股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年12月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 北京昭衍新藥研究中心股份有限公司 FF301 由於北京昭衍新藥研究中心股份有限公司(「本公司」)是於中華人民共和國註冊成立，因此" 法定股本"之概念不適用於本公司。第 I 部分所載資料是指本公司的"已發行股本"。 呈交日期: 2026年1月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06127 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 118,995,206 | RMB | | 1 RMB | | 118,995,206 | | 增加 / 減少 (-) | | | 0 | | | RMB | | 0 ...

Group 1 - A-shares opened higher today, with significant gains in innovative drug and brain-computer interface stocks, including Zhaoyan New Drug and BeiGene, which rose over 10% [1] - The innovative drug ETF Tianhong (517380) tracking the Hang Seng-Hushen-Hong Kong Innovative Drug Selected 50 Index surged over 4.8%, outperforming the Hong Kong Stock Connect Innovative Drug Index [1] - The biopharmaceutical ETF (159859) tracking the Guozhen Biopharmaceutical Index increased by over 3%, with a total scale exceeding 3.3 billion yuan and a net inflow of over 600 million yuan since September last year [1] Group 2 - The National Medical Products Administration has organized the formulation of the "Priority Approval High-end Medical Device Catalog (2025 Edition)," including medical electronic accelerators and implantable brain-computer interface medical devices [1] - Elon Musk announced that his brain-computer interface company, Neuralink, will begin large-scale production of brain-computer interface devices in 2026, transitioning to a more streamlined and nearly fully automated surgical process [1] - Analysts indicate that including implantable brain-computer interface medical devices in the priority approval category highlights policy support for related technological developments, with a broad potential market space and accelerated commercialization processes expected [1] Group 3 - McKinsey estimates that the global market size for brain-computer interface medical applications could reach $40 billion by 2030 and $145 billion by 2040, indicating significant application potential in the medical field [2] - Investors interested in the innovative drug sector can consider the innovative drug ETF Tianhong (517380) for easy access, while off-market investors may focus on linked funds [2] - The emphasis is on CXO and innovative drug mainline trends, with a recommendation to focus on the biopharmaceutical ETF (159859) that targets 30 industry leaders for higher sharpness and elasticity [2]

每经AI快讯，CRO概念股表现强势。截至发稿，昭衍新药(06127.HK)涨11.52%，报22.26港元；泰格医 药(03347.HK)涨5.98%，报44.98港元；药明康德(02359.HK)涨4.65%，报105.7港元；康龙化成 (03759.HK)涨4.59%，报20.74港元。 （文章来源：每日经济新闻） ...

Group 1 - CRO concept stocks are performing strongly, with notable increases in share prices: Zhaoyan New Drug up 11.52% to HKD 22.26, Tigermed up 5.98% to HKD 44.98, WuXi AppTec up 4.65% to HKD 105.7, and Kanglong Chemical up 4.59% to HKD 20.74 [1] - Huafu Securities reports that external demand for CXO companies has significantly improved since 2024, with a recovery in year-on-year growth expected from Q4 2024 through Q3 2025, indicating a clear trend of industry rebound [1] - Yongxing Securities notes that the domestic CXO industry is experiencing an upward trend in light of improved investment and financing conditions for innovative drugs, with strong demand for specialized CDMO services driven by the expanding market for emerging fields such as peptides, CGT, ADC, and nucleic acid drugs [1] Group 2 - The domestic CXO sector has shown relatively weaker performance compared to external demand since the beginning of 2025, but there is a strong certainty of recovery from the front-end to the back-end, suggesting potential left-side opportunities [1] - Chinese CDMO companies are expected to open growth ceilings through capacity expansion, technological layout, and model innovation, building barriers in niche markets while accommodating global orders [1]

Core Viewpoint - The medical sector is experiencing a strong performance, with the largest medical ETF (512170) showing significant gains, driven by positive market sentiment and news regarding Neuralink's plans for large-scale production of brain-computer interface devices starting in 2026 [1][3]. Group 1: Market Performance - On January 5, 2026, the medical ETF (512170) opened high and rose over 4%, potentially marking the largest single-day gain in nearly three months, with real-time transactions exceeding 650 million yuan [1]. - All 50 constituent stocks of the medical ETF saw increases, with notable surges in brain-computer interface stocks, including Sanbo Brain Science, Meihua Medical, and Lepu Medical, which hit the daily limit of 20% [1]. - The CXO sector also performed strongly, with Zhaoyan New Drug reaching the daily limit and WuXi AppTec increasing by nearly 6% [1]. Group 2: Fund and Index Details - The medical ETF (512170) has a total scale exceeding 25.259 billion yuan, making it the largest medical and healthcare ETF in the market, serving as a significant industry benchmark [3]. - The ETF focuses on "medical devices + medical services," with a CXO weight exceeding 26%, and includes leading companies in aesthetic medicine, private hospitals, and medical information technology [3]. - The current price-to-earnings ratio of the underlying index for the medical ETF is 32 times, which is lower than over 70% of the time in the past decade, indicating a favorable cost-performance ratio for investors [1].

医疗板块开门红！2026年1月5日早盘，医疗板块全线飘红，全市场规模最大医疗ETF（512170）高开高 走，盘中涨超4%，今日有望创下近3个月来最大单日涨幅！实时成交超6.5亿元。 医疗ETF50只成份股全部上涨，脑机接口概念股集体爆发，三博脑科、美好医疗、乐普医疗20CM涨 停！CXO亦强势，昭衍新药涨停，巨头药明康德涨近6%。 医疗板块开门红！2026年1月5日早盘，医疗板块全线飘红，全市场规模最大医疗ETF（512170）高开高 走，盘中涨超4%，今日有望创下近3个月来最大单日涨幅！实时成交超6.5亿元。 医疗ETF50只成份股全部上涨，脑机接口概念股集体爆发，三博脑科、美好医疗、乐普医疗20CM涨 停！CXO亦强势，昭衍新药涨停，巨头药明康德涨近6%。 消息面上，马斯克近日在社交媒体上表示，其脑机接口公司Neuralink将于2026年开始对脑机接口设备进 行"大规模生产"。 | 分时 多日 1分 5分 · | | | | | | | F9 盘前盘后 露加 九轮 面线 工具 @ 2 > | | | | | | | | | | 医疗ETF O | | | | --- | --- | --- | --- ...

截至发稿，昭衍新药(06127.HK)涨9.72%、泰格医药(03347.HK)涨5.94%、康龙化成(03759.HK)涨 3.68%。 本文源自：金融界AI电报 ...

Group 1: Core Insights - The report maintains a strong market rating for the pharmaceutical industry, indicating a clear upward trend driven by recovering demand and improved performance in the CXO sector [1][2] - The CXO sector has shown significant stock price increases, with some companies experiencing nearly 100% growth since the beginning of 2025, driven by the innovative drug market and a recovery in orders [3][6] Group 2: CXO Sector Analysis - The CXO sector's overall revenue increased by 11.8% year-on-year in the first three quarters of 2025, with a notable profit increase of 58.1% [13] - External demand for CXO services has rebounded, with significant order growth from leading CDMO companies, indicating a clear recovery trend [22][31] - Internal demand for CXO services has lagged behind external demand, but there are signs of strong growth in domestic innovative drug projects and increased investment in the domestic market [3][22] Group 3: Life Sciences Upstream - The life sciences upstream sector has seen a 37.7% increase in stock prices year-to-date, outperforming the pharmaceutical and biotechnology index by 18% [3] - Revenue for the upstream sector increased by 8.8% year-on-year in the first three quarters of 2025, with net profit rising by 27.7% [3] Group 4: Investment Recommendations - The report suggests a strategic investment focus on companies such as WuXi AppTec, WuXi Biologics, and Tigermed, while also highlighting more flexible investment options like Zhaoyan New Drug and Nossan [3]

Company Dynamics - Zhou Zhiwen, a major shareholder and actual controller of Zhaoyan New Drug (603127.SH), has announced a significant share reduction plan, potentially cashing out over 500 million yuan based on the current stock price [2] - Before the reduction, Zhou held 74,725,981 shares, accounting for 9.9704% of the total share capital, with a combined holding of 32.274% with his spouse, Feng Yuxia [2] - Following the announcement of the share reduction, Zhaoyan New Drug's stock dropped by 6.20% on December 30, closing at 34.80 yuan, indicating a potential cash-out of over 500 million yuan from the sale of 14.98 million shares [2] Industry Insights - Zhaoyan New Drug specializes in non-clinical research services, clinical services, and the supply of experimental models, gaining prominence in the capital market due to its assets in experimental monkeys [2] - The average market price of experimental monkeys has seen significant fluctuations, with prices rising from 13,800 yuan per monkey in 2017 to nearly 190,000 yuan in 2022, before experiencing a decline in 2023 [2][3] - In November 2023, the price of experimental monkeys dropped to approximately 113,000 yuan each, reflecting a decrease of over 30% from the peak [3] - Despite a decline in revenue by 26.23% year-on-year to 985 million yuan in the first three quarters of 2025, Zhaoyan New Drug managed to achieve a net profit of 80.71 million yuan, indicating a recovery in performance [3] - As of December 29, 2025, Zhaoyan New Drug's stock price has increased by over 120% within the year [3] Shareholder Activity - Zhou Zhiwen has a history of share reductions, having sold a total of 14.11 million shares since November 2020, resulting in approximately 915 million yuan in cash [4]

Core Viewpoint - The stock price of Zhaoyan New Drug (603127.SH) surged due to the rebound in the market price of experimental monkeys, prompting major shareholder Zhou Zhiwen to announce a significant share reduction plan, potentially cashing out over 500 million yuan [1] Group 1: Shareholder Actions - Zhou Zhiwen plans to reduce his holdings by up to 14,980,000 shares, representing 20.0466% of his holdings and 1.99873% of the company's total share capital, within three months after the announcement [1] - Prior to the reduction, Zhou Zhiwen held 74,725,981 shares, accounting for 9.9704% of the company, with the couple's total holding at 32.274% [1] - Following the announcement of the share reduction, Zhaoyan New Drug's stock fell by 6.20% to a closing price of 34.80 yuan [1] Group 2: Company Overview - Zhaoyan New Drug specializes in non-clinical research services, clinical services, and the supply of experimental models, with a notable focus on experimental monkeys, which are critical for various research fields [2] - The price of experimental monkeys has fluctuated significantly, with the average market price rising from 13,800 yuan in 2017 to nearly 190,000 yuan in 2022, before experiencing a decline in 2023 [2][3] Group 3: Financial Performance - In Q1 2024, Zhaoyan New Drug reported a revenue of 325 million yuan, a year-on-year decrease of 12.07%, and a net loss of 272 million yuan, attributed to a 284 million yuan loss from changes in the fair value of biological assets [3] - By the first three quarters of 2025, the company achieved a revenue of 985 million yuan, a year-on-year decrease of 26.23%, but turned a profit with a net income of 80.71 million yuan [3] - The stock price of Zhaoyan New Drug increased by over 120% throughout the year, reflecting a recovery in the market price of experimental monkeys [3] Group 4: Market Perception - Some market analysts argue that Zhaoyan New Drug primarily sells experimental services rather than monkeys, suggesting that monkey prices do not directly reflect the company's sustainable profitability [4] - Despite this, fluctuations in the value of experimental monkeys significantly impact the company's financial performance, leading to potential distortions in financial reporting [4]