Core Viewpoint - The establishment of the AI4S synthetic biology intelligent research platform by Anhui Normal University, University of Science and Technology of China, and Wuhu Yijiang District aims to advance key technologies in synthetic biology, focusing on gene design, enzyme optimization, and biomanufacturing applications in various strategic emerging industries [1][6][10]. Group 1: Platform Overview - The AI4S platform will collaborate with over 20 enterprises and medical institutions, emphasizing breakthroughs in genome design and enzyme molecular modification [1][6]. - The platform integrates AI technology with automated experimental equipment to enhance experimental efficiency and data collection through high-throughput operations [3][8]. Group 2: Research Directions - The platform focuses on six major research areas: gene circuit design, enzyme discovery and optimization, metabolic pathway exploration, synthetic biology big data analysis, artificial cell factory creation, and biopharmaceutical synthesis [1][6]. - It aims to address critical challenges in biomanufacturing, including efficient gene design, experimental automation, data-driven optimization, and industrial-scale production [7][10]. Group 3: Technological Integration - The platform will create an integrated AI simulation and experimental validation system, combining high-performance computing and machine learning with experimental data [3][9]. - It will support virtual screening, experimental validation, and the establishment of cell factory models, enhancing the product development lifecycle [3][10]. Group 4: Industry Landscape - Multiple institutions in China have established similar synthetic biology platforms, including the Shenzhen Institute of Advanced Technology and Peking University, indicating a growing trend in the sector [4][6]. - Companies like BGI, Huaheng Biotechnology, and others are adopting AI and automated fermentation optimization platforms to accelerate product development [11]. Group 5: Future Prospects - With increasing policy support and industry demand, more institutions are expected to enter the field of synthetic biology and AI integration [12]. - The upcoming SynBioCon 2025 conference will focus on AI and biomanufacturing, exploring technological innovations and industry trends [14][16].

Core Viewpoint - The article discusses the innovative production and application of spermidine, a natural polyamine with significant potential in anti-aging and cardiovascular disease prevention, through synthetic biology techniques developed by a research team at Sichuan University [1][2]. Group 1: Spermidine Production Challenges - Spermidine is recognized as a promising bioactive molecule, but its high production costs have hindered large-scale industrial application [1][2]. - Traditional extraction methods yield low purity (only 1% from wheat germ) and are inefficient, while chemical synthesis is costly, leading to market domination by foreign companies [2][3]. Group 2: Technological Innovations - The research team employs machine learning algorithms to simulate yeast metabolic networks, significantly enhancing spermidine synthesis efficiency [3]. - A breakthrough in the discovery of an extracellular secretion mechanism allows spermidine to be actively expelled from cells, reducing energy consumption and improving purity during extraction [4]. Group 3: Industry Collaboration and Education - The collaboration between academia and industry enables students to engage in practical applications, bridging the gap between laboratory research and market needs [4][8]. - The establishment of a project-based learning model in universities aims to cultivate versatile talents for the industry [4][9]. Group 4: Market Potential and Policy Support - Spermidine is positioned to drive multiple billion-dollar industries, with ongoing clinical trials in the pharmaceutical sector and product development in the food industry [6][7]. - Chengdu is emerging as a hub for synthetic biology, with supportive policies from various provinces to facilitate technology transfer and commercialization [7][8]. Group 5: Future Outlook - The global economic impact of synthetic biology is projected to yield $2-4 trillion annually between 2030 and 2040, indicating a significant opportunity for industries leveraging these technologies [6]. - The integration of academic research, industry needs, and supportive policies is expected to enhance the domestic production of critical bioactive substances like spermidine, contributing to public health initiatives [8][9].

生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （现场展示科技成果推介墙）， 公开征集100个从0—1—100的合成生物和生物制造领域创新成果 和项目 ，于现场展示、对接。 欢迎科研院所、企业报名！ 往期现场： 03 大会日程 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 ...

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Core Viewpoint - The article discusses the establishment of a new production line by SiPeng Bio-Materials (Nantong) Co., Ltd., focusing on the production of bio-based products such as 1,3-PDO, calcium lactate, vanillin, and sialic acid, highlighting the company's commitment to sustainable and innovative biomanufacturing practices [1][2]. Group 1: Company Overview - SiPeng Bio-Materials (Nantong) Co., Ltd. was established in July 2024 as a wholly-owned subsidiary of Shanghai SiPeng Technology Co., Ltd., which was founded in May 2022 [1]. - The company focuses on negative carbon synthetic biology and has completed significant funding rounds, including nearly 100 million yuan in a Pre-A round in October 2024 and several million yuan in a Pre-A+ round in May 2025 [1]. Group 2: Production Line Details - The new production line has a total investment of 50 million yuan and is located in the Rugao High-tech Industrial Development Zone [1]. - Upon completion, the production capacity will be 720 tons of 1,3-PDO, 940 tons of calcium lactate, 30 tons of vanillin, and 10 tons of sialic acid annually [1][2]. Group 3: Product Specifications - 1,3-PDO will have a purity of over 99.9% and is intended for use in new textile materials and biodegradable materials, outperforming industry standards [3][4]. - Calcium lactate, a common food additive, is noted for its high bioavailability and mild taste, making it suitable for sensitive populations [6]. - Vanillin produced from biological sources is highlighted for its environmental sustainability and wide applications in food, cosmetics, and pharmaceuticals [8]. - Sialic acid, a natural nine-carbon sugar derivative, is used in various food products, particularly for infants and health supplements [11][12].

Core Viewpoint - Zhejiang Rongrui Technology Co., Ltd. has completed nearly 100 million yuan in Pre-A round financing, which will primarily be used to accelerate product pipeline development and continue the industrialization and commercialization process [1] Company Overview - Founded in 2022, Rongrui Technology focuses on synthetic biology as its core technology, integrating the latest advancements in artificial intelligence to develop disruptive technologies for artificial life and functional molecules [2] - The company aims to achieve green biological manufacturing in areas such as health food ingredients and high-value chemicals, while also reducing product costs and improving quality [2] - The product pipeline includes dozens of successfully developed products, such as important industrial enzyme varieties (lipase, nitrile hydratase, nitrile hydrolase, amide enzyme), pharmaceuticals, pesticides, high-value fine chemicals (chiral alcohols, chiral amines, chiral non-natural amino acids, amide compounds), as well as health oils, new structural esters, vitamins, and sugar substitutes [2] - The company has established multiple collaborations with leading enterprises in its niche [2] Industry Event - The 4th Synthetic Biology and Green Biological Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the "1+4" theme: AI + Biological Manufacturing [3] - The conference will cover four major application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials, inviting international leading companies, representative industrial experts, government, parks, capital, associations, and alliances to explore the development trends of the biological manufacturing industry during the 14th Five-Year Plan [3] - The event aims to promote the transfer and transformation of scientific and technological achievements, product scaling, and talent acquisition [3]

SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 欢迎科研院所、企业报名！ 往期现场： 03 大会日程 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioC ...

Core Viewpoint - Israeli scientists from the Weizmann Institute have developed a new computer algorithm based on enzyme principles to design highly efficient synthetic enzymes, achieving 100 times the efficiency of AI-designed enzymes, marking a new phase in "on-demand" enzyme customization [1][2]. Group 1: Algorithm Development - Traditional computer algorithms for enzyme design are often inefficient and require extensive laboratory optimization [2]. - The research team utilized "Kemp elimination" as a case study, collecting natural enzyme data and decomposing protein sequences into fragments, which were then recombined to identify the optimal chemical "skeleton" [2]. - The algorithm challenged the traditional belief that enzyme active sites require cyclic amino acids, showing that non-cyclic structures can be more efficient, significantly enhancing catalytic efficiency [2][3]. Group 2: Synthetic Enzyme Characteristics - The resulting synthetic enzyme differs from natural enzymes by over 140 amino acid sequences but demonstrates comparable catalytic efficiency [3]. - The current synthetic protein structure remains simpler than natural enzymes, with future research focusing on complex multi-step reactions, such as those catalyzed by the key photosynthetic enzyme rubisco [3]. Group 3: Future Directions - While AI protein design has been prevalent over the past decade, it primarily mimics existing enzymes; the new algorithm constructs enzymes based on physical principles [3]. - The research team acknowledges that AI is irreplaceable for certain protein designs but struggles with complex catalytic reactions, suggesting a need for complementary approaches to achieve optimal enzyme designs [3]. Group 4: Upcoming Events - The 4th Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and biological manufacturing, along with four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials [5].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period, highlighting innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizers and Highlights - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. - Key highlights include forums on biomanufacturing trends, youth innovation sharing, project roadshows, and participation from leading enterprises, top universities, and investment institutions [4]. Group 3: Agenda and Special Activities - The first day features a closed-door high-level seminar focusing on the development trends and growth points of biomanufacturing, with 30 industry leaders and experts invited [7]. - The second and third days will include a macro forum on biomanufacturing, covering the overall trends and progress in the industry [10]. Group 4: Specialized Forums - Specialized forums will cover topics such as green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. - The forums will discuss various aspects of biomanufacturing, including the development of bio-based chemicals, green manufacturing technologies, and the application of AI in industrial processes [11]. Group 5: Project Roadshows and Talent Engagement - The conference will feature project roadshows aimed at connecting head parks and investment institutions with innovative biomanufacturing projects [10]. - A youth forum will be held to discover potential teams and technologies in biomanufacturing, providing a platform for efficient talent and collaboration exchanges [10].

Core Viewpoint - Changde City has passed the "Regulations on Promoting the Development of Synthetic Biology Manufacturing Industry," marking the first local legislation in China for this sector, aimed at enhancing the development of synthetic biology manufacturing as a strategic emerging industry [1][2]. Summary by Sections Legislative Background - The "Regulations" are part of a broader initiative to support the high-quality development of the synthetic biology manufacturing industry in Changde, which has been recognized as a key area for new productive forces and strategic emerging industries [2][4]. Industry Development Measures - In February, the Hunan Provincial Government issued measures to support Changde's synthetic biology manufacturing, focusing on areas such as enzyme preparations, pharmaceutical intermediates, agricultural chemicals, future foods, health products, and bio-based materials [4]. Legislative Process - The legislative project for promoting synthetic biology manufacturing began in September 2024, with multiple reviews and revisions leading to the final draft of the "Regulations," which consists of 19 articles addressing various aspects of industry development [5][6]. Key Provisions of the Regulations - The first three articles outline the legislative purpose, scope, and responsibilities of government departments. Articles four to fifteen focus on core industry development issues, including enhancing investment attraction, R&D capabilities, and talent acquisition, while also addressing high operational costs and approval efficiency [6]. - Article sixteen introduces a "no penalty for two situations, four prohibitions" system to optimize the business environment, while article seventeen establishes a fault-tolerance mechanism [6]. Next Steps - The Changde Municipal People's Congress will submit the "Regulations" to the Provincial People's Congress for approval, after which it will be published and implemented [6]. Upcoming Events - The Fourth Synthetic Biology and Green Manufacturing Conference will be held in Ningbo from August 20-22, focusing on AI and biological manufacturing, with discussions on trends and innovations in the industry [7][9].