当美股上市的科兴生物深陷退市危机与股东内斗泥潭之际，另一家同源异流的"科兴"正在A股悄然布局 一条全新赛道。 近日，科兴制药（688136.SH）旗下全资子公司科兴医疗自主研发的重组Ⅲ型人源化胶原蛋白冻干纤维 已完成首例受试者入组，这款第三类医疗器械产品的临床试验正式启动；与此同时，二类医疗器械产品 重组胶原蛋白敷贴也已提交注册申请。 这一动作标志着科兴制药正式切入千亿级重组胶原蛋白赛道。弗若斯特沙利文数据显示，中国重组胶原 蛋白市场规模预计2027年将达1083亿元，年复合增长率高达44.93%，被业界视为医美领域继玻尿酸之 后的下一个超级风口。对于营收在12亿元规模徘徊多年的科兴制药而言，这场押注既是战略转型的主动 求变，也是"吃老本"难以为继后的被动突围。 三十年前，两家"科兴"同出一源，皆以"科教兴国"的理想主义命名；三十年后，一家在美股停牌六年、 面临退市，另一家在科创板寄望于医美转型。资本与市场的裹挟之下，这对"同名不同命"的企业走向了 截然不同的命运。 千亿赛道押注：医美转型的逻辑与挑战 主业增长见顶之际，科兴制药将目光投向了重组胶原蛋白这条高速增长的赛道。 从行业趋势看，重组胶原蛋白正在成为医 ...

Core Insights - The Chinese medical aesthetics industry has surpassed 300 billion yuan, with the light medical aesthetics market expected to grow at a compound annual growth rate (CAGR) of over 20% in the next five years, becoming the mainstream segment by 2024 [1] - Injection projects, as the core growth engine of light medical aesthetics, have seen their market size grow from 25.7 billion yuan in 2018 to 67 billion yuan in 2023, with a CAGR of 21.1%, projected to reach 147 billion yuan by 2027 [1] - The industry faces challenges such as rapid market changes driven by consumer preferences and increasing competition, necessitating innovation in material research to build competitive barriers [1] Market Dynamics - In 2024, the market share of injection materials is projected to be approximately 36% for hyaluronic acid, 29% for botulinum toxin, 19% for collagen, and 16% for regenerative materials [3] - The competition in the hyaluronic acid market has intensified, leading to revenue declines for major companies like Huaxi Biological and Aimeike, with revenue drops of 18.36% and 21.49% respectively in the first three quarters of 2025 [3][4] - In contrast, the recombinant collagen market is rapidly growing, with a projected CAGR of 44.93%, expected to reach 58.57 billion yuan by 2025 [3] Innovation and Product Development - Companies are accelerating new product launches to capture market opportunities, with Huaxi Biological introducing compliant products for facial skin improvement and other companies like Jinbo Biological launching innovative recombinant collagen products [5] - The emergence of new materials such as alginate and hydroxyapatite is set to enrich the market supply, with several products receiving regulatory approval in 2025 [6] Regulatory Environment - The industry is experiencing a shift towards compliance, with increased regulatory scrutiny leading to a "survival of the fittest" scenario, pushing medical aesthetic institutions to accelerate compliance transformations [2] - Despite the growth in compliant products, issues such as illegal operations and counterfeit products remain prevalent, posing risks to consumer safety [11][12] Pricing and Market Structure - The supply expansion has led to a restructuring of interests within the industry, with upstream manufacturers and downstream medical institutions engaged in pricing power struggles [8][9] - New platforms like Xinyang are disrupting traditional pricing models by significantly reducing costs through digitalization and centralized procurement, indicating a shift from a seller's market to a buyer's market [9][10] Future Trends - The industry is expected to evolve towards a more transparent and competitive landscape, with a focus on product and scenario-driven strategies, comprehensive treatment solutions, and enhanced consumer awareness [10] - The ongoing regulatory efforts and market dynamics suggest that the medical aesthetics industry is moving towards a more mature and compliant operational model, emphasizing innovation and safety [14]

Core Viewpoint - Lepu Medical's recent partnership with Meituan to promote its medical beauty brands "Yueyayan" and "Flora" is seen as a significant transformation effort amid ongoing performance pressures, but the path to success in the increasingly competitive medical beauty market is fraught with challenges [1][6]. Group 1: Financial Performance - Lepu Medical has experienced a continuous decline in performance, with a 23.52% year-on-year drop in revenue and an 80.37% decrease in net profit for 2024, marking the worst results in its 16-year history [2]. - The company recorded a goodwill and other asset impairment loss of 251 million yuan in 2024, with goodwill still amounting to 3.62 billion yuan, representing 14.35% of total assets as of mid-2025, indicating ongoing impairment risks [2]. Group 2: Market Competition - The medical beauty market is highly competitive, with Lepu Medical entering a saturated field where price wars are emerging, exemplified by New Oxygen's introduction of a 2,999 yuan "affordable童颜针" [3]. - Lepu Medical's recent launch of its self-developed polylactic acid facial filler (童颜针) positions it as the seventh product in this category in China, but the company faces significant challenges as a latecomer in a market dominated by established players [3]. Group 3: Diversification and Resource Allocation - In addition to medical beauty, Lepu Medical is diversifying into structural heart disease, GLP-1 innovative drugs, brain-computer interfaces, and artificial intelligence, reflecting its commitment to innovation [4]. - Despite a research and development expenditure of 1.249 billion yuan in 2024, the allocation across multiple emerging fields has resulted in insufficient investment in each area, leading to a strategic shift towards medical beauty amid tightening cash flow [4]. Group 4: Capital Structure Concerns - Lepu Medical, known for its aggressive acquisition strategy, has completed 54 investments and acquisitions from 2008 to 2021, resulting in high goodwill and asset impairment risks [5]. - As of mid-2025, the company's cash reserves have fallen to 3.6 billion yuan, while accounts receivable have risen to 2.05 billion yuan, significantly exceeding industry warning levels, indicating potential liquidity issues [5].

Core Viewpoint - Jiangsu Wuzhong's subsidiary, Datou Medical, has received a termination letter from Regen Biotech, which demands the cancellation of Datou Medical's exclusive distribution rights for the AestheFill product in mainland China, raising concerns about the company's future in the medical aesthetics sector amid ongoing financial scandals [1][2]. Group 1: Company Response and Legal Actions - Jiangsu Wuzhong has initiated a response plan upon receiving the termination letter and is in communication with Regen, indicating that legal action may be taken if necessary to protect its rights [2]. - Regen's reasons for termination include allegations that Datou Medical transferred exclusive distribution rights to its parent company, and concerns over Jiangsu Wuzhong's legal violations affecting the product's reputation [2]. Group 2: Market Impact and Financial Performance - The change in the registration agent for AestheFill from Datou Medical to Lizhen (Beijing) Biotechnology Co., owned by Regen, introduces uncertainty regarding the previously secure exclusive distribution agreement [4]. - In 2024, Jiangsu Wuzhong reported a revenue of 1.599 billion yuan, a decline of 28.64% year-on-year, with the medical aesthetics segment generating 330 million yuan, a significant increase of over 40 times [4]. - If the exclusive distribution agreement is ultimately terminated, Datou Medical would lose its rights to sell AestheFill, leading to a substantial decrease in revenue and profit for the medical aesthetics segment in the latter half of the year [5].

Group 1: Medical Aesthetics Business Development - The company plans to increase investment in the medical aesthetics sector, aiming to enhance the market recognition and reputation of the Suya Medical Aesthetics brand. In 2025, new medical aesthetics institutions are planned to open in Jiangsu and Shanghai [2][3] - In 2024, the medical aesthetics segment achieved revenue of 179 million yuan and is currently profitable. The company will continue to focus on self-built facilities and expand in high-consumption areas like the Yangtze River Delta [5][6] Group 2: Shareholder Engagement and Stock Performance - In 2024, the actual controller and some executives completed a round of share buybacks, demonstrating confidence in the company's long-term investment value [3][4] - The company is committed to a "long-termism" approach, focusing on stable operations and long-term value creation, despite current market pressures affecting stock prices [4][6] Group 3: Strategic Business Direction - The company is dedicated to developing medical aesthetics and biopharmaceuticals, emphasizing a long-term strategy and resource optimization to enhance operational efficiency and profitability [3][5] - Future business expansion will include exploring new industries and opportunities, with a focus on maintaining a balanced approach to growth and avoiding reckless expansion [5][6] Group 4: Market Conditions and Company Response - The company's stock price has been under pressure due to macroeconomic factors, industry developments, and investor expectations. The company aims to improve product quality, brand building, and customer service to enhance overall competitiveness [6][7] - New medical aesthetics facilities are under construction, with plans for trial operations expected around mid-year [6][7]

Group 1 - The core viewpoint of the articles highlights the declining financial performance of the company, with a significant drop in revenue and net profit in Q1 2025 compared to the previous year [1][2] - In 2024, the company reported a revenue of 30.26 billion yuan, a year-on-year increase of 5.45%, and a net profit of 19.58 billion yuan, also up 5.33%, marking the lowest growth rates since 2016 [1][2] - The company announced a substantial dividend plan, distributing 38 yuan per 10 shares, totaling 1.145 billion yuan, which represents 58.51% of its net profit [1] Group 2 - The company's main revenue sources are solution and gel injection products, with solution products generating 17.44 billion yuan and gel products 12.16 billion yuan in 2024, both showing positive growth but at a significantly reduced rate [2] - The market for hyaluronic acid is becoming increasingly competitive, with 59 approved injection products by the end of 2023, leading to price wars that compress profit margins [2] - The overall growth rate of the medical beauty industry has decreased from over 20% in 2023 to approximately 10% in 2024, with declining consumer frequency and average transaction value adding to market pressures [2] Group 3 - To address growth challenges, the company is diversifying its operations, increasing R&D spending to 3.04 billion yuan in 2024, which is 10.04% of its revenue, focusing on products like botulinum toxin and semaglutide injections [3] - The company acquired 85% of the South Korean regenerative medical company REGEN for 1.373 billion yuan, gaining access to its global distribution network, although the high premium raised concerns about goodwill risk [3] - The company is also venturing into the health sector with a weight management product, "Supermodel Pill," aiming to replicate the market success of GLP-1 drugs, despite potential operational challenges [3] Group 4 - The short-term outlook for the hyaluronic acid market is constrained by stricter regulations, intensified competition, and more rational consumer behavior, limiting growth opportunities for traditional products [4] - Long-term prospects may improve if the company's investments in regenerative materials and weight loss drugs are successfully commercialized, potentially opening new growth avenues [4] - The company's international expansion efforts are in early stages, with overseas revenue of only 1.58 million yuan in 2024, but leveraging REGEN's qualifications in 34 countries could enhance market opportunities [4]

Core Viewpoint - The pharmaceutical distribution giant Jiuzhoutong announced its acquisition of a 20% stake in Aoyuan Meigu for 673 million yuan, aiming to become a potential controlling shareholder post-restructuring, marking a strategic shift from a medical beauty supply chain service provider to an operator of terminal medical institutions [1][2]. Group 1: Acquisition Details - Jiuzhoutong's wholly-owned subsidiary signed an investment agreement to acquire 360 million shares of Aoyuan Meigu, which is undergoing restructuring [2]. - Aoyuan Meigu, despite having well-known medical beauty resources, has faced continuous losses and is in a state of insolvency, prompting Jiuzhoutong to leverage its experience in the medical beauty industry to revitalize this asset [1][6]. Group 2: Industry Context - Aoyuan Meigu, originally listed as Hubei Jinhui in 1996, has undergone multiple ownership changes and business transformations, entering the medical beauty sector in 2020 under Aoyuan Group [6]. - The company has struggled financially, with projected losses of 320 million to 450 million yuan for 2024, leading to its restructuring application in November 2024 [6]. Group 3: Jiuzhoutong's Strategy - Jiuzhoutong has been active in the medical beauty sector since 2016, investing in companies like Aimeike and forming strategic partnerships with major players like Huaxi Biological and Langzi Medical [7][8]. - The company has seen its medical beauty segment revenue double to 342 million yuan in 2023, indicating significant growth potential despite challenges in its core pharmaceutical distribution business [9][11]. Group 4: Financial Performance - Jiuzhoutong's revenue increased from 118.06 billion yuan in 2020 to 150.14 billion yuan in 2023, but net profit declined from 3.075 billion yuan to 2.174 billion yuan during the same period, highlighting the pressures on its traditional business [9][11]. - The company has raised over 6 billion yuan through various financing methods since its listing in 2010, demonstrating its financial flexibility to support new ventures [11]. Group 5: Future Outlook - The successful restructuring of Aoyuan Meigu could allow Jiuzhoutong to transition from a supplier to a terminal service operator, leveraging its supply chain advantages and Aoyuan Meigu's member resources for enhanced product penetration [12]. - The strategic shift into the medical beauty sector is critical for Jiuzhoutong's future growth trajectory and market positioning, as it seeks to establish a second growth curve amid slowing traditional business growth [12].