Group 1 - The core viewpoint of the report is a recommendation for Jiuzhou Pharmaceutical (603456.SH) with a latest price of 18.46 yuan, highlighting its growth potential in the CDMO business and emerging technologies [2] - The revenue structure shows steady growth in the CDMO business, while the specialty API segment has experienced a year-on-year decline [2] - The project funnel for CDMO continues to expand, with a steady increase in the number of commercialized projects [2] - The establishment of new technology platforms has shown significant results, with rapid growth in overseas orders for TIDES business [2]

Summary of Jiuzhou Pharmaceutical Conference Call Company Overview - **Company**: Jiuzhou Pharmaceutical - **Industry**: Pharmaceutical Contract Development and Manufacturing Organization (CDMO) Key Points CDMO Business Growth - Jiuzhou Pharmaceutical's CDMO business is experiencing steady growth with a rich project pipeline, including 38 projects that have been launched and 90 in Phase III clinical trials, along with over 1,000 projects in Phase I and II [2][4][5] - The company serves over 80 global clients, covering more than 100 active projects, including innovative drugs, generics, and high-barrier formulations [2][4] Emerging Business Segments - Rapid growth in emerging businesses such as peptides and pentavalent vaccines, with over 20 new clients acquired, and orders nearing $10 million [2][6] - Successful delivery of over ten projects in these segments, indicating significant future growth potential [2][6] Generic Drug Business - Steady progress in the generic drug sector, with two specialty raw materials and two generic formulations approved in the first half of the year [2][7] - A total of 22 projects in the generic pipeline, with 8 approved and 9 under review [2][7] Financial Performance - For the first half of 2025, Jiuzhou Pharmaceutical reported revenue of 2.87 billion yuan, a year-on-year increase of 3.86%, and a net profit of 526 million yuan, up 10.7% [3] - The company has strengthened relationships with major clients, particularly in the Japanese and Korean markets, leading to significant project growth [3] Capacity Utilization and Profit Margins - CDMO capacity utilization is steadily increasing, with optimistic gross margin expectations for the next two to three years due to process optimization and a higher proportion of high-value products [2][10] - The gross margin for the first half of 2025 was approximately 41%, with expectations for stability throughout the year [12] New Factory Developments - The new factory in Taizhou has completed validation for five CDM raw material projects and is attracting numerous follow-up projects due to high management standards and successful FDA inspections [2][13] - The factory's capacity utilization is expected to continue increasing in the coming years [13] Market Trends and Client Structure - The client structure remains predominantly large pharmaceutical companies, accounting for 70-75% of business, with significant growth in the U.S. market [14][15] - The company anticipates an increase in collaboration with large pharmaceutical firms, driven by successful partnerships and potential acquisitions of biotech clients [15] Future Plans and Capital Expenditure - Jiuzhou Pharmaceutical plans to enhance global R&D capabilities and expand advanced production capacity, with a multi-functional GMP production line expected to be operational by late 2025 [9][21] - The company has approximately 3 billion yuan in cash reserves for strategic investments and acquisitions [21] International Expansion - The company has made significant inroads into the Japanese market, becoming a supplier for over half of the top ten pharmaceutical companies in Japan, with a growth rate of 30-40% annually [22] - Plans for further expansion into Europe and the U.S. are underway, focusing on small molecule production lines [17] New Product Development - Jiuzhou Pharmaceutical is focusing on new business areas such as small nucleic acids and ADCs, with expectations for significant contributions in the next two to three years [23][24][26] - The company is also expanding its peptide production capacity to meet growing demand, with a new facility set to produce 800 kg annually [25] Overall Confidence - The company expresses strong confidence in continued growth across all business segments, particularly in overseas client expansion and recovery in industry cycles [31]

Investment Rating - The investment rating for the company is maintained as "Buy" with a target price of RMB 29.12 [1][7]. Core Views - The company has shown a positive growth trajectory in its revenue and profit, with a notable increase in the contribution from high-margin CDMO business [2][3]. - The company’s CDMO business achieved revenue of RMB 22.91 billion in the first half of 2025, reflecting a year-on-year growth of 16% [3]. - The company is expanding its new business capabilities, with significant progress in peptide and conjugated drug production, as well as small nucleic acid projects [4]. Summary by Sections Financial Performance - In the first half of 2025, the company reported revenue of RMB 28.71 billion, a year-on-year increase of 4%, and a net profit attributable to the parent company of RMB 5.26 billion, up 11% year-on-year [1]. - The second quarter of 2025 saw revenue of RMB 13.81 billion, with net profit increasing by 16% year-on-year [1]. CDMO Business - The CDMO business is a key growth driver, with a revenue contribution increasing from 71% in 2024 to 80% in the first half of 2025, leading to an improvement in gross margin from 35% to 37% [2]. - The company has a robust project pipeline, with 1,086 projects in clinical phases and 38 in commercialization as of the first half of 2025 [3]. New Business Development - The company has made strides in building capabilities for new business areas, including the expansion of facilities for peptide and conjugated drugs, and has onboarded over 20 new clients in the first half of 2025 [4]. Profit Forecast and Valuation - The forecast for net profit attributable to the parent company for 2025-2027 is RMB 9.14 billion, RMB 9.52 billion, and RMB 9.74 billion respectively, with corresponding EPS of RMB 1.03, RMB 1.07, and RMB 1.09 [5][10]. - The company is valued at RMB 259 billion using the SOTP method, with a target price of RMB 29.12 based on a total share count of 889 million [5][12].

Core Viewpoint - The company reported strong performance in 1H25, with revenue and net profit exceeding expectations due to recovery in core CDMO demand and stabilization of raw material prices [1][4]. Financial Performance - In 1H25, the company achieved revenue of 2.871 billion yuan, a year-on-year increase of 3.9%, and a net profit attributable to shareholders of 526 million yuan, up 10.7% year-on-year [1]. - For Q2 alone, revenue was 1.381 billion yuan, reflecting a year-on-year increase of 7.2% but a quarter-on-quarter decrease of 7.4; net profit for the quarter was 276 million yuan, up 15.7% year-on-year and 10.2% quarter-on-quarter [1]. Business Segments - The core CDMO business showed robust growth, generating revenue of 2.29 billion yuan in 1H25, a year-on-year increase of 16.3%, with a gross margin of 41.0% [2]. - The company has a healthy project pipeline, with 38 projects already on the market and 1,086 projects in various clinical phases [2]. - The raw material business generated revenue of 523 million yuan in 1H25, a year-on-year decline of 28.48%, but with a gross margin of 23.26%, which is an increase of 2.07 percentage points [3]. Strategic Developments - The company is actively building capabilities in peptide, conjugate, and small nucleic acid drug technologies, having onboarded over 20 new clients and completed more than 10 projects in 1H25 [2]. - The integration strategy of "raw materials + formulations" is ongoing, with 22 formulation projects, 8 of which have been approved and 9 submitted for approval as of 1H25 [3]. Profit Forecast and Valuation - Due to the recovery in CDMO demand and stabilization of raw material prices, the company has raised its net profit forecasts for 2025 and 2026 by 14.5% and 8.7% to 950 million yuan and 1.084 billion yuan, respectively [4]. - The target price has been increased by 43.6% to 22.40 yuan, corresponding to 21.0 times the 2025 P/E ratio and 18.4 times the 2026 P/E ratio, indicating a potential upside of 20.0% from the current stock price [4].

（企业公告） 公告介绍，公司CDMO项目管线日益丰富，已经形成了可持续的临床前/临床Ⅰ、II、III期的漏斗型项目 结构。截止报告期末，公司已承接的项目中，已上市项目38个，III期临床项目90个，Ⅰ期和II 期临床试 验的有1086个，项目涵盖抗肿瘤、抗心衰、抗病毒、中枢神经和心脑血管等治疗领域。已递交NDA的 新药项目数快速增加，将持续助推公司业务稳健增长。 在多肽和偶联业务方面，报告期内，引入新客户20多家，在手订单的项目主要涵盖降糖、癌症类治疗领 域，其中海外订单增速较快。公司已完成十多个项目的交付工作，获得客户的高度评价。随着多肽及偶 联药物全球市场的快速发展，未来项目承接数量将持续增加。 近日，九洲药业发布2025年半年报。披露上半年营收增长3.86%至28.71亿元，归属净利提高10.70%至 5.26亿元。 ...

Group 1: Small Molecule CDMO Business - The company focuses on technological innovation to build a leading global CDMO platform for innovative drugs, serving major pharmaceutical companies like Novartis [1] - The sales of the company's Noxintin project raw materials have significantly increased, with sales growing from $507 million in 2017 to $7.822 billion in 2024, reflecting a CAGR of 47.83% [1] - In the first half of 2025, sales reached $4.618 billion, representing a year-on-year growth of 22.27% [1] Group 2: Peptide Conjugate CDMO Services - The company has established a TIDES division to expand peptide conjugate drug and small nucleic acid technology platforms, providing comprehensive CDMO services from preclinical research to commercial production [2] - The company is actively expanding its peptide production capacity, with the second phase of peptide capacity construction initiated by the end of 2024, including the expansion of OEB5 level high-activity workshops [2] Group 3: API Business - The company is strategically positioning itself in the market by focusing on specialty APIs in areas such as anti-infectives, central nervous system drugs, non-steroidal anti-inflammatory drugs, and hypoglycemic agents [3] - Sales of anti-infective APIs increased from 292.46 tons in 2021 to 325.32 tons in 2024, with a CAGR of approximately 3.61% [3] - Sales of central nervous system APIs grew from 863.34 tons in 2021 to 1003.08 tons in 2024, with a CAGR of approximately 5.13% [3] - Sales of non-steroidal APIs rose from 298.93 tons in 2021 to 368.45 tons in 2024, with a CAGR of approximately 7.22% [3] - Sales of hypoglycemic APIs increased from 328.26 tons in 2021 to 362.66 tons in 2024, with a CAGR of approximately 3.38% [3] Group 4: Investment Recommendations - The company is projected to achieve net profits attributable to shareholders of 921 million yuan, 1.052 billion yuan, and 1.158 billion yuan from 2025 to 2027, representing year-on-year growth of 52.0%, 14.2%, and 10.0% respectively [4] - Based on the average valuation of comparable A-share listed companies, a PE ratio of 23 times is assigned for 2025, with an expected EPS of 1.04 yuan per share, leading to a target price of 23.92 yuan per share in six months [4]

Group 1: Financial Performance and Projections - The contribution of the agricultural CDMO business to revenue is expected to remain around 50% for both 2023 and 2024 [1] - The company anticipates gradual recovery in the agricultural sector, with improved demand from downstream customers [25] - The company has conducted reasonable impairment provisions for goodwill in 2023 and 2024, with risks of further impairment existing [12] Group 2: Market Trends and Competitive Landscape - The market for chlorantraniliprole intermediates is experiencing intense competition due to a surge in domestic production capacity, impacting raw material prices [2][3] - The company maintains a "big client strategy" to navigate the competitive landscape and enhance cost control for downstream clients [3] Group 3: Strategic Partnerships and Collaborations - The company has established a strategic partnership with Hengrui Medicine, focusing on a full lifecycle collaboration model for product development and commercialization [7][8] - The collaboration with Hengrui is expected to cover major therapeutic areas, including oncology and cardiovascular diseases, with a focus on supply chain needs [8][16] Group 4: Production Capacity and Development Plans - The company is in the process of upgrading its production bases, with a focus on core raw material production and innovative product development [9][14] - The Lanzhou base is expected to see performance improvements as the agricultural sector recovers and customer demand increases [13] Group 5: Risk Management and Inventory Control - The company employs dynamic inventory management based on historical sales data and market trends to ensure stable supply for major clients [11] - The company is closely monitoring international trade policies and their impact on export operations, maintaining flexibility in supply chain management [14]

Group 1 - The market saw a total of 31 stocks hitting the daily limit up, with a success rate of 63% for limit up attempts [1] - Xizang Tourism became a market focus, achieving a consecutive limit up for 7 trading days, making it a representative high-limit stock [1] - Innovative drug concept stocks showed strong performance, with Apac Pharmaceutical achieving 5 limit ups in 10 trading days due to improved earnings expectations from a subsidiary sale [1] Group 2 - The overall market performance indicated a slight decline in the Shanghai Composite Index by 0.08% and Shenzhen Component Index by 0.04%, while the ChiNext Index rose by 0.92% [1] - The total trading volume in the three major markets reached 11,460.26 billion yuan, with 3,901 stocks declining and 1,468 stocks rising [1] - The chemical pharmaceutical sector attracted the highest net inflow of funds at 1.568 billion yuan, followed by the biopharmaceutical sector with 1.245 billion yuan [1] Group 3 - Other stocks that hit the limit up included Xingfu Blue Ocean, Kejingyuan, and Haichang New Materials, with some ChiNext stocks achieving a 20% limit up, indicating strong market enthusiasm for related concepts [2] - Medical research outsourcing institutions (CRO) and contract development manufacturing organizations (CDMO) were among the top-performing sectors, along with FPGA chips and CXO medical outsourcing [2]

Summary of Pro Pharmaceutical Conference Call Company Overview - Pro Pharmaceutical is a leading pharmaceutical integration platform under the Hongdian Group, established in 1989 and headquartered in Dongyang, Zhejiang [4][5][16] - The company has developed a significant business scale over 30 years, focusing on CDMO, APIs, and formulations, with global competitiveness [4][5] Strategic Focus - The company has launched a 2030 strategy focusing on four key areas: raw materials, CDMO, pharmaceuticals, and medical aesthetics, with CDMO identified as the core growth driver [2][4] - CDMO business is currently in an explosive growth phase, benefiting from years of accumulation and expanding into cutting-edge technologies like ADC and peptides [2][6] Financial Performance - In 2024, the revenue from the three main segments is projected to be: raw materials and intermediates at 8.651 billion yuan, CDMO at 1.884 billion yuan, and formulations at 1.256 billion yuan [4] - Gross profit margins for these segments are expected to be 45.17%, 26.98%, and 26.63% respectively, indicating a strong performance in raw materials [4] CDMO Business Development - Pro Pharmaceutical has established itself as a core player in the global innovative drug CDMO market, with over 600 R&D personnel and a significant increase in project numbers [5][6] - The number of API projects in the R&D phase has grown from 28 in 2021 to 79 in 2024, with commercialized human drug projects increasing from 74 to 262 [6] Domestic Innovation Drug Industry - The domestic innovative drug industry is experiencing rapid growth, with significant revenue increases reported by leading biotech companies [7] - Pro Pharmaceutical has established partnerships with 572 domestic and international innovative drug companies, with over 300 agreements signed with leading domestic firms [7] International Market Performance - The overseas market remains a major revenue source, with expectations of achieving over 10 commercialized projects annually through strategic partnerships with international pharmaceutical companies [8] - The company has a long-standing presence in the CDMO sector, contributing to stable revenue growth [8] API Commercialization - Key products entering the API commercialization phase include Donafenib tosylate, Paltomide mesylate, and Fuzuloparib, with expected demand reaching ton-level [9] - These products are crucial growth drivers for the company, supported by their inclusion in national insurance directories and treatment guidelines [9] Collaborations with Multinational Companies - Pro Pharmaceutical has established close collaborations with major multinational pharmaceutical companies, including Pfizer and Merck, focusing on early-stage development orders [10][11] - The company has also built strong relationships in the veterinary medicine sector, with consistent growth in commercialized projects [11] Formulation Business Outlook - The formulation business is expected to enter a rapid growth phase starting in 2026, driven by increased approvals and a focus on market demand [13][14] - The company anticipates approval for approximately 10 formulations in 2025, with a target of over 15 by 2026 [13] Raw Materials and Intermediates Business - The raw materials and intermediates segment is the core revenue and profit contributor, with projected revenue of 8.651 billion yuan in 2024 [15] - The company is diversifying its raw material offerings across antibiotics, veterinary drugs, chronic disease medications, and medical aesthetics [15] Future Growth Expectations - Pro Pharmaceutical is expected to enter a new growth cycle starting in 2025, with a projected compound profit growth rate of over 20% [16] - The company is considered to have a favorable valuation, encouraging investors to pay attention to related assets [16]

Core Viewpoint - The medical device sector is experiencing significant growth driven by the explosion in CXO, medical consumables, and AI medical segments, leading to a notable increase in the performance of related ETFs [1][2][3]. Group 1: ETF Performance - The medical device ETF (159883) opened high and rose by 0.96% during the early session, with a peak increase of nearly 2%, marking an attempt for an eight-day consecutive rise [1]. - As of July 24, the medical device ETF (159883) had a net subscription of 180 million shares in the early session, with a total circulation of 4.762 billion shares, reflecting an increase of nearly 1 billion shares over the past month [1]. - The latest circulation scale of the medical device ETF (159883) reached 2.466 billion yuan, making it the largest medical device ETF product among Wind industry ETFs [1]. Group 2: Policy and Market Dynamics - The Hong Kong medical ETF (159366) saw a rise of 2.08% in early trading, with an intraday peak exceeding 4%, indicating a potential three-day consecutive increase [2]. - The National Medical Insurance Administration recently held a seminar to discuss new measures for supporting innovative drugs and medical devices, including the establishment of new medical service pricing projects and encouraging the global development of Chinese innovative drugs and devices [2]. - The latest round of national drug procurement has started, with new rules being optimized to reduce reliance on minimum pricing, which is expected to alleviate competitive pressure in the high-value consumables sector [2][3]. Group 3: Sector Outlook - Analysts from Ping An Securities suggest that the high-value consumables sector may benefit from favorable policy expectations, with ongoing optimization of procurement policies expected to reduce valuation pressure [3]. - Huatai Securities indicates that the pressure from the US interest rate hike cycle on new drug financing is gradually easing, leading to a recovery in overseas new drug research and development demand, which is beneficial for Chinese companies [3]. - The medical device ETF (159883) tracks the CSI All-Index Medical Device Index, covering various sub-sectors such as medical equipment, consumables, and in vitro diagnostics, positioning it as a key player in the market [3].