Investment Rating - The report maintains an "Outperform" rating for the pharmaceutical and biotechnology sector [5] Core Views - The pharmaceutical sector underperformed the overall market this week, with the healthcare services sector leading the gains. The overall A-share market rose by 1.50%, while the biopharmaceutical sector increased by 1.82%, outperforming the market [1][33] - Merck announced a $10 billion acquisition of Verona Pharma to obtain the COPD drug Ohtuvayre, which is expected to be a significant product in the respiratory disease treatment market [2][10] - WuXi AppTec is projected to achieve a 102% increase in net profit for the first half of 2025, with revenues expected to reach 20.799 billion yuan, reflecting a growth of 20.64% [3] Summary by Sections Market Performance - The biopharmaceutical sector's price-to-earnings ratio (TTM) stands at 35.79x, which is at the 77.7 percentile of its historical valuation over the past five years [1][38] - The overall A-share market and various sub-sectors showed positive performance, with healthcare services up by 6.46% [1][33] Key Company Updates - Merck's acquisition of Verona Pharma will provide access to Ohtuvayre, a dual-target PDE3/4 inhibitor approved for COPD maintenance therapy, marking a significant advancement in treatment options [2][10] - Ohtuvayre's sales reached $71 million in Q1 2025, indicating strong market uptake and potential for expansion into other indications [22][24] Company Earnings Forecasts - WuXi AppTec's net profit for H1 2025 is expected to be 8.561 billion yuan, a 101.92% increase, driven by strong operational performance [3] - The report includes earnings forecasts for several companies, with WuXi AppTec and Mindray Medical both rated as "Outperform" [4][42] Investment Recommendations - Mindray Medical is highlighted as a leading domestic medical device company benefiting from new healthcare infrastructure and product upgrades [42] - WuXi AppTec is recognized for its comprehensive service capabilities in the new drug development outsourcing market [42] - Other recommended companies include New Industries, Huatai Medical, and Aibo Medical, each with strong market positions and growth potential [42][43][44]

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 無錫藥明康德新藥開發股份有限公司 呈交日期： 2025年7月15日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | A | | 於香港聯交所上市 | 否 | | | 證券代號 (如上市) | | 說明 | 於上海證券交易所上市 | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | 事件 | | 已發行股份（不包括庫存股份）變動 佔有關事件前的現有已發 | | 庫存股份變動 | 每股發行/出售價 (註4) ...

FF305 | 第一章節 | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | A | | 於香港聯交所上市 | 否 | | | 證券代號 (如上市) | | 說明 | 於上海證券交易所上市 | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | 事件 | | 已發行股份（不包括庫存股份）變動 佔有關事件前的現有已發 | | 庫存股份變動 | 每股發行/出售價 (註4) | 已發行股份總數 | | | | 已發行股份（不包括庫存股份）數 目 | 行股份（不包括庫存股 份）數目百分比 (註3) | | 庫存股份數目 | | | | 於下列日期開始時的結存(註1) | 2025年7月14日 | | 2,485,141,055 | | 0 | | 2,485,141,055 | | 1). 其他 (請註明) | | | | % | | | | | 參見B部 | | | | | | | | | 變動日期 | 2025年7月15日 | | | | | | ...

Core Viewpoint - WuXi AppTec Co., Ltd. (药明康德) expects a significant increase in its 2025 half-year performance, with projected revenue of 20.64% growth year-on-year, driven by its integrated CRDMO business model and operational efficiency improvements [1][3]. Group 1: Financial Performance - The company anticipates a revenue of approximately 20.799 billion yuan for the first half of 2025, reflecting a year-on-year increase of about 20.64% [1]. - The net profit attributable to shareholders, excluding non-recurring gains and losses, is expected to be around 5.582 billion yuan, representing a year-on-year growth of approximately 26.47% [3]. - The impact of non-recurring gains primarily stems from the sale of part of its holdings in WuXiXDC Cayman Inc., with expected gains of about 3.210 billion yuan [3]. Group 2: Market Sentiment and Industry Outlook - Investors are optimistic about the CXO sector, with comments indicating a potential recovery in the innovative drug market [4]. - Analysts from Dongwu Securities highlighted the significant performance turnaround in the sector, noting that companies like WuXi AppTec and others are showing improved growth [4]. - Citigroup's report emphasizes a strong resurgence in interest in the healthcare sector, particularly in innovative drugs, suggesting that the CXO sector will attract more attention due to improved fundamentals and attractive valuations [5].

Group 1 - The medical health ETF Taikang (159760) has seen a 0.17% increase, marking its fifth consecutive rise, while the index it tracks, the National Certificate Public Health and Medical Health Index (980016), rose by 0.13% [1] - As of July 14, the latest scale of the medical health ETF Taikang reached 82.4979 million yuan, a new high in nearly three months [2] - The medical device sector is expected to experience a performance turning point, driven by policies such as the old-for-new program and the gradual clearance of channel inventory [2] Group 2 - The top ten weighted stocks in the National Certificate Public Health and Medical Health Index account for 51.67% of the index, with leading companies including WuXi AppTec (603259) and Hengrui Medicine (600276) [3] - The CDMO sector has rebounded, with WuXi AppTec expected to see significant growth in revenue and profit by mid-2025, indicating strong global market demand [2] - The innovation drug industry chain is anticipated to enter a new upward cycle, supported by an improving domestic investment environment and active financing activities [2]

Investment Rating - The report upgrades Tigermed-A to Buy from Sell, with target prices increased to Rmb67/HK$73 from Rmb34/HK$37 [3][10] - WuXi AppTec and WuXi Bio are identified as top picks in the CDMO sector, expected to report beats in 1H25 [10][11] Core Insights - The CXO sector in China's healthcare is gaining attention due to improving fundamentals, attractive valuations, and growth in orders backlog [1] - WuXi AppTec is projected to beat its FY25 guidance, supported by strong growth in orders backlog and strategic disposals [2][11] - Tigermed is expected to benefit from innovative drug development and increasing out-licensing activities, leading to stronger revenue growth [3][10] Summary by Sections Top Picks in CDMO Sector - WuXi AppTec and WuXi Bio are favored for their potential to outperform in 1H25, with Tigermed-A also upgraded due to increased clinical trial activities [10] 1H25 Results Preview - WuXi AppTec's 1H25 results are expected to exceed consensus, driven by strong TIDES business and asset disposals [11] - WuXi Biologics and WuXi XDC are also anticipated to report revenue beats [11] Backlog vs. Revenue Growth - WuXi AppTec's backlog growth accelerated to 47% year-on-year in 1Q25, indicating potential revenue growth acceleration [5][48] - Tigermed's backlog grew 12% year-on-year in 2025, suggesting a positive revenue outlook [34] Global Biotech Funding - Overseas innovative drugs' primary market financing rose 28% year-on-year in 2024, with expectations for recovery in 2H25 [44] Company-Specific Insights - WuXi AppTec's management projects revenue to reach Rmb41.5-43.0 billion in 2025, with a focus on profitability improvements [47] - Tigermed is positioned as a key beneficiary of China's drug innovation, with expected revenue growth driven by clinical trial activities [3][10]

Group 1 - The core point of the news is that WuXi AppTec's subsidiary, Tianjin WuXi AppTec New Drug Development Co., Ltd., was listed in the administrative penalty announcement but was not penalized for failing to implement emergency response regulations regarding emergency materials and equipment [1][3] - The Tianjin Emergency Management Bureau decided not to impose administrative penalties on the company, citing that the violation was minor and promptly corrected, with no harmful consequences [3] - WuXi AppTec provides integrated, end-to-end new drug research and production services globally, with operational bases in Asia, Europe, and North America, serving around 6,000 partners from over 30 countries [5] Group 2 - WuXi AppTec was established in 2000 with a registered capital of 2,933.34 million RMB, while Tianjin WuXi AppTec New Drug Development Co., Ltd. was founded in 2006 with a registered capital of 800 million RMB [6] - As of July 14, 2025, WuXi AppTec's stock price was 78.60 RMB, reflecting a 1.88% increase [7]

Group 1: Company Performance - Aopu Mai expects to achieve approximately 177 million yuan in revenue for the first half of 2025, representing a year-on-year growth of about 23.25% [1] - The company anticipates a net profit attributable to shareholders of approximately 37 million yuan, an increase of about 53.28% year-on-year [1] - Aopu Mai's net profit after deducting non-recurring gains and losses is expected to be around 29.03 million yuan, reflecting a year-on-year increase of approximately 73.46% [1] Group 2: Industry Trends - Multiple CXO companies have reported positive performance forecasts for the first half of 2025, indicating a potential turning point for the CXO industry [2] - WuXi AppTec expects to achieve approximately 20.64% year-on-year revenue growth, with adjusted net profit projected to increase by about 44.43% [2] - The overall market sentiment for the CXO sector is improving, driven by a recovery in global healthcare financing and a favorable domestic policy environment [3] Group 3: Market Dynamics - The global healthcare investment and financing amount is showing a recovery trend, with a projected growth rate of 25.3% in 2024 [3] - The domestic innovative drug sector is experiencing a positive market trend, with over 80 business development transactions in the first half of the year, significantly higher than the previous year's average [3] - Analysts suggest that the CXO sector may benefit from a chain of encouraging innovation policies and improved financing conditions, although there are concerns about market overheating [3]

無錫藥明康德新藥開發股份有限公司（「本公司」，連同其子公司「本集團」）董 事會（「董事會」）謹此宣佈將於2025年7月28日（星期一）召開董事會會議，以考 慮及批准（其中包括）本集團截至2025年6月30日止六個月之未經審計中期業績 及其發佈。 承董事會命 無錫藥明康德新藥開發股份有限公司 董事長 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並表明概不就因本公告全部或任何部份內容而產生或因倚賴 該等內容而引致的任何損失承擔任何責任。 WUXI APPTEC CO., LTD. * 無錫藥明康德新藥開發股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：2359） 董事會會議召開日期 * 僅供識別 李革博士 香港，2025年7月14日 於本公告日期，董事會包括本公司執行董事李革博士、陳民章博士、胡正國先生、楊青博士 及張朝暉先生；本公司非執行董事童小幪先生及吳亦兵博士；以及本公司獨立非執行董事 盧韶華女士、俞衛博士、張新博士、詹智玲女士及冷雪松先生。 ...

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 無錫藥明康德新藥開發股份有限公司 呈交日期： 2025年7月14日 第 1 頁 共 9 頁 v 1.3.0 | 1). | 購回股份(或其他證券)但沒有註銷 | 302,500 | 0.01 % | RMB | 66.14 | | --- | --- | --- | --- | --- | --- | | | 茲提述本公司於2025年3月17日刊發的公告，於2025年3月26日刊發的 | | | | | | | 通函，及於2025年4月29日刊發的投票結果公告。 | | | | | | | 於2025年6月26日，本公司實施2025年以集中競價交易方式回購本公司 | | | | | | | A股股份方案（"2025年第一次回購"），并回購302,500股A股股份。 | | | | | | | 變動日期 2025年6月26日 | | | | | | | 購回股份(或其他證券)但沒有註銷 | | | | | | 2). | | 303,367 | 0.01 % ...