Core Viewpoint - The article emphasizes the harmful impact of sugary drinks on the progression of colorectal cancer (CRC), highlighting a significant correlation between the consumption of these beverages and the increased incidence and mortality rates of CRC among younger populations [2][6][9]. Group 1: Sugary Drinks and Colorectal Cancer - Sugary drinks, defined as liquids containing added sugars like sucrose and high-fructose corn syrup, have seen a global increase in consumption since the 1980s, closely linked to metabolic diseases such as obesity and diabetes [2][6]. - A study published by researchers at the MD Anderson Cancer Center indicates that fructose and glucose from sugary drinks enhance CRC metastasis through the activation of the enzyme sorbitol dehydrogenase (SORD) [3][9]. - Epidemiological studies have shown that the intake of sugary drinks is associated with a doubling of the risk of developing CRC in younger individuals [6]. Group 2: Mechanisms of Action - The latest research reveals that a combination of glucose and fructose enhances the migratory and metastatic potential of CRC cells compared to glucose alone, reflecting the composition of sugary drinks [7]. - The mechanism involves the activation of the polyol pathway, which increases the NAD⁺/NADH ratio, thereby accelerating glycolytic activity and promoting the activation of the mevalonate pathway, ultimately facilitating cancer cell migration and metastasis [7][9]. Group 3: Implications for Treatment - The findings suggest potential dietary interventions and treatment strategies to inhibit the metastasis of CRC in patients, highlighting the need for awareness regarding the consumption of sugary drinks [9].

Core Viewpoint - The article discusses the association between radiation exposure from medical imaging, particularly CT scans, and the increased risk of hematologic cancers in children and adolescents, emphasizing the need for safer and more judicious use of imaging technologies [3][11]. Summary by Sections Medical Imaging and Cancer Risk - A large cohort study published in NEJM indicates that approximately 10.1% of hematologic cancer cases in children and adolescents can be attributed to radiation from medical imaging, primarily from CT scans [3][11]. - The study highlights the importance of balancing the benefits of medical imaging with the potential risks associated with radiation exposure [3]. Study Details - The research tracked 3,724,623 children born between 1996 and 2016 across six healthcare systems in the U.S. and Ontario, Canada, with a follow-up period averaging 10.1 years [6]. - During the follow-up, 2,961 cases of hematologic cancers were diagnosed, with a significant correlation found between cumulative radiation exposure and cancer risk [6][11]. Radiation Exposure and Cancer Incidence - The average radiation exposure for children diagnosed with hematologic cancers was 24.5±36.4 mGy, with a notable increase in cancer risk corresponding to higher cumulative doses [7]. - Relative risks (RR) for different radiation exposure levels were reported: - 1-5 mGy: RR of 1.41 - 15-20 mGy: RR of 1.82 - 50-100 mGy: RR of 3.59 - Each additional 100 mGy increases the excess relative risk by 2.54 [7][11]. Related Research - A study published in JAMA Internal Medicine projected that CT scans could account for 5% of cancer cases annually, with infants being the most affected demographic [12]. - Another study in Nature Medicine found that for every 100 mGy of radiation, the risk of developing hematologic malignancies doubles, with typical CT scans increasing the risk of lymphatic or myeloid malignancies by approximately 16% [13]. Conclusion - The findings underscore the necessity for healthcare providers to minimize unnecessary CT scans and radiation exposure while recognizing the life-saving potential of these imaging techniques [12][13].

Core Viewpoint - The article discusses the advancements in prime editing technology, particularly the development of the next-generation prime editor (vPE) that significantly reduces genomic errors compared to its predecessor, the original prime editor (PE) [3][4][5]. Group 1: Prime Editing Technology - Prime Editor (PE) is an advanced CRISPR gene editing tool developed by Professor Liu Ruqian's team in 2019, capable of editing and repairing 89% of 75,000 known pathogenic human genetic mutations [3][5]. - The editing process involves the prime editor binding to the genomic target, creating a single-strand DNA cut, and using pegRNA to guide the insertion or replacement of new DNA sequences [5][6]. - A significant challenge remains in eliminating errors produced as byproducts of prime editing, specifically insertion/deletion mutations (indels) that can lead to unpredictable and potentially harmful DNA sequences [5][6]. Group 2: Advances in Error Reduction - The research team identified key factors driving indel error formation, including the potential for the edited 3' new strand to extend beyond the pegRNA template and the conversion of single-strand cuts into double-strand breaks due to mismatch repair [6][7]. - By engineering the prime editor to induce instability in the competitive 5' strand, the team discovered a significant reduction in indel errors, leading to the development of the next-generation prime editor (vPE) [7][9]. - The vPE demonstrates a substantial improvement in editing efficiency while reducing the indel error rate to 1/60 of the original prime editor, with errors occurring only once every 543 edits [9].

撰文丨王聪 编辑丨王多鱼 排版丨水成文 具有一维 （1D） 几何形状的生物医学设备，例如手术缝线、活检针、导丝、内窥镜、测压探头和脑深部刺激电极，几十年来已在患者身上得到广泛应用。与 三 维 （3D） 系统和 二维 （2D）薄膜相比，一维设备体积小巧，能够通过曲折路径，有利于通过微创植入程序深入组织和体内通道。此外，在完成诊断或治疗功 能后，它们可以轻松取出和/或移除。 在众多一维器件中， 电子纤维 备受关注。随着材料、制造工艺、光学和电子学方面的最新进展，电子纤维已具备了许多新功能，包括传感、驱动、组织调节、能 量收集和发光等。尽管其具有大量潜在优势，但由于电子纤维与最初为平面基板开发的传统微制造技术不兼容，其制造仍面临挑战。因此，目前可用的电子纤维 器件存在密度低、功能有限以及组件定位不精确等问题。 2025 年 9 月 17 日，斯坦福大学 鲍哲南 院士团队在 Nature 期刊 发表了题为： High-density soft bioelectronic fibres for multimodal sensing and stimulation 的研究论文。 该研究开发出了一种名为" NeuroStr ...

Core Viewpoint - The article highlights the increasing concern regarding the consumption of sugary drinks and their association with colorectal cancer (CRC), particularly among younger populations, emphasizing the need for further research on the impact of these beverages on cancer progression and metastasis [2][6]. Group 1: Sugary Drinks and Colorectal Cancer - Sugary drinks, defined as liquids containing added sugars like sucrose and high-fructose corn syrup, have seen a global increase in consumption since the 1980s, correlating with rising rates of obesity, diabetes, and fatty liver disease [2]. - The consumption of sugary drinks has been linked to a doubling of the risk of developing colorectal cancer in younger individuals, as confirmed by large-scale epidemiological studies [6]. Group 2: Research Findings - A recent study published in Nature Metabolism reveals that fructose and glucose from sugary drinks enhance colorectal cancer metastasis through the activation of sorbitol dehydrogenase (SORD) [3][9]. - The research indicates that a combination of glucose and fructose significantly increases the migration and metastatic potential of colorectal cancer cells compared to glucose alone, suggesting a specific mechanism involving the NAD⁺/NADH ratio and glycolytic activity [7]. Group 3: Implications for Treatment and Diet - The findings of this research underscore the harmful effects of sugary drinks on the progression of colorectal cancer and suggest potential dietary interventions and treatment strategies to inhibit metastasis in patients [9].

Core Viewpoint - The research highlights the significance of the cotton rat (Sigmodon hispidus) as a model for studying respiratory syncytial virus (RSV) infections, demonstrating its evolutionary conserved responses that closely resemble human reactions to the virus [4][7]. Group 1: Research Findings - The study published in *Science Translational Medicine* reveals a complete genome of the cotton rat and a dynamic single-cell transcriptomic analysis during RSV infection, showcasing the high conservation of RSV-related genes and cell types between cotton rats and humans [4][8]. - Evolutionary analysis indicates that the cotton rat is on a different evolutionary branch compared to common mouse and rat models, with respiratory cell maps and alveolar cell differentiation trajectories showing high similarity to human tissues [7]. - The research identifies differential transcriptional regulatory factors, specific antiviral proteins, and cytokines that can be translated into human clinical markers, providing resources for studying host-RSV interactions and developing therapeutic targets [8]. Group 2: Implications for Future Research - The findings from the cotton rat model are expected to contribute significantly to understanding the pathogenic mechanisms of RSV, immune responses, and the development of antiviral drugs [4][8]. - The identification of potential host factors and antiviral responses in the cotton rat model may facilitate the discovery of new treatment strategies for RSV infections [8].

2025 年 9 月 19 日， 中山大学附属第七医院 陈韵 、 陈纯 团队在 Cell 子刊 Cell Reports Medicine 上发表了题为： FLT3L-based drug conjugate effectively targets chemoresistant leukemia stem cells in acute myeloid leukemia 的研究论文。 该研究开发了一种基 于 FLT3 配体 （ FLT3L ） 的药物偶联物—— FL-Fc-DM1 ，其能够有效靶向 急性髓系白血病 （AML） 中的化学耐药的 白血病干细胞 。 撰文丨王聪 编辑丨王多鱼 排版丨水成文 急性髓系白血病 （AML） 是一种异质性恶性肿瘤，由于复发和化疗耐药性，患者预后不良。 FLT3 基因突变会促进 AML 的发展，并预示不良的治疗结局。由于 大多数 AML 细胞表达 FLT3，因此它是一个很有前景的治疗靶点。 急性髓系白血病 （AML） 是一种由多种基因突变驱动的异质性造血系统恶性肿瘤。目前 AML 的一线治疗药物包括阿糖胞苷、柔红霉素和伊达比星。然而，细胞 毒性化疗的非选择性导致了严重的不良反应和 ...

Core Viewpoint - The article discusses the significant advancements in the computational design of sequence-specific DNA-binding proteins (DBPs), highlighting a recent study that successfully created small, easily deliverable DBPs for gene editing and regulation applications [4][13]. Group 1: Importance of DBPs - Sequence-specific DNA-binding proteins play a crucial role in biology and biotechnology, particularly in gene editing applications [2]. - There has been widespread interest in modifying DBPs to achieve new or altered specificities [2]. Group 2: Challenges in DBP Design - Despite some success in reprogramming natural DBPs through screening methods, the computational design of novel DBPs that can recognize arbitrary target sites remains a significant challenge [3]. - The prediction of DNA binding affinity and specificity for natural proteins is still difficult, and the high free energy cost associated with desolvating the highly polarized DNA surface poses challenges for de novo DBP design [7]. Group 3: Recent Research Findings - A research team led by Nobel laureate David Baker published a study demonstrating the successful design of sequence-specific DBPs that function in both E. coli and mammalian cells, capable of inhibiting or activating the transcription of adjacent genes [4]. - The designed DBPs showed high specificity and were able to target five different DNA sites with affinities ranging from nanomolar to high nanomolar levels [8][10]. Group 4: Methodology and Results - The design process involved using RFdiffusion to rigidly position the binding proteins along the DNA double helix, achieving higher-order specificity [10]. - The crystal structure of the designed DBP-target complexes closely matched the computational models, confirming the effectiveness of the design approach [10]. Group 5: Implications for Gene Editing - The methods used in this research provide a new pathway for developing small, easily deliverable sequence-specific DBPs for gene editing and regulation, complementing existing technologies like zinc finger proteins, TALE, and CRISPR-Cas systems [8][13].

撰文丨王聪 编辑丨王多鱼 排版丨水成文 在 脑机接口 等神经接口系统中， 电极 是连接电子设备和生物神经系统的核心界面传感器，是脑机接口中"接口"的核心所在。 然而，当前植入式电极均是" 静态 "的，植入后只能"固定位置、局限采集"，还在免疫反应中"被动挨打"乃至传导失效，这严重制约了脑机接口的应用和未来发 展。 2025 年 9 月 17 日， 中国科学院深圳先进技术研究院 刘志远 研究员、 徐天添 研究员、 韩飞 副研究员和东华大学 严威 教授合作，在国际顶尖学术期刊 Na ture 上发表了题为：： A movable long-term implantable soft microfibre for dynamic bioelectronics 的研究论文。 研究团队受到 蚯蚓 在土壤中灵活运动和分段感知能力的启发，成功开发出了一种 柔性、可驱动、可长期植入的纤维电极—— 神经蠕虫 （ NeuroWorm ） ，标 志着生物电子接口 （脑机接口、人机接口） 从静态走向动态、从被动记录走向主动智能探测的范式转变。 为实现具有分布式传感能力的柔性动态电极，从自然界汲取灵感是一个前景广阔的方向。自然界中， ...

Core Viewpoint - The article discusses the development of a novel room temperature rechargeable all-solid-state hydride ion battery, highlighting the significance of hydride ions (H⁻) in advancing electrochemical devices and addressing the challenges in electrolyte materials for such batteries [2][10]. Group 1: Research Development - The research team from the Dalian Institute of Chemical Physics, Chinese Academy of Sciences, published a paper in Nature detailing the creation of a new core-shell structure hydride ion electrolyte, leading to the first prototype of a hydride ion battery [3]. - In April 2023, the same team proposed a strategy to suppress electronic conductivity through lattice distortion, resulting in a low-temperature superfast hydride ion conductor based on rare earth hydrides [6]. Group 2: Battery Performance - The newly developed composite hydride, 3CeH₃@BaH₂, exhibits rapid hydride ion conduction at room temperature and becomes a superionic conductor above 60°C, making it an ideal electrolyte material [7]. - The prototype battery, constructed with NaAlH₄ and CeH₂ as active materials, achieved a discharge capacity of 984 mAh/g at room temperature, maintaining a reversible capacity of 402 mAh/g after 20 charge-discharge cycles [7]. - The team successfully increased the working voltage to 1.9 V in a stacked battery configuration, demonstrating the battery's capability to power electronic devices, such as lighting a yellow LED [7]. Group 3: Implications for Clean Energy - This all-solid-state hydride ion secondary battery utilizes hydrogen as a charge carrier, effectively avoiding harmful metallic dendrite formation and the associated short-circuit risks, thus paving new avenues for clean energy storage and conversion [10].