Core Viewpoint - The synthetic biology sector in food and agriculture has entered a period of explosive investment and development, focusing on the production of alternative proteins and other innovative food products [2]. Group 1: Investment and Development Trends - The application of synthetic biology in food nutrition is increasing annually, with a focus on products such as edible microbial proteins, functional sugars, probiotics, human milk oligosaccharides, EPA, DHA, collagen, and cultured meat [2]. - The Fourth Synthetic Biology and Green Bio-Manufacturing Conference will be held from August 20-22 in Ningbo, Zhejiang, featuring representatives from various universities and companies sharing insights on synthetic biology technology and product development [3]. Group 2: Conference Agenda Highlights - The conference will include sessions on innovative research and industrial transformation of probiotics, bio-manufacturing of human milk oligosaccharides, and the development of vitamins and agricultural enhancers [6][19][39]. - Notable speakers include experts from Jiangnan University, Yili Group, and other leading companies in the field, discussing topics such as sweet proteins and green agricultural enhancers [6][39]. Group 3: Industry Collaboration and Support - The conference is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd., in collaboration with various academic and research institutions, highlighting the importance of industry-academia partnerships in advancing synthetic biology [9][10]. - Strategic cooperation with media and industry alliances is emphasized to promote the growth of the synthetic biology sector [10][31].

Core Viewpoint - The article discusses the approval and details of the Guangdong Province Synthetic Biology Manufacturing Pilot Platform Project, highlighting its investment, construction scale, and the upcoming SynBioCon 2025 conference focused on synthetic biology and green manufacturing trends [3][4][5]. Project Approval and Details - The Guangdong Provincial Development and Reform Commission approved the preliminary design budget for the Synthetic Biology Manufacturing Pilot Platform Project, with a total investment of 21,733,000 yuan, including engineering costs of 19,459,000 yuan and other expenses [3]. - The project will establish four major pilot platforms: an intelligent microbial pilot platform, a functional macromolecule pilot platform, a green biomass methanol pilot platform, and an intelligent plant pilot platform, covering a construction area of approximately 8,500 square meters and acquiring about 365 sets of instruments and equipment [3][4]. SynBioCon 2025 Conference - The SynBioCon 2025 conference will be held from August 20 to 22 in Ningbo, Zhejiang, focusing on four main areas: AI in biological manufacturing, green chemical engineering and new materials, future food, and future agriculture [5]. - The conference aims to explore the development trends of the biological manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the continuous vitality brought by new technologies and products [5]. - Various activities will take place during the conference, including a youth forum, high-level discussions, and a closed-door seminar on the "2025 Blue Book for AI Empowering Biological Manufacturing Industry Innovation" [5][11].

Core Viewpoint - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI with bio-manufacturing, green chemistry, new materials, future food, and agriculture [2][3]. Group 1: Conference Overview - The conference aims to explore the development trends of bio-manufacturing during the 14th Five-Year Plan, innovations driven by AI in the bio-manufacturing industry, and the technologies and products that will sustain the vitality of the bio-manufacturing sector [3][10]. - Various activities will be held concurrently, including a Youth Forum on Bio-Manufacturing, a high-level roundtable on the bio-manufacturing industry, and a closed-door seminar for the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [3][20]. Group 2: Event Schedule - Day 1 (August 20): Registration and various forums including a high-level roundtable and a Youth Forum [7][10]. - Day 2 (August 21): Opening ceremony, macro forum on bio-manufacturing, and specialized forums on green chemistry and new materials [15][17]. - Day 3 (August 22): Specialized forums on AI empowerment in bio-manufacturing and future food and agriculture [21][23]. Group 3: Supporting Organizations - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. and supported by various institutions including Peking University Ningbo Institute of Ocean Medicine and the China Society of Bioengineering [4][10]. - Strategic media partners and numerous industry experts are also involved in the event [4][10]. Group 4: Participation and Networking - The conference will facilitate networking among industry leaders, government representatives, and academic experts, promoting technology transfer and talent acquisition in the bio-manufacturing field [3][10]. - A list of participants includes executives from various bio-manufacturing companies and research institutions, indicating a strong interest in collaboration and innovation [28][29].

据了解，莱茵生物在合成生物学领域的布局可追溯至2016年，公司先后与中国科学院天津工业生物技术 研究所、江南大学等科研机构合作，深耕天然甜味剂及生物多糖的生物合成技术。目前已建立桂林莱茵 合成生物技术有限公司和成都赛迪科生物科技有限公司两大研发平台，分别聚焦天然甜味剂和生物多糖 领域。 截至2024年9月，莱茵生物已获得8项合成生物学相关专利授权，另有10项专利申请处于受理状态。其 中，2024年6月某一创新型甜叶菊RM系列产品已获得Self-GRAS认证，具备商业化条件；与江南大学陈 坚院士团队合作研发的罗汉果甜苷V全合成技术，更使公司成为业内首家跑通该技术路径的企业，为解 决传统种植模式的局限性提供了全新方案。 据了解，此次通过FDA GRAS认证的瑞鲍迪苷M2，是甜菊糖苷类甜味剂中的稀有高价值单体。相较于 市场上流行的RebD、RebM等成分，RebM2在甜味特性、口感纯净度、稳定性及溶解性等方面均具优 势，与其他甜味剂复配时能显著提升整体效果，应用场景覆盖食品、饮料、膳食补充剂等多个领域。 值得关注的是，莱茵生物采用酶转化法生产RebM2，在效率、成本和质量上形成显著竞争力，有效解决 了传统生产工艺产 ...

Core Viewpoint - The Fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on the integration of AI in bio-manufacturing, green chemicals, new materials, future food, and agriculture [3][4]. Group 1: Conference Overview - The conference will explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the technologies and products that will sustain the industry's vitality [3][4]. - Various activities will be held concurrently, including a youth forum, high-level discussions, and a closed-door seminar on the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [3][4][9]. Group 2: Organizational Structure - The conference is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. and supported by several academic and industry institutions, including Peking University Ningbo Institute of Ocean Medicine and the Zhejiang Synthetic Biology Industry Technology Alliance [4][5]. Group 3: Agenda Highlights - Day 1 will feature a high-level discussion on bio-manufacturing industry trends and a youth forum aimed at discovering innovative outcomes in bio-manufacturing [9][10]. - Day 2 will include a macro forum on the bio-manufacturing industry, thematic discussions on green chemicals and new materials, and a welcome dinner [8][9][10]. - Day 3 will focus on AI's role in bio-manufacturing and future food and agriculture discussions [8][9][10]. Group 4: Key Technologies and Innovations - The conference will showcase various innovative projects, including the bio-manufacturing of functional sugars, microalgae-based selenium protein synthesis, and the design of humanized "4D" collagen proteins [31][32][33][34]. - Notable advancements include the production of natural terpenes for mosquito repellent applications and the development of low-burden glycerol diester oils through synthetic biology [33][34][30]. Group 5: Industry Representation - The conference will feature over 500 representative enterprises in the bio-manufacturing sector, with a focus on regional contributions from Zhejiang, Jiangsu, Shanghai, Guangdong, and the Beijing-Tianjin-Hebei area [54][55].

Core Viewpoint - China Resources Double Crane (华润双鹤) is strategically investing in synthetic biology, establishing a biopharmaceutical industry fund with a target of 500 million RMB to enhance its investment capabilities in key areas like synthetic biology and health products [2][4]. Group 1: Investment and Strategic Direction - On August 12, China Resources Double Crane announced plans to establish a biopharmaceutical industry fund with a target fundraising scale of 500 million RMB, with the company and its wholly-owned subsidiary contributing up to 87 million RMB, accounting for no more than 17.4% of the total fund [2]. - The company has identified synthetic biology as one of its strategic development directions and has established a comprehensive "R&D + pilot test + industrialization" three-tier system, including a synthetic biology industrialization platform in Hohhot [2][4]. - The establishment of the fund aims to optimize the company's strategic layout in synthetic biology and other key areas, leveraging synergies with Hohhot's industrial development to enhance investment methods in synthetic biology [2]. Group 2: Financial Performance - In the first quarter of 2025, China Resources Double Crane achieved revenue of 3.079 billion RMB and a net profit attributable to shareholders of 507 million RMB [3]. Group 3: Historical Context and Acquisitions - In 2022, China Resources Double Crane invested 500 million RMB to acquire Shenzhou Biology, establishing it as a base for synthetic biology industrialization [4]. - In 2023, the company established the China Resources Double Crane Synthetic Biology Research Institute, focusing on talent acquisition and the simultaneous construction of a pilot test base [4]. Group 4: Technological Development - The small-scale testing platform has been largely completed, focusing on core capabilities such as molecular modification, high-throughput screening, strain validation, and enzyme engineering [6]. - The company is prioritizing the construction of pilot fermentation workshops to enhance its pilot conversion capabilities [6]. Group 5: Market Positioning - Shenzhou Biology is recognized as the world's second-largest supplier of coenzyme Q10, holding a stable global market share of 30% [7]. - The chairman of the company emphasized that the focus on synthetic biology is primarily around health products, aiming to enhance the competitiveness of existing core products through synthetic biology technology [7].

Core Viewpoint - SynBioCon reports that Jiangsu Siweibo Biotechnology Co., Ltd. has successfully signed a multi-million B round investment agreement with Shenzhen Jiadao Green Low-Carbon Investment Fund, which will inject strong momentum into the company's continuous development. Notably, Ant Financial Chairman Jing Xiandong continues to invest in this round, demonstrating confidence in the company's prospects [2][4]. Company Overview - Siweibo is a leading enterprise in the agricultural microbiology sector and is a key laboratory for green intelligent fertilizers under the Ministry of Agriculture and Rural Affairs. The company has established a comprehensive research, production, sales, and service system that includes core technologies such as microbial strain exploration, high-throughput screening, molecular biology research, active gene regulation, metabolite preparation, and customized applications of composite microorganisms [4]. Funding Utilization - The funds from this round of financing will primarily be used for agricultural biotechnology research and development, industrial investment layout, and team building. By increasing R&D investment, Siweibo aims to accelerate the productization and industrialization of core technologies, enhancing its technological advantages and market competitiveness in areas such as microbial fertilizers and agricultural waste resource utilization [4]. Strategic Goals - Siweibo plans to expand its business footprint through industrial investment layout, strengthen cooperation with upstream and downstream enterprises, and improve overall operational efficiency. Enhanced team building will provide talent support for continuous innovation and stable development [4]. Future Outlook - Siweibo intends to leverage the funds and strategic resources obtained from this financing to accelerate technological innovation and product upgrades, providing high-quality products and services to a broader customer base and creating greater value for society. With the growing demand for agricultural green development, Siweibo is expected to play a leading role in the agricultural biotechnology field, driving innovation and development in the industry [4].

Core Viewpoint - The Fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI-enabled bio-manufacturing, green chemicals and new materials, future food, and future agriculture [9][10]. Group 1: Conference Overview - The conference aims to explore the development trends of the bio-manufacturing industry during the "14th Five-Year Plan" period, innovations driven by AI, and the technologies and products that will sustain the vitality of the bio-manufacturing sector [9][10]. - Various activities will be held concurrently, including a youth forum, high-level discussions, and a closed-door seminar on the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [9][10]. Group 2: Event Schedule - The event will feature a series of forums and discussions over three days, including topics on green chemicals, AI in bio-manufacturing, and future food and agriculture [14][15]. - Notable sessions include a high-level discussion with industry leaders and a youth forum aimed at discovering innovative achievements in bio-manufacturing [15][30]. Group 3: Participating Organizations - The conference is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd., in collaboration with various academic and industry partners, including Peking University Ningbo Institute of Ocean Medicine and Ningbo Enzyme Science Biotechnology Co., Ltd. [10][11]. - Support is provided by several associations and alliances focused on synthetic biology and bio-manufacturing [10][11]. Group 4: Key Topics and Innovations - The conference will showcase advancements in synthetic biology, including the production of functional sugars, microbial protein synthesis, and the design of humanized collagen [37][38][40]. - Innovations in enzyme engineering and the application of AI in bio-manufacturing processes will also be highlighted [30][31].

Core Viewpoint - The article discusses the development of a spatially decoupled electro-biosystem for efficient CO2 conversion into valuable chemicals, highlighting the integration of electrochemical and microbial fermentation processes to enhance product yield and selectivity [4][13]. Summary by Sections CO2 Reduction Technology - CO2 electroreduction (CO2 RR) technology utilizes clean electricity to convert CO2 into high-value chemicals, addressing resource scarcity [3]. - Current advancements allow for efficient conversion of CO2 into C1-C2 products like carbon monoxide, methane, and ethanol, but challenges remain in synthesizing high-energy-density long-chain hydrocarbons [3]. Innovative System Design - The research team from Beijing University of Chemical Technology has developed a modular design integrating CO2 electro-catalytic reduction with microbial fermentation, published in Advanced Energy Materials [4][13]. - The electro-catalytic system employs tannic acid-based metal-polyphenol complex nanoparticles to synthesize a covalent organic polymer catalyst, achieving high selectivity and current density for ethanol production [7][12]. Performance Evaluation - The MPN@deCOP@Ag-Cu2O catalyst demonstrated a Faradaic efficiency (FE) for ethanol of approximately 44.5% at a current density of 400 mA cm², outperforming traditional copper catalysts [12]. - The system maintained ethanol selectivity around 25% over a prolonged operation of 5.8 hours, with a product purity of 86.6% [12][13]. Microbial Conversion - Engineered E. coli strains were developed to convert ethanol into industrially valuable products such as itaconic acid, isopropanol, and polyhydroxybutyrate (PHB) [16]. - The study achieved significant yields of 482.6 mg/L for itaconic acid, 109.3 mg/L for isopropanol, and 295.1 mg/L for PHB, demonstrating the feasibility of using CO2-derived ethanol as a sustainable carbon source [16]. Future Implications - The findings suggest that the developed electro-catalysts and reactor designs have significant potential for scaling up CO2 conversion processes, addressing key challenges in CO2 RR technology applications [13].

Core Viewpoint - The article emphasizes the development of the biomanufacturing industry through the integration of artificial intelligence, as highlighted in the government's work report for 2025, which aims to foster future industries like biomanufacturing [2]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI-enabled innovation in biomanufacturing and related fields [11][12]. - The conference will include various activities such as a youth forum, high-level discussions, and a closed-door seminar for the "2025 Artificial Intelligence Empowering Biomanufacturing Industry Innovation Development Blue Book" [11][18]. Group 2: Research and Development Focus - The "2025 Artificial Intelligence Empowering Biomanufacturing Industry Innovation Development Blue Book" will be developed through extensive field research in cities like Beijing, Shanghai, and Shenzhen, focusing on the integration of AI in biomanufacturing [2][9]. - The conference will feature discussions on the current applications of AI in biomanufacturing, showcasing typical case studies from the Ministry of Industry and Information Technology [4][34]. Group 3: Conference Agenda Highlights - The agenda includes specialized forums on topics such as green chemistry, new materials, future food, and agriculture, with a focus on the trends and growth points in biomanufacturing during the 14th Five-Year Plan [11][12][18]. - Notable sessions will cover data-driven programmable protein engineering, industrial bioprocess intelligent manufacturing technologies, and high-throughput screening solutions in synthetic biology [34][40]. Group 4: Industry Collaboration - The event is supported by various institutions, including the Ningbo Detaizhong Research Information Technology Co., Ltd., Peking University Ningbo Institute of Ocean Medicine, and several industry alliances [12][13]. - The conference aims to facilitate technology transfer, product scaling, and talent acquisition within the biomanufacturing sector [11][12]. Group 5: Future Directions - The conference will also announce the "China Synthetic Biology Industry Distribution Map (2025 Edition)," which includes a list of over 500 representative enterprises in the biomanufacturing sector [43][44]. - The focus on AI integration is expected to drive innovation and sustainability in biomanufacturing, positioning the industry for future growth [2][11].