared to 2024. This trend reflects the increasing global competitiveness and value of Chinese pharmaceutical assets, while also prompting a deeper examination of transaction quality and product value realization post-agreement [1][2]. Summary by Sections BD Market Dynamics - The BD market in China is experiencing a significant boom, with a projected compound annual growth rate (CAGR) for external BD activities expected to remain in double digits over the next five years, despite a forecasted decline in growth rate [2]. - Key characteristics of future transactions include an increase in late-stage pipeline contributions and a shift from pure technology transfer to models involving "licensing + co-development + commercialization" [2]. Major Transactions - Notable transactions in 2025 include: - Hengrui Medicine's collaboration with GSK, involving a total potential amount of approximately $120 billion, with an upfront payment of $500 million [3]. - Innovent Biologics' agreement with Takeda, with a potential total of $114 billion and an upfront payment of $1.2 billion [3]. - A record-setting deal between 3SBio and Pfizer, with an upfront payment of $12.5 billion and potential milestone payments reaching $48 billion [5][6]. Global Interest in Chinese Biotech - Chinese innovative drugs are gaining significant traction in global markets, with multinational corporations increasingly sourcing early-stage innovation pipelines from China due to cost-effectiveness and potential efficacy [7][8]. - The trend indicates a shift where Chinese biotech firms are evolving from technology providers to value co-creators in the global pharmaceutical landscape [7]. Transaction Models - The dominant transaction model remains "License-out," which accounted for 91% of upfront payments and 99% of total amounts in related transactions in the first half of the year [10]. - NewCo models are gaining popularity, allowing companies to inject parts of their product pipelines into newly formed entities with foreign capital, reflecting a flexible asset operation strategy [10][11]. Future Outlook - The BD market is expected to continue thriving, driven by the need for multinational companies to replenish their pipelines as many blockbuster drugs face patent expirations, creating a significant market opportunity [15]. - Emerging technologies, particularly in ADCs and bispecific antibodies, are anticipated to dominate future BD transactions, with a notable interest in metabolic and autoimmune products [16][17]. Challenges and Considerations - Despite the growth, challenges remain in ensuring compliance with international standards and protecting intellectual property during global collaborations [13]. - The market is expected to stabilize, with a rational return to expectations regarding BD transactions, as the industry matures and the focus shifts from explosive growth to sustainable value creation [17].

文 | 财华社 因元旦假期安排，12月31日港股市场仅开放上午半天交易，午后正式完成2025全年收官。 回望这一年，港股市场延续了2024年的涨势，再度走出强劲上涨行情，恒生指数全年累涨27.77%，恒生科技指数同步上涨23.45%，更值得关注的是，全 年成交量较往年显著放大，交投活跃度大幅提升，估值修复与产业景气共振之下，市场赚钱效应全面释放。 阶段轮动清晰：不同主线接力驱动市场上行 从板块轮动节奏来看，2025年港股呈现清晰的阶段性主线切换，从年初的AI科技热潮，到年中的创新药BD交易爆发，再到反内卷政策驱动的产业优化， 最终以有色金属板块的全年领跑画上句点，不同阶段的核心主线共同推动港股市场全年上行。 具体而言，年初阶段，DeepSeek赶在蛇年春节前发布了大模型DeepSeek-R1，直接惊艳全球。其"多快好省"的特性在给英伟达（NVDA.US）一记暴击之 外，也打开了中国资产的牛市之路。 在这一阶段，港股市场的科技板块成为绝对主角，恒生科技指数在2025年一季度累计上涨20.74%，远超同期恒生指数15.25%的涨幅。 资金则重点追捧算力基建、大模型研发及AI应用相关标的，不仅传统互联网大厂，如阿里 ...

Group 1: Industry Overview - The Chinese innovative drug industry is experiencing a significant recovery in 2025, with record high external BD totals and an increase in the number of drug approvals [1][2] - Despite the positive trends, there are concerns about the sustainability of the market, high valuations of some companies, and the potential for structural differentiation in the industry [2][3] Group 2: IPO Market - The IPO market for innovative drug companies has seen a resurgence, with many firms successfully listing on the Hong Kong stock exchange and exceeding fundraising expectations [3][4] - However, the market experienced a downturn in December, with initial public offerings facing challenges such as market sentiment cooling and stricter regulatory scrutiny [4] Group 3: Commercial Insurance and Drug Pricing - The introduction of a commercial insurance directory for innovative drugs aims to address the payment challenges associated with high-priced therapies, with 24 drugs participating in price negotiations [4][5] - The negotiated price reductions for these drugs range from 15% to 50%, but the effectiveness of this new payment model in promoting clinical use remains to be seen [5] Group 4: BD Opportunities and Challenges - The trend of significant BD transactions continues, with companies like 3SBio and Innovent Biologics leading the way, prompting speculation about the next major BD opportunities [6][7] - There is a growing concern about the legal risks associated with BD transactions, as the industry may face an increase in litigation related to these deals [8] Group 5: Future Prospects and Uncertainties - Key questions remain regarding the future of companies like Summit, including potential acquisitions and the performance of their clinical trials [9][10] - The domestic vaccine sector is struggling, with significant declines in stock prices and ongoing challenges related to product differentiation and commercialization [11] - Geopolitical factors continue to pose risks to the innovative drug sector, with ongoing uncertainties regarding regulatory policies and market access [12] Group 6: Unexpected Developments - Some biotech companies have made surprising decisions, such as the acquisition of Lixte Biotechnology by China National Pharmaceutical Group, which deviated from expectations of an independent IPO [13][14] - The sudden dissolution of Run Biotech highlights the high-risk nature of the industry and the challenges of balancing short-term financial returns with long-term innovation [15]

随着我国生物医药产业竞争力与创新活力持续攀升，2025创新药高质量发展大会上国家医保局披露最新数据显示，年内中国批准上市的创新药 已达69个，超过去年全年的48个，再次创下历史新高。当前，中国医药产业规模已位居全球第二，创新药在研数目约占全球的30%。 2025年，我国创新药领域掀起了前所未有的BD热潮，不仅印证了中国医药资产在全球范围内性价比与核心竞争力的提升，更推动行业迈入"创 新兑现+全球布局"的关键发展期。 《21世纪》：2025年中国创新药BD交易金额突破千亿美元，你如何看待这一"爆发式增长"的可持续性？这种增长是否已从单纯的"规模扩 张"转向"价值深化"？ 于建林：2025年中国首次超越美国成为全球最大授权来源国，全球TOP20跨国药企中90%已与中国创新药管线开展合作，中国占全球授权交易 近一半。 但也应注意，中国FIC占比仍偏低，源头创新不足。当下BD大部分仍集中在早期授权，临床后期项目交易占比不到一半，从而损失后期巨额收 益。仅少数头部企业（如百济神州、恒瑞医药）具备全链条出海能力，多数企业还是依赖"借船出海"。 这一高质量发展态势的背后，离不开政策的持续赋能，也得益于我国创新药企的深耕加码 ...

百亿市场待重构，替代空间广阔 今年，多款国产抗流感创新药密集获批上市，引发市场高度关注，2025年甚至被称为"国产流感创新药 元年"。有业内人士表示，国产流感创新药密集取得进展，是我国医药创新能力持续提升的必然结果。 这背后蕴藏着什么投资机遇？（资料参考：证券日报《国产创新药破局 为应对流感提供"中国方 案"》，2025.11.12） 国产流感创新药商业化提速 2025年3月至7月，我国有三款抗流感创新药（玛舒拉沙韦片、昂拉地韦片、玛硒洛沙韦片）获批上市， 另有两款药物（玛氘诺沙韦、玛帕西沙韦）完成临床试验，已经提出了上市申请，预计不久将加入市场 竞争。专业人士分析称，目前国产创新药上市以后，销量在稳步提升，反映出这些产品在疗效、安全性 方面获得了认可。（资料参考：央广网《全国整体进入流感流行季 多款国产流感创新药密集上市》， 2025.11.21；36氪《围剿"流感神药"奥司他韦，药厂卷起"一次治疗"新战场》，2025.11.14） 突破进口药局限，实现多重优化 国产新药与进口流感药玛巴洛沙韦作用机制相同，都是通过抑制流感病毒的CAP帽子结构依赖性内切 酶，从而阻断病毒复制。值得关注的是，这批国产新药并非简 ...

一品红（300723），突然崩了！ 今日早盘，5倍大牛股一品红突然20%跌停。就在昨晚，该公司还发布了利好公告，其产品芩香清解口服液获批为国家中药二级保护品种。然而，这则利 好，并未对冲掉其利空消息。 集体回调 可能是受一品红的影响，创新药今天整体表现也不好。港股创新药板块指数跌幅超过2%，科伦博泰生物、百济神州、翰森制药、三生制药、基石药业等跌 幅都达5%以上。A股创新药板块指数也跌了0.7%，泽璟制药、三生国健、博瑞医药、益方生物等跌幅都比较大。 分析人士认为，一品红的交易可能改变了一些市场预期。今年以来，创新药爆发的主因是BD。今年，中国创新药BD交易呈现爆发式增长。有机构预计， 2025年底交易额将超过1000亿美元，占全球交易额近50%。 交易完成后，该公司将不再持有Arthrosi股权。目前，一品红通过全资子公司瑞騰生物(香港)有限公司持有Arthrosi公司13.45%的股权。若交易最终达成，预 计将对公司产生积极影响。 然而，今天早上，一品红的股价却直接被按死在跌停板上。该股从去年9月底到今年7月，涨幅超过500%，但随后一路走弱，股价较最高位已经腰斩。 有投资者算了一笔账，一品红这笔投资+B ...

Core Insights - The global biopharmaceutical innovation landscape, traditionally dominated by multinational corporations, is undergoing significant structural changes, with China's innovative drug industry emerging as a key player on the global stage [1] - China's transition from a "fast follower" to an "originator" in innovative drugs is becoming an irreversible trend, as highlighted by international media [1] - Data shows a notable increase in China's share of global clinical trials and licensing transactions, with Chinese biotech companies outperforming their U.S. counterparts in stock price growth over the past year [1][3] Group 1: Market Dynamics - Multinational corporations are increasingly inclined to source early-stage innovative pipelines from China due to cost-effectiveness, with costs in China being 30%-40% lower than in the U.S. [2] - The collaboration between domestic companies and multinationals is exemplified by the $12.5 billion upfront payment from Pfizer to 3SBio for overseas rights to a bispecific antibody, marking a record for domestic innovative drugs [2][3] - The Chinese innovative drug sector is expected to see a surge in licensing transactions, with projections indicating that total licensing amounts could exceed $100 billion in the first three quarters of 2025 [3] Group 2: Investment Trends - The biopharmaceutical sector is experiencing a business development (BD) boom, with significant transactions such as the $12 billion collaboration between Hengrui Medicine and GSK, indicating strong interest from multinational companies [3][4] - Investment institutions are focusing on the biopharmaceutical sector, with approximately 80% of the market value concentrated in biotechnology and pharmaceuticals, driving capital flow into these areas [5] - The market is witnessing a shift from "story-driven" investment decisions to a focus on the hard capabilities of companies, emphasizing the importance of clinical data and product quality [9][10] Group 3: Future Outlook - The innovative drug market is expected to thrive, with projections indicating that the Hang Seng Index could double by 2025, driven by favorable policies and a rebound in industry valuations [7] - The Chinese innovative drug sector is anticipated to recover strongly in 2025, with the overall revenue of listed companies in this sector reaching 48.83 billion yuan, a 22% year-on-year increase [7] - The market is seeing a resurgence in IPO activity, with over 20 companies currently queued for listing in Hong Kong, reflecting renewed investor interest in the biopharmaceutical sector [12][13]

Core Insights - The domestic innovative drug BD (business development) transactions have reached $104.2 billion by the end of October 2025, with upfront payments totaling $8.1 billion, both figures surpassing the total for the previous year, indicating a significant surge in BD transactions in China's innovative drug sector [1] Group 1: BD Transactions and Industry Dynamics - BD transactions are reshaping the innovative drug ecosystem by integrating internal R&D with external markets, enhancing funding, global collaboration, and ecosystem building [4] - The efficient integration of funds and resources allows multinational pharmaceutical companies facing patent expirations to leverage BD collaborations to introduce Chinese innovative drugs at low costs, while local companies can quickly recoup funds to support further R&D [5] - China has become the largest source of authorized transactions in the innovative drug sector globally, with over 90% of leading international MNCs engaging in BD collaborations with domestic innovative drug pipelines [5] Group 2: Strategic Evolution of BD - The concept of BD is evolving from short-term transactions focused on "selling pipelines" to long-term strategic layouts aimed at "building ecosystems," with the Co-Co model (co-development + co-commercialization) becoming mainstream [6] - In the technology platform sector, BD strategies are transitioning from "single technology licensing" to "platform output," enhancing global pharmaceutical companies' R&D capabilities and creating sustained technical licensing revenue [7] Group 3: Investment Logic in Innovative Drugs - The innovative drug sector is exhibiting dual investment value characterized by "supported profit growth" and "logical valuation enhancement" [10] - Policy support from the government in R&D, review, and payment processes is providing a safeguard for corporate profitability, while Chinese innovative drugs are achieving global leadership in areas like ADC and bispecific antibodies, opening up global growth opportunities [11] - The market's perception of Chinese innovative drugs is improving due to their low R&D costs and rapid iterations, making them preferred options for multinational companies facing patent cliffs [12]