Core Points - The theme for World Rabies Day 2023 is "Together We Act, Building a Rabies Prevention Line" [1] - Rabies is a zoonotic disease caused by the rabies virus, primarily transmitted through bites or scratches from infected animals like dogs and cats [1] - The mortality rate of rabies approaches 100% once clinical symptoms such as hydrophobia and difficulty swallowing appear [1] Group 1 - The increase in pet ownership, improved ecological conditions, and more frequent contact with wildlife heighten the importance of rabies prevention [1] - During the upcoming National Day holiday, individuals are advised to maintain distance from dogs, cats, and wild animals to avoid rabies infection [1] Group 2 - The recommended emergency response for animal bites includes three steps: washing the wound with plenty of water for about 15 minutes, bandaging the wound, and seeking medical attention promptly [2][3] - Rabies vaccination is the most crucial method for controlling and preventing rabies, with two vaccination schedules: the "5-dose" and "4-dose" regimens [3] - The "5-dose" regimen involves vaccinations on the day of exposure and on days 3, 7, 14, and 28, while the "4-dose" regimen consists of two doses on the day of exposure and one dose on days 7 and 21 [3]

人民网北京9月28日电 （记者乔业琼）被咬伤后没有及时注射狂犬病疫苗，是否一定有患狂犬病的 风险？被家养宠物挠伤或咬伤，有必要接种疫苗吗？近日，河南疾控微信公众号发布相关科普内容。 被咬伤后没有及时注射狂犬病疫苗，是否一定有患狂犬病的风险？ 被咬伤后未及时注射狂犬病疫苗是否一定会患病，取决于以下关键因素： 高风险动物：犬、猫、蝙蝠等哺乳动物可能携带病毒。 低风险动物：啮齿类（如仓鼠、兔子）极少传播狂犬病，通常无需接种。 二是暴露的严重程度 咬、抓伤，皮肤破损处或黏膜接触病毒等均有感染风险，但贯穿伤、头面部伤口、粘膜接触病毒及 蝙蝠接触风险更高。 三是暴露后的处置措施 及时、规范完成全程暴露后处置（含伤口冲洗消毒、疫苗接种、必要时被动免疫制剂注射），可近 乎 100% 阻断感染风险，且接种越早效果越好。 被咬伤后没有及时注射狂犬病疫苗并非"一定"会患病，但如果暴露于携带狂犬病毒的动物，且为头 面部伤或严重伤，未进行或未及时进行伤口处置、疫苗接种、被动免疫制剂接种的话，发病的风险将大 大增加。 被家养宠物挠伤或咬伤，有必要接种疫苗吗？ 如果宠物已经疑似病态，被伤后一定要及时进行暴露后处置，如果是看起来健康的宠物， ...

Investment Rating - The report assigns a "Buy" rating to the company with a target price of 8.96 CNY over the next six months, up from the previous rating [1][10]. Core Insights - The company has shown significant performance recovery, with a notable increase in revenue and net profit driven by its pet business and ongoing research and development efforts [1][7]. - The revenue for the first half of 2025 reached 2.793 billion CNY, reflecting a year-on-year growth of 12.63%, while the net profit attributable to the parent company was 82 million CNY, up 30.19% year-on-year [7]. - The company is focusing on large customer development and synergistic services in the animal health sector, which is expected to enhance its profitability [7]. Financial Performance Summary - Revenue projections for 2024A, 2025E, 2026E, and 2027E are 6,017 million CNY, 6,569 million CNY, 7,190 million CNY, and 7,798 million CNY respectively, with growth rates of 11.30%, 9.17%, 9.46%, and 8.46% [2][9]. - The net profit attributable to the parent company is forecasted to be 71 million CNY in 2024A, increasing to 287 million CNY in 2025E, 351 million CNY in 2026E, and 386 million CNY in 2027E, with growth rates of -82.41%, 305.33%, 22.12%, and 9.99% respectively [2][9]. - The company’s earnings per share (EPS) are projected to be 0.07 CNY in 2024A, rising to 0.28 CNY in 2025E, 0.34 CNY in 2026E, and 0.38 CNY in 2027E [2][9]. Business Segment Performance - The pharmaceutical segment reported strong performance with sales revenue of 999 million CNY, while the biological products segment faced a decline in revenue to 450 million CNY due to increased competition [7]. - The feed segment generated revenue of 536 million CNY, indicating stable performance despite some pricing pressures [7]. - The company is actively investing in the pet health product market, with significant advancements in product development and brand promotion [7]. Research and Development - The company invested 60 million CNY in R&D in the first half of 2025, representing a year-on-year increase of 4.73%, with a research expense ratio of 2.14% [7]. - The company is focusing on developing vaccines and pharmaceuticals for pets, with several new products launched during the reporting period [7]. Valuation and Market Position - The company is valued at a PE ratio of 32 times for 2025, which is competitive compared to its peers in the animal health industry, which have an average PE of 31 times [10][11]. - The company’s market capitalization is approximately 7.577 billion CNY, with a total asset value of 8.882 billion CNY [5].

Investment Rating - The industry investment rating is maintained at "Overweight" [1] Core Insights - In H1 2025, rabies vaccines and HPV vaccines showed positive growth in batch approvals, with rabies vaccines leading with a 37.13% year-on-year increase [3][5] - The HPV vaccine approvals totaled 103 batches, reflecting a slight increase of 8.42% year-on-year, primarily driven by the two-valent HPV vaccine [3][4] - The pneumococcal vaccine approvals saw a significant decline, with a total of 44 batches, down 44.3% year-on-year [4] - The report highlights that the vaccine industry is currently under pressure, but long-term prospects remain positive due to innovation and international expansion [9][10] Summary by Sections Rabies Vaccine - Total approvals reached 421 batches in H1 2025, marking a 37.13% increase year-on-year, with Vero cell rabies vaccines accounting for 90% of the total [5] - Major contributors include companies like Fosun Yalifeng and Huashan Biological, with Liaoning Chengda leading with 189 batches [5] HPV Vaccine - The two-valent HPV vaccine saw a remarkable increase of 252% in approvals, while the nine-valent HPV vaccine faced a 75.81% decline [3][12] Pneumococcal Vaccine - The total approvals for pneumococcal vaccines were 44 batches, down 44.3% year-on-year, with the 13-valent vaccine decreasing by 15.91% [4][12] Influenza Vaccine - Total approvals for influenza vaccines were 140 batches, reflecting a 24.73% decline, with the four-valent split vaccine being the most significant contributor [6][12] Meningococcal Vaccine - The total approvals for meningococcal vaccines were 172 batches, down 20.37% year-on-year, with the four-valent polysaccharide vaccine showing strong growth [7][8] Investment Recommendations - The report suggests that while short-term performance is under pressure, long-term focus on innovation and international market expansion is crucial for growth [9][10]

Core Viewpoint - The company has implemented a "Quality Improvement and Efficiency Enhancement" action plan for 2025, focusing on enhancing operational efficiency, strengthening market competitiveness, and safeguarding investor interests. Group 1: Company Overview - The company is focused on the human vaccine sector, particularly influenza vaccines, and has developed a product line covering ten vaccines for five infectious diseases [4][5]. - The company has a strong commitment to maintaining high safety and efficacy standards for its products, with its quadrivalent influenza vaccine exceeding national and European pharmacopoeia standards [4]. Group 2: Financial Data - The company reported a total R&D investment of 23.85 million yuan in the first half of 2025, reflecting a year-on-year increase of 15.25% [8]. - The company has effectively managed its costs, resulting in a decrease in management expenses compared to the previous year [12]. Group 3: Operational Highlights - The company has accelerated the production and approval process for its quadrivalent influenza vaccine, aiming to increase market share by improving production efficiency [6][7]. - The company has established a marketing network covering over 2,000 disease control centers across 30 provinces, enhancing customer service and exploring new sales channels [10]. Group 4: R&D and Innovation - The company is actively pursuing R&D in various vaccine areas, including rabies, chickenpox, and pneumonia, with several projects progressing through clinical trials [8]. - The company has initiated the III phase clinical trial for its quadrivalent influenza vaccine for children, demonstrating its commitment to innovation [8]. Group 5: Governance and Compliance - The company has strengthened its governance structure, ensuring compliance with regulatory requirements and enhancing decision-making efficiency through various board committees [13][20]. - The company has conducted multiple board meetings and shareholder meetings to ensure transparency and effective governance [14][19]. Group 6: Investor Relations - The company emphasizes investor communication, planning to hold a performance briefing to address investor concerns and enhance transparency [26][27]. - The company has established a mechanism for timely responses to investor inquiries, ensuring that information is accurate and complete [18][19]. Group 7: Fund Management - The company has raised 1.21396 billion yuan through its public offering, with net proceeds of 1.13567 billion yuan after deducting issuance costs [35][36]. - As of June 30, 2025, the company had a balance of 119.05 million yuan in unutilized raised funds, demonstrating effective fund management [37]. Group 8: Future Outlook - The company plans to continue enhancing its R&D efforts and operational efficiency in the second half of 2025, aiming to strengthen its market position and investor returns [9][23].

Group 1 - The latest stock price of Kanghua Biotech is 86.24 yuan, an increase of 2.54 yuan or 3.03% from the previous trading day. The intraday high reached 87.52 yuan and the low was 83.70 yuan, with a trading volume of 527 million yuan and a turnover rate of 5.13% [1] - Kanghua Biotech operates in the biopharmaceutical sector, focusing on the research, production, and sales of human vaccines. Its main products include rabies vaccines and Japanese encephalitis vaccines, and the company is actively expanding into the pet vaccine market [1] - The Shanghai Biopharmaceutical M&A Fund strategically took control of Kanghua Biotech in July, with plans to accelerate the diversification of the vaccine product line and build a vaccine ecosystem. This collaboration is seen as a significant move by Shanghai state-owned assets in the biopharmaceutical field [1] Group 2 - On August 21, Kanghua Biotech experienced a net inflow of 37.11 million yuan in main funds, accounting for 0.36% of its circulating market value. However, over the past five days, there was a net outflow of 114 million yuan, representing 1.11% of its circulating market value [1]

Group 1 - The core viewpoint of the report is that Aimei Vaccine (06660.HK) is expected to achieve profitability by 2026, which will lead to a revaluation of its stock price due to its leading position in the pneumonia and rabies vaccine segments [1][2] - Aimei Vaccine's current stock price is at a 56% discount compared to its peers' projected sales for 2026, indicating it is at the lower end of the valuation range among competitors [1] - The report predicts a significant reduction in R&D expenses by 39% after the completion of major clinical trials in 2025, contributing to the expected profitability in 2026 [1] Group 2 - Aimei Vaccine is anticipated to achieve a compound annual growth rate (CAGR) of 45% in sales from 2025 to 2027, driven by the expected launch of the 13-valent pneumococcal conjugate vaccine (PCV13) and a serum-free rabies vaccine [1] - The company is projected to capture approximately 20% and 10% market shares in the rabies and pneumonia vaccine markets in China by 2026, respectively [1] - Aimei's vaccines are reported to have superior efficacy compared to Pfizer's products, and the rabies vaccine's serum-free formulation is expected to result in fewer side effects [2] Group 3 - Aimei Vaccine's stock rose by 9.96% to close at HKD 5.74 per share, reflecting the ongoing enthusiasm for vaccine stocks in the Hong Kong market [2] - The report highlights the recent bullish trend in the Hong Kong innovative drug sector, exemplified by the significant market performance of Zhonghui Biotechnology-B, which saw its stock price increase by over 162% on its first trading day [2] - Multiple institutions have indicated that the Hong Kong innovative drug market is entering a bull market, suggesting that Aimei Vaccine will also experience a value revaluation as its fundamentals improve [2]

Group 1 - The National Healthcare Security Administration announced that drug procurement will no longer simply reference the lowest bid, indicating a shift in policy that could benefit companies with strong quality systems and cost advantages [1] - The recent announcement led to a significant increase in Hong Kong's biopharmaceutical stocks, particularly in the vaccine sector, with notable gains for companies such as Ai Mei Vaccine (+13.5%) and CanSino Biologics (+9.03%) [1] - The 11th batch of centralized procurement has been initiated, with new rules optimizing the calculation of price differences and requiring transparency from the lowest bidders regarding the rationality of their pricing [1] Group 2 - The vaccine sector has shown remarkable performance due to multiple favorable factors, including a warning from the World Health Organization regarding mosquito-borne diseases, which has boosted market sentiment [2] - Ai Mei Vaccine has successfully commercialized eight vaccines, including leading products like rabies and hepatitis B vaccines, and has a robust pipeline of 21 vaccines in development, with three key products nearing market launch [2] - The vaccine sector is seen as having significant potential for valuation recovery, as many companies' pipeline values have not yet been fully reflected in their market valuations [2]

Summary of the Conference Call on the Pet Pharmaceutical Industry Industry Overview - The pet pharmaceutical market in China is experiencing rapid growth, with a compound annual growth rate (CAGR) of 22%, driven by rigid demand throughout the pet lifecycle [1][2] - The aging pet population is increasing, with the proportion of senior dogs over seven years old rising significantly, leading to higher demand for medications for age-related diseases [1][2] Key Insights - The market size is projected to grow from less than 9.4 billion yuan in 2020 to nearly 21 billion yuan by 2024, indicating a robust growth trajectory [2] - The demand for pet medications is characterized by its rigidity, affecting various age groups, with high incidence rates of conditions like dental calculus and skin diseases [2] - The industry faces supply bottlenecks, particularly in medications for elderly diseases, which are heavily reliant on imports [4] Supply Chain and Innovation - The industry is exploring human drug conversion to alleviate supply-demand conflicts, exemplified by the release of a directory of urgently needed human medications for pets [4] - There is a push for accelerated research and innovation to develop effective treatments for chronic diseases and tumors, with the first domestic monoclonal antibody drug clinical approval achieved in June [4] Progress in Domestic Vaccine Development - Domestic companies have made significant strides in the core vaccine sector, particularly with the launch of the first approved domestic cat trivalent vaccine by Ruipuhua in January 2024 [5][6] - By June 2025, a total of 11 domestic cat trivalent vaccines are expected to be on the market, breaking the monopoly previously held by foreign companies [5][6] Market Dynamics - The pet vaccine market is vast, with the mandatory rabies vaccine market valued at approximately 3-4 billion yuan, and both cat and dog trivalent vaccines around 2 billion yuan each [6] - Domestic vaccines have advantages in strain matching and pricing, typically being 20% cheaper than imported alternatives [7] Competitive Landscape - The cat trivalent vaccine market remains in a blue ocean state, with less than 10% immunization penetration among urban pet cats, indicating significant growth potential [8][9] - Over 10 domestic companies are involved in the pet vaccine sector, including traditional veterinary medicine firms and those transitioning from human pharmaceuticals [10] Challenges and Future Trends - Domestic companies face challenges in channel development, needing to overcome the premium pricing power of foreign brands [11] - Companies like Ruipuhua and PlaiKe are working to narrow the gap by building their own or partnering with pet hospitals [11][12] - Future trends include a focus on mRNA technology and innovative drug delivery methods, which could reshape the competitive landscape and create larger market opportunities due to the increasing management needs of aging pets [13]

Industry Overview - Vaccines are essential biological products for preventing and controlling infectious diseases, representing a core defense in public health systems [1][5] - The Chinese vaccine industry is experiencing rapid growth, with the market size projected to increase from 306.22 billion yuan in 2015 to 1,762.19 billion yuan in 2024, and expected to exceed 300 billion yuan by 2031 [1][5] Industry Chain - The upstream of the vaccine industry includes raw material supply, such as microcarriers, human serum albumin, and packaging materials [3] - The midstream involves vaccine research and production, with key players including Sinopharm, Sinovac, CanSino, Zhifei, and Watson [3] - The downstream consists of vaccine distribution and consumption, reaching end consumers through health service centers and medical institutions [3] Current Industry Status - As of December 31, 2024, 47 companies in China have received vaccine batch approvals, totaling 543 million doses, with a decrease of 5.6% compared to 2023 [7] - The most approved vaccines in 2024 were influenza and rabies vaccines, each exceeding 80 million doses, accounting for 30% of total approvals [9] Market Competition - The Chinese vaccine market is characterized by a diverse competitive landscape, with local companies like Sinopharm and Zhifei rising against foreign giants like Merck and Pfizer [11] - Zhifei has achieved significant growth in international markets, with a 300% increase in exports of its WHO-precertified 23-valent pneumococcal polysaccharide vaccine [11] - Innovative companies like CanSino and Watson are making breakthroughs in mRNA and recombinant protein vaccines, enhancing their market presence [11][12] Future Trends - Technological innovation is driving the vaccine industry forward, with new platforms like mRNA and gene-engineered vaccines emerging [17] - The adult vaccine market is growing, with a 45% increase in HPV vaccine uptake in 2024, indicating a shift in public health awareness [18] - Chinese vaccine companies are expanding internationally, with over 2.5 billion doses of COVID-19 vaccines supplied abroad, focusing on markets in Africa and Southeast Asia [19]