Core Viewpoint - Changchun High-tech has reported its first annual revenue decline in nearly 20 years, with a 7.55% decrease in revenue and a 43.01% drop in net profit for 2024 compared to the previous year [1][2]. Financial Performance - In 2024, the company achieved revenue of 13.466 billion yuan, down 7.55% year-on-year, and a net profit of 2.583 billion yuan, down 43.01% year-on-year [1]. - For Q1 2025, revenue was 2.997 billion yuan, a decrease of 5.66% year-on-year, with a net profit of 473 million yuan, down 44.95% year-on-year [1]. - The company’s main subsidiary, Jinsai Pharmaceutical, saw total revenue decrease by 3.73% to 10.671 billion yuan, despite a 454% increase in overseas sales [2]. - Baike Biological, another subsidiary, reported a revenue decline of 32.64% to 1.229 billion yuan and a net profit drop of 53.67% [2]. - Gaoxin Real Estate experienced a revenue decline of 17.32% to 756 million yuan and a net profit drop of 80.09% [3]. Business Segments - The company operates in four main segments: genetic engineering pharmaceuticals, biological vaccines, traditional Chinese medicine, and real estate, corresponding to its four subsidiaries [1]. - The only subsidiary showing positive growth was Huakang Pharmaceutical, but its revenue contribution is minimal, making it insufficient to offset the overall decline [3]. Investment and Strategy - To counteract the revenue decline, the company has increased its R&D investment by 11.20% to 2.690 billion yuan, which now accounts for 19.97% of revenue [3]. - Sales expenses also rose by 11.81% to 4.439 billion yuan, with the number of sales personnel increasing by nearly 60% from 3,155 to 4,995 [3]. - However, the number of R&D personnel decreased by 4.89%, from 1,329 to 1,264 [3]. Product Development - The company has several key products in development, including a new pediatric cough syrup and treatments for gout and other conditions, with some products expected to be approved this year [4][5]. - Notably, the company decided to terminate a U.S. application for a long-acting growth hormone, resulting in a 133 million yuan impairment charge that affected 2024 profits [6].

Investment Rating - The investment rating for the company is "Buy" [7][4]. Core Views - The company is experiencing pressure on its domestic revenue due to centralized procurement policies, leading to a significant decline in domestic sales, while overseas performance remains strong with a notable increase in international market contributions [2][4]. - The company is expected to benefit from the recovery of its performance post-price adjustments from centralized procurement, with a focus on increasing sales volume [1][4]. Summary by Sections Financial Performance - For 2024, the company's revenue is projected at 806 million RMB, with a year-on-year decline of 33.3%. The attributable net profit is expected to be 125 million RMB, down 55.0% year-on-year [1][6]. - In Q4 2024, revenue is expected to be 298 million RMB, with a year-on-year decline of 28.5% [1][3]. Domestic vs. Overseas Revenue - Domestic revenue is projected at 450 million RMB for 2024, down 55.2% year-on-year, accounting for 56.2% of total revenue. In contrast, overseas revenue is expected to reach 350 million RMB, up 78.3% year-on-year, making up 43.8% of total revenue [2][4]. Gross Margin Analysis - The gross margin for domestic operations is expected to be 67.23%, a decrease of 6.98 percentage points year-on-year, while the overseas gross margin is projected at 65.90%, an increase of 2.10 percentage points [2][3]. Expense Management - The company has managed to reduce its sales expense ratio in Q4 2024 to 25.80%, down 10.08 percentage points year-on-year, despite an overall increase in expenses for the year [3][4]. Earnings Forecast - The forecast for attributable net profit for 2025-2027 is adjusted to 240 million, 290 million, and 340 million RMB respectively, reflecting a downward revision of 28.2% and 27.5% for 2025 and 2026 compared to previous estimates [4][15]. - The expected EPS for 2025 is 0.62 RMB, with a projected PE ratio of 21.88 for the same year [6][15]. Valuation - The target price for the A-share is set at 19.83 RMB, corresponding to a PE of 32x, while the target price for the H-share is set at 11.42 HKD, corresponding to a PE of 17x [4][7].

Investment Rating - The report maintains a neutral rating for the company with a target price of HKD 5.80, indicating a potential upside of 14.6% from the current price of HKD 5.06 [1][2][9]. Core Insights - The company's performance in Q4 2024 was negatively impacted by the procurement of Domperidone, but there is a noticeable improvement in the neurology segment. The raw material drug business continues to face slight pressure. It is anticipated that the impact of Domperidone procurement will stabilize entering 2025, and new product launches will drive revenue recovery [2][6]. - The current forward P/E ratio is 11 times, with an expected profit CAGR of 11% from 2024 to 2027, suggesting that the valuation is reasonable with limited upside potential [2][6]. - The company is expected to achieve positive revenue growth in 2025, driven by stable inventory levels of Domperidone, the rapid market penetration of new products, and the inclusion of certain drugs in medical insurance [6][11]. Financial Forecast Changes - Revenue for 2025 is projected at RMB 29,600 million, a decrease of 1.0% from previous forecasts. The gross profit is expected to be RMB 20,868 million, down 3.8% from prior estimates. The net profit forecast for 2025 is RMB 4,754 million, reflecting a 4.4% reduction [5][11]. - The gross margin is expected to be 70.5% for 2025, down from 72.6% previously, indicating a slight decline in profitability [5][11]. Performance Metrics - The company’s stock price has shown a year-to-date increase of 5.86%, with a 52-week high of HKD 7.12 and a low of HKD 4.34 [5][11]. - The average daily trading volume is reported at 214.03 million shares, with a market capitalization of approximately HKD 58,227.19 million [5][11]. Pipeline and Product Development - The company is advancing its pipeline with seven new products expected to launch in 2025, including significant drugs that are anticipated to gain regulatory approval in the U.S. [6][11]. - The most notable pipeline product, EGFR ADC, is undergoing simultaneous registration studies in China and the U.S., indicating a strong commitment to expanding its product offerings [6][11].

两年造假超十亿的普利制药走向退市 登录新浪财经APP 搜索【信披】查看更多考评等级 界面新闻记者 | 唐卓雅 界面新闻编辑 | 谢欣 历经近8个月的调查，普利制药虚增业绩一事迎来最终裁决。 3月21日晚间，普利制药收到中国证监会下发的《行政处罚决定书》，因虚增业绩触及重大违法强制退市情形，公司股 票可能被终止上市。自3月24日起公司股票及可转债停牌。 经查明，2021年至2022年，普利制药通过虚构成品药和原料药销售业务的方式，虚假确认药品销售收入和利润。其中， 2021年多计营业收入4.36亿元，占当年披露营业收入的28.90%，多计利润总额2.90亿元，占当年披露利润总额的 62.06%；2022年多计营业收入4.56亿元，占当年披露营业收入的25.23%，多计利润总额3.79亿元，占当年披露利润总额 的86.36%。 同期，普利制药将其开展的不具有控制权的乙酰碘化物、碘化物（碘佛醇专用）和酵母抽提物贸易业务按总额法核算， 导致2021年多计营业收入7799.73万元，占当年披露营业收入的5.17%；2022年多计营业收入5925.97亿元，占当年披露 营业收入的3.28%。 普利制药成立于1992年，销 ...

合作伙伴征集：2025全球手术机器人大会 报名：首届全球眼科大会 | 名额有限 报名：首届全球心血管大会 | 奖项申报 报名：首届全球骨科大会 | 奖项评选 近日， 爱博医疗（688050.SH） 发布公告，披露了 公司股东白莹通过大宗交易方式累计减持公司股份110 万股 ，占公司股份总数的0.58%，减持价格为87.58元/股， 金额为9633万元 。本次减持完成后，白莹及其 一致行动人合计持有公司股份1516.72万股，占公司股份总数的8.002%。 值得注意的是，白莹作为 公司的天使投资人 ，并未参与公司的日常管理，而 此次减持却发生在公司营收和净 利润连续7年双增长的"高光时刻" 。自登陆科创板以来，爱博医疗的净利润逐年增长，从2018年的2031万元 增长至2024年的3.87亿元，七年复合增长率（CAGR）达78%， 累计涨幅18倍 。这增长速度，连茅台（同 期CAGR 29%）看了都得连连称赞。 然而，尽管财务数据亮眼， 业绩一路高歌，但公司股价却像被按了暂停键 ，资本退潮迹象明显。这一现象背 后折射出眼科器械行业的深层变化，包括带量采购对利润的挤压、国产替代的激烈竞争，以及企业转型的压 力。 ...

Investment Rating - The report maintains a "Strong Buy" rating for the pharmaceutical sector, indicating a positive outlook for investment opportunities in this industry [2]. Core Insights - The pharmaceutical sector has shown a recovery in valuation, with the pharmaceutical and biological sector rising by 1.77%, outperforming the CSI 300 index by 0.18 percentage points. This places it 15th among 31 primary industry sectors [6][4]. - The report highlights that favorable policies are emerging for the pharmaceutical sector, suggesting a steady recovery in industry sentiment. It recommends focusing on high-quality targets in the formulation sector and biotech companies with efficient management and strong product pipelines [4][24]. Summary by Sections 1. Pharmaceutical Sector Performance - The pharmaceutical sector's performance includes a 1.77% increase, with sub-sectors such as pharmaceutical commerce rising by 6.44% and traditional Chinese medicine II by 2.63% [6][4]. - Notable stock performances include: - **Top Gainers**: - Pharmaceutical commerce: Seer Medical (+34.47%), Lao Bai Xing (+22.47%) [17]. - Chemical pharmaceuticals: Jincheng Pharmaceutical (+42.43%), Kangzhi Pharmaceutical (+20.50%) [13]. - **Top Losers**: - Chemical pharmaceuticals: Shuangcheng Pharmaceutical (-16.56%), Haichuang Pharmaceutical (-12.21%) [11]. 2. Key Company Recommendations - The report recommends focusing on companies such as: - Aosaikang, which is advancing in the development of domestic CLDN18.2 targeted drugs [4]. - Cloudtop New Medicine-B, which is expected to see significant sales growth from its major product [4]. - Dizhe Pharmaceutical, which is poised for market expansion with its core products [4]. - Renfu Pharmaceutical, recognized as a leader in anesthesia [4]. 3. Industry News Highlights - Recent approvals include: - The approval of the fourth indication for the PD-1 inhibitor by Zhengda Tianqing/Kangfang Biotech for treating recurrent or metastatic nasopharyngeal carcinoma [24][25]. - Roche's PI3Kα inhibitor, Inavolisib, has been approved for use in combination therapy for hormone receptor-positive, HER2-negative breast cancer [26][27]. - The first domestic solid tumor cell therapy, Aikelong, is set for priority review for preventing postoperative recurrence of liver cancer [29][30]. 4. Market Trends - The report notes a positive trend in the pharmaceutical sector, with a focus on innovative therapies and domestic drug development, indicating a robust growth potential in both domestic and international markets [4][24].