刚刚，据上海统计局公布的最新数据显示，今年前三季度，上海市三大先导产业制造业产值同比增长8.5%，增速快于全市规模以上工业总产值2.8个百分 点。其中，生物医药制造业增长3.6%。 在资本赋能层面，上海持续加码生物医药产业支持力度。2024年，总规模225亿元的上海生物医药产业母基金正式设立，目前已完成13个子基金遴选工 作，资金放大效应达5.59倍。同步设立规模 100亿元的并购基金，重点在中药、疫苗及高端医疗器械等领域开展战略并购布局。 在投融资领域，上海生物医药产业展现出强劲韧性与活力，2021-2024 年，上海市生物医药领域累计融资2383.72亿元，发生融资事件1494起。今年前9个 月，在一级市场还未完全转暖的情况下，实现融资255.31亿元，融资事件169起，投融资事件数量与融资金额均位居全国前列。 值得关注度的是，今年前三季度，得益于创新药国际化步伐加快及上海产业政策和贸易环境的持续优化，医药品、西药原料药出口分别增长21.5%、 40.7%。 全年突破万亿大关在即 作为国内最早布局生物医药产业的城市之一，早在1993年，上海就将现代生物与医药产业列为重点发展的高新技术产业。上海生物医药产业 ...

10月22日，诺诚健华盘中下跌2.01%，截至11:03，报23.38元/股，成交7490.69万元，换手率1.18%，总 市值412.57亿元。 资金流向方面，主力资金净流出1292.02万元，特大单买入129.50万元，占比1.73%，卖出712.57万元， 占比9.51%；大单买入944.42万元，占比12.61%，卖出1653.37万元，占比22.07%。 诺诚健华今年以来股价涨90.39%，近5个交易日跌4.57%，近20日跌14.39%，近60日跌25.92%。 机构持仓方面，截止2025年6月30日，诺诚健华十大流通股东中，中欧医疗健康混合A（003095）位居 第六大流通股东，持股1304.78万股，相比上期增加398.07万股。富国精准医疗灵活配置混合A （005176）位居第七大流通股东，持股1258.20万股，持股数量较上期不变。鹏华医药科技股票A （001230）位居第八大流通股东，持股1020.21万股，相比上期减少501.14万股。易方达医疗保健行业混 合A（110023）位居第九大流通股东，持股918.57万股，为新进股东。汇添富创新医药混合A （006113）位居第十大流通股东 ...

信达生物目前的销售收入主要依靠国内市场。按照公司规划，到2027年，该公司商业化品种数量可达到20款，收入可达到200亿元；到2030年，公司至少有5 个管线进入全球多中心三期临床研究。 武田制药创立于1781年，总部位于日本，是一家全球数字化生物制药公司。该公司于1994年进入中国，武田中国总部位于上海，目前在中国拥有约2500名员 工。2022年，武田制药宣布启动"拓维中国"战略，至2031年，中国将成为武田全球第二大市场。 信达生物(01801.HK)达成一项百亿美元商业合作。 10月22日，信达生物公告称，公司当日与武田制药达成全球战略合作，旨在加速推进信达生物新一代IO及ADC疗法开发。本次合作包括两款后期在研疗法 IBI363及IBI343，以及一款早期研发项目IBI3001的选择权。 根据合作，信达生物与武田制药将在全球范围内共同开发新一代IO基石疗法IBI363，并在美国共同商业化，武田制药将在共同治理和协同一致的开发计划下 主导相关工作；同时，信达生物授予武田制药IBI363在除大中华区及美国地区的商业化权益、IBI343在大中华区以外地区的独家权益，以及IBI3001在大中华 区以外地区权 ...

Group 1 - The Hang Seng Shanghai Shenzhen Hong Kong Innovation Drug Selected 50 Index (HSSSHID.HK) decreased by 0.38% on October 22, with Rongchang Biologics and Huyou Pharmaceutical rising over 2% [1] - The National Biomedicine Index (399441.SZ) fell by 0.11%, with Rongchang Biologics again showing a rise of over 2% [1] - The Tianhong Innovation Drug ETF (517380) dropped by 0.74%, with a trading volume of 13.43 million yuan and a real-time premium rate of 0.02% as of October 21 [1] Group 2 - Innovent Biologics announced a global strategic partnership with Takeda Pharmaceutical to advance the development of next-generation immuno-oncology (IO) and antibody-drug conjugate (ADC) therapies, with an upfront payment of $1.2 billion and potential milestone payments totaling up to $10.2 billion, making the total deal value up to $11.4 billion [2] - The National Medical Products Administration (NMPA) is enhancing the legal standard system and increasing support for R&D innovation to accelerate the market entry of innovative medical devices [2] - Beijing's medical instrument and device exports reached 5.83 billion yuan in the first eight months of the year, reflecting a year-on-year growth of 21.5% [2] Group 3 - The Tianhong Innovation Drug ETF (517380) is the largest in the market, tracking the Hang Seng Shanghai Shenzhen Hong Kong Innovation Drug Selected 50 Index, covering both A-shares and Hong Kong stocks [3] - The National Biomedicine Index includes the top 30 stocks based on market capitalization and liquidity from the A-share market, reflecting the overall performance of the biomedicine industry [3] - Huafu Securities believes that China's innovative drugs are experiencing a "qualitative change driven by quantitative change," and suggests focusing on companies with both business development (BD) expectations and commercial sales support [3]

分红方面，艾力斯A股上市后累计派现6.53亿元。 艾力斯所属申万行业为：医药生物-化学制药-化学制剂。所属概念板块包括：抗癌药物、生物医药、抗 癌治癌、创新药、百元股等。 截至6月30日，艾力斯股东户数1.30万，较上期增加3.61%；人均流通股34578股，较上期减少3.48%。 2025年1月-6月，艾力斯实现营业收入23.74亿元，同比增长50.57%；归母净利润10.51亿元，同比增长 60.22%。 10月22日，艾力斯盘中上涨2.05%，截至10:14，报106.05元/股，成交1.46亿元，换手率0.31%，总市值 477.23亿元。 资金流向方面，主力资金净流入1486.42万元，特大单买入1653.04万元，占比11.30%，卖出1052.14万 元，占比7.19%；大单买入4288.76万元，占比29.31%，卖出3403.23万元，占比23.26%。 艾力斯今年以来股价涨79.44%，近5个交易日跌0.20%，近20日跌3.91%，近60日涨10.93%。 资料显示，上海艾力斯医药科技股份有限公司位于上海市浦东新区周浦镇凌霄花路268号，成立日期 2004年3月22日，上市日期2020年 ...

Core Viewpoint - The innovative drug concept is gaining strength in the market, with notable stocks experiencing significant increases, indicating a positive trend in the pharmaceutical sector [1] Group 1: Stock Performance - Harbin Sanlian and Anglikang both reached the daily limit increase, reflecting strong investor interest [1] - Other companies such as Shutaishen, Asia-Pacific Pharmaceutical, Duori Pharmaceutical, Yipinhong, Shanghai Yizhong, and Jinshiyao also saw price increases, contributing to the overall positive sentiment in the sector [1]

（文章来源：每日经济新闻） 海通国际此前表示，近期多起BD密集落地，有望催化创新药行情。如10月16日普瑞金宣布与Kite达成 1.2亿美元首付款、总计最高可达15.2亿美元里程碑付款交易；维立志博宣布与Dianthus达成2000万美元 首付款、总金额最高可达10亿美元交易；10月17日翰森制药、奥赛康也分别宣布与罗氏、Visara达成交 易。 恒生医药ETF（159892）重仓股信达生物在港交所公告，其与武田制药达成全球战略合作，旨在加速推 进信达生物新一代IO及ADC疗法开发。本次合作包括两款后期在研疗法IBI363及IBI343，以及一款早期 研发项目IBI3001的选择权。 信达生物将获得12亿美元的首付款，包括以认购事项方式获得的1亿美元的战略股权投资。信达生物另 外有权获得合计最高可达102亿美元的潜在里程碑付款，本次合作交易总金额最高可达114亿美元。此 外，信达生物还将获得每个候选药物在大中华区以外的潜在销售分成。在美国市场，双方就IBI363将采 用利润损失共担模式。 ...

114亿美元，这一金额不仅刷新国内药企对外合作纪录，更标志着本土管线首次以"全球共研"姿态，与 跨国巨头共同冲击千亿级肿瘤市场。 中国创新药重磅！最新消息，信达生物与武田制药达成114亿美元战略合作。信达生物将获得12亿美元 首付款（含1亿美元的溢价战略股权投资）以及潜在里程碑付款，同时还将获得最高可达十几百分比的 高位的销售分成。 | | | 港股通创新药ETF (520880) 标的指数 | | | --- | --- | --- | --- | | | | 前十成份股权重高达71.63%,龙头优势显著 | | | મદાસ | 简称 | 权重(%) | 总市值(亿港元) | | 6160.HK | 三济神州 | 10.47 | 3,304 | | 1177.HK | 中国生物制药 | 10.01 | 1,527 | | 1093.HK | 行句儿初 | 9.58 | 1,080 | | 1801.HK | 信达生物 | 9.20 | 1,652 | | 9926.HK | 康方生物 | 8.86 | 1,301 | | 1530.HK | 三生制药 | 7.28 | 730 | | 3692.HK | ...

Core Viewpoint - The strategic collaboration between Innovent Biologics and Takeda Pharmaceutical, valued at $11.4 billion, marks a significant milestone in China's innovative drug sector, aiming to penetrate the global oncology market [1][3]. Group 1: Collaboration Details - Innovent will receive an upfront payment of $1.2 billion, which includes a $100 million premium for strategic equity investment, along with potential milestone payments and a high sales revenue share [1][3]. - This partnership is the first of its kind for a domestic pipeline to engage in "global co-development" with a multinational giant, targeting the $200 billion global oncology market [3][5]. Group 2: Pipeline Focus - The collaboration centers on two innovative pipelines: IBI363 and IBI343, which have been previously discussed in industry conferences and reports as potential next-generation oncology drugs [5][6]. - IBI363 targets the PD-1 upgrade market, addressing key issues such as efficacy in PD-1 resistant patients and expanding the applicability of immunotherapy to "cold tumors" like pancreatic and liver cancers [8][10]. - IBI343 focuses on precision treatment for gastrointestinal cancers, with a significant objective response rate of 58%, far exceeding traditional chemotherapy [10][13]. Group 3: Strategic Implications - Takeda's investment aims to fill the market gap during the PD-1 patent expiration phase, betting on the differentiated potential of Innovent's pipelines as future growth engines [6][8]. - Innovent's involvement in clinical design and commercialization decisions through a global co-development model enhances its long-term capabilities in global trial operations and market access [13]. - The partnership exemplifies the alignment of China's innovative drug capabilities with multinational commercialization expertise, positioning Innovent as a key player in defining new competitive landscapes in the global market [13].

Market Overview - A-shares have shown a continuous fluctuation since the fourth quarter, with the Shanghai Composite Index returning to 3900 points on October 21, 2023, and all three major A-share indices closing higher [1][2] - As of October 21, the Shanghai Composite Index, Shenzhen Component Index, and ChiNext Index reported increases of 1.36%, 2.06%, and 3.02% respectively, with year-to-date increases of 16.84%, 25.57%, and 43.99% [2] New Investor Activity - In September 2023, A-share new account openings reached 2.9372 million, a year-on-year increase of 60.73% and a month-on-month increase of 10.83%, marking the second-highest monthly figure of the year [2][3] - Institutional new account openings also reached 10,914, the second-highest monthly record in nearly four years [2] Investment Strategies - Multiple public funds have released their fourth-quarter strategies, with a general optimism towards the long-term performance of the Chinese stock market, particularly in sectors like technology, robotics, and innovative pharmaceuticals [3][5] - Some institutions, such as招商基金, express caution regarding short-term performance, indicating that further market increases may require additional policy or economic support [3] Sector Performance - The AI, innovative pharmaceuticals, and technology sectors have shown significant performance this year, with the STAR Market Composite Index, STAR 50, and Shanghai Pharmaceutical Index increasing by 44.65%, 42.21%, and 13.14% respectively [4] - Funds focusing on these sectors have also reported impressive returns, with some achieving over 175% year-to-date returns [4] Debt Market Outlook - The bond market is currently experiencing a "stock-bond seesaw" effect, with the ten-year government bond yield rising to 1.8552% as of October 21, 2023, up nearly 20 basis points since June 30 [7] - Institutions like招商基金 believe that the bond market will not enter a sustained "bear" phase, but caution that credit bonds may lack independent trends due to market fluctuations [7][8]