Core Viewpoint - The article highlights the progress of Dongxiao Biotechnology Co., Ltd. in the synthetic biology manufacturing sector, focusing on its diverse corn deep processing capabilities and its upcoming listing on the New Third Board [2][4]. Group 1: Company Overview - Dongxiao Biotechnology specializes in synthetic biology manufacturing and fermentation technology, primarily engaged in the deep processing of corn to produce animal nutrition products, solid beverages, food additives, organic acids, and health sweeteners [2][4]. - The company has an annual corn deep processing capacity of 1.6 million tons, producing various products such as L-lysine hydrochloride, erythritol, and glucose [4]. Group 2: Market Position and Innovation - Dongxiao is positioned as a leader in the corn deep processing industry, transforming traditional agricultural raw materials into high-value products through technological innovation [4]. - The company utilizes renewable resources like corn and green energy sources such as wind and solar power to achieve sustainable product transformation across multiple sectors, including food, pharmaceuticals, and personal care [4]. Group 3: Financial Performance - For the fiscal years 2023 and 2024, Dongxiao's projected revenues are 7.993 billion yuan and 7.840 billion yuan, respectively, with main business revenues contributing significantly at 7.845 billion yuan and 7.630 billion yuan, accounting for 98.15% and 97.33% of total revenues [5]. - The net profits for the same periods are expected to be 298 million yuan and 578 million yuan, with a slight decline in revenue attributed to lower procurement prices for corn and energy [5]. - The overall gross profit margin is projected to improve to 10.33% and 13.91%, driven by reduced raw material costs despite limited price declines in the market [5].

Core Insights - The article discusses the first batch of bio-manufacturing landmark products announced by Hubei Province's Economic and Information Technology Department on October 9, highlighting significant advancements in the bio-manufacturing sector [2]. Group 1: Landmark Products - The first batch of landmark bio-manufacturing products includes: - Dongyang Sunshine: Thiocyanate Erythromycin - Tianji Bioenergy: Ultra-clean biodiesel - Bafeng Pharmaceutical: Amino acid raw materials - Xinhua Yang: Feed enzyme preparations - Guangji Pharmaceutical: High-quality riboflavin - China National Pharmaceutical Group: Inactivated vaccine for Porcine Circovirus Type 2 - Aibotai Bio: Research antibodies - Huisheng Biotechnology: Tylosin tartrate - Hite Bio-pharmaceutical: Injectable Epinephrine - Fuxing Biotechnology: Arachidonic acid (ARA) powder [2][3]. Group 2: Product Categories - The products are categorized into different types: - Scale Replacement Type: Thiocyanate Erythromycin, Ultra-clean biodiesel, Research antibodies, Tylosin tartrate - Key Improvement Type: Amino acid raw materials, Feed enzyme preparations, High-quality riboflavin, Arachidonic acid powder - Major Innovation Type: Inactivated vaccine for Porcine Circovirus Type 2, Injectable Epinephrine [3].

Core Viewpoint - The article discusses the advancements in non-grain biomass utilization, highlighting innovative research outcomes and their commercial viability in the bio-based sector, particularly focusing on the development of bio-based dicarboxylic acids [2][3]. Summary by Sections Event Overview - The fifth Non-Grain Biomass High-Value Utilization Forum will be held from November 27-29 in Hangzhou, Zhejiang, focusing on innovative research results and commercial feasibility in the non-grain bio-based field, with over 1500 technology and project connections completed to date [2]. Innovation Achievements - The article presents the innovative development of bio-based medium-chain dicarboxylic acids (C5-C8), which include glutaric acid, adipic acid, heptanedioic acid, and octanedioic acid, with a global market size exceeding 20 billion and continuing to expand [5]. Technical Advantages - The project utilizes biomass-derived platform compounds (such as glycerol, furfural, and 5-hydroxymethylfurfural) to create a renewable supply chain for producing bio-based dicarboxylic acids, significantly reducing reliance on petroleum and lowering carbon emissions compared to petrochemical routes [7][8]. Production Process - The innovative one-step dicarbonylation synthesis technology achieves product selectivity of ≥85% and catalyst recovery rate of ≥99.99%, shortening production cycles and reducing overall costs, addressing high energy consumption and cost challenges [7][8]. Market Compliance - Bio-based products are certified for carbon footprint, overcoming international green barriers and filling the gap in high-end applications for domestic bio-based C5-C8 dicarboxylic acids, creating a competitive advantage through "cost reduction - green compliance - market adaptation" [8]. Intellectual Property and Collaboration - The project has published five domestic patents and is open to collaborative development, result transformation, or intellectual property transfer [9].

Core Viewpoint - The research team at the Tianjin Institute of Industrial Biotechnology has made significant advancements in the bioconversion of lignin into microbial oils and proteins, addressing the challenges of lignin degradation and high-value utilization [5][7]. Summary by Sections Research Breakthroughs - The team successfully developed a genetically engineered strain, Curvularia clavata M6, which efficiently degrades lignin and simultaneously synthesizes oils and proteins. This was achieved by combining genome editing technology with high-throughput screening methods [5][6]. - The engineered strain M6 exhibited a 75% increase in laccase activity, reaching 228.58 U/L, and achieved an oil accumulation of 49% of the cell dry weight while maintaining a stable protein content of 33% [6]. Industrial Application Potential - In a 5-liter fermentation scale-up, the laccase activity further increased to 240.43 U/L, with oil content rising to 51%, indicating strong stability and potential for industrial applications [6][7]. - The research highlights the effective conversion of lignin into valuable microbial oils and proteins, providing a feasible pathway for high-value utilization of lignin resources [7][9]. Future Directions - The research is supported by national strategic technology initiatives, and the team has filed for two patents related to their findings. They will present their latest research at the upcoming NFUCon 2025 forum, focusing on biomass utilization strategies [8][9].

Core Insights - The article discusses the development of an AI-driven digital cloning selection platform (Digital Colony Picker, DCP) for high-throughput single-cell screening, which addresses the challenges in microbial strain selection and industrial application [2][4]. Group 1: Technology Development - The DCP system utilizes three major technological innovations: micro-chamber separation culture, AI-assisted image recognition, and non-contact laser single-clone picking, enabling precise high-throughput screening of microbial multi-dimensional phenotypes [4][5]. - The DCP platform can independently culture individual microbial cells using a microfluidic chip with thousands of micro-chambers, allowing real-time monitoring of cell growth dynamics, metabolic activity, and morphological characteristics [5][6]. Group 2: Application and Results - In application validation, researchers successfully isolated a "super strain" of Zymomonas mobilis, which showed a 19.6% increase in lactic acid production and a 75.9% improvement in growth rate under 30 g/L lactic acid stress conditions [5]. - The superior phenotype of the isolated strain is linked to mutations and overexpression of the outer membrane transporter gene ZMOp39x027, enhancing lactic acid transmembrane transport capacity [5]. Group 3: Future Prospects - The DCP platform is expected to significantly accelerate the discovery of superior strains, providing strong technical support for metabolic engineering, environmental microbial resource exploration, and industrial strain optimization [5]. - The DCP platform works synergistically with the FlowRACS system, which excels in instantaneous snapshot/sorting capabilities, creating a comprehensive solution for functional strain discovery [6].

Core Viewpoint - The NFUCon 2025 forum will focus on the innovative research and commercial feasibility in the non-grain biomass sector, aiming to promote large-scale applications of non-grain biomass and support carbon neutrality goals [2]. Group 1: Event Overview - The NFUCon 2025 will be held from November 27 to 29, 2025, in Hangzhou, Zhejiang, under the theme "Top-notch Intelligence, Industrial Symbiosis" [2]. - The forum will invite representatives from government, enterprises, and experts to discuss key strategic directions such as biomass green pretreatment, non-grain sugars, biomass-based chemicals and materials, and biomass energy [2]. Group 2: Organizing Institutions - The forum is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. (DT New Materials) and the National Key Laboratory of Biomass Transportation Fuel Technology [3]. - Key figures include Zhu Jin, Li Zhenglong, and Zhang Xinghong, who hold significant positions in relevant research institutions and laboratories [3][4][5]. Group 3: Guest Speakers - Notable speakers include Zhu Jin, who has achieved multiple industrialization results in heat-resistant polylactic acid foaming materials and other biomass materials [4]. - Li Zhenglong focuses on the conversion and utilization of low-carbon resources, particularly in renewable aviation fuel and biomass high-value utilization [5]. - Zhang Xinghong is involved in polymer synthesis research and CO2-based polycarbonate technology [6]. Group 4: Forum Agenda - The forum will feature various activities, including a youth forum on non-grain biomass, a sustainable aviation fuel industry exchange, and thematic discussions on biomass chemicals and energy [15][16]. - A technology achievement display area will be set up to showcase 50 innovative results and projects with commercial potential in biomass utilization [17]. Group 5: Laboratory Focus - The National Key Laboratory of Biomass Transportation Fuel Technology focuses on four core areas: fiber ethanol technology, bio-aviation fuel technology, CO2-based polycarbonate technology, and biofuel evaluation standards [22].

Core Viewpoint - The article discusses the recent policy developments in the petrochemical industry in China, emphasizing the shift towards high-end and green transformation, particularly focusing on non-grain biomass utilization and bio-based materials as new growth areas [2][5][6]. Group 1: Policy Developments - On September 25, 2023, seven Chinese government departments released a work plan aimed at stabilizing and optimizing the petrochemical industry from 2025 to 2026, addressing challenges such as intensified competition in organic raw materials and slowing domestic demand [2]. - The work plan encourages the development of emerging fields like bio-based chemicals and non-grain biomass utilization, providing new momentum for the industry's green transformation [2][4]. Group 2: Focus on Bio-based Materials - The policy has shifted from "technology transformation" to "supply and demand quality improvement," indicating a maturation of industry technology and a focus on enhancing the quality of bio-based materials [5][6]. - The emphasis on non-grain bio-based materials has evolved from "industrial demonstration" to "typical case collection and promotion," suggesting that some bio-based materials can achieve a replicable business model [6]. Group 3: Growth in Bio-chemicals - The new work plan introduces a focus on "bio-chemicals," highlighting the rapid growth of synthetic biology in the chemical sector due to its green and efficient characteristics [7]. - Multiple government departments have issued documents supporting the development of bio-based and bio-manufacturing sectors throughout 2023, indicating a strong governmental push towards these industries [8][10].

Core Insights - The article discusses the establishment of a Synthetic Biology Innovation and Entrepreneurship Center in Jiang'an District, Hubei Province, in collaboration with Hubei University, aimed at fostering the synthetic biology industry and linking local industrial needs with academic research resources [2][4]. Group 1: Establishment of the Center - Jiang'an District signed an agreement with Hubei University to co-establish a Synthetic Biology Innovation and Entrepreneurship Center, which will serve as a crucial link between local industry demands and university research capabilities [2][4]. - The center will accelerate the gathering of synthetic biology industries in Jiang'an, leveraging Hubei University's strengths in this field [4]. Group 2: High-Tech Enterprises Involvement - Several high-tech companies, including Wuhan Xingquan Gene and Health Technology Co., Ltd. and Wuhan Ruidu Biotechnology Co., Ltd., have moved into the collaborative innovation building, showcasing the effectiveness of the university-industry cooperation platform [5]. - Xingquan Gene focuses on early cancer screening technologies based on canine olfactory capabilities, while Ruidu Biotechnology specializes in unique DNA synthesis and assembly technologies derived from academic research [5]. Group 3: Supportive Infrastructure - The collaborative building offers a "zero-cost entrepreneurship space," providing two years of rent-free and three years of reduced rent for university entrepreneurs, promoting the growth of the synthetic biology innovation center and related industries [5]. - The initiative aims to create a comprehensive support system that includes industry funds, intellectual property, and professional services to enhance innovation and entrepreneurship [5]. Group 4: Future Plans and Policies - Jiang'an District plans to launch the "Bian Plan" in 2024, introducing nine key policies to support technological innovation in various sectors, including environmental protection and artificial intelligence [6]. - The district has also implemented a plan to promote zero-cost entrepreneurship, fostering a conducive ecosystem for innovation and job creation [6].

Core Viewpoint - The NFUCon 2025 forum will focus on the innovative research and commercial feasibility in the non-grain biomass sector, aiming to promote large-scale applications of non-grain biomass and support carbon neutrality goals [2]. Group 1: Event Overview - The NFUCon 2025 will be held from November 27 to 29, 2025, in Hangzhou, Zhejiang, under the theme "Top Talent Gathering, Industry Symbiosis" [2]. - The forum will invite representatives from government, enterprises, and experts to discuss key strategic directions such as biomass green pretreatment, non-grain sugars, biomass-based chemicals and materials, and biomass energy [2]. Group 2: Organizing Institutions - The forum is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. (DT New Materials) and the National Key Laboratory of Biomass Transportation Fuel Technology [3]. - Key figures include Zhu Jin, Li Zhenglong, and Zhang Xinghong, who hold significant positions in relevant research institutions and laboratories [3][4][5]. Group 3: Guest Speakers - Notable speakers include Zhu Jin, who has achieved multiple industrialization results in heat-resistant polylactic acid foaming materials and other biomass materials [4]. - Li Zhenglong focuses on the conversion and utilization of low-carbon resources, particularly in renewable aviation fuel and biomass separation technologies [5]. - Zhang Xinghong is involved in polymer synthesis research and CO2-based polycarbonate technology [6]. Group 4: Forum Agenda - The forum will feature various activities, including a youth forum on non-grain biomass, a sustainable aviation fuel industry exchange, and thematic discussions on biomass chemicals and energy [15][16]. - A technology achievement display area will be set up to showcase 50 innovative projects with commercial potential in the biomass utilization field [17]. Group 5: Laboratory Focus - The National Key Laboratory of Biomass Transportation Fuel Technology focuses on four core areas: fiber ethanol technology, bio-aviation fuel technology, CO2-based polycarbonate technology, and biofuel evaluation standards [22].

/生物制造产业社群/ 让上下游聚在一起, 未来食农、绿色化工、大健康、美妆个护 等产业同行❤️↓ 资本事件 | 美尚洁生物 【SynBioCon】 获 悉 ，近日，江苏美尚洁生物科技有限公司 （以下简称 "美尚洁生物"）宣布已 成功完成数千万人民币的新一轮 A+ 轮 融资。 本轮募集资金将用于进一步加速公司在基因工程合成生物领域的研发投入， 推动其重组人源化胶原 蛋白产品的临床转化与市场拓展，并持续优化其技术平台 ，计划在宜兴落地新的三类器械生产管线 。 此外， 本轮跟投还有数千万的跟投额度，其它数家投资机构仍在积极跟进中。 自2018年成立以来，美尚洁生物始终深耕于基因工程合成生物科技领域，尤其在 重组人源化胶原蛋 白产品的研发及医疗应用 方面取得了突破性进展。此次融资的成功，不仅是对我们现有成果和未来 潜力的肯定，更是对我们坚持技术创新的有力证明。我们将以此为契机，进一步加大研发力度，加快 产品上市步伐，为医疗健康领域带来更安全、更有效的解决方案。" 美尚洁生物的核心竞争力在于其创新性的技术平台。 作为 国内首家基于 AI 技术进行重组融合蛋白 研发 的公司， 已成功运用 AI模型技术完成了序列片段的多样 ...