智通财经APP获悉，11月4日，默沙东针对芦康沙妥珠单抗(sac-TMT)启动专项融资的罕见动作，向Blackstone融资7亿美元用于这 款产品在2026年的全球开发。默沙东保留sac-TMT的开发、生产和商业化的决策权和控制权，并以sac-TMT未来一定的收益权来 换取本次的融资。Sac-TMT，作为2022年科伦博泰生物-B(06990)授权给默沙东的重磅ADC药物，早已吸引了行业的目光。细品 这笔融资背后的战略布局，不难看出默沙东对sac-TMT的高度重视。 相比之下，sac-TMT却在多方面展现出强劲的势头，不仅率先在中国获批，近期在ESMO大会上，还一举夺下2项LBA(含一项重 磅主席论坛报告)和5项poster，成为重磅报告最多的国产创新药之一，并在非小细胞肺癌等领域展现出突破性的疗效。其中， sac-TMT与K药的联合方案在前列腺癌等领域的表现打破了K药的治疗瓶颈，进一步发挥了强势的联合潜力，成为了默沙东ADC 战略布局中至关重要的资产。 目前，默沙东已围绕sac-TMT在肺癌、乳腺癌、胃癌、妇科肿瘤多个领域开展15项III期全球性临床研究。而此次专项融资更是 对该产品的重视程度推向新高度，默 ...

在过去的几年里，默沙东持续加码ADC赛道，先后与科伦博泰、第一三共等企业达成百亿美元规模的合作。随着K药(Keytruda) 专利悬崖的临近，默沙东对ADC药物的决心愈发坚定，但管线中的其他ADC药物进展并不如预期，如HER3-DXd未能在全球III 期临床中突破关键终点，导致其上市申请被撤回。 相比之下，sac-TMT却在多方面展现出强劲的势头，不仅率先在中国获批，近期在ESMO大会上，还一举夺下2项LBA(含一项重 磅主席论坛报告)和5项poster，成为重磅报告最多的国产创新药之一，并在非小细胞肺癌等领域展现出突破性的疗效。其中， sac-TMT与K药的联合方案在前列腺癌等领域的表现打破了K药的治疗瓶颈，进一步发挥了强势的联合潜力，成为了默沙东ADC 战略布局中至关重要的资产。 11月4日，默沙东针对芦康沙妥珠单抗(sac-TMT)启动专项融资的罕见动作，向Blackstone融资7亿美元用于这款产品在2026年的 全球开发。默沙东保留sac-TMT的开发、生产和商业化的决策权和控制权，并以sac-TMT未来一定的收益权来换取本次的融资。 Sac-TMT，作为2022年科伦博泰生物-B(06990)授权 ...

Investment Rating - The report indicates a positive outlook for the weight loss drug sector within the pharmaceutical and biotechnology industry, suggesting potential acceleration in business development (BD) opportunities [2]. Core Insights - The pharmaceutical and biotechnology sector experienced a slight decline of -0.36% from April 14 to April 18, underperforming compared to the Wind All A index (0.39%) and the CSI 300 index (0.59). The market showed a preference for defensive sectors, with chemical preparations (0.62%), traditional Chinese medicine (0.6%), and offline pharmacies (0.19%) showing minor gains, while blood products (-4.39%), other biological products (-1.78%), and vaccines (-1.49%) saw significant pullbacks [2][7]. - The GLP-1 receptor agonists are expected to catalyze growth in the weight loss drug sector. Notably, Eli Lilly announced positive results from the Phase III ACHIEVE-1 study for its oral drug Orforglipron, which is set to expand the application of GLP-1 drugs. This class of drugs is becoming a focal point for multinational corporations (MNCs) in the metabolic disease space, with domestic companies poised to benefit from rapid innovation and lower R&D costs [2][12]. Market Weekly Review - The pharmaceutical and biotechnology sector's performance from April 14 to April 18 showed a decline of -0.36%, with the market favoring defensive stocks. The top gainers included Shuangcheng Pharmaceutical (56.4%), Kangpeng Technology (56.3%), and Lifang Pharmaceutical (47.1%), while the largest losers were *ST Jiyuan (-50.7%), Hasanlian (-19.1%), and Changyao Holdings (-18.5%) [7][10]. Industry News and Key Company Announcements - On April 17, Eli Lilly announced that its oral GLP-1 receptor agonist Orforglipron achieved positive results in its Phase III study, showing significant reductions in A1C levels and weight loss compared to placebo [12]. - Pfizer terminated the development of its GLP-1 small molecule receptor agonist Danuglipron due to potential liver damage in trial participants [12]. - The report highlights several companies making strides in the industry, including the approval of new indications for Merck's Gardasil 9 HPV vaccine and the progress of various clinical trials for innovative drugs [13][14].