Core Viewpoint - The article discusses the challenges and advancements in the industrialization of natural macromolecular active substances, highlighting a novel bioreactor developed to enhance fermentation processes for these substances [1][2][4]. Group 1: Challenges in Industrialization - Natural macromolecular active substances, such as polyamino acids, functional proteins, and microbial polysaccharides, face extraction difficulties due to their high molecular weight and complex conformations [1]. - The fermentation process of these substances is characterized by high viscosity, high oxygen demand, and high energy consumption, which complicates production [2][4]. - The accumulation of products during fermentation leads to high-viscosity non-Newtonian fluid characteristics, creating barriers that inhibit oxygen and nutrient metabolism, thus limiting yield improvements [1]. Group 2: Innovations in Bioreactor Technology - A new microbubble bioreactor platform has been developed using laser sintering 3D printing technology and computational fluid dynamics principles, aimed at overcoming the challenges of high-viscosity fermentation processes [2][4]. - This bioreactor design allows for the transition from macro to micro bubbles (less than 100 μm), significantly increasing the contact surface area between microorganisms and oxygen, thereby enhancing oxygen transfer efficiency by 120%-135% [4]. - The energy efficiency of the fermentation process is improved by 1.6 to 2.9 times compared to traditional bioreactors [4]. Group 3: Performance Improvements in Fermentation - The new bioreactor technology has been validated in a 7 L fermentation tank for the production of γ-polyglutamic acid (γ-PGA), achieving over a 40% increase in yield [5]. - The technology has also demonstrated versatility, with fermentation yields for other macromolecules such as mussel adhesive protein, panibacterial polysaccharide, welan gum, β-glucan, and ε-polylysine increasing by 79%, 58%, 39%, 50%, and 43% respectively [5]. Group 4: Implications for the Industry - This innovative research provides a reference and technical support for the efficient biosynthesis and industrial application of macromolecular active substances, as well as insights for enhancing fermentation processes in other synthetic biology products [7]. - The advancements in biomanufacturing are expected to contribute to the ongoing development of the synthetic biology industry, particularly in the context of green manufacturing and sustainable practices [7].

Core Insights - The article discusses the launch of the "Synthetic Human Genome Project" (SynHG), led by Professor Jason Chin from the University of Oxford, with funding of £10 million from the Wellcome Trust, aiming to chemically synthesize a complete human genome [1][2] - The project is expected to develop foundational tools and methods that will support future research in synthetic biology, potentially leading to new discoveries about how cells utilize their genomes [2][3] Group 1: Project Overview - SynHG is the first of its kind globally, with a goal to construct a complete human genome through chemical synthesis [1] - The project aims to establish a technical framework within five years and to synthesize a complete human chromosome within 5-10 years, facing significant scientific challenges [2] Group 2: Scientific Implications - Professor Jason Chin emphasizes that the ability to synthesize large genomes could fundamentally change the understanding of genomic biology and expand the capabilities of biotechnology and medicine [3] - The project is not about creating life but focuses on understanding gene expression regulation mechanisms [3] Group 3: Future Directions and Events - The upcoming "Synthetic Biology and Green Bio-Manufacturing Conference" (SynBioCon 2025) will take place from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and bio-manufacturing [4][5] - The conference will explore trends in bio-manufacturing, innovative technologies, and the potential for technology transfer and talent acquisition in the industry [4]

SynBioCon 大会 | 致力于科技成果转化 第四届合成生物与绿色生物制造大会 (简称：SynBioCon 2025) 将于 8月20-22日 在 浙江·宁波 举办，由DT新材料主办，酶赛生物协办，中国 生物工程学会生物基材料专业委员会、上海市未来产业生物制造专委会、广州合成生物产学研技术创新联盟共同支持 。 DT新材料致力于科技成果转移转化。SynBioCon大会聚焦产业生态发展与科技成果转移转化，已完成1000+次科研院所和初创项目对接。本届大会 同期将继续举办 特色活动 「合成生物制造创新科技成果展示与对接 」 ， 收集并 展示100个0~100的合成生物制造创新科技成果 ， 以 促进行 业高效科技成果与转化。 SynBioCon大会持续发布科技成果。本期介绍项目如下： 成果简介 L-哌啶甲酸，简称L-PA，是一种重要的刚性环状非蛋白质氨基酸，广泛用于罗哌卡因等手性药物和雷帕霉素等生物活性物质的制备。近来发现可作 为植物刺激素，激活植物免疫。 本技术利用先进代谢工程技术，通过从头设计合成路径和系统、优化大肠杆菌，构建了第一代生产哌啶甲酸的大肠杆菌细胞工厂，含IPTG诱导质粒， 遗传稳定，以赖氨酸无机 ...

SynBioCon 大会 | 同舟纵横 集"膜材料生产---工艺研发及装备制造---工艺设计---技术服务"为一体的物料分离全产业链企业—— 同舟纵横 将出席 2025年8月20-22日，浙江·宁波 举办的 SynBioCon 2025 第四届合成生物与绿色生物制造大会 同舟纵横 已入驻 全球生物基和生物制造产业服务 平台-新品库（ bio-basedlink ） 。 同舟纵横新品库网址 ： https://www.bio-basedlink.net/index/brand/brand_show/article_id/193.html ↓↓↓ 公司介绍 同舟纵横 (厦门)流体技术有限公司专注于工 业流体领域的分离纯化，是一家集材料生产 -工艺 研发 ---设备制造--药剂生产-EPC设计及工程总包为 一体的 国家级高新技术企业和国家级专精特新小巨 人企业。 多年来同舟纵横不断探索已经完成了数百工程 项目，涉及医药、化工、食品添加剂、淀粉糖、生 物发酵、植物提取、新能源、环保等各个领域， 在 实 战中公司积累了大量的工程经验，树立了良好的 行业口碑，已经成为了利用压力驱动膜技术板块、 电驱动膜技术板块和连续离交 ...

Core Viewpoint - The establishment of the AI4S synthetic biology intelligent research platform by Anhui Normal University, University of Science and Technology of China, and Wuhu Yijiang District aims to advance key technologies in synthetic biology, focusing on gene design, enzyme optimization, and biomanufacturing applications in various strategic emerging industries [1][6][10]. Group 1: Platform Overview - The AI4S platform will collaborate with over 20 enterprises and medical institutions, emphasizing breakthroughs in genome design and enzyme molecular modification [1][6]. - The platform integrates AI technology with automated experimental equipment to enhance experimental efficiency and data collection through high-throughput operations [3][8]. Group 2: Research Directions - The platform focuses on six major research areas: gene circuit design, enzyme discovery and optimization, metabolic pathway exploration, synthetic biology big data analysis, artificial cell factory creation, and biopharmaceutical synthesis [1][6]. - It aims to address critical challenges in biomanufacturing, including efficient gene design, experimental automation, data-driven optimization, and industrial-scale production [7][10]. Group 3: Technological Integration - The platform will create an integrated AI simulation and experimental validation system, combining high-performance computing and machine learning with experimental data [3][9]. - It will support virtual screening, experimental validation, and the establishment of cell factory models, enhancing the product development lifecycle [3][10]. Group 4: Industry Landscape - Multiple institutions in China have established similar synthetic biology platforms, including the Shenzhen Institute of Advanced Technology and Peking University, indicating a growing trend in the sector [4][6]. - Companies like BGI, Huaheng Biotechnology, and others are adopting AI and automated fermentation optimization platforms to accelerate product development [11]. Group 5: Future Prospects - With increasing policy support and industry demand, more institutions are expected to enter the field of synthetic biology and AI integration [12]. - The upcoming SynBioCon 2025 conference will focus on AI and biomanufacturing, exploring technological innovations and industry trends [14][16].

Core Viewpoint - The article discusses the innovative production and application of spermidine, a natural polyamine with significant potential in anti-aging and cardiovascular disease prevention, through synthetic biology techniques developed by a research team at Sichuan University [1][2]. Group 1: Spermidine Production Challenges - Spermidine is recognized as a promising bioactive molecule, but its high production costs have hindered large-scale industrial application [1][2]. - Traditional extraction methods yield low purity (only 1% from wheat germ) and are inefficient, while chemical synthesis is costly, leading to market domination by foreign companies [2][3]. Group 2: Technological Innovations - The research team employs machine learning algorithms to simulate yeast metabolic networks, significantly enhancing spermidine synthesis efficiency [3]. - A breakthrough in the discovery of an extracellular secretion mechanism allows spermidine to be actively expelled from cells, reducing energy consumption and improving purity during extraction [4]. Group 3: Industry Collaboration and Education - The collaboration between academia and industry enables students to engage in practical applications, bridging the gap between laboratory research and market needs [4][8]. - The establishment of a project-based learning model in universities aims to cultivate versatile talents for the industry [4][9]. Group 4: Market Potential and Policy Support - Spermidine is positioned to drive multiple billion-dollar industries, with ongoing clinical trials in the pharmaceutical sector and product development in the food industry [6][7]. - Chengdu is emerging as a hub for synthetic biology, with supportive policies from various provinces to facilitate technology transfer and commercialization [7][8]. Group 5: Future Outlook - The global economic impact of synthetic biology is projected to yield $2-4 trillion annually between 2030 and 2040, indicating a significant opportunity for industries leveraging these technologies [6]. - The integration of academic research, industry needs, and supportive policies is expected to enhance the domestic production of critical bioactive substances like spermidine, contributing to public health initiatives [8][9].

生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （现场展示科技成果推介墙）， 公开征集100个从0—1—100的合成生物和生物制造领域创新成果 和项目 ，于现场展示、对接。 欢迎科研院所、企业报名！ 往期现场： 03 大会日程 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 ...

荣格个人护理 . 以下文章来源于荣格个人护理 ，作者荣格研讨会 MicroZenith@紫球藻提取物 抗皱,紧致,防晒,保湿、抗 氧化、抗菌、抗病毒 我司海洋微藻细胞培养的优势: 个人护理、美容、化妆品、香水、包装等行业专业人士必读，覆盖全球资讯，关注中国市场，荣格工业 传媒旗下《happi China 国际个人护理品生产商情》杂志，美国《happi》与《Beauty Packaging》杂志在 中国唯一合作伙伴。 在竞争激烈的美妆赛道中，美妆品牌如何走向差异化与高端化，这家微藻合成生物公司希望用新一代藻类提取物 （三角褐指藻提取物、紫球藻提取物、小球藻提取物）助力国产品牌走向高端化、国际化。 MicroZenith@小球藻提取物 抗皱,紧致,祛痘、舒缓、保 湿、抗氧化 1) 微藻活性物密度高5-10倍。海洋微藻一般难以采 用异养等高密度培养方法,但通过合成生物+光控培养 技术可以将微藻细胞密度和生物活性成分提高5-10倍。 2）微藻活性物高品质。传统的跑道池、管式反应器中 重金属或塑化剂的污染难以有效避免和控制，我司开 发了独家专利的新型生物反应器,有效解决污染问题。 3)无菌、无重金属、无农残,无核污染。 ...

Core Viewpoint - The article discusses the establishment of a new production line by SiPeng Bio-Materials (Nantong) Co., Ltd., focusing on the production of bio-based products such as 1,3-PDO, calcium lactate, vanillin, and sialic acid, highlighting the company's commitment to sustainable and innovative biomanufacturing practices [1][2]. Group 1: Company Overview - SiPeng Bio-Materials (Nantong) Co., Ltd. was established in July 2024 as a wholly-owned subsidiary of Shanghai SiPeng Technology Co., Ltd., which was founded in May 2022 [1]. - The company focuses on negative carbon synthetic biology and has completed significant funding rounds, including nearly 100 million yuan in a Pre-A round in October 2024 and several million yuan in a Pre-A+ round in May 2025 [1]. Group 2: Production Line Details - The new production line has a total investment of 50 million yuan and is located in the Rugao High-tech Industrial Development Zone [1]. - Upon completion, the production capacity will be 720 tons of 1,3-PDO, 940 tons of calcium lactate, 30 tons of vanillin, and 10 tons of sialic acid annually [1][2]. Group 3: Product Specifications - 1,3-PDO will have a purity of over 99.9% and is intended for use in new textile materials and biodegradable materials, outperforming industry standards [3][4]. - Calcium lactate, a common food additive, is noted for its high bioavailability and mild taste, making it suitable for sensitive populations [6]. - Vanillin produced from biological sources is highlighted for its environmental sustainability and wide applications in food, cosmetics, and pharmaceuticals [8]. - Sialic acid, a natural nine-carbon sugar derivative, is used in various food products, particularly for infants and health supplements [11][12].

Core Viewpoint - Zhejiang Rongrui Technology Co., Ltd. has completed nearly 100 million yuan in Pre-A round financing, which will primarily be used to accelerate product pipeline development and continue the industrialization and commercialization process [1] Company Overview - Founded in 2022, Rongrui Technology focuses on synthetic biology as its core technology, integrating the latest advancements in artificial intelligence to develop disruptive technologies for artificial life and functional molecules [2] - The company aims to achieve green biological manufacturing in areas such as health food ingredients and high-value chemicals, while also reducing product costs and improving quality [2] - The product pipeline includes dozens of successfully developed products, such as important industrial enzyme varieties (lipase, nitrile hydratase, nitrile hydrolase, amide enzyme), pharmaceuticals, pesticides, high-value fine chemicals (chiral alcohols, chiral amines, chiral non-natural amino acids, amide compounds), as well as health oils, new structural esters, vitamins, and sugar substitutes [2] - The company has established multiple collaborations with leading enterprises in its niche [2] Industry Event - The 4th Synthetic Biology and Green Biological Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the "1+4" theme: AI + Biological Manufacturing [3] - The conference will cover four major application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials, inviting international leading companies, representative industrial experts, government, parks, capital, associations, and alliances to explore the development trends of the biological manufacturing industry during the 14th Five-Year Plan [3] - The event aims to promote the transfer and transformation of scientific and technological achievements, product scaling, and talent acquisition [3]