Core Insights - In September, the A-share market continued to rise, particularly driven by technology stocks, with the ChiNext Index increasing by over 12% [1] - Among 1,038 ordinary equity funds, 815 funds achieved positive performance in September, representing 78% of the total [1] - The top five funds with gains exceeding 30% were all managed by Harvest Fund, highlighting strong performance in the new energy and clean energy sectors [1] Fund Performance - The top-performing funds included Harvest New Energy New Materials Stock A and C, Harvest Intelligent Automotive Stock, and Harvest Clean Energy Stock, with gains ranging from 30.20% to 31.28% [1] - The management team for Harvest New Energy New Materials Stock consists of experienced managers Yao Zhipeng and Xiong Yuzhou, who have been with Harvest Fund for several years [1] Top Holdings - The top ten holdings of Harvest New Energy New Materials Stock include major companies such as CATL, Putailai, and Yiwei Lithium Energy, most of which saw significant increases in September [2] - Harvest Intelligent Automotive Stock has a similar portfolio to Harvest New Energy New Materials Stock, indicating a focused investment strategy in lithium battery materials [3] - Other funds like Manulife New Energy Stock and Eimi Low Carbon Economy Stock also reported gains of over 25%, with a focus on new energy and semiconductor sectors [3] Sector Analysis - The clean energy sector, particularly companies involved in lithium battery materials, has shown strong performance, with funds like Harvest Clean Energy Stock and others heavily invested in this area [4] - The overall performance of ordinary equity funds was positive, with only 22 funds experiencing a decline of more than 5% in September [4] - Funds focused on the healthcare sector, such as Red Soil Innovation Medical Health Stock and Golden Eagle Medical Health Stock, faced declines, indicating sector-specific challenges [5]

Investment Rating - The report assigns a "Buy" rating for the stock, indicating a positive outlook for the company's performance [1][7]. Core Insights - The company reported a stable revenue of 4.36 billion yuan for the first half of 2025, with a net profit of 1.36 billion yuan, reflecting a year-on-year increase of 24.6% [4][5]. - The core products and subsidiary revenues are performing steadily, with significant contributions from various product lines [5]. - The licensing agreement for the 707 product with Pfizer is expected to enhance profits and reduce risks associated with global market expansion [6][7]. Company Overview - Latest closing price: HKD 30.94 - Total shares: 2.432 billion, with a market capitalization of HKD 75.2 billion - 52-week high/low: HKD 36.80 / HKD 5.43 - Debt-to-asset ratio: 25.51% - Price-to-earnings ratio: 27.4 [3]. Financial Projections - Revenue projections for 2024A, 2025E, 2026E, and 2027E are 9.108 billion, 19.723 billion, 10.840 billion, and 12.075 billion yuan respectively, with growth rates of 17%, 117%, -45%, and 11% [9]. - The net profit attributable to the parent company is projected to be 2.090 billion, 9.693 billion, 2.405 billion, and 2.762 billion yuan for the same years, with growth rates of 35%, 364%, -75%, and 15% [9]. - The expected earnings per share (EPS) for 2025 is 3.99 yuan, with a corresponding price-to-earnings ratio of 6.96 [9]. Product Development and Market Potential - The 707 product, a dual antibody targeting PD-1/VEGF, has shown promising clinical data and is expected to be a cornerstone in global oncology treatment [6][7]. - The product has received breakthrough therapy designation in China and is undergoing multiple clinical trials for various cancers [7].

Core Viewpoint - Shanxi Securities initiates a "Buy-B" rating for 3SBio (01530), projecting revenues of 17.456 billion, 10.746 billion, and 11.335 billion yuan for 2025-2027, with net profits of 8.289 billion, 2.860 billion, and 3.163 billion yuan respectively, and PE ratios of 8.1, 23.4, and 21.2 [1] Group 1 - The SSGJ-707 is considered a potential cornerstone drug for oncology, with the global PD-(L)1 monoclonal antibody market expected to reach 99 billion dollars by 2029 [1] - SSGJ-707, a tetravalent PD-1/VEGF bispecific antibody, shows enhanced binding affinity to PD-1 by 100 times in the presence of VEGF, and its unique IgG4 Fc design aims to reduce immune-related side effects [1] - Clinical efficacy and safety of SSGJ-707 are outstanding, particularly in non-small cell lung cancer (NSCLC) and colorectal cancer (CRC), with a 23.5% rate of grade 3 or higher treatment-related adverse events (TRAEs) and a 2.9% discontinuation rate due to TRAEs [1] Group 2 - SSGJ-707 demonstrates breakthrough overall response rates (ORR) in first-line NSCLC II clinical trials, achieving a cORR of 64.7% in low PD-L1 expressing NSCLC, with ORRs of 62% and 77% in PD-L1 TPS 1-49% and ≥50% respectively [2] - In first-line NSCLC without EGFR/ALK mutations, SSGJ-707 combined with chemotherapy shows ORRs of 81.3% for squamous NSCLC and 58.3% for non-squamous NSCLC [2] Group 3 - SSGJ-707 also exhibits breakthrough ORR efficacy in later-line CRC II clinical trials, achieving an ORR of 33.3% in third-line RAS mutant or BRAFV600E mutant non-MSI-H/pMMR colorectal cancer [3]

Investment Rating - The report maintains an "Overweight" rating for the industry [3] Core Viewpoints - The report continues to recommend innovative pharmaceuticals and medical devices along the industry chain [2][7] - The performance of the pharmaceutical sector in September 2025 was weaker than the broader market, with the SW Pharmaceutical Biotech index declining by 1.7% compared to a 0.6% increase in the Shanghai Composite Index [16][22] - The report highlights that the medical service sub-sector performed relatively well, increasing by 1.8%, while medical devices and chemical preparations saw slight declines [22] Summary by Sections - **Investment Recommendations**: The report includes a list of A-share stocks with an "Overweight" rating, including Heng Rui Pharmaceutical, Kelun Pharmaceutical, East China Pharmaceutical, Changchun High-tech, Enhua Pharmaceutical, WuXi AppTec, Tigermed, Lepu Medical, United Imaging Healthcare, and Huatai Medical [7][9] - **Performance Analysis**: The report notes that the monthly portfolio of Guotai Junan Pharmaceuticals outperformed the pharmaceutical index in September 2025, with an average increase of 1.1% compared to a 0.7% increase in the overall pharmaceutical index [12][13] - **Market Comparison**: The report indicates that the pharmaceutical sector's premium level relative to all A-shares is currently at a normal level, with a relative premium rate of 77.5% as of the end of September 2025 [26][28]

Summary of Key Points from the Conference Call Industry Overview - The pharmaceutical sector in China is driven by innovative drugs, particularly companies with Business Development (BD) and Technical Services (TS) capabilities, leading to a BD-driven bull market for innovative drugs [1][2][10] - The Chinese pharmaceutical industry benefits from advantages such as an engineer dividend, rapid clinical advancement, and low costs, making it competitive in areas like dual antibodies, triple antibodies, and weight loss drugs [1][4][5] Core Insights and Arguments - The innovative drug sector receives policy support across research, payment, and commercialization, with high-end commercial insurance and medical insurance covering innovative drugs, encouraging rapid market entry post-approval [1][11] - The CRO (Contract Research Organization) industry is benefiting from the return of BD funds, with significant investments in innovative drug research, leading to strong performances from companies like WuXi AppTec and Kelun [1][13] - The medical device sector is characterized by high competition in traditional devices, while innovative devices like robots and endoscopes are in an import substitution phase, with market rotation favoring companies with new products [1][12] Investment Opportunities - Current and future investment opportunities are concentrated in innovative drugs, CROs, and consumer healthcare sectors, with companies like Heng Rui Medicine and BeiGene emerging as leaders in the previous bull market [7][10] - The focus on innovative drugs is expected to continue, with significant potential in PD-1 upgrade technology platforms and breakthroughs in areas like oncology, diabetes, and autoimmune diseases [3][15] Market Trends and Dynamics - The pharmaceutical industry has undergone significant changes, with a shift from pandemic-related demand to a focus on innovative drugs, particularly after a downturn in the market over the past four to five years [2][10] - The global pharmaceutical market is seeing a surge in interest in oncology, weight loss, and autoimmune diseases, with Chinese companies achieving upgrades through diligent restructuring and accelerated clinical progress [17][20] Challenges and Risks - The consumer healthcare sector faces challenges due to economic changes leading to price sensitivity among consumers, particularly in dental services and blood products, which are affected by strict hospital prescription regulations [14][30] - The CRO industry has faced difficulties due to poor financing data and reduced orders, although there are signs of recovery driven by BD funding [13][25] Future Outlook - The innovative drug market is expected to see a rise in the proportion of innovative drug spending from approximately 5%-11% to potentially 20% in the future, supported by national policies [21] - The medical device market is stable, with significant players in the U.S., Switzerland, and China, while domestic companies are encouraged to enhance their competitiveness through innovation and international collaboration [23][28] Conclusion - The focus on innovative companies and essential medical products is crucial for future growth, with a global perspective on valuation comparisons to uncover more investment opportunities [9][10]

Group 1 - The core viewpoint of the report highlights that SSSJ-707, a PD-1/VEGF dual antibody developed by the company, is a potential cornerstone drug for cancer treatment, expanding the boundaries of traditional PD-(L)1 monoclonal antibody therapies [5] - The company has 30 products in its pipeline, with SSSJ-707 being a key asset that has been licensed to Pfizer for an upfront payment of $1.5 billion, including $1.4 billion in cash and $100 million in stock [5] - The company's revenue for H1 2025 was 4.36 billion yuan, showing no growth, while the net profit attributable to shareholders was 1.36 billion yuan, reflecting a 24.6% increase [5] Group 2 - The report projects the company's revenue for 2025-2027 to be 17.456 billion, 10.746 billion, and 11.335 billion yuan respectively, with net profits of 8.289 billion, 2.860 billion, and 3.163 billion yuan, resulting in PE ratios of 8.1, 23.4, and 21.2 [5] - The global market for PD-(L)1 monoclonal antibodies is expected to reach $99 billion by 2029, indicating significant growth potential for SSSJ-707, which has superior efficacy potential compared to traditional therapies [5] - SSSJ-707 has shown promising clinical efficacy in various cancers, including non-small cell lung cancer (NSCLC) and colorectal cancer (CRC), with notable overall response rates (ORR) in clinical trials [5]

Core Insights - The report highlights an increasing investment trend from both domestic and foreign investors in service-oriented companies and innovative pharmaceutical firms, particularly in the context of anticipated interest rate cuts in Q4 [1][2] - The Hang Seng Healthcare Index rose by 2.2% this week, underperforming the broader market, with CXO, biopharmaceuticals, and traditional Chinese medicine sectors showing better performance [1] Investment Insights - The upcoming ESMO conference in mid-October is expected to provide significant data releases from companies such as Kangfang Biotech, Kelun-Biotech, and Rongchang Biotech, which are recommended for close monitoring [2] - With an increase in industry catalysts starting in October, the market is anticipated to rebound, focusing on the following segments: 1. Innovative drugs: Companies like 3SBio and Eucure Biopharma have rich short-term catalysts, and their valuations do not yet reflect the value of core blockbuster products. Companies like Sinopharm and Legend Biotech are considered undervalued with clear long-term growth logic [2] 2. CXO: Leading companies in this segment are expected to benefit from high downstream demand and marginal improvements in financing conditions, such as WuXi AppTec [2]

Core Viewpoint - The Hang Seng Healthcare Index increased by 2.2% last week, underperforming the broader market, with the CXO, biopharmaceutical, and traditional Chinese medicine sectors showing better performance [1] Group 1: Market Trends - Domestic investors have been increasing their holdings through the Hong Kong Stock Connect since September, while foreign investors' holdings have slightly decreased since mid-year, although both continue to focus on innovative drug companies [1] - Both domestic and foreign investors have increased their positions in service-related stocks, particularly those that may benefit from interest rate cuts, such as CXO companies [1] Group 2: Upcoming Events - The ESMO conference is scheduled for mid to late October, and the report suggests focusing on companies like CanSino Biologics (09926), Kelun-Biotech (06990), and Rongchang Biologics (09995), which are expected to release significant data [1] Group 3: Investment Recommendations - The report recommends attention to the following sectors: 1) Innovative drugs: Companies like 3SBio (01530) and Eucure Biopharma-B (06996) have abundant short-term catalysts and their valuations do not yet reflect the value of core products; companies like Ascletis Pharma (02096), Hutchison China MediTech (00013), and Legend Biotech are significantly undervalued with clear long-term growth logic [1] 2) CXO: Leaders in this segment, such as WuXi AppTec (02268), are expected to benefit from high downstream demand and improving financing conditions [1]

Core Insights - The report from CMB International highlights the release of the first batch of innovative pharmaceutical technology medical insurance payment incentive catalog by Zhejiang Province, which is expected to alleviate the challenges of innovative drugs entering hospitals [1] - Despite the Trump administration's announcement of a 100% tariff on imported innovative drugs, the overall impact on China's pharmaceutical industry chain is considered manageable, with a recommendation to monitor subsequent developments [1] - The upcoming ESMO conference in mid to late October is noted as a key event, with a focus on companies such as CanSino Biologics (09926), Kelun-Biotech (06990), and Rongchang Biologics (688331.SH) that are expected to release significant data [1] Industry Summary - The Hong Kong pharmaceutical sector has shown relatively flat performance in September, but with increasing industry catalysts such as academic conferences and favorable policy implementations in October, a market rebound is anticipated [1] - The report recommends focusing on specific segments: 1) Innovative drugs: Companies like 3SBio (01530) and Eucure Biopharma-B (06996) have rich short-term catalysts and their valuations do not yet reflect the core value of major products; companies like Ascletis Pharma (02096), Hutchison China MediTech (00013), and Legend Biotech are considered significantly undervalued with clear long-term growth logic [1] 2) CXO: Leaders in this segment, such as WuXi AppTec (02268), are expected to benefit from high downstream demand and marginal recovery in financing [1]

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年9月30日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 三生制药（「本公司」） 呈交日期: 2025年10月2日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 01530 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 50,000,000,000 | USD | | 0.00001 | USD | | 500,000 | | 增加 / 減少 (-) | | | | | | | USD | | | | 本月底結存 | | | 50,000,000,000 | USD | | 0.00001 | USD | | 500,000 | 本月底法定/ ...