Group 1 - The Magnificent 7 index of major US tech stocks fell by 0.58%, closing at 182.42 points [1] - Meta Platforms experienced a decline of 2.46%, while Tesla dropped by 1.35%, and Apple decreased by 1.3% [1] - Amazon and Nvidia also saw declines of 0.76% and 0.70% respectively, while Microsoft slightly increased by 0.01% and Google A rose by 1.65% [1] Group 2 - Eli Lilly's stock fell by 5.59%, closing at $762.95, with a trading volume of 7.07 million shares [2] - Meta's stock price was $700.00, down by 2.46%, with a market capitalization of $1.76 trillion, reflecting a 19.75% increase [2] - Tesla's stock closed at $321.20, down 1.35%, with a market cap of $1.04 trillion, showing a decrease of 20.46% [2] - Apple's stock price was $211.27, down 1.30%, with a market cap of $3.16 trillion, down 15.43% [2] - Berkshire Hathaway B shares fell by 1.07%, closing at $476.56, with a market cap of $1.03 trillion, up 5.14% [2] - Amazon's stock closed at $231.01, down 0.76%, with a market cap of $2.45 trillion, up 5.30% [2] - Nvidia's stock price was $175.51, down 0.70%, with a market cap of $4.28 trillion, reflecting a 30.72% increase [2] - AMD's stock rose by 2.18%, closing at $177.44, with a market cap of $287.70 billion, up 46.90% [2]

8月7日，礼来将于(美东)盘前披露2025财年中报（数据来源于纳斯达克官网，预计披露日期为美国当地 时间，实际披露日期以公司公告为准）。 7月29日，礼来(LLY)开盘下跌5.56%，截至21:31，报763.201美元/股，成交4.65亿美元，总市值7233.13 亿美元。 财务数据显示，截至2025年03月31日，礼来收入总额127.28亿美元，同比增长45.17%；归母净利润 27.59亿美元，同比增长23.02%。 大事提醒： 资料显示，礼来公司("礼来")是一家全球医疗保健领先公司,将关怀与发现结合起来,为全世界的人们提 供更好的生活。礼来成立于一个多世纪前,由一位致力于创造满足实际需求的高品质药物的人创立。 在 全球范围内,礼来的员工致力于为需要的人发现并带来改变生活的药物,提高对疾病的了解和管理,并通过 慈善事业和志愿服务回馈社区。 本文源自：金融界 作者：行情君 ...

Market Overview - US stock indices opened slightly higher, with the Dow Jones up 0.02%, Nasdaq up 0.5%, and S&P 500 up 0.22% [1] - European markets showed broad gains, with the UK FTSE 100 up 0.74%, France's CAC40 up 1.3%, Germany's DAX up 1.32%, and Italy's FTSE MIB up 1.53% [2] Company Performance - Major tech stocks mostly rose, with Broadcom up over 2%, while Nvidia, Microsoft, Apple, Amazon, Meta, and Google A saw slight increases; however, Tesla dropped over 1% [3] - Novo Nordisk's stock plummeted over 21% after the company lowered its 2025 outlook [4] Novo Nordisk's Financial Guidance - Novo Nordisk revised its sales growth forecast for the year to 8% to 14%, down from the previous estimate of 13% to 21%; operating profit growth is now expected to be 10% to 16%, reduced from 21% to 24% [6] - The company cited competition for its weight loss drug Wegovy and the presence of cheaper generic versions as reasons for the lowered expectations [6] - Novo Nordisk plans to combat generic competition through legal means and invest in direct marketing to patients [6] Leadership Changes - Novo Nordisk announced the appointment of Maziar Mike Doustdar as the new CEO, replacing Lars Fruergaard Jorgensen, who was unexpectedly removed in May [7] - The company aims to recover from a series of setbacks and has entered a new contract with CVS Health Corp to boost Wegovy sales, despite facing strong competition from Eli Lilly's Zepbound [7] German Public Debt - Germany's total public debt exceeded €2.5 trillion, with a per capita debt of €30,000, marking a historical high [11] - The increase in public debt is primarily attributed to local governments, which saw a 10.3% rise in debt compared to 2023 [11]

礼来指出，虽然无进展生存期(PFS)这一次要终点的数据尚未成熟，但已显示出有利于吡妥布替尼的趋 势。这家总部位于印第安纳州的制药巨头表示，后续分析将进一步验证PFS优势。在安全性方面， Jaypirca的表现与既往研究结果一致。公司计划在今年晚些时候的医学会议上公布详细数据。 目前，Jaypirca与Imbruvica均是美国FDA批准的口服靶向药物，获批适应症包括CLL和SLL等血液系统 恶性肿瘤。 这项名为BRUIN CLL-314的三期研究直接比较了Jaypirca(吡妥布替尼)与Imbruvica(伊布替尼)在初诊或未 接受过BTK抑制剂治疗的CLL/SLL患者中的疗效。根据公布的顶线数据，吡妥布替尼在总体缓解率 (ORR)方面展现出统计学优势，无论是针对预先治疗组还是意向治疗人群，均达到非劣效性主要终点。 礼来(LLY.US)周二宣布，其经美国食品药品监督管理局(FDA)批准的布鲁顿酪氨酸激酶抑制剂Jaypirca在 针对慢性淋巴细胞白血病(CLL)或小淋巴细胞淋巴瘤(SLL)患者的三期头对头临床试验中，达到了主要研 究终点，成功挑战了强生(JNJ.US)与艾伯维(ABBV.US)的同类重磅药物Im ...

Group 1 - The healthcare sector in the US stock market experienced a collective decline [1] - Novo Nordisk saw a drop of over 19% [1] - Merck declined by more than 8% [1] - Eli Lilly fell by over 5% [1]

礼来指出，虽然无进展生存期(PFS)这一次要终点的数据尚未成熟，但已显示出有利于吡妥布替尼的趋 势。这家总部位于印第安纳州的制药巨头表示，后续分析将进一步验证PFS优势。在安全性方面， Jaypirca的表现与既往研究结果一致。公司计划在今年晚些时候的医学会议上公布详细数据。 智通财经APP获悉，礼来(LLY.US)周二宣布，其经美国食品药品监督管理局(FDA)批准的布鲁顿酪氨酸 激酶抑制剂Jaypirca在针对慢性淋巴细胞白血病(CLL)或小淋巴细胞淋巴瘤(SLL)患者的三期头对头临床 试验中，达到了主要研究终点，成功挑战了强生(JNJ.US)与艾伯维(ABBV.US)的同类重磅药物 Imbruvica。 目前，Jaypirca与Imbruvica均是美国FDA批准的口服靶向药物，获批适应症包括CLL和SLL等血液系统 恶性肿瘤。 这项名为BRUIN CLL-314的三期研究直接比较了Jaypirca(吡妥布替尼)与Imbruvica(伊布替尼)在初诊或未 接受过BTK抑制剂治疗的CLL/SLL患者中的疗效。根据公布的顶线数据，吡妥布替尼在总体缓解率 (ORR)方面展现出统计学优势，无论是针对预先治疗组还是 ...

Core Viewpoint - Novo Nordisk's stock price plummeted over 20% following the announcement of a new CEO and a downward revision of its annual performance expectations, primarily due to weak growth projections for its weight loss drug Wegovy in the U.S. market [1][5]. Group 1: Performance Revision - The company lowered its sales growth forecast for the year to 8% to 14%, down from the previous target of 13% to 21% [4]. - Operating profit growth expectations were also reduced to 10% to 16%, compared to earlier projections of 21% and 24% [4]. - This marks the second adjustment of the company's performance outlook for 2025, following a disappointing first-quarter sales report earlier this year [7]. Group 2: Competitive Landscape - Novo Nordisk faces increasing competition in the obesity market, particularly from Eli Lilly's drug Zepbound, which is impacting Wegovy's market share [5]. - The presence of cheaper generic versions of Wegovy in the U.S. market is also a significant factor contributing to the company's revised outlook [5][6]. - The company plans to combat the competition from generics through legal actions and by investing in direct-to-patient marketing efforts [5]. Group 3: Leadership Changes - Maziar Mike Doustdar has been appointed as the new CEO, replacing Lars Fruergaard Jørgensen, who was unexpectedly removed in May [4]. - The leadership change is part of the company's strategy to regroup after a series of setbacks [5].

智通财经APP获悉，在减肥药销量增速意外下滑导致营业利润预警，以及公司市值瞬间蒸发逾900亿美元后，总部位于丹麦的医药巨头诺和诺德公司(Novo Nordisk A/S)将其国际业务负责人提拔为新任的首席执行官。 在这家丹麦制药商面临减肥药市场最强竞争对手——美国医药巨头礼来公司(LLY.US)奋起直追之际，拥有三十余年公司经营经验的内部老兵马齐亚尔·迈克· 杜斯塔(Maziar Mike Doustdar)将肩负扭转减肥药市场份额不断萎缩局面的重任。诺和诺德最新公告显示，旗下曾有着"减肥神药"称号的重磅减肥药物Wegovy 销售额增速变得愈发疲弱且比市场预期增长更加疲软，导致整体利润预期被意外大幅削减，这也意味着该公司在减肥药市场的份额正不断被礼来公司旗下减 肥药替尔泊肽(商品名Zepbound)蚕食。 就在此最新的人事任命公告公布前，诺和诺德周二在一份业绩预告中意外下调了财务预测，按固定汇率计算，该公司预计今年销售额将仅仅增长8%至 14%，营业利润预计增长10%至16%，此前该公司给出的预期最高分别为21%和24%。 受业绩大幅下调带来的冲击，诺和诺德股价在欧洲哥本哈根股市一度暴跌30%，该公司总市值一 ...

与单纯增加胰岛素剂量相比，联合使用替尔泊肽可显著改善血糖控制、减少胰岛素用量、降低体重，且不增加低血糖风险，为胰岛素治疗效果不佳的患者提 供了更优的治疗选择。 对于新增联合疗法适应症的获批，北京医院国家老年医学中心内分泌科主任郭立新教授表示："在研究中，替尔泊肽在既往胰岛素治疗的中国2型糖尿病患者 中，与安慰剂相比，在血糖控制和体重减轻方面展现出具有临床意义的显著改善，且未增加低血糖风险。" 复旦大学附属中山医院内分泌科主任李小英教授此前告诉第一财经记者，GLP-1药物联合胰岛素控制糖尿病是临床上正在探索的一个具有潜力的方向。 胰岛素为何不可或缺？ 7月28日，礼来公司的GLP-1类药物替尔泊肽注射液（商品名：穆达峰）又添新增适应症——联合胰岛素治疗，用于在饮食控制和运动基础上，改善成人2型 糖尿病（T2DM）患者的血糖控制。 此前，替尔泊肽已经在中国获批三项适应症，包括用于成人2型糖尿病的血糖控制，长期体重管理以及阻塞性睡眠呼吸暂停。 在我国，针对糖尿病的治疗，胰岛素的使用率相对较高，但患者整体血糖控制率仍不理想，且胰岛素治疗常伴随低血糖风险及体重增加等不良反应。 与单纯增加胰岛素剂量相比，联合使用替尔泊肽 ...

礼来(LLY.N)盘前下跌2.6%，此前竞争对手诺和诺德下调了2025年的销售增长和营业利润预期。 ...