Core Viewpoint - The stock price of Gilead Sciences-B (01672) has increased over 3%, with a cumulative rise of over 100% in the past month, reflecting strong market performance and investor interest [1] Financial Performance - For the six months ending June 30, 2025, the company reported total revenue of RMB 104 million, representing a year-on-year increase of 111.4% [1] - Research and development costs amounted to RMB 147 million, showing a year-on-year increase of 10.9% [1] - The loss attributable to equity shareholders was RMB 87.95 million, a reduction of 32.5% compared to the previous year [1] - The loss per share was reported at 9.14 cents [1] Product Development Progress - Significant advancements were made in the metabolic disease pipeline, immune disease pipeline, and expansion indication product pipeline [1] - The ASC30 oral tablet for obesity treatment demonstrated a weight reduction of up to 6.5% after 28 days in a U.S. Phase Ib study, indicating its potential as a best-in-class candidate for obesity treatment [1] - The company has initiated a U.S. Phase IIa study and rapidly enrolled 125 participants within just over a month [1] - The ASC30 subcutaneous injection for obesity treatment showed a half-life of 36 days after a single injection in patients, supporting the feasibility of monthly or less frequent dosing [1]

Investment Rating - The report maintains an investment rating of "Outperform" [4] Core Insights - Novo Nordisk's semaglutide has received FDA approval for a new indication for the treatment of Metabolic Dysfunction-associated Steatotic Liver Disease (MASH), which is expected to increase the sales scale of GLP-1 drugs beyond diabetes and weight loss indications [21][24] - The report highlights the significant market potential for GLP-1 drugs and the deep positioning of domestic companies in this field, particularly regarding overseas licensing opportunities for domestic GLP-1 products [25] Summary by Sections Weekly New Drug Market Review - From August 11 to August 17, 2025, the top five gainers in the new drug sector were: Beihai Kangcheng (+35.6%), Basilea Pharmaceutica (+32.6%), Deqi Pharmaceuticals (+30.2%), Heyu Biotech (+30.1%), and Gilead Sciences (+29.7%). The top five losers were: Boan Biologics (-11.6%), Laika Pharmaceuticals (-3.9%), Ailis (-3.2%), Nossland (-1.2%), and CanSino Biologics (-1.1%) [16][18] Recommended Stocks - The report suggests focusing on domestic GLP-1 products for overseas licensing, including: 1. RAY1225 from Zhongsheng Pharmaceutical for GLP-1/GIP dual weekly administration 2. ASC30 from Gilead Sciences for oral GLP-1 small molecules 3. BGM0504 from Borui Pharmaceuticals and ZX2021 from Kangyuan Pharmaceuticals for multi-target GLP-1 receptor agonists 4. UBT251 from Lianfa Pharmaceuticals and HS-10535 from Hansoh Pharmaceutical for already licensed MNC products [20][25] Key Analysis of the New Drug Industry - The approval of semaglutide for MASH marks it as the first GLP-1 therapy approved for this condition, expanding treatment options for patients and potentially increasing market size [21][24] New Drug Application Approvals and Acceptances - This week, there were 6 new drug applications accepted, including semaglutide injection from Huisheng Biopharmaceutical and others [29][31] Clinical Application Approvals and Acceptances - This week, 18 new drug clinical applications were approved, and 39 new drug clinical applications were accepted [32][35]

Policy Developments - The National Healthcare Security Administration (NHSA) has issued the "Interim Measures for the Management of Disease-Specific Payment" to promote a multi-faceted healthcare payment reform focused on disease-specific payments [1][2] - The framework consists of eight chapters and thirty-nine articles, emphasizing budget management, grouping scheme formulation, and core elements and supporting measures [2][3] - The introduction of this measure is expected to enhance the standardization of disease-specific payment systems and improve the efficiency of healthcare fund utilization [3] Drug and Medical Device Approvals - Kehua Bio's syphilis antibody quality control product has received a medical device registration certificate, which will enhance the company's product line [4] - Haikang Pharmaceutical's new indication application for HSK39297 tablets has been accepted, targeting age-related macular degeneration and generalized myasthenia gravis [5] Financial Reports - Leksin Medical reported a revenue of 521 million yuan for the first half of the year, a year-on-year increase of 4.57%, with a net profit of 42.29 million yuan, up 21.35% [6] - Gilead Sciences reported a revenue of 104 million yuan for the first half of the year, a significant increase of 111.4%, with a net loss of 87.95 million yuan, narrowing by 32.5% [7] Mergers and Acquisitions - Yunnan Baiyao plans to acquire 100% equity of Juyitang Pharmaceutical for 660 million yuan to enhance its business layout and expand its market presence [8] - Kangzhong Medical intends to invest 20 million yuan to acquire a 6.67% stake in Shanghai Renyan Information Technology to support its strategic transformation [9] Industry Events - Ji Xunming has been appointed as the president of the Chinese Academy of Medical Sciences and Peking Union Medical College [10] - The National Health Commission and the Ministry of Education are urging Beijing Union Medical College to rectify issues related to its "4+4" pilot program [11] Other Developments - Buchang Pharmaceutical's subsidiary plans to sign a technology transfer contract with Shandong University of Traditional Chinese Medicine for 15 million yuan [12] - Zhongke Investment plans to reduce its stake in Nanwei Medical by up to 2% due to funding needs [13] - Sichuan Medical Technology has received a notice from the Hangzhou Public Security Bureau regarding evidence collection related to a securities fraud investigation [14]

Policy Developments - The National Healthcare Security Administration (NHSA) has issued the "Interim Measures for the Management of Disease-Specific Payment in Medical Security" to promote a multi-faceted payment reform focused on disease-specific payments [2] - The measures consist of eight chapters and thirty-nine articles, emphasizing budget management, grouping scheme formulation, and core elements and supporting measures [2][3] - The new regulations aim to enhance the scientific level of medical insurance payments and standardize the payment process [2] Drug and Device Approvals - Kehua Bio's syphilis antibody quality control product has received a medical device registration certificate, which will enhance the company's product line [5] - Haikang's new indication application for HSK39297 tablets has been accepted, targeting age-related macular degeneration and myasthenia gravis, indicating potential for effective treatment [6] Financial Reports - Leksin Medical reported a revenue of 521 million yuan for the first half of the year, a year-on-year increase of 4.57%, with a net profit of 42.29 million yuan, up 21.35% [8] - Gilead Sciences reported a revenue of 104 million yuan for the first half of the year, a significant increase of 111.4%, with a net loss of 87.95 million yuan, narrowing by 32.5% [9] Capital Market Activities - Yunnan Baiyao plans to acquire 100% of the equity of Juyitang for 660 million yuan to enhance its business layout and expand its market presence [11] - Kangzhong Medical intends to invest 20 million yuan to acquire a 6.67% stake in Shanghai Renyan Information Technology to support its strategic transformation [12] Industry Events - Ji Xunming has been appointed as the president of the Chinese Academy of Medical Sciences and Peking Union Medical College, indicating a leadership change in a key medical institution [14] - The National Health Commission and the Ministry of Education are urging Beijing Union Medical College to rectify issues related to its "4+4" pilot program, focusing on stricter management and oversight [15] Public Sentiment Alerts - Zhongke Investment plans to reduce its stake in Nanwei Medical by up to 2%, indicating potential changes in shareholder structure [18] - Sichuan Medical received a notice from the Hangzhou Public Security Bureau regarding evidence collection related to a fraud investigation, highlighting ongoing legal scrutiny [20]

Core Insights - The company announced promising preclinical efficacy results for its obesity treatment candidate ASC47 in combination with the dual-target peptide ASC31 [1][2] - ASC31 is a novel GLP-1R and GIPR dual-target agonist peptide developed by the company, showing favorable pharmacokinetic characteristics and positive in vivo efficacy in DIO mice [1][2] - ASC47 is a selective small molecule agonist of thyroid hormone receptor β (THRβ) designed for monthly subcutaneous injection, targeting fat tissue to achieve high drug concentrations [1] Clinical Study Results - A study comparing low-dose ASC47 (9 mg/kg, subcutaneous) combined with ASC31 (3 nmol/kg, subcutaneous) versus ASC47 combined with terzepatide (3 nmol/kg, subcutaneous) over 14 days showed that the ASC47 and ASC31 combination resulted in an average weight loss of 44.8%, which is 17.6% more than the ASC47 and terzepatide combination (38.1%) [2] - The CEO highlighted the significant differentiation potential of the new therapy compared to existing weight loss drugs and other candidates in development, indicating a robust pipeline for obesity treatments that includes both small molecules and peptides [2]

Core Insights - The company announced promising preclinical efficacy results for its obesity treatment candidates ASC47 and ASC31, which are a combination of a novel GLP-1R/GIPR dual agonist and a selective THRβ agonist [1][2] Group 1: Drug Candidates - ASC31 is a novel GLP-1R and GIPR dual agonist peptide developed by the company, showing good pharmacokinetic characteristics in non-human primates and positive in vivo efficacy in DIO mice [1] - ASC47 is a fat-targeting, once-monthly subcutaneous THRβ selective small molecule agonist, which achieves high drug concentrations in adipose tissue in a dose-dependent manner [1] Group 2: Clinical Study Results - A study comparing low-dose ASC47 (9 mg/kg, subcutaneous) combined with ASC31 (3 nmol/kg, subcutaneous) versus ASC47 combined with teriparatide (3 nmol/kg, subcutaneous) over 14 days showed that the ASC47 and ASC31 combination resulted in an average weight loss of 44.8%, which is 17.6% more than the 38.1% weight loss observed with ASC47 and teriparatide [2] - The CEO highlighted the significant differentiation potential of the new therapy compared to existing weight loss drugs and other candidates in development, indicating a robust pipeline of obesity treatment options that include both small molecules and peptides [2]

Core Insights - The company, Gilead Sciences, has announced promising preclinical efficacy results for its obesity treatment candidates ASC47 and ASC31, which are a combination of a dual receptor agonist and a selective small molecule agonist [1][2] Group 1: Drug Development - ASC31 is a novel GLP-1R and GIPR dual receptor agonist peptide developed by the company, showing favorable pharmacokinetic characteristics in non-human primates and positive in vivo efficacy in DIO mice [1] - ASC47 is a selective small molecule agonist of thyroid hormone receptor β (THRβ) that targets fat and is designed for monthly subcutaneous injection, achieving high drug concentrations in adipose tissue [1] Group 2: Market Potential - The combination of ASC31 and ASC47 demonstrates superior weight loss effects in animal models compared to existing weight loss drugs and other candidates in development, indicating significant differentiation potential in the obesity treatment market [2] - The company is building a robust pipeline of potential obesity therapies that includes both small molecules and peptides, with expectations for future progress updates [2]

Ascletis Pharma Inc. （股份代號：1672） 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容所產生或因依 賴該等內容而引致的任何損失承擔任何責任。 歌禮製藥有限公司 （於開曼群島註冊成立的有限公司） － 在飲食誘導肥胖(DIO)小鼠模型中，低劑量ASC47與新型GLP-1R/GIPR雙受 體激動劑多肽ASC31聯用治療14天後，小鼠體重下降44.8%。 － 在DIO小鼠模型中，低劑量ASC47與ASC31聯用的療效（減重44.8%）優於低 劑量ASC47與替爾泊肽聯用（減重38.1%），療效差異具有統計學顯著性。 該DIO小鼠研究旨在對比低劑量ASC47（9 mg/kg，皮下）聯合ASC31（3 nmol/kg， 皮下）與低劑量ASC47（9 mg/kg，皮下）聯合替爾泊肽（3 nmol/kg，皮下）的減 重療效，治療期為14天。結果顯示，ASC47聯合ASC31治療DIO小鼠平均減重 44.8%，比ASC47聯合替爾泊肽(38.1%)多減重17.6%（ p =0.02）。 「我們的 ...

Core Viewpoint - The company has shown strong progress in its core pipelines and financial performance in the first half of 2025, with significant revenue growth and promising clinical data expected in the near future [1][2][3] Financial Performance - The company's main operating revenue for H1 2025 was 1.08 million, primarily from R&D services [1] - R&D expenses for H1 2025 were 146 million, a year-on-year increase of 10.9%, with effective pipeline adjustments and cost optimizations [1] - Cash and cash equivalents at the end of H1 2025 reached 1.58 billion, a year-on-year increase of 361.9%, mainly due to the maturity of time deposits [1] Pipeline Development - ASC30, the company's core small molecule GLP-1 pipeline, demonstrated a 6.5% weight loss in a 4-week Phase I trial in the U.S., outperforming Eli Lilly's small molecule GLP-1 [1] - The company is currently conducting a Phase IIa trial for ASC30, with top-line data expected in Q4 2025 [1] - ASC47, a new THR-β target pipeline, is in Phase I clinical trials in the U.S., with top-line data anticipated in Q4 2025 [2] - ASC50, an oral small molecule for IL-17, is also in Phase I clinical trials, with top-line data expected by the end of 2025 [2] - The oral small molecule FASN inhibitor, Denifasita, is projected to submit a market application in China by 2026 based on excellent Phase III data [2] Profit Forecast and Investment Rating - The company’s pipeline progress aligns with expectations, increasing the likelihood of successful product launches [3] - Revenue forecasts for 2025-2027 have been adjusted to 0.02 billion, 0.64 billion, and 2.03 billion respectively [3] - The target price has been raised to 29.26 HKD, maintaining a "buy" rating based on improved pipeline success rates [3]

Investment Rating - The report maintains a "Recommended" investment rating for the pharmaceutical industry [1] Core Views - The global GLP-1 market is expanding steadily, presenting strategic opportunities for Chinese companies [3] - Chinese pharmaceutical companies are increasingly recognized in global innovative drug transactions, contributing nearly 50% of total transaction value and over 30% of transaction volume [2] - The CXO industry is expected to gradually recover, with a notable increase in orders anticipated in Q3 [7] - The 2025 medical insurance negotiation and commercial insurance innovative drug directory work has commenced, with a focus on orphan drugs and breakthrough treatment varieties [8] Summary by Sections 1. Pharmaceutical Market Tracking - The pharmaceutical industry outperformed the CSI 300 index by 0.7% in the past week, with a weekly increase of 3.08% [22] - Over the past month, the pharmaceutical industry index increased by 11.07%, surpassing the CSI 300 index by 6.51% [25] 2. Pharmaceutical Sector Trends and Valuation - The current PE (TTM) for the pharmaceutical industry index is 39.94, above the 5-year historical average of 31.83 [44] 3. Recent Research Achievements - The report highlights various research achievements, including the deepening understanding of the GLP-1 drug market and its implications for innovative drug development [46] 4. Recent Industry Policies and News - The National Medical Insurance Administration has initiated the preliminary review of the 2025 medical insurance drug directory, with 121 drug names passing the initial review [8][49] - Significant clinical trial approvals and new drug applications have been reported, indicating active development in the pharmaceutical sector [49][50] 5. Stock Recommendations - The report recommends stocks in the weight loss field, CAR-T technology, and CXO companies, highlighting specific companies such as Zhongsheng Pharmaceutical and Anke Biotechnology [9]