截至发稿，康希诺市值为189亿元。 每经AI快讯，康希诺（SH 688185，收盘价：76.4元）9月26日晚间发布公告称，公司第三届第二次董事 会临时会议于2025年9月26日在公司会议室以现场及通讯的方式召开。会议审议了《关于公司<2025年A 股限制性股票激励计划（草案）>及其摘要的议案》等文件。 2024年1至12月份，康希诺的营业收入构成为：生物医药占比97.47%，其他业务占比2.53%。 每经头条（nbdtoutiao）——5年增长33倍，这类新险种卖爆了，身边很多人都需要，30多家险企蜂拥而 入⋯⋯ （记者 王晓波） ...

Market Overview - The biopharmaceutical sector experienced a decline of 0.21% on September 25, with Nossland leading the drop [1] - The Shanghai Composite Index closed at 3853.3, down 0.01%, while the Shenzhen Component Index closed at 13445.9, up 0.67% [1] Stock Performance - Notable gainers in the biopharmaceutical sector included: - Aopu Mai (688293) with a closing price of 62.85, up 7.42% and a trading volume of 30,600 [1] - Rongchang Biotech (688331) closed at 108.50, up 3.43% with a trading volume of 89,200 [1] - Baipusais (301080) closed at 62.16, up 3.43% with a trading volume of 43,500 [1] - Major decliners included: - Nossland (430047) closed at 22.99, down 3.69% with a trading volume of 57,000 [2] - Wufan Biotech (301393) closed at 53.12, down 3.42% with a trading volume of 24,600 [2] - Kexing Pharmaceutical (688136) closed at 38.75, down 3.34% with a trading volume of 53,500 [2] Capital Flow - The biopharmaceutical sector saw a net outflow of 207 million yuan from institutional investors, while retail investors contributed a net inflow of 45.07 million yuan [2] - Notable capital flows included: - Rongchang Biotech (688331) with a net inflow of 1.021 billion yuan from institutional investors [3] - Junshi Biosciences (688180) with a net inflow of 35.36 million yuan from institutional investors [3] - Aopu Mai (688293) with a net inflow of 9.41 million yuan from institutional investors [3]

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" (maintained) [1] Core Insights - The industry is entering a new development phase driven by optimized procurement and innovation [3] - The raw material pharmaceutical sector is at a cyclical bottom, with companies actively transitioning to innovative drug development [5][8] - The vaccine sector is experiencing a decline in performance but is accelerating the layout of new technologies and products [6] - The medical services sector is leveraging AI technology to enhance efficiency and quality [7] Summary by Sections Raw Material Pharmaceutical Sector - The raw material pharmaceutical industry has faced a downturn for nearly four years, with prices of various products, such as sartans and heparins, reaching historical lows [5] - Revenue and net profit in the raw material pharmaceutical sector showed a downward trend in the first half of 2025 due to significant price drops in anti-infective products and increased R&D investments [5] - Companies like Huahai Pharmaceutical and Borui Pharmaceutical are focusing on innovative drug development, with several products in various clinical trial phases [5][68] Vaccine and Blood Products Sector - The vaccine industry is facing continuous performance decline due to a decrease in newborn numbers and changing competitive dynamics, although some companies are introducing new technologies and products [6] - The blood products sector is also experiencing a downturn, with revenue and net profit declining due to high inventory levels and suppressed demand from medical insurance [6][75] - The industry is expected to see increased consolidation as leading companies accelerate mergers and acquisitions [6][8] Medical Services Sector - The medical services sector's performance has declined due to DRGs and the consumption environment, but the application of AI technology is expected to enhance service quality and efficiency [7] - The core competitiveness of the medical services industry lies in acquiring and training quality doctors and hospital management [7] Investment Recommendations - The report suggests that companies in the raw material pharmaceutical sector are likely to enter a harvest period as they transition to innovative drugs [8] - The blood products sector is anticipated to accelerate consolidation, with significant mergers expected in the near future [8] - Recommended stocks include Federal Pharmaceutical, Pro Pharmaceutical, Guobang Pharmaceutical, and others, while benefiting stocks include Tianyu Co., Meinuo Pharma, and others [8]

中国经济网北京9月19日讯 康希诺(688185.SH)今日收报79.84元，跌幅2.63%。 康希诺募集资金总额为52.01亿元，扣除发行费用后，募集资金净额为49.79亿元。康希诺最终募集 资金净额较原计划多39.79亿元。康希诺2020年8月6日发布的招股说明书显示，公司计划募集资金10亿 元，分别用于"生产基地二期建设""在研疫苗开发""疫苗追溯、冷链物流体系及信息系统建设""补充流 动资金"。 康希诺上市发行费用为2.21亿元，其中保荐及承销费用2.05亿元。 中信证券投资有限公司（参与跟投的保荐机构相关公司）获配股票数量为49.60万股，占本次发行 总股数的2.00%，跟投金额为1.04亿元。 康希诺于2020年8月13日在上交所科创板上市，发行数量为2480万股，发行价格209.71元/股，保荐 机构（主承销商）为中信证券，保荐代表人为焦延延、马可；联席主承销商为中金公司，副主承销商为 渤海证券。目前该股处于破发状态。 （责任编辑：关婧） ...

中期報告 2025 2025 中期報告 | 目錄 | | --- | | 公司資料 | 02 | | --- | --- | | 財務概要 | 04 | | 管理層討論及分析 | 05 | | 其他資料 | 24 | | 獨立核數師報告 | 32 | | 簡明合併損益及其他綜合收益表 | 33 | | 簡明合併財務狀況表 | 34 | | 簡明合併權益變動表 | 36 | | 簡明合併現金流量表 | 37 | | 簡明合併財務報表附註 | 38 | | 釋義 | 63 | 02 康希諾生物股份公司 公司資料 董事會 執行董事 Xuefeng YU博 士 （董事長、首席執行官兼總經理） Shou Bai CHAO博 士 （首席運營官兼副總經理） 王靖女士 （首席商務官兼副總經理） 非執行董事 李志成先生 獨立非執行董事 桂水發先生 劉建忠先生 張耀樑先生 審計委員會 張耀樑先生 （主任委員） 桂水發先生 劉建忠先生 薪酬與考核委員會 桂水發先生 （主任委員） 張耀樑先生 Xuefeng YU博 士 提名委員會 劉建忠先生 （主任委員） 張耀樑先生 桂水發先生 李志成先生 Xuefeng YU 博 士 監 事 肖 ...

Core Viewpoint - 康希诺's stock price has shown volatility with a year-to-date increase of 33.84%, but recent trading indicates a slight decline in the short term [1][2]. Financial Performance - As of June 30, 康希诺 reported a revenue of 3.82 billion yuan for the first half of 2025, reflecting a year-on-year growth of 26.00% [2]. - The company experienced a net profit loss of 1348.54 million yuan, which is an improvement of 94.02% compared to the previous period [2]. Stock Market Activity - On September 17, 康希诺's stock price decreased by 2.07%, trading at 81.71 yuan per share with a total market capitalization of 202.19 billion yuan [1]. - The stock saw a net outflow of 616.01 million yuan in principal funds, with significant selling pressure from large orders [1]. Shareholder Information - As of June 30, 康希诺 had 17,500 shareholders, a decrease of 1.92% from the previous period [2]. - The average number of circulating shares per shareholder remained at 0 [2]. Dividend Information - 康希诺 has distributed a total of 1.98 billion yuan in dividends since its A-share listing, with no dividends paid in the last three years [3].

Core Viewpoint - The vaccine industry is experiencing a downturn, with significant revenue and profit declines among major companies, attributed to price wars, vaccine hesitancy, and intense competition [4][5][10][20]. Group 1: Industry Performance - In the first half of 2025, the overall vaccine revenue of listed companies in China decreased by 60% year-on-year, and net profit dropped by 113% [5]. - Major vaccine companies like Zhifei Biological and Wantai Biological reported their first half-year losses since going public, with net profits declining by 127% and 155% respectively [5][10]. - Only six out of 17 listed vaccine companies achieved profitability, with the highest profit being 122 million yuan from Chengda Biological [5]. Group 2: Price Wars - The price of flu vaccines has significantly dropped, with some prices reaching as low as 5.5 yuan per dose, leading to a continuous price war in the market [8][9]. - Wantai Biological's revenue from its main product, the bivalent HPV vaccine, fell by 38% to 844 million yuan, marking its first loss since listing [10]. - The price competition has also affected other vaccines, including HPV and shingles vaccines, with prices dropping dramatically in recent years [9][10][11]. Group 3: Vaccine Hesitancy - Vaccine hesitancy has become a significant issue, particularly for non-mandatory vaccines like HPV and flu vaccines, with many individuals expressing doubts about their effectiveness [13][14][15]. - The average flu vaccine coverage in China remains below 4%, significantly lower than in developed countries where it is around 50% [15]. - Factors contributing to vaccine hesitancy include dissatisfaction with COVID-19 vaccine outcomes, misinformation, and a lack of awareness regarding adult vaccinations [15][16]. Group 4: Future Outlook - Experts predict that the current downturn in the vaccine industry may last for five to ten years, with potential consolidation and elimination of weaker companies [20]. - The industry faces challenges in changing public perception and increasing adult vaccination rates, which are crucial for market expansion [20]. - The competition is expected to remain fierce, with many companies struggling to differentiate their products in a saturated market [19][20].

Core Insights - Guangzhou Industrial Investment Holding Group held its first collective investor meeting for the first half of 2025, attracting over 221,700 participants both online and offline [2] - The total market capitalization of the seven listed companies under Guangzhou Industrial Investment Group has surpassed 70 billion yuan, outperforming the market and industry averages [2] - The group has made significant technological breakthroughs in various sectors, including offshore wind power, elevator manufacturing, and battery technology, while maintaining a leading position in ESG (Environmental, Social, and Governance) initiatives [2][4] Group Performance - The seven listed companies reported improved asset ratios and development quality, effectively integrating industrial operations with capital management [4] - R&D investments included 114 million yuan by Guangri Co., with 95 new patents, and significant advancements in electric and intelligent technologies by other subsidiaries [4] - The group aims to build a world-class state-owned capital investment group, focusing on technological innovation and capital operations to enhance core competitiveness [4] Government Support - The Guangzhou Municipal Government emphasized the importance of the group in stabilizing industrial growth and promoting investment amid complex external conditions [3] - The government encourages the concentration of state capital in key industries and expects the group to leverage its market value management tools to enhance returns [3] Investor Relations - The group has been recognized for its effective investor relations management and commitment to sustainable development, aligning with the principles advocated by the China Association of Listed Companies [2] - The management's focus on respecting and rewarding investors is seen as a model for the capital market [2]

Group 1 - The real estate sector experienced significant upward movement, with companies such as Rongsheng Development, Xiangjiang Holdings, and Huali Family reaching their daily price limit [1] - Other companies that saw gains include Wolong New Energy, Shoukai Co., Zhujiang Shares, Tiandi Source, and Haitai Development [1]

Investment Rating - The industry investment rating is maintained at "Overweight" [1] Core Views - The HPV vaccine is expected to be included in the National Immunization Program, indicating a substantial expansion of the program [3][4] - The vaccine industry is currently facing performance pressure, with a focus on innovation and international expansion as long-term strategies [8][9] Industry Dynamics - The HPV vaccine will be offered for free to eligible girls, with approximately 60% of eligible girls covered by the free vaccination policy [3] - The government has initiated a comprehensive cervical cancer prevention plan, promoting HPV vaccination services [3] - The vaccine market has shown a cumulative increase of 2.42% in 2025, with a recent weekly increase of 1.04% [4][11] Market Performance - The vaccine sector's PE (ttm) is 108.78X, with a PB (lf) of 2X, indicating a slight increase in valuation metrics [7] - The vaccine industry is experiencing a supply-demand imbalance, leading to performance challenges [8][9] Investment Recommendations - Focus on companies with strong innovation capabilities and differentiated products, such as CanSino and Kanghua Biotech [9][28] - Long-term growth drivers for the vaccine industry include policy support, increasing demand due to aging populations, and technological advancements [9][26]