近期，第76届AASLD年会召开，作为全球权威肝脏病学会议之一，我国创新药企在会上表现如何？展 望后市，创新药行业景气度会持续延续吗？（资料参考：证券日报《我国乙肝创新药物临床研究取得突 破性进展》，2025.11.10） 我国创新药企业在会上表现如何？ 1. 中国学者与团队整体表现突出 我国多个研究团队发表AASLD 2025大会报告，发布乙肝基础研究、临床诊治、新药研发、肝癌发病机 制、肝硬化、脂肪肝等肝病领域多方面最新研究成果。多位中国专家获得重要荣誉，年轻学者也屡 获"青年研究者"奖；国内多家医院的年轻医生积极参与学术交流，展现出中国肝病领域雄厚的人才储 备，中国肝病研究在国际舞台上的影响力正在不断提升。（资料参考：上海证券报《我国乙肝创新药物 研究获进展 多项研究成果亮相AASLD》，2025.11.10）；国际肝病《AASLD名家连线丨尤红教授：聚 焦乙肝指南革新、新药研发突破与中国学术力量——大会三大核心亮点》，2025.11.16） 创新药后续景气度如何？ 创新药领域再添重磅研究成果，产业后续景气度会持续吗？综合来看，创新药正受益于多个积极的行业 趋势： 一、出海热潮持续。创新药"出海"已成为 ...

Group 1 - The core focus of the news is the introduction of the commercial insurance innovative drug directory, which aims to bridge the gap between basic medical insurance and high-end demand for innovative drugs, providing a policy advantage for group health insurance [2][3] - A total of 121 drugs have passed the formal review, with CAR-T drugs being a notable example that may enter the commercial insurance innovative drug directory [2] - The first version of the commercial insurance innovative drug directory is set to be officially released in early December 2025 and will be implemented starting January 1, 2026 [2] Group 2 - The commercial insurance directory is seen as a key tool to break the payment deadlock for innovative drugs, focusing on drugs that exceed the basic insurance coverage but have significant clinical value [3] - The current commercial insurance market is still in its infancy regarding innovative drug payments, with commercial health insurance contributing only 7.7% to the overall payment structure, while over 90% is covered by medical insurance funds and personal cash payments [3][4] - The low coverage ratio of commercial health insurance payments presents an opportunity for industry growth, as there is a mismatch between the supply of insurance products and the diverse needs of customers, particularly in high-cost medical areas [4][6] Group 3 - The growth of individual health insurance has slowed, making group health insurance a potential key to expanding the innovative drug market [5][6] - Group health insurance can effectively reduce adverse selection risks and improve funding efficiency through collective participation by enterprises [6][7] - In mature markets, group health insurance typically accounts for 70%-80% of premium income, highlighting its importance in innovative drug payments [7] Group 4 - The dual incentives of policy support and market demand are driving insurance institutions to accelerate innovation in group insurance products [8][10] - The future competition in group insurance will focus on service ecosystem integration, shifting from passive compensation to proactive health management [11] - Despite promising prospects, the group insurance market faces multiple challenges that need to be addressed through policy tools like tax incentives and subsidies to encourage collective participation [11][12]

2025.11.14 本文字数：3733，阅读时长大约6分钟 作者 |第一财经 吴斯旻 惠民保面向全国推广即将进入第六年，"特药责任"俨然已成标配。据行业估算，去年惠民保以不到200 亿的保费规模贡献了约18亿元的创新药支付金额，是2021年的约9倍。 但对于全国每年约1.5亿左右的参保人而言，理赔获得感却不尽相同——有人单次获赔近80万元，有人 一年获赔了30次，但也有慢病患者"月月就医却没有一次达到起付门槛"，有患者因既往症而遭遇"赔付 减半"，还有的异地就医者、新市民被惠民保拒之门外。 低保费、高赔付率目标，叠加老年人和带病体的参保比例增加，让惠民保的发展面临"死亡螺旋"。部分 惠民保为了应对赔付压力，通过提高免赔额、下调高值药支付限额等方式，减缓保费上涨压力，却又隐 形地降低了医疗福利水平。与此同时，今年首版商保创新药目录出台后，惠民保被寄予承接该目录、增 加创新药支付的业界期待。 在此背景下，今年发布的《国家金融监督管理总局办公厅关于推动城市商业医疗险高质量发展的通知》 （下称《通知》）提出，城市商业医疗险（即惠民保）要按照商业保险的基本原则和客观规律开展业 务，坚持保费收取与保障程度相适配、扩面提 ...

Core Viewpoint - The article discusses the evolution and challenges of the "Hui Min Bao" (惠民保) insurance scheme in China, highlighting its rapid growth in coverage and the increasing complexity of claims and benefits, particularly in relation to innovative drugs and treatments [3][4][6]. Group 1: Overview of Hui Min Bao - Hui Min Bao has been promoted nationwide for nearly six years, with "special drug liability" becoming a standard feature. In the previous year, it contributed approximately 1.8 billion yuan in innovative drug payments from a premium scale of less than 20 billion yuan, marking a ninefold increase from 2021 [3][4]. - The scheme faces challenges due to varying experiences among the 150 million insured individuals, with some receiving substantial claims while others struggle to meet deductibles or face reduced payouts due to pre-existing conditions [3][4]. Group 2: Regulatory Changes and Trends - The recent notification from the National Financial Regulatory Administration emphasizes the need for commercial health insurance, including Hui Min Bao, to align premium collection with coverage levels and avoid chaotic low-price competition [4][8]. - The 2026 version of Hui Min Bao is introducing a trend of "premium stratification," moving away from low premiums to better match coverage levels, with new inclusions for chronic diseases and overseas drugs [4][6]. Group 3: Expansion of Special Drug Coverage - As of 2024, 90% of Hui Min Bao projects include "special drug liability," with a total of 672 drugs covered, reflecting a 1.8 times increase since 2021. The focus remains on cancer and rare disease medications, with over 40% of the drugs being innovative cancer treatments [6][7]. - Some regions are expanding their special drug coverage to include high-value drugs for chronic diseases, with certain plans approaching the coverage levels of pure commercial health insurance [7][8]. Group 4: Pricing and Risk Management - The core of commercial health insurance is the dynamic balance between funding and benefits. The low premium model of Hui Min Bao has slowed funding growth, impacting benefit enhancements [10][12]. - The 2026 version of Hui Min Bao is adopting a risk stratification approach, allowing for differentiated pricing based on factors like age and health status, which aims to enhance fairness and adaptability in product offerings [10][11]. Group 5: Inclusion of New Citizens and Cross-Regional Medical Services - The new Hui Min Bao products are increasingly targeting healthy individuals and young people by lowering deductibles and enhancing coverage for outpatient services and common illnesses [16][18]. - Several regions are allowing the use of personal medical insurance accounts for family members and expanding coverage to include new citizens and those seeking medical services across regions [17][18].

Core Insights - The "惠民保" (Huimin Insurance) has expanded its coverage to include chronic diseases, mental health medications, outpatient drugs, overseas drugs, and original research drugs, reflecting a shift in the insurance landscape [1][2] - The insurance scheme has seen a significant increase in claims, with approximately 18 billion yuan paid for innovative drugs in the previous year, a ninefold increase from 2021 [1] - However, the experience of claims varies widely among the 150 million insured individuals, with some facing high out-of-pocket costs due to thresholds and pre-existing conditions [1][6] Group 1: Policy Changes and Trends - The recent notification from the National Financial Regulatory Administration emphasizes the need for commercial health insurance to align premium collection with coverage levels and avoid low-price competition [2] - The 2026 version of "惠民保" has introduced a tiered premium structure, moving away from the previous low-cost model, and has expanded coverage to include more drug categories [2][3] - The number of drugs covered under "惠民保" is expected to reach 672 by 2024, with a significant focus on innovative treatments for cancer and rare diseases [3] Group 2: Coverage Expansion - The 2026 "北京普惠健康保" (Beijing Universal Health Insurance) will cover 87 disease categories and 159 drugs, including new treatments for Alzheimer's and CAR-T therapy [4] - The "齐鲁保2026版" (Qilu Insurance 2026) has expanded its coverage to include 3 high-value medical devices and additional innovative drugs for chronic conditions [4] - Many regions are now including outpatient drugs and original research drugs in their coverage, indicating a trend towards more comprehensive health insurance products [3][4] Group 3: Risk Management and Pricing Strategies - The insurance sector is adopting a risk-based pricing model, allowing for differentiated premiums based on age, health status, and pre-existing conditions [6][10] - The introduction of tiered coverage options aims to balance the need for affordable premiums with adequate benefits, particularly for high-risk groups [6][10] - Recent adjustments have led to increased reimbursement rates for patients with pre-existing conditions, reflecting a shift towards more equitable coverage [8][10] Group 4: Inclusion of New Demographics - The 2026 "惠民保" products are increasingly targeting new citizens and those seeking medical care outside their registered locations, broadening the scope of insured individuals [10][11] - Initiatives to allow family members to share health insurance accounts and to include flexible workers and retirees in coverage are being implemented in various regions [10][11] - The trend towards inclusivity aims to enhance the overall participation rate in the "惠民保" scheme, particularly among younger and healthier individuals [10]

Core Insights - The innovative drug ETF Tianhong (517380) has seen significant trading activity, with a transaction volume of 34.38 million yuan and a strong index performance, reflecting a 3.66% increase in the Hang Seng Shanghai-Shenzhen Hong Kong Innovative Drug Selected 50 Index [1] - The introduction of a commercial insurance innovative drug directory marks a significant step in China's multi-tiered medical security system, aimed at improving the accessibility and affordability of high-priced innovative drugs [2] - BeiGene reported a turnaround in profitability for the third quarter of 2025, achieving a net profit of 689 million yuan, driven by strong sales of its flagship product, Zanubrutinib [2] - Citic Securities anticipates a stable growth trend in the pharmaceutical industry, supported by policy initiatives and a return to a market pricing system based on clinical value and demand [3] Group 1: ETF Performance - The innovative drug ETF Tianhong (517380) reached a new high in scale at 1.398 billion yuan as of November 12, with a net inflow of 83.52 million yuan over the past ten trading days [1] - The ETF covers the entire industry chain from preclinical research to commercialization, capturing opportunities in the innovative drug sector [1] Group 2: Policy Developments - The recent conclusion of the national medical insurance negotiations and the introduction of a commercial insurance innovative drug directory are expected to enhance the market for high-value innovative drugs [2] - The new directory will focus on rare disease medications and unique innovative drugs, potentially breaking existing sales bottlenecks [2] Group 3: Company Performance - BeiGene's third-quarter revenue reached 10.077 billion yuan, a year-on-year increase of 41.1%, with a total revenue of 27.595 billion yuan for the first three quarters, reflecting a 44.2% growth [2] - The global sales of Zanubrutinib amounted to 7.423 billion yuan in the third quarter, with the U.S. market contributing 5.266 billion yuan, highlighting strong demand in the hematologic oncology sector [2] Group 4: Market Outlook - The pharmaceutical industry is expected to benefit from a stable and continuous growth trend, driven by supportive policies and a focus on clinical value [3]

Core Viewpoint - The introduction of the commercial insurance innovative drug directory is expected to address the accessibility and affordability issues of high-priced innovative drugs by guiding market forces [1][3]. Group 1: Policy Changes - The National Medical Insurance Administration organized a 5-day negotiation for the medical insurance drug directory and commercial insurance innovative drug directory, with 120 domestic and foreign companies participating [2]. - The new directory is set to be released in early December and will officially take effect on January 1 of the following year [2]. Group 2: Market Opportunities - The commercial insurance innovative drug directory aims to open market space for high-cost or rare disease medications, particularly for rare disease treatments and high-value innovative drugs [3]. - Notably, five CAR-T drugs have been submitted for approval, which could significantly benefit patients due to their high annual treatment costs [3]. Group 3: Drug Submission Strategies - The introduction of the "dual directory" submission allows companies to choose between submitting for both the basic medical insurance directory and the innovative drug directory, providing more strategic options [4]. - For example, BMS's O drug (Nivolumab) opted for dual submission after previous failures, while competitors like Merck's K drug (Pembrolizumab) have not submitted any applications [4]. Group 4: Competitive Landscape - Domestic innovative drugs are becoming major competitors to imported drugs, with examples like the TROP2 ADC drug Gosituzumab (Gilead) and its domestic counterpart [5]. - The increasing support for innovative drugs from the government and the diversification of the medical insurance payment system are expected to create new market demand for innovative drugs [5]. Group 5: Investment Recommendations - The medical insurance bureau is encouraging the high-quality development of innovative drugs, indicating a warming trend in payment policies [6]. - Relevant investment targets include companies such as Heng Rui Medicine, Kelun Pharmaceutical, and others that are actively transitioning towards innovation [6].

Core Insights - The annual adjustment of the National Medical Insurance (NMI) catalog has progressed, with negotiations for the 2025 NMI drug catalog and commercial insurance innovative drug catalog taking place from October 30 to November 3, involving 120 domestic and foreign companies [1] - The introduction of the commercial insurance innovative drug catalog is a significant highlight, marking its first establishment, with 141 submissions and 121 passing the preliminary review [1][2] - The NMI's focus is on "basic protection," which has led to high-value innovative drugs like CAR-T therapies not being included in the basic catalog, while the commercial insurance catalog aims to cover high-innovation drugs that exceed basic insurance limits [2] Group 1 - The NMI negotiations involved 127 drugs for the basic catalog and 24 for the commercial insurance catalog, with the new catalogs expected to be released in early December and implemented on January 1 [1] - The commercial insurance innovative drug catalog respects the market position of commercial insurance companies, differing from the NMI catalog adjustments [2] - Five CAR-T therapies are in the preliminary review for the commercial insurance catalog, indicating a growing acceptance of high-value therapies in the market [2][3] Group 2 - The support from commercial insurance for high-value innovative products like CAR-T therapies is seen as essential for risk-sharing among patients and promoting industry development [3] - There is a need for national involvement to enhance the role of commercial insurance in rare disease coverage, as profitability concerns may limit insurance companies' willingness to cover patients with pre-existing conditions [3] - The potential for innovative drugs included in both NMI and commercial insurance catalogs to experience rapid revenue growth is highlighted, benefiting patients and leading to increased flexibility for related companies [4]

Core Insights - The National Healthcare Security Administration is conducting negotiations for the 2025 National Basic Medical Insurance Drug List and the first version of the commercial insurance innovative drug list, marking a significant step towards implementation [1][2] - The commercial insurance innovative drug list aims to include high-value innovative drugs that exceed basic insurance coverage, creating a multi-tiered medical security system [1][2] - The implementation of the commercial insurance innovative drug list aligns with China's pharmaceutical industry internationalization and the need for a competitive innovation ecosystem [2][3] Group 1 - The commercial insurance innovative drug list will be officially implemented next year, indicating a substantial policy shift towards a multi-layered value realization system [1] - This new list is designed to complement the National Medical Insurance List, addressing the growing demand for innovative drugs that are not covered by basic insurance [1][2] - The rapid growth of China's commercial insurance market, with a premium income of 977.3 billion yuan in 2024, supports the establishment of a layered payment system [2] Group 2 - The introduction of the commercial insurance innovative drug list is expected to drive the upgrade and restructuring of the entire pharmaceutical value chain, prioritizing clinical value over mere affordability [3] - This policy change encourages pharmaceutical companies to invest more in original innovation and provides a reasonable market return mechanism for breakthrough therapies [3] - Future policy coherence is crucial for the successful integration of the commercial insurance list with the national medical insurance and other support systems, ensuring a stable and sustainable industry ecosystem [3]

Core Points - The National Healthcare Security Administration (NHSA) announced that the new basic medical insurance drug list and the first version of the commercial insurance innovative drug list will be released online and offline in Guangzhou on the first weekend of December, with implementation starting January 1, 2024 [1] - The negotiation for the basic medical insurance drug list concluded on November 3, with 120 domestic and foreign companies participating, including 127 drugs outside the list and 24 drugs for the commercial insurance innovative drug list [3] - The commercial insurance innovative drug list was established to better meet the diverse medication needs of the public, with 121 high-value drugs approved through this new list [3][7] Industry Insights - The commercial health insurance market in China is experiencing rapid growth, with the original insurance premium income for commercial health insurance reaching 977.3 billion yuan in 2024, a year-on-year increase of 8.2% [7] - The total expenditure of the basic medical insurance fund is projected to reach 2.97 trillion yuan in 2024, providing solid support for public healthcare [7] - The NHSA is working to address challenges in synchronizing medical insurance and commercial insurance settlements, with initiatives like the establishment of a national "medical insurance + commercial insurance" clearing settlement center in Beijing [9]