FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 無錫藥明康德新藥開發股份有限公司 呈交日期： 2025年7月14日 第 3 頁 共 9 頁 v 1.3.0 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | A | | 於香港聯交所上市 | 否 | | | 證券代號 (如上市) | | 說明 | | 於上海證券交易所上市 | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | 事件 | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | 每股發行/出 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並表明概不就因本公告全部或任何部份內容而產生或因倚賴 該等內容而引致的任何損失承擔任何責任。 香港，2025年7月14日 （於中華人民共和國註冊成立的股份有限公司） （股份代號：2359） 董事會會議召開日期 無錫藥明康德新藥開發股份有限公司（「本公司」，連同其子公司「本集團」）董 事會（「董事會」）謹此宣佈將於2025年7月28日（星期一）召開董事會會議，以考 慮及批准（其中包括）本集團截至2025年6月30日止六個月之未經審計中期業績 及其發佈。 承董事會命 無錫藥明康德新藥開發股份有限公司 董事長 WUXI APPTEC CO., LTD. * 無錫藥明康德新藥開發股份有限公司 李革博士 於本公告日期，董事會包括本公司執行董事李革博士、陳民章博士、胡正國先生、楊青博士 及張朝暉先生；本公司非執行董事童小幪先生及吳亦兵博士；以及本公司獨立非執行董事 盧韶華女士、俞衛博士、張新博士、詹智玲女士及冷雪松先生。 * 僅供識別 ...

Group 1 - The core viewpoint is that the medical innovation sector is experiencing a phase of differentiation, with a focus on innovative drugs and performance-driven stocks [2] - The Medical Innovation ETF (516820) has seen a net inflow of 57.86 million yuan recently, indicating positive market sentiment towards the sector [1] - The industry is expected to continue stable and sustainable growth in healthcare spending, with innovation and high-end manufacturing being key drivers for future investment opportunities [3] Group 2 - The report suggests that innovative drugs remain the most promising sub-industry within the pharmaceutical sector, with a clear upward trend and growth potential [2] - There is a recommendation to actively invest in high-performing segments such as CRO&CDMO, GLP-1, and specialty raw materials, which are expected to show improvement [2] - The CS Pharmaceutical Innovation Index, which the Medical Innovation ETF tracks, uses objective quantitative indicators to select stocks in high-growth areas, making it a unique investment vehicle in the market [2]

Investment Rating - The report maintains a "Buy-A" investment rating for the company with a target price of 95.60 CNY per share over the next six months [5][6]. Core Insights - The company is expected to achieve significant growth in its financial performance, with projected revenues of 20.799 billion CNY and adjusted net profit of 6.315 billion CNY for the first half of 2025, representing year-on-year increases of 20.64% and 44.43% respectively [1][2]. - The expansion of the small molecule D&M pipeline is driving steady growth in this segment, with 203 new molecules added in Q1 2025 and successful FDA inspections of production facilities [3]. - The TIDES business is experiencing rapid growth, with a 105.5% year-on-year increase in orders and a significant expansion in production capacity from 32,000 liters in 2023 to 100,000 liters by the end of 2025 [4]. Financial Projections - The company’s projected net profits for 2025 to 2027 are 13.735 billion CNY, 13.872 billion CNY, and 16.210 billion CNY, reflecting year-on-year growth rates of 45.3%, 1.0%, and 16.9% respectively [5][11]. - The expected earnings per share (EPS) for 2025 is 4.78 CNY, with a price-to-earnings (PE) ratio of 20 times [5][11]. - The company’s total market capitalization is approximately 221.59 billion CNY, with a circulating market capitalization of about 191.73 billion CNY [6]. Stock Performance - The stock has shown strong relative performance, with a 1-month return of 15.5%, a 3-month return of 41.0%, and a 12-month return of 83.0% [9].

Investment Rating - The report indicates a positive outlook for the pharmaceutical and biotechnology sector, with a focus on innovative drug companies [2][3]. Core Insights - The pharmaceutical and biotechnology sector saw a weekly increase of 1.82%, outperforming the CSI 300 index (0.82%) and the Wind All A index (1.71%). The market is currently focused on the expectations surrounding semi-annual reports and business development (BD) activities [8][9]. - The launch of the 2025 National Basic Medical Insurance and Commercial Health Insurance innovative drug directory is a significant development. This directory will include high-innovation drugs that provide substantial clinical value and patient benefits, which are not covered by basic medical insurance but recommended for commercial health insurance [3][13]. - The report highlights the importance of the commercial health insurance sector in the payment for innovative drugs, suggesting that the accessibility of high-priced innovative drugs is expected to improve, particularly in the areas of cell and gene therapy [3][13]. Market Weekly Review - The medical research outsourcing sector led the gains with a 9.29% increase, primarily driven by WuXi AppTec's positive semi-annual report announcement. Conversely, offline pharmacies and other biological products experienced declines of -1.29% and -1.55%, respectively [8][9]. - Notable stock performances included Frontier Biotech-U (41.4%), Mediso (38.9%), and Lianhuan Pharmaceutical (38.6%) leading the gains, while ST Unimed (-18.5%), Shenzhou Cell-U (-13.4%), and Shutai Shen (-11.6%) faced significant losses [11][12]. Industry News and Key Company Announcements - The report outlines several key industry events, including the approval of innovative drugs and strategic partnerships among major pharmaceutical companies, which are expected to enhance their market positions and product offerings [13][16][17]. - The report also mentions significant financial forecasts from various companies, indicating strong growth potential in the sector, with some companies projecting net profit increases of over 100% year-on-year [17][18].

Summary of Conference Call Records Industry Overview - The global pharmaceutical industry is facing a significant patent cliff, with approximately $180 billion in annual revenue drugs set to lose patent protection between 2027 and 2028, representing nearly 12% of the global market share [3][4][10] - The domestic innovation industry chain is experiencing an increase in orders, particularly among upstream companies such as Baipusais, Bidai Pharmaceutical, and Bai'ao Pharmaceutical [1][5] - The CRO (Contract Research Organization) sector is seeing growth in companies like Zhaoyan New Drug, Yinuosi, and Tigermed, while the CDMO (Contract Development and Manufacturing Organization) sector is highlighted by strong performances from WuXi AppTec, Boteng Co., Tianyu Co., and Pro Pharma [1][5] Key Insights and Arguments - The recovery in the CXO (Contract Research Organization and Contract Development and Manufacturing Organization) sector is driven by increased domestic demand and a resurgence in orders, which is expected to translate into clinical research opportunities within 6 to 12 months [11][12] - The trend of innovation drug out-licensing (BD) is becoming more pronounced, as large pharmaceutical companies seek to diversify their pipelines and manage costs amid pressures from legislation such as the IRA (Inflation Reduction Act) [4][7] - Domestic listed companies have shown an increasing trend in R&D expenses as a percentage of revenue since the second half of last year, indicating a more proactive approach to R&D investment in response to market changes [8][10] Financial Performance and Trends - In the CDMO sector, WuXi AppTec reported a 47% year-on-year increase in orders by the end of last year, while Boteng Co. saw a 30% increase [11][13] - For the first half of 2025, WuXi AppTec's revenue is expected to grow by 21%, with a 44% increase in NON-IFRS net profit, while Boteng Co. is projected to achieve profitability after a turnaround [13] - The structure of R&D expenses in Biotech companies has shifted, with a notable increase in clinical trial costs, reflecting a conservative investment strategy amid market uncertainties [9] Potential Investment Opportunities - Recommended companies in the domestic innovation industry include Yinuosi, Zhaoyan New Drug, and Tigermed, as well as leading CDMO firms like WuXi AppTec and Pro Pharma [16] - The recovery in the domestic innovation industry is expected to create further investment opportunities, particularly as IPOs are being opened up and more companies are preparing to list [14] Additional Considerations - The overall recovery of the innovation industry chain is segmented into phases, with the current transition from phase 1.0 to 2.0 indicating a shift towards increased early-stage project investments by financially robust companies [10] - The competitive landscape of the domestic innovation industry chain should be assessed comprehensively, including comparisons with Indian and other overseas companies to better understand competitive advantages [17]

Core Viewpoint - WuXi AppTec (603259.SH) continues to demonstrate robust growth in its operating performance, with significant increases in revenue and net profit expected for the first half of 2025 [2][3]. Financial Performance - For the first half of 2025, the company anticipates revenue of approximately 20.79 billion yuan, representing a year-on-year growth of about 20.64% [3]. - The expected adjusted net profit for the same period is around 6.315 billion yuan, reflecting a year-on-year increase of approximately 44.43% [3]. - In Q1 2025, the company achieved revenue of 9.655 billion yuan, a year-on-year growth of 20.96%, with net profits of 3.672 billion yuan, marking an impressive growth of 89.06% [3]. Business Model and Strategy - The company focuses on a unique "integrated, end-to-end" CRDMO (Contract Research, Development, and Manufacturing) business model, which is crucial for meeting customer empowerment needs [5]. - WuXi AppTec has positioned itself as one of the few open-access new drug research and development service platforms capable of providing services across the entire new drug development chain [7]. R&D and Capacity Expansion - As of the end of 2024, the company employed approximately 31,800 R&D personnel, accounting for 80.7% of its total workforce [9]. - The company has made significant investments in expanding its production capacity, with new facilities expected to come online in the coming years, including a doubling of oral formulation capacity at its Swiss facility [8]. Client Base and Orders - WuXi AppTec serves around 6,000 active clients, including all of the top 20 global pharmaceutical companies, and has added approximately 1,000 new clients in its ongoing business [8]. - The company reported a backlog of orders in its ongoing business of 49.31 billion yuan at the end of 2024, a year-on-year increase of 47% [8].

Group 1 - The market showed positive performance last week, with the China Securities Xinhua National Brand Index rising by 1.78% to 1679.33 points [1] - Key stocks such as Sungrow Power, Tigermed, and Kangtai Biological performed strongly, with Sungrow Power leading with a 12.50% increase [1] - Year-to-date, notable performers include Xinlitai with a 47.42% increase, WuXi AppTec with a 43.21% rise, and Anji Technology up by 38.52% [2] Group 2 - The market sentiment is shifting towards a bullish outlook, with institutions optimistic about future performance due to a lack of systemic risks and positive reactions to favorable information [2] - Key sectors of interest include computing power chains, new consumption, and innovative pharmaceuticals, with high-dividend assets expected to attract institutional investment [2] - The ongoing revaluation of Chinese assets is supported by continuous breakthroughs in domestic technology innovation and favorable policies, which are expected to enhance supply-demand dynamics in the domestic market [3]

RISC-V - The fifth RISC-V China Summit will be held from July 16 to 19, 2025, in Shanghai, featuring a main forum, nine vertical sub-forums, five workshops, and a 4,500 square meter technology exhibition area, expecting nearly 2,000 attendees [1] - RISC-V architecture is rapidly rising due to its open-source, flexible design, and low power consumption, with a projected compound annual growth rate of over 40% in product shipments by 2030 [1] Innovative Drugs - The National Healthcare Security Administration announced a plan for the adjustment of the 2025 National Basic Medical Insurance drug list and the commercial health insurance innovative drug list, which will be synchronized [2] - WuXi AppTec, a leading CXO company with a market value of 200 billion, expects a revenue of approximately 20.64% growth year-on-year for the first half of 2025 [2] - The innovative drug sector is experiencing a surge in outbound transactions, with optimistic expectations for pipeline value, leading to increased domestic new drug R&D demand [2] Industrial Intelligence - The Ministry of Industry and Information Technology released work points for the integration of information technology and industrialization in 2025, emphasizing the development of industrial intelligent systems and support for pilot projects [3] - The AI industry is at a critical turning point, with predictions that AI smartphones and PCs will capture over 50% and 80% market share in China by 2027, respectively [3] Environmental Protection - The world's first 200,000 tons/year mixed waste plastic deep cracking industrialization project has successfully begun trial production in Guangdong, utilizing innovative chemical recycling technology [4] - The waste plastic resource utilization market in China is expected to reach 120 billion by 2025 and exceed 400 billion by 2030, with a compound annual growth rate of over 10% [4] Hydrogen Energy - The Alcohol-Hydrogen Electric Ecosystem Alliance was established at the 2025 China Automotive Forum, aiming to enhance collaboration across the industry chain [5] - Alcohol-hydrogen technology is viewed as an optimal path for commercial vehicle electrification, addressing the limitations of pure electric and hydrogen fuel technologies [5] Insurance - The Ministry of Finance issued a notice to guide insurance funds towards long-term stable investments, enhancing the performance evaluation of state-owned commercial insurance companies [6] - The proportion of equity investments by insurance companies is expected to significantly increase, contributing to the long-term stability and health of the capital market [6] Macro and Industry News - The Shanghai Stock Exchange has implemented further reforms to the Sci-Tech Innovation Board, including new self-regulatory guidelines [7] - The China Securities Association released 28 measures to promote high-quality development in the securities industry [8]

Investment Rating - The report rates the pharmaceutical industry as "Overweight," indicating a positive outlook for the sector compared to the overall market performance [2][30]. Core Insights - The pharmaceutical sector saw a weekly increase of 1.8%, outperforming the Shanghai Composite Index, which rose by 1.1% [3][4]. - The National Healthcare Security Administration officially launched the 2025 medical insurance catalog adjustment, introducing a commercial health insurance innovative drug catalog for the first time, focusing on high-innovation and clinically valuable drugs [10]. - China has imposed restrictions on the procurement of medical devices from the EU, affecting government purchases exceeding 45 million RMB [10]. - Merck announced a $10 billion acquisition of Verona Pharma, focusing on a new COPD drug, marking a significant transaction in the pharmaceutical sector [11]. Market Performance - The pharmaceutical and biotechnology index increased by 1.8%, ranking 16th among 31 sub-industries [3][4]. - The overall valuation of the pharmaceutical sector stands at 30.2 times PE for 2025E, ranking 6th among 31 primary industries [4][9]. Key Events - The adjustment of the medical insurance catalog officially commenced on July 10, 2025, with a submission period for eligible entities from July 11 to 20 [10]. - The Chinese government has taken measures to restrict the procurement of certain medical devices from the EU, impacting the competitive landscape [10]. - Merck's acquisition of Verona Pharma is a notable event, emphasizing the trend of large-scale business development transactions in the innovative drug sector [11]. Investment Analysis - The innovative drug sector has shown rapid growth in product revenue and licensing deals over the past three years, with significant business development transactions occurring this year [11]. - Companies to watch include Heng Rui Medicine, Bei Da Medicine, and WuXi AppTec, which are expected to benefit from the upcoming changes in the medical insurance catalog and the overall growth in the innovative drug market [11].