一、召开会议的基本情况 海南海药股份有限公司 关于召开 2025 年第三次临时股东大会的通知 1、股东大会届次：本次股东大会为 2025 年第三次临时股东大会 2、股东大会的召集人：公司第十一届董事会。公司第十一届董事会第二十六次会 议于2025年7月7日审议通过了《关于召开2025 年第三次临时股东大会的议案》。 3、会议召开的合法、合规性：本次股东大会的召开程序符合有关法律、行政法规、 部门规章、规范性文件和《公司章程》等的规定。 4、会议召开的日期、时间： 证券代码：000566 证券简称：海南海药 公告编号：2025-046 本公司及董事会全体成员保证信息披露的内容真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 现场会议召开时间：2025年7月23日下午15：00 网络投票时间：2025年7月23日 （1）通过深圳证券交易所交易系统进行网络投票的时间为：2025年7月23日 9：15～9：25，9：30～11：30和13：00～15：00； （2）通过深圳证券交易所互联网投票系统投票的时间为：2025年7月23日9:15～ 15:00期间的任意时间。 5、会议的召开方式：本次股东大会采用现场 ...

证券代码：000566 证券简称：海南海药 公告编号：2025-044 海南海药股份有限公司 第十一届董事会第二十六次会议决议公告 本公司董事会及全体董事保证公告内容的真实、准确和完整，没有虚假记载、 误导性陈述或者重大遗漏。 海南海药股份有限公司（以下简称"公司"） 第十一届董事会第二十六次 会议于 2025 年 7 月 7 日以通讯表决方式召开。本次会议于 2025 年 7 月 5 日以 电子邮件等方式送达了会议通知及文件。会议应到董事 9 人，实到董事 8 人，缺 额 1 人。会议的召开符合《公司法》和《公司章程》有关规定。经与会董事认真 审议，表决通过了如下议案： 一、审议通过《关于接受关联方财务资助的议案》 根据公司资金需求和未来发展战略需要，公司拟接受控股股东海南华同实业 有限公司之控股股东新兴际华医药控股有限公司向公司提供的财务资助，本次财 务资助金额最高不超过人民币 5 亿元，财务资助期限为三年，在上述借款额度 内，资金可以滚动使用。本次借款的资金主要用于海南海药主营业务及补充流动 资金。 根据《深圳证券交易所股票上市规则》相关规定，本次交易构成关联交易， 王建平先生、封多佳先生、田勇先生系关 ...

Investment Rating - The report suggests a positive outlook for the epilepsy drug industry, highlighting potential breakthroughs in new drug targets and a rich pipeline of anti-seizure medications (ASMs) under development [3][59]. Core Insights - Epilepsy is a common neurological disorder with a significant patient population, estimated at 51.7 million globally and approximately 9 million in China, with 500,000 to 600,000 active cases annually [3][59]. - The mechanisms of epilepsy are complex, leading to a substantial treatment gap, as about 30% of patients do not achieve effective seizure control with current therapies [3][59]. - The research and development pipeline for ASMs is active, focusing on precision medicine and multi-target mechanisms, with promising candidates like XEN1101, Bexicaserin, and Zorevunersen showing advanced clinical progress [3][59]. Summary by Sections Section 1: Epilepsy as a Common Neurological Disorder - Epilepsy affects a large number of individuals, with a global prevalence rate of 658 per 100,000 people and a 10.8% increase in prevalence from 1990 to 2021 [8]. - In China, the estimated prevalence is about 7.0 per 1,000, with 40,000 new cases each year, making it the second most common neurological condition after headaches [8][29]. Section 2: ASMs as the Current Treatment of Choice - ASMs are the primary treatment for epilepsy, but they have limited efficacy and significant side effects, which continue to impact patient outcomes [20][29]. - The market for epilepsy treatment is projected to grow from approximately $8.6 billion in 2024 to $13.9 billion by 2034, with a CAGR of 5.1% [24][29]. Section 3: Active R&D Pipeline for ASMs - The focus of ASM development is on precision treatment and individualized medication, with over 200 projects currently disclosed, many in advanced clinical stages [33][36]. - Notable candidates include XEN1101, a potassium channel opener, which has shown promising results in reducing seizure frequency in clinical trials [39][44]. Section 4: Valuation of Key Companies - The report includes a valuation table for key companies in the epilepsy drug market, highlighting their market capitalization and projected revenues [61]. - Companies such as Hainan Haiyao and Lizhu Group are noted for their active pipelines and potential for growth in the epilepsy treatment sector [61].

Core Viewpoint - Yunnan International Trust Co., Ltd. - Ju Li No. 36 Single Fund Trust has completed a share reduction that has triggered a change in shareholding exceeding 1% for Hainan Haiyao Co., Ltd. [1][2] Shareholding Changes - As of June 11, 2025, Yunnan International Trust held 9,164.28 million shares, representing 7.0638% of the total share capital, which decreased to 6,829.55 million shares, or 5.2642% after the reduction [2][3] - The reduction was executed through block trading, with a total of 3,892.09 million shares reduced, accounting for 3% of the company's total share capital [3][7] Reduction Details - The reduction included 1,297.36 million shares sold at an average price of 7.2093 CNY per share through centralized bidding on June 4, 2025, and 2,594.73 million shares sold at an average price of 6.43 CNY per share through block trading from June 4 to June 6, 2025 [3][6] - The total shares reduced did not exceed the planned reduction of 38,920,953 shares, which was 3% of the total share capital [3][7] Compliance and Regulations - Yunnan International Trust confirmed that the share reduction complied with relevant laws and regulations, and there were no violations of shareholding lock-up commitments [6][7]

证券代码：000566 证券简称：海南海药 公告编号：2025-043 海南海药股份有限公司 关于持股 5%以上股东股份变动触及 1%整数倍暨减持完成的公告 公司持股 5%以上股东云南国际信托有限公司－聚利 36 号单一资金信托保证 向本公司提供的信息内容真实、准确、完整，没有虚假记载、误导性陈述或重大 遗漏。 本公司及董事会全体成员保证公告内容与信息披露义务人提供的信息一致。 1 | 合 计 | | | | | | --- | --- | --- | --- | --- | | 本次权益变动方式 | | 通过证券交易所的集中竞价交易 | □ | | | （可多选） | | 通过证券交易所的大宗交易 | √ | | | | 其他 | | □（请注明） | | | 3. 本次变动前后，投资者及其一致行动人拥有上市公司权益的股份情况 | | | | | | 股份性质 | 本次触及 | 1%整数倍变动前持 | 本次触及 | 1%整数倍变动后持有 | | | | 有股份 | | 股份 | | 云南国际信托有限公 | | 占当时总股本 | | 占目前总股本 | | 司-聚利 36 号单一资 金信托 | 股数(万股) | ...

证券代码：000566 证券简称：海南海药 公告编号：2025-042 海南海药股份有限公司 关于持股 5%以上股东股份变动超过 1%的公告 公司持股 5%以上股东云南国际信托有限公司－聚利 36 号单一资金信托保证 向本公司提供的信息内容真实、准确、完整，没有虚假记载、误导性陈述或重大 遗漏。 本公司及董事会全体成员保证公告内容与信息披露义务人提供的信息一致。 海南海药股份有限公司（以下简称"公司"或"海南海药"）近日收到公司 5%以上股东云南国际信托有限公司－聚利 36 号单一资金信托（简称"云南国际 信托"）《股份变动情况告知函》。现将相关情况公告如下： 1.基本情况 信息披露义务人 云南国际信托有限公司-聚利 36 号单一资金信托 住所 云南省昆明市南屏街（云南国托大厦） 权益变动时间 2025 年 6 月 4 日 股票简称 海南海药 股票代码 000566 变动类型（可多 选） 增加□ 减少√ 一致行动人 有√ 无 是否为第一大股东或实际控制人 是□ 否√ 2.本次权益变动情况 股份种类（A 股、B 股 等） 减持股数（万股） 减持比例（%） A 股普通股（无限售条件 股份） 1,557.36 1. ...

Group 1: New Consumption Stocks - The new consumption stocks, including Pop Mart, Lao Pu Gold, and Mixue Group, experienced significant declines, with Lao Pu Gold down 9%, Mixue Group down 7%, and Pop Mart down 1% [3][6] - These stocks had previously seen massive gains, with Lao Pu Gold increasing by 23 times and Pop Mart rising from 8.6 HKD to 256 HKD over two and a half years, leading to high market expectations [6] - Current valuations are concerning, with Pop Mart's P/E ratio at 96, Lao Pu Gold at 99, and Mixue Group at 46, indicating potential overvaluation [6][9] Group 2: Pharmaceutical Sector - The pharmaceutical sector has seen a notable pullback, with various segments such as CRO, medical aesthetics, generic drugs, and innovative drugs experiencing significant declines [10] - Individual stocks like Jinkai Biotechnology fell by 9.79%, and other popular stocks like Qianhong Pharmaceutical and Kexing Pharmaceutical also showed marked declines [11][13] Group 3: Sports Industry - The "Su Super League" has gained immense popularity, driving related sports stocks in the A-share market to surge, with Jinling Sports hitting a 20% limit up for three consecutive days, totaling a 104% increase over five trading days [19] - The league's matches have seen high attendance, with some matches exceeding attendance levels of the Chinese Super League, indicating strong market interest [19][20] Group 4: Military Equipment Sector - The military equipment sector is leading the market, with several companies disclosing restructuring progress related to the China Ordnance Equipment Group, resulting in stock price increases for companies like Dong'an Power and Huasheng Technology [22][23] - The restructuring is part of a broader initiative approved by the State Council, which is expected to enhance operational efficiency and market positioning for the involved companies [22]

各位老铁，这里是帮主郑重的收评时间。今天这市场啊，就像端午节包粽子——外面看着热闹，里头藏着门道。沪指涨了0.43%，深成指和创业板指也跟着 回暖，但仔细看，近3400只个股上涨的背后，资金明显在玩"抓大放小"的游戏。咱们今天就拆解拆解，这反弹里到底藏着啥玄机。 先说指数反弹的"底气"从哪来 今天市场能反弹，跟政策预期升温脱不了干系。最近市场对稳增长政策的期待越来越强，加上外资回流的迹象，让不少观望资金试探性进场。不过成交量只 放量了4个亿，说明大家还是有点犹豫，就像煮粽子时火候不够，米粒还没完全开花。这时候得盯紧北向资金的动向，它们要是持续加仓，反弹才有持续 性。 创新药板块爆发：政策松绑+研发提速的双击 创新药今天集体嗨了，舒泰神、海南海药这些票涨停，可不是偶然。去年开始，创新药审批流程大幅缩短，加上老龄化带来的刚性需求，这个板块就像压紧 的弹簧。我跟药企研发总监聊过，现在一款创新药从立项到上市周期比三年前快了30%，这就好比做菜从慢炖变成高压锅，效率上去了，利润空间自然就打 开了。不过要提醒老铁们，别光看涨停就追高，得看企业真正的研发管线厚度，有些票可能只是蹭概念。 银行股稳如泰山：高股息成避风港 沪农 ...

Core Viewpoint - The cell immunotherapy sector has shown significant growth, with a 3.87% increase, ranking second among concept sectors, driven by strong performances from several stocks [1][2]. Group 1: Sector Performance - As of June 3, the cell immunotherapy concept saw 51 stocks rise, with notable gainers including Shutaishen and Guanhao Biological, both reaching a 20% limit up [1]. - Other top performers in the sector included Hainan Haiyao, Rui Zhi Pharmaceutical, and Zuo Li Pharmaceutical, with increases of 9.97%, 13.15%, and 10.66% respectively [1][2]. - Conversely, stocks like Xue Rong Biological, *ST Biological, and Fosun Pharmaceutical experienced declines of 1.76%, 1.14%, and 0.39% respectively [1]. Group 2: Capital Flow - The cell immunotherapy sector attracted a net inflow of 269 million yuan, with 34 stocks receiving significant capital inflows [2]. - Leading the net inflow was Huahai Pharmaceutical, which saw 266 million yuan enter, followed by Guanhao Biological and Hainan Haiyao with inflows of 159 million yuan and 64.85 million yuan respectively [2][3]. - The highest net inflow ratios were recorded for ST Zhongzhu, Hainan Haiyao, and Huahai Pharmaceutical, at 15.16%, 13.79%, and 12.53% respectively [3]. Group 3: Stock Specifics - Huahai Pharmaceutical had a daily increase of 7.63% with a turnover rate of 7.71% and a net capital flow of 266.08 million yuan [3]. - Guanhao Biological surged by 19.97% with a turnover rate of 28.68% and a net capital flow of 159.24 million yuan [3]. - Hainan Haiyao also performed well, increasing by 9.97% with a turnover rate of 6.18% and a net capital flow of 64.85 million yuan [3].

一、股票交易异常波动的情况介绍 海南海药股份有限公司（以下简称"公司"）（股票简称：海南海药，股票 代码：000566）股票于 2025 年 5 月 29 日至 6 月 3 日连续 3 个交易日收盘价 格涨幅偏离值累计达到 20%以上。根据深圳证券交易所（以下简称"深交所"） 的有关规定，属于股票交易异常波动情况。 二、公司关注并核实的相关情况 证券代码：000566 证券简称：海南海药 公告编号：2025-041 海南海药股份有限公司 关于股票交易异常波动公告 本公司董事会及全体董事保证公告内容的真实、准确和完整，没有虚假记载、 误导性陈述或者重大遗漏。 本公司董事会确认，本公司目前没有任何根据深交所《股票上市规则》等有 关规定应予以披露而未披露的事项或与该事项有关的筹划、商谈、意向、协议等； 董事会也未获悉本公司有根据深交所《股票上市规则》等有关规定应予以披露而 未披露的、对本公司股票及其衍生品种交易价格产生较大影响的信息；公司前期 披露的信息不存在需要更正、补充之处。 四、 风险提示 1 针对公司股票交易异常波动情况，公司对有关事项进行了核查，并询问了公 司控股股东和实际控制人，现将相关情况说明如下： ...