Market Overview - US stock indices closed lower, with the Dow down 0.7%, Nasdaq down 0.91%, and S&P down 0.84. The VIX index rose 13.13% to 21.62. The dollar index increased by 0.69% to 98.83. The yield on the 10-year US Treasury fell by 1.237% to 4.392%, with a spread of 43.6 basis points compared to the 2-year Treasury yield. Spot gold rose by 0.09% to $3388.4 per ounce, while Brent crude oil increased by 5.4% to $76.92 [1]. Industry & Stocks - The energy sector was the only one to gain, up 0.93%, while the other nine sectors in the S&P 500 declined, with healthcare down 1.65%, materials down 0.98%, and technology down 0.71% [1]. - Chinese concept stocks mostly fell, with TSMC down 0.83%, Alibaba down 0.8%, Pinduoduo down 1.12%, and JD down 0.93%. Brain Rejuvenation Technology surged 30%, with a year-to-date increase of 64,208%. Li Auto fell 4.47%, and there was a significant share reduction by Wang Xing in Li Auto [1]. - Major tech stocks also saw declines, with Microsoft down 0.23%, Nvidia down 0.39%, and Apple down 1.4%. Oracle fell 1.38% as it launched a project to facilitate technology sales to the US Department of Defense [2][3]. Daily Focus 1. Brain Rejuvenation Technology saw a 30% increase, with a peak rise of 430% recently. The company announced FDA approval for its new neural modulation chip and plans to collaborate with the Mayo Clinic for Parkinson's disease research. However, it has not generated any revenue and faces high failure probabilities in its core therapy [4]. 2. Cathie Wood's Ark Invest sold over 340,000 shares of Circle after a significant price increase, realizing approximately $51.7 million from the sale [5][6]. 3. Eli Lilly is reportedly in talks to acquire Verve Therapeutics for up to $1.3 billion, which is nearly double Verve's current market value of $559 million [8]. 4. Elon Musk's xAI is attempting to raise $9.3 billion but is burning through cash at a rate of $1 billion per month, reflecting the high funding demands of the AI industry [8][9]. 5. Tesla's autonomous driving technology is reported to have surpassed Waymo's in terms of mileage and safety metrics, with Tesla's collision rate significantly lower than Waymo's [10].

Group 1 - Verve Therapeutics' stock surged over 70% following an announcement by Eli Lilly to acquire the company for up to $1.3 billion, including a nearly $1 billion upfront payment and potential additional funds based on clinical milestones [3][4] - The acquisition price is set at $10.5 per share for all outstanding shares of Verve, indicating strong investor interest and confidence in the company's future prospects [4] - Verve is developing a groundbreaking in vivo gene editing drug, Verve-102, which utilizes CRISPR technology to modify liver cell DNA, potentially transforming the treatment of cardiovascular diseases from chronic care to a one-time therapy [4] Group 2 - The broader market saw declines in major indices, with the Dow Jones down 0.24%, S&P 500 down 0.29%, and Nasdaq down 0.40%, reflecting a mixed sentiment in the market despite the positive news for Verve [2] - In the biotech sector, BrainCo, a company focused on brain-computer interface technology, experienced a significant stock increase, reflecting investor enthusiasm for innovative health technologies [4][5] - The energy sector also saw gains, with major oil companies like Chevron and ExxonMobil rising over 1%, amid rising oil prices and geopolitical developments affecting energy supply [6][8]

Market Overview - The US stock market opened lower on June 17, with the Dow Jones down 0.24%, S&P 500 down 0.29%, and Nasdaq down 0.40% [1][2] - Major tech stocks mostly declined, with Tesla dropping nearly 2% and Microsoft, Apple, Google A, and Meta experiencing slight decreases [2] - The Nasdaq China Golden Dragon Index fell by 0.74% [2] Economic Data - The US Census Bureau reported a 0.9% month-over-month decline in retail sales for May, with April's figure revised to a 0.1% decrease [2] - The US Bureau of Labor Statistics indicated that the import price index remained unchanged, while the export price index decreased by 0.9% [2] Corporate News - Verve Therapeutics saw its stock price surge over 70% following an announcement from Eli Lilly that it would acquire the company for up to $1.3 billion [4][6] - Eli Lilly's acquisition includes a nearly $1 billion upfront payment and up to $300 million contingent on achieving certain clinical milestones [5][6] - Verve is developing gene editing drugs, with its lead project, Verve-102, currently in a Phase 1b clinical trial and has received Fast Track designation from the FDA [6] Sector Performance - Chinese concept stocks mostly declined, with notable drops in Kingsoft Cloud and Li Auto, while JD, Pinduoduo, and Alibaba saw slight increases [3] - Brain-computer interface stocks, particularly Brain ReGen Technologies, experienced significant gains, with a year-to-date increase of over 460 times [6][7] International Developments - Oil prices rose over 2.5%, with energy stocks in the US also seeing gains [8] - The European Commission proposed legislation to phase out imports of Russian natural gas and oil by the end of 2027, aiming to reduce dependency on Russian fossil fuels [9][10]

Core Viewpoint - Eli Lilly (LLY.US) has announced an agreement to acquire Verve Therapeutics (VERV.US) for up to $1.3 billion, indicating a significant investment in gene editing technology aimed at cardiovascular disease treatment [1][2] Group 1: Acquisition Details - Eli Lilly will make a cash offer of $10.50 per share, totaling approximately $1 billion, to acquire all outstanding shares of Verve [1] - Each share will also include a non-tradable contingent value right, allowing holders to receive up to an additional $3, bringing the total potential value per share to $13.50 [1] - The base purchase price represents a premium of about 113% over Verve's 30-day volume-weighted average price as of June 16, 2025 [1] Group 2: Market Reaction - Following the announcement, Verve's stock price surged nearly 80% in pre-market trading [1] Group 3: Product Pipeline - Verve is advancing a series of in vivo gene editing projects aimed at safely inactivating genes that increase the risk of atherosclerotic cardiovascular disease [1] - The candidate drug VERVE-102 is currently in Phase 1b clinical trials targeting patients with heterozygous familial hypercholesterolemia and early-onset coronary artery disease [1] - VERVE-102 has received Fast Track designation from the U.S. Food and Drug Administration [1][2]

Group 1 - Eli Lilly is preparing to acquire gene-editing startup Verve Therapeutics for up to $1.3 billion, with $1 billion as an upfront payment and an additional $300 million contingent on clinical milestones [1][2] - Verve Therapeutics is developing a gene therapy to lower cholesterol levels, which is expected to be used in conjunction with other medications [2] - If the acquisition is completed, it will represent a significant strategic move for Eli Lilly in the gene-editing space, following its success with weight loss drugs [2] Group 2 - The pharmaceutical industry is currently experiencing a downturn in merger and acquisition activity due to market volatility and regulatory uncertainties [3] - Unlike competitors facing patent cliffs and revenue pressures, Eli Lilly is in a strong financial position, with projected sales of $30.2 billion from its weight loss and diabetes drugs Mounjaro and Zepbound this year [4] - Eli Lilly has already spent $2.5 billion this year on acquisitions, including cancer biotech company Scorpion Therapeutics and pain treatment-focused SiteOne Therapeutics [5]

Core Viewpoint - Ordos City is focusing on developing the biopharmaceutical industry as a key industrial chain, aiming to create an ideal environment for industry transfer and growth [1][2]. Group 1: Business Environment - Ordos has been ranked first in Inner Mongolia's business environment assessment for five consecutive years, promoting a "warm city" business environment brand [1]. - The city has implemented the "Release, Management, and Service" reform and optimized the business environment 6.0 version, enhancing project approval processes and reducing costs for enterprises [1]. Group 2: Policy Support - Ordos has introduced unprecedented policies in technology and talent, including a new version of the technology and talent policy, to attract innovation and development [1][2]. - The city collaborates with top universities and research institutions to establish high-level scientific innovation platforms, fostering a strong talent pool [1]. Group 3: Financial Empowerment - Ordos has developed venture capital, equity investment, and patient capital, with state-owned enterprises participating in the establishment of 13 funds totaling 30.8 billion yuan to support industrial projects [2]. Group 4: Industry Advantages - The city possesses unique advantages in the biopharmaceutical sector, particularly in chemical raw materials, traditional Chinese medicine, and biopharmaceuticals, with a rich variety of high-quality medicinal materials [2]. - Ordos has over 60,000 acres of traditional Chinese medicine cultivation bases, producing 73,000 tons of high-quality medicinal materials annually, providing abundant natural resources for the biopharmaceutical industry [2]. Group 5: Research and Development - The city is actively promoting the innovation and development of traditional Chinese medicine through policies and collaborations with top research institutions [2]. - Ordos is engaging with leading research institutions and enterprises to advance cutting-edge biotechnologies, including synthetic biology and gene editing, accelerating clinical research applications of new technologies [2].

瑞·达利欧：AI将影响方方面面。图片来源：Jemal Countess/Getty Images for TIME 瑞・达利欧（ Ray Dalio ）是一位作家、全球经济学家，也是全球最大对冲基金桥水联合基金（ Bridgewater Associates ）的创始人、首席投资官导师。 译者：朴成奎 在财富Plus，网友们对这篇文章发表了许多有深度和思想的观点。一起来看看吧。也欢迎你加入我们，谈谈你的 想法。今日其他热议话题： 在我看来，我们已经到达了一个新时代的边缘。在这个新时代，机器思维将在很多方面补充甚至超越人 类思维，就像在工业时代，机器补充甚至超越了人类的劳动力那样。随着计算工具的发明，靠人脑来进 行数学运算和存储记忆的重要性变得大大降低。现在我们查找信息会用谷歌这种搜索引擎，而不是用更 传统的方式。同样，或许用不了多久，当我们在各种情境下需要进行理性决策时，我们也会寻求计算机 的指引，因为它能给出比我们自己的大脑更快、更好的指导。 未来五年，我们将会见证大多数领域的显著进步。创造AI只是应用AI的第一步。我和桥水公司专业从 事AI投资已经有几十年了，我们现在正在发掘的机会，在普通人看来简直难以置 ...

Summary of GeneDx Conference Call Company Overview - GeneDx was established 25 years ago at the National Institutes of Health, focusing on diagnosing difficult cases, particularly in rare diseases [4][5] - The company has built the largest rare disease data asset in the U.S., with over 800,000 exomes and genomes and more than 6,100,000 phenotypic data points [5][6] Strategic Initiatives - GeneDx aims to reduce the diagnostic odyssey, which currently takes about five years, to weeks or even hours [5][6] - The company is focusing on increasing utilization in pediatric outpatient settings and NICUs [6] Differentiation and Market Position - GeneDx's tests are differentiated by their extensive data assets, which include a highly representative database and a robust phenotypic data set [7][8] - Approximately 60% of the time, both parents are tested, enhancing the accuracy of diagnoses [7] - The company claims an 80% market share among expert geneticists, with significant growth potential in pediatric neurology and NICU settings [14][16] Market Penetration - In pediatric neurology, GeneDx has only penetrated about 14% of the patient population, indicating substantial growth opportunities [16] - In NICUs, fewer than 5% of babies currently receive genetic testing, despite studies showing that 60% would benefit from it [19][22] - GeneDx aims to increase its NICU testing to approximately 225,000 tests annually, targeting a quarter million children by 2026-2027 [24] Product Development and Testing - GeneDx has launched a two-day ultra-rapid turnaround time for genome testing, which is expected to enhance market uptake [25][26] - The company is expanding its testing indications to include conditions like cerebral palsy and hearing loss, focusing on the best clinical outcomes [29][30] Financial Performance and Cost Management - GeneDx has achieved profitability and aims for continued profitable growth, focusing on areas with sufficient reimbursement [17][18] - The company has reduced denial rates from 65% to less than 50% for pediatric neurologists, improving reimbursement rates and gross margins [48][49] - Current gross margins for exome and genome testing are around 80%, with ongoing efforts to reduce costs further through automation and technology [54][56] Future Growth and Market Strategy - GeneDx plans to expand into adult genetic testing as reimbursement pathways develop, aiming for early diagnosis across all age groups [62][63] - The company is also exploring monetization of its extensive data set for biopharma, aiming to contribute to drug discovery and clinical trial development [64][66] Conclusion - GeneDx is positioned as a leader in genetic testing for rare diseases, with a strong focus on data-driven diagnostics and expanding market opportunities in pediatric and adult settings. The company is committed to improving patient outcomes through faster and more accurate testing while maintaining a focus on profitability and cost management.

Core Viewpoint - The article highlights the significant contributions of Huang Zhiwei, a returning scientist, in advancing basic research in life sciences at Harbin Institute of Technology, emphasizing the importance of foundational research for achieving high-level technological self-reliance and building a world-class scientific power [1][4]. Group 1: Research Achievements - Huang Zhiwei established a laboratory from scratch at Harbin Institute of Technology in 2012, focusing on basic research in immunology and infectious diseases [1]. - In 2014, his team discovered the structure of the HIV virus virulence factor, which had been elusive for over 30 years, providing a foundation for developing anti-HIV drugs [2]. - The research findings were published in the journal "Nature," attracting international attention and collaboration [2]. Group 2: Research Environment and Philosophy - Huang Zhiwei created a supportive research environment at the Life Sciences Center, allowing researchers to explore innovative ideas freely [3]. - He emphasizes the importance of hands-on involvement in experiments and meticulous record-keeping to ensure reproducibility and high-quality research outcomes [2][3]. - The center has produced significant breakthroughs in gene editing and metabolic disease mechanisms, establishing a competitive research platform internationally [3]. Group 3: Future Aspirations - Huang Zhiwei expresses a commitment to tackling unresolved scientific questions in life sciences, maintaining a beginner's mindset to explore frontiers and contribute to the field's advancement [4].

Core Insights - The article discusses the advancements in CRISPR technology, particularly focusing on the Fanzor system, which has shown potential for genome editing in eukaryotic organisms, including mammals [2][3][6]. Group 1: Fanzor System Development - The Fanzor system, discovered by Zhang Feng's team, is a compact RNA-guided DNA cutting enzyme that allows for precise genome editing in eukaryotes, overcoming limitations of traditional CRISPR-Cas systems [2][3]. - The original Fanzor system exhibited low editing efficiency in mammalian cells, which restricted its applications in biomedical research and genetic improvements [2][6]. Group 2: Enhanced Fanzor System - A collaborative research team developed an enhanced version of the Fanzor system, named enNlovFz2, which improved genome editing efficiency by 11 times compared to the wild-type [3][7]. - The enNlovFz2 system was successfully applied in creating mouse models for diseases such as albinism and Duchenne muscular dystrophy (DMD), demonstrating its potential in disease modeling and gene therapy [3][9]. Group 3: Technical Innovations - The research utilized AI-assisted structural predictions and protein engineering to optimize the enNlovFz2 system, expanding its target recognition range significantly [6][7]. - The enNlovFz2 system achieved an insertion/deletion efficiency of 81.2% across 26 target sites in the human genome, comparable to other advanced genome editing tools [7][9]. Group 4: Implications for Future Research - The advancements in the Fanzor system highlight its versatility as a multifunctional toolbox for biological research and therapeutic applications, particularly in gene editing [9][10].