Group 1: Company Actions and Financials - Lianlian Digital plans to issue 38.4 million new H-shares at a price of HKD 10.25 per share, representing a 10.09% discount from the last closing price, aiming to raise approximately HKD 393.6 million for global payment innovations and business expansion [1] - Kangji Pharmaceutical announced its intention to list on the Singapore Exchange, which is expected to enhance its international visibility and broaden financing channels [3] - China Shipbuilding Defense anticipates a net profit of HKD 460 million to HKD 540 million for the first half of 2025, reflecting a year-on-year increase of 213.25% to 267.73%, driven by improved production efficiency and revenue from ship products [4] Group 2: Industry Trends - The healthcare sector in Hong Kong has seen a significant increase in IPOs, with 11 companies raising a total of approximately HKD 18.119 billion, indicating strong market interest in the healthcare industry [2] - The overall performance of the Hong Kong stock market shows positive trends, with the Hang Seng Index rising by 0.26% [5]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其 準確性或完整性亦不發表任何聲明，並表明概不就因本公告全部或任何部分內容而產生 或因倚賴該等內容而引致的任何損失承擔任何責任。 自願性及業務進展公告 創新藥高選擇性TYK2抑制劑CMS-D001 獲得特應性皮炎適應症藥物臨床試驗批准通知書 China Medical System Holdings Limited（「本公司」，連同附屬公司統稱為「本集團」） 欣然宣佈，旗下德鎂醫藥有限公司（「德鎂醫藥」，專業聚焦皮膚健康的創新型醫藥企 業，正申請於香港聯合交易所有限公司主板獨立上市，詳見本公司日期為二零二五年四 月 二 十 二 日 發 佈 的 公 告 ） 連 同 其 附 屬 公 司 自 主 研 發 的 創 新 藥 CMS-D001 片 （「CMS-D001」）於二零二五年七月十一日獲得中國國家藥品監督管理局（「NMPA」） 簽發的藥物臨床試驗批准通知書。NMPA同意開展臨床試驗以評價CMS-D001治療特應 性皮炎（AD）的安全性和有效性。 CMS-D001 存在便利性、有效性不足或安全性不佳等問題，臨床亟需新的治療選擇。 臨床前研究數 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其 準確性或完整性亦不發表任何聲明，並表明概不就因本公告全部或任何部分內容而產生 或因倚賴該等內容而引致的任何損失承擔任何責任。 本公告僅供參考，並不構成收購、購買或認購本公司任何證券的邀請或要約。 CHINA MEDICAL SYSTEM HOLDINGS LIMITED 康哲藥業控股有限公司* （於開曼群島註冊成立的有限公司） 本公告載有若干換算，匯率為1.00新元兌6.13港元。該等換算僅供參考，概不表示亦不 應視為任何新元或港元金額可以或應當按上述匯率或任何其他匯率換算，甚至可能完全 無法換算。 承董事會命 China Medical System Holdings Limited 主席 林剛 香港，二零二五年七月十四日 *僅供識別 (股份代號：867) 建議於新加坡交易所作第二上市之預計上市日期 茲提述China Medical System Holdings Limited（「本公司」）日期分別為二零二五年六 月二十四日及二十七日之有關本公司普通股（「股份」）於新加坡證券交易所有限公司 （「新交所」）主板作建議第二上市（「建 ...

Group 1 - The China Securities Regulatory Commission (CSRC) has issued supplementary material requirements for overseas listing applications for 22 companies, including SANY Heavy Industry and TUS Holdings [1][2][3] - SANY Heavy Industry is required to clarify the reasons for inconsistencies in the identification of its controlling shareholder and provide a conclusive opinion on the matter [1][3] - TUS Holdings must explain the real estate development activities of its subsidiaries and their future business plans, as well as the involvement of foreign capital in its operations [2][3] Group 2 - The supplementary requirements for Dipo Technology include an explanation of a share transfer at zero cost that led to a change in control, and whether there are any shareholding arrangements that need regulatory scrutiny [3][4] - Anxuyuan is required to clarify the compliance of its offshore structure and reverse mergers, including foreign exchange management and tax compliance [3][4] - The requirements for Zhihui Mining focus on the scope of its exploration activities and whether its projects fall under high energy consumption or high emissions categories [2][3] Group 3 - The CSRC has mandated that companies provide legal opinions on their compliance with regulations regarding offshore structures and foreign investments [5][6] - Companies must also clarify their business models, including any involvement in restricted foreign investment sectors, and provide details on their user data management practices [5][6][7] - Specific companies like World Road and Copper Master are required to explain their shareholder structures and any potential conflicts of interest [6][10] Group 4 - The supplementary materials for companies like Huaxi Da and Zhongwei New Materials require detailed explanations of their business operations and compliance with foreign investment regulations [24][25] - Companies must also address any discrepancies in their previous filings and how these may affect their current overseas listing applications [9][10] - The focus is on ensuring that all business activities align with the latest foreign investment policies and regulations [5][6][7]

Investment Rating - The report maintains a positive outlook on the cosmetics and medical beauty industry, indicating a "Buy" recommendation for several companies within the sector [2][14]. Core Insights - The cosmetics and medical beauty sector has shown weaker performance compared to the market, with the Shenwan Beauty Care Index rising by 1.5% from July 4 to July 11, 2025, which is below the market average [3][5]. - The introduction of new products in the regenerative medicine sector, particularly in the "童颜针" (youthful needle) category, is expected to enhance consumer interest and expand the market [2][8]. - The report highlights strong anticipated earnings growth for several key companies in the cosmetics sector for the second quarter of 2025, with notable increases in revenue and net profit for brands like 上美股份 (Shangmei), 丸美股份 (Marubi), and 珀莱雅 (Proya) [9][10][11]. Summary by Sections Industry Performance - The cosmetics and medical beauty sector has underperformed the market, with specific indices showing varied performance, such as the Shenwan Cosmetics Index increasing by 2.6% [3][5]. - The report notes that the demand for cosmetics is recovering, with a 4.1% year-on-year increase in retail sales for the first five months of 2025 [19][20]. Company Performance - 上美股份 (Shangmei) is expected to see a revenue increase of 16% and a net profit increase of 25% in the first half of 2025 [10]. - 丸美股份 (Marubi) anticipates a 22% revenue growth and a 28% increase in net profit for the second quarter of 2025 [10]. - 珀莱雅 (Proya) is projected to achieve a 10% revenue growth and a 15% increase in net profit for the second quarter of 2025 [10]. - 毛戈平 (Mao Geping) expects a significant revenue increase of 38% and a net profit increase of 35% in the first half of 2025 [10]. - 若羽臣 (Ruoyuchen) forecasts a remarkable 70% revenue growth and a 75% increase in net profit for the second quarter of 2025 [10]. Market Trends - The report emphasizes the ongoing trend of domestic brands gaining market share, with national brands occupying five of the top ten positions in the skincare market [32]. - The regenerative medicine sector is expanding, with new products enhancing consumer engagement and market growth potential [2][8]. Investment Recommendations - The report recommends focusing on companies with strong brand matrices and high growth potential, such as 上美股份 (Shangmei), 珀莱雅 (Proya), and 丸美股份 (Marubi) [14]. - It suggests monitoring companies that leverage e-commerce and social media platforms effectively, such as 若羽臣 (Ruoyuchen) and 毛戈平 (Mao Geping) [14].

Summary of Key Points Core Viewpoint - As of July 3, a total of 120 stocks reached their 52-week highs, indicating a strong market performance with notable leaders in the list [1]. Group 1: Top Performers - The top three stocks with the highest increase rates are: - 富誉控股 (Fuyou Holdings) at 90.76%, closing at 0.435 with a peak of 0.475 [1] - 信义能源 (Xinyi Energy) at 65.00%, closing at 1.200 with a peak of 1.980 [1] - 中国三三传媒 (China San San Media) at 42.86%, closing at 1.710 with a peak of 1.900 [1] Group 2: Additional Notable Stocks - Other notable stocks include: - ITE HOLDINGS at 34.21% increase, closing at 0.047 with a peak of 0.051 [1] - 星凯控股 (Xingkai Holdings) at 30.00%, closing at 0.480 with a peak of 0.650 [1] - 北京北辰实业股份 (Beijing Beichen Industrial) at 26.47%, closing at 0.940 with a peak of 1.290 [1] Group 3: Overall Market Trends - The overall trend shows a significant number of stocks achieving new highs, reflecting positive investor sentiment and market conditions [1].

Summary of 康哲药业 Conference Call Company Overview - 康哲药业 is undergoing a strategic transformation from original research drugs to innovative drugs, driven by both collaborative development and independent research. The company has received approval for 5 innovative drugs covering 6 indications and is actively expanding internationally, including a secondary listing in Singapore without involving financing or equity dilution [2][4]. Key Business Segments - The company operates four main business segments: - Cardiovascular and Digestive Health: Stabilized after the impact of the National Volume-Based Procurement (VBP) - Ophthalmology: Strong profitability - Skin Health: 德美医药 is set for a spin-off listing - International Business: Focused on Southeast Asia, expected to contribute to future growth [2][5]. Financial Performance - The core products' revenue has declined due to VBP, with projected revenue of 2.6 billion yuan for three core products in 2024. However, the impact of centralized procurement is expected to be cleared, leading to a phase of rapid growth as innovative drugs are approved [2][7]. - The company’s key product portfolio includes: - Existing national procurement products (波依定, 黛力新, 优思弗) expected to contribute 2.6 billion yuan in 2024 - Exclusive and brand drugs anticipated to maintain around 10% growth [8]. Innovative Product Pipeline - 康哲药业 has nearly 20 self-researched projects, with 5-6 in clinical development. Key upcoming products include: - Y3 injection for stroke treatment, expected to exceed 3 billion yuan in sales - ABP671 for hyperuricemia, with NDA submission expected in mid-2025 - 德西度司他片 for chronic kidney disease anemia, expected to be approved this year [3][10][12][13]. Impact of VBP - The company faced significant impacts from VBP, with core products previously accounting for over 50% of sales. The sales retention rate post-VBP was around 50% [6][7]. Spin-off of 德美医药 - The spin-off of 德美医药 is expected to be completed by the end of 2025, which will not significantly affect 康哲药业's overall financial status but will help improve its valuation. 康哲 will distribute 90.8% of 德美 shares to shareholders [3][15]. Market Expansion and Internationalization - 康哲药业 is expanding into Southeast Asia, establishing a regional headquarters in Singapore and planning a secondary listing. This move aims to explore new growth avenues without limiting business development [20][21]. R&D and Sales Expenses - In 2025, 康哲's R&D and sales expenses are expected to rise due to high costs associated with marketing and brand building for newly launched innovative drugs. Profit growth is anticipated to lag behind revenue growth this year, but significant profit increases are expected starting in 2026 as 德美 is no longer consolidated [22][23]. Conclusion - 康哲药业 is positioned for growth through its innovative drug pipeline and international expansion, despite facing challenges from VBP. The upcoming spin-off of 德美医药 and the focus on Southeast Asian markets are strategic moves to enhance overall company valuation and market presence.

康哲藥業控股有限公司* （於開曼群島註冊成立的有限公司） 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其 準確性或完整性亦不發表任何聲明，並表明概不就因本公告全部或任何部分內容而產生 或因倚賴該等內容而引致的任何損失承擔任何責任。 本公告僅供參考，並不構成收購、購買或認購本公司任何證券的邀請或要約。 CHINA MEDICAL SYSTEM HOLDINGS LIMITED 承董事會命 China Medical System Holdings Limited 主席 林剛 (股份代號：867) 建議於新加坡交易所作第二上市之最新消息 接獲新交所上市資格函 茲提述China Medical System Holdings Limited（「本公司」，連同其附屬公司統稱為「本 集團」）日期為二零二五年六月二十四日之公告，內容有關公司普通股（「股份」）以 介紹方式於新加坡證券交易所有限公司（「新交所」）作第二上市（「建議第二上市」）， 於二零二五年六月二十五日，本公司接獲新交所有關建議第二上市之上市資格函（「上 市資格函」），待當中所載條件達成後，預期股份將於二零二五年七月十五日前後在 ...

Core Viewpoint - China Medical System Holdings Limited (康哲药业控股有限公司) has received approval from the China Securities Regulatory Commission (中国证监会) for its overseas issuance and listing, indicating a significant step towards its planned IPO on the Singapore Stock Exchange [1]. Group 1 - The company is planning to list through an introduction method on the Singapore Stock Exchange [1].

Group 1: Brain-Computer Interface Standards - The National Standard for Non-Invasive Medical Devices Using Brain-Computer Interface Technology is open for public consultation, aiming to establish performance indicators and testing methods for such devices [1] - The standardization is expected to enhance international cooperation and improve regulatory efficiency, addressing the rapid development in the non-invasive neural modulation sector [1] Group 2: Pharmaceutical Industry Innovation - The head of the National Medical Products Administration emphasized the importance of supporting drug and medical device R&D innovation to strengthen China's pharmaceutical industry [2] - Key strategies include early intervention, tailored guidance for enterprises, and promoting international multi-center clinical trials to synchronize the development and approval of innovative drugs and devices [2][3] Group 3: Clinical Trials and Approvals - Shenzhou Cell announced that its product SCTB39G received approval for clinical trials in advanced solid tumors [4] - Hanyu Pharmaceutical's subsidiary received approval for the listing of the raw material drug Acetate Degarelix, which is used for treating advanced prostate cancer [6] Group 4: Market Expansion and IPOs - Kangzhe Pharmaceutical plans a secondary listing in Singapore, reflecting a trend of pharmaceutical companies expanding into Southeast Asian markets [7] - Lianya Pharmaceutical's IPO application has been accepted, focusing on complex drug formulations and high-end generic drugs [9] Group 5: Strategic Collaborations - Bayer and Tsinghua University signed a strategic cooperation agreement to enhance research in various medical fields, aiming to accelerate drug innovation [11][12] Group 6: Clinical Trial Developments - Fuhong Hanlin announced the first patient enrollment in a bridging clinical trial for its drug H, which is approved for first-line treatment of small cell lung cancer in multiple countries [13] Group 7: Corporate Leadership Changes - Fosun Pharma held a shareholder meeting to elect new board members, appointing Chen Yuqing as chairman and Liu Yi as CEO [14]