主办单位 宁波德泰中研信息科技有限公司（DT新材料） 协办单位 SynBioCon 2025 第四届合成生物与绿色生物制造大会 8月20-22日 浙 江 ·宁波东港喜来登酒店 8月20-22日 将于 浙江·宁波 举办 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 。本届大会聚焦 "1+3"：AI+生物制造、绿色化工 与新材料、未来食品、未来农业四大方向 ，邀请行业领先企业、代表性产业化专家、政府、园区、资本、协会和联盟等各方共探"十五五"生物制造产业 发展趋势；AI赋能生物制造产业创新；哪些革新技术和产品将给生物制造产业带来持续的生命力；并致力于促进科技成果转移转化、产品规模化与人才挖 掘。 大会将同期举办 生物制造青年论坛 、 生物制造产业高层座谈会（第三期） 、 《2025人工智能赋能生物制造产业创新发展蓝皮书》闭门研讨会 、 合成 生物科技成果展示与对接 等活动 。 扫码参会报名 SynBioCon 2 025 8月20-22日，浙江·宁波 01 组织机构 北京大学宁波海洋药物研究院 宁波酶赛生物工程有限公司 支持单位 中国生物工程学会生物基材料专业委员会 浙江省合成生物 ...

Core Insights - The article discusses the innovative use of synthetic biology to produce sandalwood essential oil sustainably, addressing the scarcity and high cost of natural sandalwood resources [2][3][15] Group 1: Research Breakthroughs - The research team developed a P450 enzyme peroxisome surface display technology, overcoming catalytic bottlenecks and achieving a record production yield of 10.4 g/L of sandalwood alcohol [3][5] - Initial attempts to synthesize sandalwood alcohol resulted in low yields, prompting the team to optimize the supply of acetyl-CoA and reducing power by targeting key enzymes to peroxisomes [5][10] - The innovative strategy of displaying P450 enzymes on the peroxisome surface significantly improved the proximity of the enzyme to the substrate, increasing sandalwood alcohol yield to 1.3 g/L and conversion rate to 36.2% [7][10] Group 2: Production Optimization - The team induced the proliferation of peroxisomes in engineered yeast, which increased the number of "factories" for storing acetyl-CoA and expanded the membrane surface area for enzyme anchoring, leading to a 42.6% increase in sandalwood alcohol yield and a conversion rate of 60.6% [10][12] - The optimized strain was scaled up in a 5L fermentation tank, achieving a record yield of 13.1 g/L of sandalwood olefin and 10.4 g/L of sandalwood alcohol, with a conversion rate of 44.2% [12][14] - The cost of producing sandalwood essential oil using this method is projected to be under $100 per kilogram, significantly lower than the market price of $2500 per kilogram [12][15] Group 3: Implications and Future Prospects - The research demonstrates the potential of peroxisome engineering in synthesizing high-value natural products, particularly those involving complex terpenes catalyzed by P450 enzymes [14][15] - The significant reduction in production costs for sandalwood essential oil could transform the traditional supply chain reliant on scarce plant resources, contributing to the conservation of endangered sandalwood species [15]

Core Insights - The article highlights the recent progress of Heilongjiang Xinhecheng in launching multiple fermentation projects, indicating a strategic expansion in biobased energy and materials production [2][3][4]. Group 1: Project Developments - Heilongjiang Xinhecheng is undertaking two major fermentation projects, including the A9, A10, and functional fermentation products project, which aims to establish a production capacity of 5,000 tons/year for A10, 6,000 tons/year for A9, and smaller capacities for other products [3]. - The A18, A20, and isocyanic acid project will utilize existing facilities to produce 1,000 tons/year of A18, 10,000 tons/year of isocyanic acid, and 3,000 tons/year of A20, with an estimated investment of 83.16 million yuan [4]. Group 2: Financial Performance - Heilongjiang Xinhecheng reported impressive financial results, with revenues reaching 21.6 billion yuan and a net profit of 5.869 billion yuan, showcasing significant growth in its operations [5]. Group 3: Industry Events - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, focusing on synthetic biology and green manufacturing, highlighting the industry's trends and opportunities [9][10][11].

菌株是生物质炼制的 "芯片"，是以生物质为原材料的新型生物制造产业链和绿色低碳生物经济的核心。 用于生物制造的菌株细胞通常面临中间代谢产物积累、毒性产物抑制，导致反应效率低、终产物浓度低的问题，严重制约了绿色生物制造的发展。因 此，" 如何构建菌株细胞并强化反应过程合成生物基产品 "是该领域重要的研究课题。 以" 菌株细胞工厂构建及产物合成强化 "为核心，以" 人工细胞器创制、菌株细胞工厂构建、反应分离耦合调控 "从微观到宏观强化产物生物合成，可 以强化生物制造过程。 多 年来， 大连理工大学薛闯教授 团队创建了多酶自组装蛋白质笼的人工细胞器，该人工细胞器可实现化学诱导、光诱导提升细胞器的可调节性，揭 示了人工细胞器的时空调控机制；创建了"多枪-多靶"快速菌株构建方法，揭示了磷酸化激酶多维度协同调控菌株的新机制，阐明了梭状芽孢杆菌群体 感应系统中信号分子自诱导肽的合成途径和调控功能；制备了碳纳米管阵列复合膜，开发了反应分离耦合技术。实现了 以生物能源为主的产品生物合 成强化 ， 为解决工业生物技术领域催化效率低的瓶颈问题提供了新突破点与新思路 。 点击更多阅读 ： 祝贺！80后生物制造专家-薛闯教授获大奖，全 ...

Core Viewpoint - DSM-Firmenich, a major player in the chemical industry, has shown significant financial growth in the first half of 2025, with total sales reaching €6.51 billion (approximately ¥53.64 billion), a year-on-year increase of 3% [2]. Group 1: Financial Performance - The adjusted EBITDA for DSM-Firmenich was €1.26 billion, reflecting a 29% increase year-on-year, with the EBITDA margin rising from 15.5% to 19.4% [2]. - The net profit surged from €50 million in the same period last year to €541 million, marking an almost tenfold increase [2]. Group 2: Business Segments - The Animal Nutrition and Health segment reported sales of €1.751 billion, a 14% increase year-on-year, with adjusted EBITDA soaring by 293% due to improved core business and temporary vitamin price effects [3]. - The Fragrance and Beauty segment saw sales of €1.989 billion, a slight decline of 1%, impacted by weak demand for sun care products and customer inventory destocking [3]. - The Taste, Texture, and Health (TTH) segment achieved sales of €1.686 billion, a 3% increase year-on-year [3]. - The Health, Nutrition, and Care (HNC) segment reported sales of €1.072 billion, down 2%, but organic sales grew by 6% [3]. Group 3: Strategic Developments - DSM has undergone significant transformations since its founding in 1902, evolving from a coal mining company to a leader in specialty chemicals and nutrition [4][5]. - The merger with Firmenich in May 2023 has positioned DSM-Firmenich as a global leader in flavor and fragrance manufacturing and the largest vitamin producer [5]. - The company has strategically divested from capital-intensive sectors to focus on high-margin specialty chemicals and nutrition, aligning with market trends [5]. Group 4: Competitor Landscape - Competitors like Wanhua Chemical and New Hope Liuhe are also expanding their nutrition and flavor businesses, indicating a competitive landscape in the sector [6][7]. - New Hope Liuhe reported a record revenue of ¥21.609 billion in 2024, with a 42.95% year-on-year growth, highlighting the robust performance of its nutrition segment [6].

未来食品&农业 | 微元合成 【SynBioCon】 获 悉 ，近日，合成生物学领域的新锐力量—— 芝诺科技 ，成功完成了 数千万元 人民币的Pre-A轮融资 ，在此之前，芝诺科技已经完成了来自中信创投和嘉程资本等知名投资方的 历史 投资。 此次融资将为 芝诺科技 注入强大动力，助力公司在 生产能力提升、管线拓展、团队扩 张以及商业化落地等方面实现跨越性发展。 专题论坛3 来来最品&农业GEN 芝诺科技成立于2020年，是一家专注于合成生物学技术的国家高新技术企业，总部位于北京， 在苏 州、山东东营设有研发中心与百吨级生产基地 。公司核心团队汇聚了来自牛津大学、北京大学等顶 尖机构的跨学科人才，创始人朱天择博士深耕糖化学与代谢流优化十余年，其领衔的技术团队通过 CRISPR 等新一代基因编辑技术，实现工程菌产率较野生型提升千倍以上，生产效率较传统方法提 高十倍。 其关键技术亮点： ▌ 参考信息： 本文部分素材来自公开信息。由作者重新编写，系作者个人观点，本平台发布仅为了传达一种不同观点，不代表 对该观点赞同或支持。如果有任何问题，请联系我们：15356747796（微信同号）。 代谢流精准设计：构建覆盖模式菌 ...

Core Insights - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI with bio-manufacturing, green chemicals, new materials, future food, and agriculture [2][30] - The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the technologies and products that will sustain the vitality of the bio-manufacturing sector [2][30] Organizational Structure - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by various academic and industry institutions, including Peking University Ningbo Institute of Ocean Medicine and the Zhejiang Synthetic Biology Industry Technology Alliance [3][4] Conference Agenda - The agenda includes a series of forums and discussions, such as the Bio-Manufacturing Industry Leaders Forum and the closed-door seminar for the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [7][19] - Key topics will cover AI applications in bio-manufacturing, green chemistry, and new materials, with specific sessions dedicated to future food and agriculture innovations [9][25] Notable Participants - The conference will feature industry leaders and experts from various organizations, including universities and biotech companies, who will present their research and innovations in synthetic biology and bio-manufacturing [10][11][12] Special Activities - Concurrent activities will include a youth forum on bio-manufacturing, technology showcases, and networking opportunities for industry professionals [2][19]

Core Insights - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI with bio-manufacturing, green chemicals, new materials, future food, and agriculture [2][3]. Group 1: Conference Overview - The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the technologies and products that will sustain the vitality of the bio-manufacturing sector [2]. - Various activities will be held concurrently, including a Youth Forum on Bio-Manufacturing, a high-level roundtable discussion, and a closed-door seminar on the "2025 Blue Book for AI Empowering Bio-Manufacturing Innovation" [2][3]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by several academic and industry institutions, including Peking University Ningbo Institute of Ocean Medicine and the Zhejiang Synthetic Biology Industry Technology Alliance [3][4]. Group 3: Agenda Highlights - The agenda includes a macro forum on the bio-manufacturing industry, thematic forums on green chemicals and new materials, and AI empowerment in bio-manufacturing [7][9]. - Specific sessions will cover topics such as the application of enzyme molecular engineering, the design of cell factories, and the production of bio-based materials [11][19]. Group 4: Industry Participation - Numerous industry leaders and representatives from over 20 companies will participate in the high-level roundtable discussion, including notable firms like Ningbo Enzyme Science Bioengineering Co., Ltd. and Beijing University Ningbo Institute of Ocean Medicine [10]. - The conference will also feature a showcase of synthetic biology innovations and technology transfer opportunities [2][23]. Group 5: Future Developments - The conference will announce the "China Synthetic Biology Industry Distribution Map (2025 Edition)" and the list of 500+ representative enterprises in the bio-manufacturing sector [34][35].

Core Viewpoint - Lifebio has recently completed a multi-billion B2 round financing led by the listed company Xin Fengming, with participation from GGV Capital and several existing shareholders [2][3]. Group 1: Company Overview - Lifebio is a leading global company in bio-based aromatic materials, having developed a unique "biomass-glucose-HMF-FDCA" process over more than a decade, which allows for the production of furan-based bio-materials without relying on food-sourced fructose [3][10]. - The company has established the world's first FDCA production line with a capacity of 1,000 tons and has initiated the construction of a 10,000-ton production line in Tongling, Anhui, in September 2024 [10][11]. Group 2: Investment and Partnerships - Xin Fengming, the lead investor in the recent financing round, is a major player in the polyester industry, with over 15% of global polyester filament capacity [4][7]. - GGV Capital, another significant investor, is a top-tier venture capital firm with over $9 billion in assets under management and a history of investing in over 500 companies, including Alibaba and Airbnb [7][8]. - Lifebio's previous investors include Lan Chuang Capital, which is associated with the listed company Zhongkong Technology, and Chengkai Fund, linked to Wankai New Materials, which has completed trial production of bio-based furan polyester [7][8]. Group 3: Industry Development - Lifebio has achieved the industry's first large-scale production of 100% bio-based polyester PEF filament through collaboration with leading companies [6][16]. - The company is focusing on non-food biomass sources such as corn cobs and straw to produce bio-based PEF, which can be applied in packaging materials, textiles, and electronics [13][19]. - Lifebio has signed a strategic cooperation agreement with Moutai to accelerate the application of bio-based materials in bottle caps and containers [19][20].

Core Viewpoint - The collaboration between Micro Yuan Synthetic and Cargill aims to promote the application of Allulose in the Chinese market, focusing on healthier, lower-calorie, and flavorful product innovations [2][3]. Group 1: Partnership and Market Expansion - Micro Yuan Synthetic has signed a partnership agreement with Cargill, the largest food and ingredient company globally, to distribute Allulose in China [2]. - Cargill will leverage its extensive B2B platform and diverse customer network to expand the application scenarios of Allulose in the Chinese market [7]. Group 2: Product Innovation and Approval - Allulose has been approved by relevant national authorities as a new food ingredient in China, marking a significant step for its market introduction [3]. - As a natural, low-calorie rare sugar, Allulose offers a taste experience similar to sucrose while demonstrating advantages in blood sugar response and energy intake control [3]. Group 3: Production Capabilities - Micro Yuan Synthetic is the only company globally that produces Allulose using fermentation technology and has obtained the first administrative license for its production in China [4]. - The company has established an efficient production chain from biological fermentation to purification, resulting in high purity, good sensory properties, and wide applicability across various food categories such as functional beverages, dairy, candies, and baked goods [6]. Group 4: Industry Events - The 2025 Synthetic Biology and Green Bio-Manufacturing Conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the industrialization progress and opportunities in synthetic biology and green manufacturing [13]. - The conference will include various activities such as a youth forum, high-level discussions, and a showcase of synthetic biology technology achievements [13].