中国科研团队研发出AI看病系统诊断罕见病"有根有据" 2月19日凌晨，上海交通大学医学院附属新华医院孙锟教授、余永国教授领衔团队与上海交通大学张娅教授、谢伟迪副教授领衔团队联合研发出一款能看 罕见病的人工智能系统，相关成果北京时间2月19日在国际顶尖期刊《自然》上发表。这套名为DeepRare的系统，被称作全球首个"推理过程可追溯"的罕 见病智能医生。 长期以来，罕见病很难确诊，病人常常跑多家医院也查不出是什么病。以往的医疗AI虽然能给出诊断结果，但就像一个只给结论、不给依据的医生，医 生们不敢轻易相信。这套新系统最大的不同，是它每下一个诊断，都会附带完整的"证据链"——就像老医生查房时，一步一步讲清楚为什么这么诊断。 系统的"脑子"里装满了全球顶尖的医学知识和真实病例。它不只是简单查资料，而是会像人类医生一样思考：先提出假设，再找证据验证，发现不对还会 自我纠正，反复推敲后才下结论。 测试数据显示，就算没有基因检测结果，只靠病人的临床症状，这套系统也能判断，第一次诊断的准确率达到57.18%，比原来的国际最好模型提高了近 24个百分点。这意味着，在缺少基因检测设备的基层医院，医生也能用它给罕见病患者做初步筛 ...

Core Insights - The article highlights the growing trend of electric vehicle (EV) purchases in rural areas of China, particularly during the 2026 Spring Festival, driven by multiple subsidy policies and the practice of trading in old vehicles for new ones [1][3][10]. Group 1: Market Dynamics - The county-level automotive market in China is showing robust performance, with EVs becoming a significant growth engine due to government and manufacturer subsidies [1][3]. - The majority of customers in county markets are opting for vehicles priced between 100,000 to 150,000 yuan, indicating a clear demand for affordable EV options [4][10]. - The transition from traditional fuel vehicles to EVs is being accelerated by concerns over emissions standards and the rising costs of maintaining older vehicles [3][4]. Group 2: Consumer Behavior - Consumers in rural areas are increasingly willing to trade in old fuel vehicles for new EVs, with a notable percentage of transactions occurring through trade-in programs [3][4]. - The decision-making process for customers in the 100,000 to 150,000 yuan price range is generally quicker compared to those with budgets over 200,000 yuan, reflecting a pragmatic approach to vehicle purchases in these regions [4][10]. Group 3: Future Projections - The sales of EVs in rural areas are expected to grow significantly, with projections indicating that by 2030, the car ownership rate in rural regions could reach nearly 160 vehicles per 1,000 people, translating to over 70 million vehicles and a market size of approximately 500 billion yuan [11][13]. - The penetration of EVs in the county and rural markets is anticipated to exceed 30% of total vehicle sales, driven by favorable economic conditions and improved charging infrastructure [10][13].

Core Insights - The article highlights the growing trend of electric vehicle (EV) purchases in rural and county areas of China, particularly during the 2026 Spring Festival, driven by multiple subsidy policies [1][2][8] - Experts suggest that the automotive market in rural and small cities holds significant consumer potential, which could positively impact the overall automotive market in China [1][8][14] Subsidy Policies and Market Dynamics - The combination of national, local, and manufacturer subsidies has made electric vehicles, particularly those priced around 100,000 to 150,000 yuan, the mainstay of county-level consumption [2][4] - Consumers are increasingly opting for trade-in programs, with a reported 60-70% of new car sales in certain dealerships being made through trade-ins of old vehicles [3][4] Consumer Behavior and Preferences - The primary consumer groups for trade-ins include owners of older fuel vehicles and early adopters of EVs looking to upgrade due to battery degradation [3][4] - The dealership experience has been enhanced with services like vehicle appraisal and transfer assistance, lowering the barriers for consumers to trade in their old cars [4] Market Growth and Projections - The sales of electric vehicles in rural areas are expected to grow significantly, with projections indicating that by 2030, the car ownership rate in rural areas could reach nearly 160 vehicles per 1,000 people, translating to over 70 million vehicles and a market size of approximately 500 billion yuan [12][14] - The number of recommended electric vehicle models has doubled from 61 in 2020 to 124 in 2025, indicating a broadening of the market supply to meet diverse consumer needs [11] Infrastructure Development - As of the end of 2025, China's electric vehicle charging infrastructure is projected to exceed 20 million units, with a significant increase in charging stations in rural areas, rising from less than 5% in 2020 to 13% of public charging stations [11] - The expansion of charging networks is expected to improve the usability of electric vehicles in rural regions, further driving adoption [11]

Core Insights - HHLR Advisors, a fund management platform under Hillhouse Capital, reported its U.S. stock holdings as of the end of Q4 2025, with a significant focus on Chinese concept stocks, which accounted for 92% of its portfolio [1][2]. Group 1: Holdings Overview - HHLR holds a total of 33 U.S. listed companies, with its top ten holdings including Pinduoduo, Alibaba, BeiGene, Futu Holdings, Legend Biotech, Arrivent Biopharma, Beike, Webull Corp, Cytek Biosciences, and Clearwater Analytics, with seven of these being Chinese concept stocks [2][4]. - The market value of HHLR's holdings in Pinduoduo reached approximately $1.22 billion, with a total of 10.72 million shares, reflecting an increase of 2.13 million shares from the previous quarter [4][5]. - Alibaba's holdings increased from 3.29 million shares to 5.43 million shares, with the market value rising from $588 million to $796 million, making it the second-largest holding in HHLR's portfolio [7]. Group 2: Trading Actions - HHLR significantly increased its positions in Pinduoduo and Alibaba while reducing its holdings in Futu Holdings and Webull Corp, with Futu's shares decreasing by nearly 50% from 3.24 million to 1.63 million [5][7]. - The firm also completely exited positions in several companies, including NetEase, Baidu, Manbang Group, Donghai Group, and Bright Scholar [7]. - HHLR's strategy aligns with other major private equity firms, such as Highfields and Jinglin Asset, which also increased their stakes in Pinduoduo during the same period [5]. Group 3: Sector Focus - HHLR is maintaining a focus on technology stocks, having made a small purchase of Google shares, bringing its total to 7,300 shares [8]. - The firm also invested in semiconductor company TSMC, acquiring 11,300 shares valued at approximately $3.43 million [8][10]. - Industry experts suggest that the AI sector is rapidly evolving, with various sub-sectors achieving commercial viability, indicating potential investment opportunities in areas like computing power, AI applications, energy storage, and electrical equipment [8].

Group 1: Core Insights - HHLR Advisors, a fund management platform under Hillhouse Capital, reported its US stock holdings as of the end of Q4 2025, with a focus on Chinese concept stocks, which constitute 92% of its portfolio [1][2]. - The top ten holdings of HHLR include Pinduoduo, Alibaba, BeiGene, Futu Holdings, Legend Biotech, Arrivent Biopharma, Beike, Webull Corp, Cytek Biosciences, and Clearwater Analytics, with seven of these being Chinese concept stocks [2][4]. Group 2: Investment Actions - HHLR significantly increased its holdings in Pinduoduo and Alibaba, while reducing its positions in Futu Holdings and Webull, indicating a strategic shift towards e-commerce leaders, biomedicine, and technology sectors [1][5][7]. - As of the end of Q4 2025, HHLR held 10.72 million shares of Pinduoduo, an increase of 2.13 million shares from the previous quarter, and 5.43 million shares of Alibaba, up by 2.14 million shares [5][7]. Group 3: Market Trends and Sector Focus - The investment in Pinduoduo aligns with similar moves by other major private equity firms, suggesting a consensus on the stock's potential despite a recent decline in its share price [5]. - HHLR also showed interest in technology stocks, acquiring shares in Google and TSMC, reflecting a broader trend of investment in AI and semiconductor sectors, which are seen as having significant growth potential [8][10].

Core Viewpoint - The logistics and express delivery industry is experiencing high demand during the 2026 Spring Festival, with major companies like SF Express, JD Logistics, and China Post ensuring uninterrupted services throughout the holiday period [1][2]. Group 1: Company Initiatives - Multiple express delivery companies are implementing differentiated strategies to meet the Spring Festival delivery demand, adjusting resource allocation and service fees accordingly [2]. - SF Express announced it will operate during the Spring Festival, implementing emergency response measures and adjusting service fees based on demand, with a resource adjustment fee ranging from 0.1 to 1.5 yuan per kg for certain packages [2]. - JD Logistics will also charge a peak resource adjustment fee of 0.1 to 1.2 yuan per kg during the holiday period to manage increased delivery demands [2]. Group 2: Operational Adjustments - Companies like China Post and YTO Express have indicated that delivery times may be affected during the holiday due to legal holidays and other factors, although they will maintain service operations [3]. - YTO Express plans to adjust personnel and resources to ensure smooth operations during the Spring Festival, while also acknowledging potential delays in certain regions due to weather and volume [3]. Group 3: Industry Performance - The express delivery sector is witnessing a surge in business volume, with the National Postal Bureau reporting approximately 4.686 billion packages delivered from February 2 to February 8, marking a 3.19% increase from the previous period [4]. - In January, YTO Express and Shentong Express reported significant year-on-year growth in business volume, with increases of 29.75% and 25.57% respectively, and Shentong Express also saw a 14.08% rise in single ticket revenue [4]. Group 4: Resource Optimization - SF Express has focused on optimizing resource allocation in key production areas, increasing collection points and dedicated vehicles to enhance delivery efficiency, particularly for local meat products [5]. - The company has upgraded its aircraft to the B-767 model, increasing its cargo capacity and improving delivery times for perishable goods [5].

Core Viewpoint - As of the end of 2025, H&H International Investment, managed by Duan Yongping, has a total holding value of approximately $17.489 billion, equivalent to over 120 billion RMB [1] Group 1: Investment Activities - In Q4 2025, Duan Yongping significantly increased his holdings in NVIDIA, as well as in Pinduoduo and Berkshire Hathaway [1] - Additionally, small positions were taken in three new AI-related companies [1] - Conversely, Duan Yongping reduced his stakes in Apple, Alibaba, and Occidental Petroleum [1]

俄美乌日内瓦会谈结束 新华社日内瓦2月18日电据俄罗斯媒体报道，俄罗斯、美国、乌克兰三方代表18日结束在瑞士日内瓦举 行的会谈。 俄罗斯代表团团长梅金斯基表示，当天谈判持续了两小时，"谈判虽然艰难，但很务实"。 泽连斯基称特朗普要求乌方单方让步"不公平" 来源：新华社 （文章来源：上海证券报） 新华社日内瓦2月18日电据美国阿克西奥斯新闻网站17日报道，乌克兰总统泽连斯基就正在瑞士日内瓦 进行的美乌俄三方谈判表示，美国总统特朗普在试图解决乌俄冲突时，对他施加了不当压力。乌克兰不 接受任何要求乌方单方面从顿巴斯地区撤军并将其移交给俄方的和平协议。 泽连斯基表示，特朗普不断公开呼吁乌克兰而非俄罗斯为和平作出让步，这"不公平"。 ...

"我们就是两个普通小孩，可能长得也比较喜庆，很荣幸登上了春晚的舞台。"在央视春晚前接受上海证 券报等媒体专访时，"00后"喜剧演员徐浩伦与谭湘文这样评价自己。 从脱口秀综艺的"黑马"选手到连续两年站上央视春晚舞台，这对"00后"喜剧搭档以对口白话这一形式为 载体，将生活中的烟火气揉进笑点，在主流舞台上唱出了属于南方喜剧的声音。 除了央视春晚，这个春节，徐浩伦与谭湘文还登上了B站大年初一联欢会、湖南卫视春晚等多个舞台， 被网友调侃为"春晚大满贯"。但二人却十分谦逊："没觉得多受欢迎，可能我们两个小孩长得比较喜 庆，适合过年的气氛吧。我们只是做好本职工作，湖南是家乡，对我们也很包容。" 在打磨中适配大众舞台 徐浩伦与谭湘文是国内新锐"00后"喜剧搭档，深耕对口白话这一喜剧形式。他们从线下开放麦起步，征 战脱口秀综艺并拿下冠军，2025年初登央视春晚舞台便凭借对口白话作品收获不俗的观众评分与收视 率。 2026年，他们不仅再度受邀登上春晚，还接连亮相多个舞台，成为当下喜剧舞台上颇具活力的南方喜剧 新力量。 对于徐浩伦与谭湘文而言，2025年初登春晚是惊喜与紧张交织，2026年再度受邀，则是在熟悉与沉淀中 完成自我突 ...

Market Overview - On February 17, US stocks experienced volatility under the backdrop of "AI narrative divergence," with the S&P 500 index briefly falling nearly 1% before closing up 0.1% [1] - The software sector remains under pressure, with the iShares expanded technology software industry ETF down 23.23% year-to-date, as investors worry that AI may disrupt existing software business models [1][5] - Major tech companies like Microsoft and Meta face scrutiny over high capital expenditures, yet the market still recognizes their leading positions in AI infrastructure development [1] Berkshire Hathaway's 13F Filing - Berkshire Hathaway disclosed its latest 13F filing to the SEC, showing continued adjustments in its tech holdings during Warren Buffett's final quarter as CEO [1][7] - Berkshire reduced its stake in Apple by over 10.29 million shares, a 4.32% decrease from the previous quarter, resulting in a market value reduction of approximately $2.8 billion [7][8] - This marks the third consecutive quarter of Apple share reductions, although it remains Berkshire's largest holding [7] Other Holdings Adjustments - Berkshire also sold nearly 50.8 million shares of Bank of America, reducing its stake by 8.94%, with the holding now accounting for 10.38% of its portfolio [7][8] - Amazon's share in Berkshire's portfolio dropped significantly from 0.82% to 0.19%, a decrease of over 77.2% in share quantity [8] - The only new position taken by Berkshire in the fourth quarter was in The New York Times, acquiring 5.0657 million shares valued at over $350 million [10] Sector Performance - The Dow Jones Industrial Average rose 0.07% to 49,533.19 points, while the S&P 500 and Nasdaq increased by 0.1% and 0.14%, respectively [3] - Apple shares rose over 3%, and Nike increased by more than 2%, leading the Dow [5] - The semiconductor sector showed mixed results, with the Philadelphia Semiconductor Index down 0.02% [5] Economic Data - ADP Research reported that the average weekly new job additions in the US increased to 10,250, marking the third consecutive week of growth [5]