Group 1 - The core point of the article highlights the performance of the Huatai Fuhua Medical Service Flexible Allocation Mixed A Fund, which has shown significant returns over various time frames, including a 69.10% return over the past six months and a 65.45% return year-to-date, ranking first in its category [1] - The fund's latest net value is reported at 1.9920 yuan, reflecting a decrease of 0.75% [1] - The fund's top ten stock holdings account for a total of 68.66%, with notable investments in companies such as Heng Rui Pharmaceutical (9.90%) and Ke Lun Pharmaceutical (9.03%) [1] Group 2 - The Huatai Fuhua Medical Service Flexible Allocation Mixed A Fund was established on June 18, 2015, and as of June 30, 2025, it has a total scale of 2.915 billion yuan [1] - The fund manager, Zhang Wei, has a strong background in biomedical studies and extensive experience in the pharmaceutical sector, having held various positions in research and fund management [2]

Core Viewpoint - The company, 诺诚健华, reported a significant increase in total revenue and a substantial reduction in losses for the six months ending June 30, 2025, primarily driven by strong sales of 奥布替尼 and licensing revenue from Prolium [1][2] Financial Performance - Total revenue increased by 74.3% to RMB 730 million compared to the same period last year [1] - Revenue from 奥布替尼 rose by 52.8% from RMB 417 million to RMB 637 million, attributed to an expanded coverage and an increase in treated patients [1] - Losses decreased by 86.7% from RMB 268 million to RMB 35.6 million during the same period [1] - Cash and cash equivalents stood at approximately RMB 7.7 billion as of June 30, 2025, providing the company with a robust financial position to accelerate clinical development and invest in competitive product lines [1] Product Development and Milestones - The company achieved significant milestones in product line advancement, including the approval of 奥布替尼 for first-line treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) [2] - The combination therapy of坦昔妥单抗 and 来那度胺 was approved for adult patients with relapsed or refractory DLBCL who are not eligible for autologous stem cell transplantation (ASCT) [2] - The BCL-2 inhibitor ICP-248 (mesutoclax) entered two registrational clinical studies, and the company's proprietary ADC platform made significant breakthroughs with the first IND submission and clinical trial approval [2] Strategic Partnerships and Global Expansion - The company expanded its global footprint through strategic collaborations, including a partnership with Prolium in January 2025 to explore the global potential of a CD3×CD20 bispecific antibody [2] - The company remains committed to fostering global partnerships to enhance innovation, maximize the value of its product lines, and support long-term development [2] Commercial Execution - Strong commercial execution is evident with increased market penetration and significant revenue growth from 奥布替尼, highlighting the company's ability to translate scientific innovation into sustainable business performance [2]

Core Insights - The company reported a significant increase in total revenue, rising 74.3% to RMB 730 million for the six months ending June 30, 2025, primarily driven by strong sales of Oubatinib and licensing revenue from Prolium [1] - The loss for the period decreased by 86.7% to RMB 35.6 million, compared to a loss of RMB 268 million for the same period ending June 30, 2024 [1] - The company has a robust cash position of approximately RMB 7.7 billion as of June 30, 2025, allowing for flexible clinical development and investment in competitive product lines [1] Product Development and Milestones - The company achieved significant milestones in product line advancement, including the approval of Oubatinib for first-line treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) [2] - The combination therapy of Tanshituzumab and Lenalidomide was approved for adult patients with relapsed or refractory DLBCL who are not eligible for autologous stem cell transplantation (ASCT) [2] - The BCL-2 inhibitor ICP-248 (mesutoclax) entered two registrational clinical studies, and the company's proprietary ADC platform made significant breakthroughs with the first IND submission and clinical trial approval [2] Strategic Partnerships and Market Execution - The company expanded its global footprint through strategic collaborations, including a partnership with Prolium in January 2025 to explore the global potential of a CD3×CD20 bispecific antibody [2] - The commercial execution remains strong, with increased market penetration and substantial revenue growth for Oubatinib, highlighting the company's ability to translate scientific innovation into sustainable business performance [2]

诺诚健华(09969)发布截至2025年6月30日止6个月中期业绩，该集团取得收益人民币7.31亿元(单位下 同)，同比增加74.26%;期内经调整亏损1550.4万元，同比减少93.62%;母公司拥有人应占亏损3009.1万 元，同比减少88.51%;每股亏损0.02元。 公告称，收入增加主要是由于奥布替尼销量增长强劲及来自Prolium的许可收益。奥布替尼的收益由截 至2024年6月30日止6个月的4.17亿元增加52.8%至截至2025年6月30日止6个月的 6.37亿元，是由于覆盖 范围拓宽及治疗患者增加所致。 ...

公告称，收入增加主要是由于奥布替尼销量增长强劲及来自Prolium的许可收益。奥布替尼的收益由截 至2024年6月30日止6个月的4.17亿元增加52.8%至截至2025年6月30日止6个月的 6.37亿元，是由于覆盖 范围拓宽及治疗患者增加所致。 智通财经APP讯，诺诚健华(09969)发布截至2025年6月30日止6个月中期业绩，该集团取得收益人民币 7.31亿元(单位下同)，同比增加74.26%;期内经调整亏损1550.4万元，同比减少93.62%;母公司拥有人应占 亏损3009.1万元，同比减少88.51%;每股亏损0.02元。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不就因本公告 全部或任何部分內容而產生或因依賴該等內容而引致的任何損失承擔任何責任。 InnoCare Pharma Limited 諾誠健華醫藥有限公司 （ 於 開 曼 群 島 註 冊 成 立 的 有 限 公 司 ） （股份代號：9969） 截至2025年6月30日止六個月中期業績公告 諾誠健華醫藥有限公司（「本公司」，連同其附屬公司統稱「本集團」）董事（「董 事」）會（「董事會」）欣然公佈，本集團截至2025年6月30日止六個月（「報告期」） 之未經審核綜合業績連同截至2024年6月30日止六個月之比較數字。 在本公告內，「我們」及「我們的」均指本公司，如文義另有所指，則指本集團。 本公告所載若干金額及百分比數字已約整或已四捨五入至小數點後一位或兩 位數（如適用）。任何表格、圖表或其他地方所示總額與所列數額總和如有任何 差異乃因四捨五入所致。除另有界定外，本公告所使用詞彙與招股章程已界定 者具有相同涵義。 – 1 – | 財務摘要 | | | | --- | --- | --- | ...

Group 1 - The A-share market has seen a decline in several biopharmaceutical stocks, with notable drops including Nanmo Bio down 9%, Shanghai Yizhong down over 7%, and Nuocheng Jianhua down over 5% [1] - Other companies experiencing declines include Yangguang Nuohuo and Guangshengtang down over 4%, and Haichuang Pharmaceutical, Baicheng Pharmaceutical, Yaokang Bio, and Qianyan Bio down over 3% [1] Group 2 - Specific stock performance includes: - Nanmo Bio (688265) down 9.06% with a market cap of 5.027 billion and a year-to-date increase of 178.89% - Shanghai Yizhong (688091) down 7.23% with a market cap of 15.7 billion and a year-to-date increase of 89.98% - Nuocheng Jianhua (688428) down 5.25% with a market cap of 56 billion and a year-to-date increase of 158.55% - Yangguang Nuohuo (688621) down 4.57% with a market cap of 8.727 billion and a year-to-date increase of 107.29% - Guangshengtang (300436) down 4.26% with a market cap of 26.3 billion and a year-to-date increase of 404.68% [2]

Group 1 - A-share market sees weakness in certain biopharmaceutical stocks, with notable declines in several companies [1] - Nanmo Bio falls by 9%, while Shanghai Yizhong drops over 7% [1] - Nocare Health declines by over 5%, and Sunshine Nuohe and Guangshengtang both decrease by over 4% [1] - Haichuang Pharmaceutical, Baicheng Pharmaceutical, Yaokang Bio, and Qianyan Bio all experience declines of over 3% [1]

Core Insights - The core viewpoint of the news is the performance and holdings of the E Fund Healthcare Industry Mixed A Fund, highlighting its recent returns and key stock positions [1]. Fund Performance - The latest net value of E Fund Healthcare Industry Mixed A is 4.7830 yuan [1]. - The fund has achieved a weekly return of 3.57% [1]. - Over the past three months, the fund's return is 44.07% [1]. - Year-to-date, the fund has generated a return of 57.03% [1]. Fund Details - E Fund Healthcare Industry Mixed A was established on January 28, 2011 [1]. - As of June 30, 2025, the fund's total assets amount to 3.944 billion yuan [1]. - The fund is managed by Yang Zhenshao [1]. Top Holdings - The top ten stock holdings of the fund include: - Heng Rui Medicine - Hotgen Biotech - Xinlitai - BeiGene-U - Haizhi Science - Nocren Health-U - Yipinhong - Kelun Pharmaceutical - Shutaishen - Baili Tianheng [1]. - The combined proportion of the top ten holdings is 58.14% [1].

Core Viewpoint - The emergence of "technical managers" as a bridge between scientific research and market needs is transforming the employment landscape in the context of technological innovation and entrepreneurship [2][8]. Group 1: Industry Trends - Technology-driven and knowledge-intensive entrepreneurship has become a significant trend in recent years, with many researchers aspiring to transition from PI (Principal Investigator) to IP (Innovation Project) and eventually to IPO (Initial Public Offering) [2]. - The formal recognition of "technical managers" as a profession in the national occupational classification system in 2022 marks a shift towards professionalization and specialization in this role [2][8]. Group 2: Regional Developments - In July 2023, Shenzhen recognized its first batch of 154 "senior professional technical managers" from 133 different institutions, indicating a growing emphasis on this role in the region [3][15]. - The establishment of the first "Technical Manager Academy" at Shenzhen Technology University aims to cultivate a new generation of technical managers, with a focus on interdisciplinary education [14]. Group 3: Challenges in Scientific Entrepreneurship - Many scientists face challenges in entrepreneurship due to a lack of market insight, often focusing solely on technological advancements rather than market needs, leading to high failure rates in startups [5][6]. - The need for effective collaboration between scientists and technical managers is emphasized, as the latter can help translate scientific innovations into commercially viable products [8][11]. Group 4: Educational Initiatives - Several universities, including Tsinghua University and Shanghai Jiao Tong University, have begun offering specialized master's programs in technology transfer to address the shortage of qualified technical managers [14]. - The "Five Forces Model" proposed for training technical managers includes skills in technology, market insight, finance, law, and management, highlighting the multifaceted nature of the role [9][10]. Group 5: Future Outlook - The goal set by the Ministry of Science and Technology is to exceed 30,000 technical managers nationwide by 2025, reflecting the increasing importance of this role in facilitating technology transfer and commercialization [9]. - Shenzhen's dual approach of professional recognition and educational development is expected to provide a model for enhancing technology transfer capabilities across the country [15].