Core Viewpoint - The "Changping Model" selection activity for 2025 has recognized exemplary individuals who contribute to the spirit of the times and promote the development of Changping District through their dedication and actions [1]. Group 1: Recognition of Exemplary Individuals - The event has highlighted a diverse group of individuals from various sectors, showcasing their impactful stories and contributions to society [1]. - The selected individuals include Zhao Tianmeng, Xu Peng, Zhang Nan, and others, who have demonstrated commitment and innovation in their respective fields [1]. Group 2: Contributions in Science and Technology - Zhao Tianmeng, CTO of Beijing Qihe Biotechnology Co., has made significant advancements in gene editing, developing a new base editing system recognized as a milestone in the field [5][6]. - His work has led to the creation of the "PrimeRoot" technology, which drastically reduces the time for gene insertion in rice from years to weeks, earning accolades in scientific publications [6]. Group 3: Community and Emergency Services - Xu Peng, a firefighter, has excelled in both administrative and operational roles, improving documentation processes and training programs within the fire department [10][11]. - Zhang Nan, a police officer, has implemented innovative risk management mechanisms, effectively resolving numerous community disputes and enhancing public safety [15][16]. Group 4: Cultural Preservation and Education - Gao Xuhong, a villager, has dedicated her life to preserving traditional cultural practices, creating educational materials, and training new generations in the art of Huabao drum [20][21]. - Her initiatives have fostered community engagement and cultural continuity, impacting nearly a thousand students across various educational institutions [21]. Group 5: Healthcare and Medical Innovation - He Baowei, a physician, has significantly improved healthcare access in Xinjiang through his medical expertise and community outreach, increasing patient visits and establishing a robust healthcare framework [30][31]. - His efforts have led to the establishment of a medical work studio, enhancing the local healthcare system and benefiting thousands of residents [31]. Group 6: Environmental and Renewable Energy Initiatives - Jiang Hechuan, a senior engineer at China Huaneng Group, has developed a flexible photovoltaic support system that optimizes land use and reduces material costs in solar energy projects [25][26]. - His contributions have been recognized as pivotal in advancing the renewable energy sector, with numerous patents and published research [26]. Group 7: Social Responsibility and Community Service - Lan Dong, a business owner, has integrated social responsibility into his operations by providing free haircuts to the elderly and underprivileged, demonstrating a commitment to community welfare [51][52]. - His initiatives have served over 80,000 elderly individuals, showcasing the impact of local businesses in addressing social needs [52]. Group 8: Future Directions - The Changping District aims to continue promoting the "Changping Model" initiative, fostering a culture of learning from exemplary figures and encouraging civic engagement for high-quality development [54].

Core Viewpoint - The 2026 APEC first senior officials' meeting in Guangzhou focuses on building a shared community in the Asia-Pacific region and promoting common prosperity through three priority areas: openness, innovation, and cooperation [1]. Group 1: Meeting Overview - The APEC meeting will take place from February 1 to 10, 2026, in Guangzhou, marking the first official event of the "China Year" for APEC [1]. - Over 70 meetings and related activities will be held, covering topics such as trade investment, economic and technological cooperation, and technological innovation, with more than 1,000 representatives expected to attend [1]. Group 2: City Tours and Experiences - Five themed city tour routes have been planned, including "Millennium Business Capital: Innovative Future City Tour" and "Green Heart of the Flower City: Ecological and Cultural Journey" [1]. - Participants will visit various locations to experience the revitalization of the ancient city, including the Canton Fair Exhibition Hall and cultural sites [1]. Group 3: Investment and Economic Development - Guangzhou has attracted nearly $120 billion in foreign investment from APEC economies, accounting for 82.8% of the city's actual foreign investment [2]. - The city aims to leverage the APEC "China Year" to enhance its openness and economic dynamism through initiatives like the "Ten Hundred Thousand Action" for investment attraction [2]. Group 4: Innovation and Technology - Guangzhou plans to attract young entrepreneurial teams in future industries such as vertical large models, gene editing, and quantum computing, supported by newly established industry development funds [2]. - The city will focus on enhancing its core competitiveness in attracting foreign investment through innovation in the technology sector and collaboration in the supply chain with APEC economies [3].

Core Insights - The article discusses recent advancements in the medical field, particularly focusing on new cholesterol-lowering drugs and metabolic drugs like tirzepatide, which are being researched for cardiovascular outcomes [1] - There is a notable trend in the industry towards the use of AI in drug development, gene editing, and synthetic biology, which is expected to enhance efficiency from research and development to production [1] - Chinese companies, including Huaxi Biological, are actively investing in synthetic biology and biomanufacturing to improve the scalability and accessibility of certain bioactive components [1] Group 1 - Recent approvals of new cholesterol-lowering drugs and ongoing research into metabolic drugs are significant developments in the healthcare sector [1] - AI-assisted technologies are accelerating the efficiency of drug development and production, potentially lowering costs and increasing accessibility [1] - The need for more clinical evidence and long-term follow-up to validate the safety and effectiveness of these new technologies remains a critical consideration [1] Group 2 - Companies like Huaxi Biological are focusing on synthetic biology and biomanufacturing to enhance the production of bioactive components [1] - There is an emphasis on early risk identification and management of lifestyle and chronic disease indicators as practical health strategies for the general public [1]

为此，团队创新性地采用脂质纳米颗粒作为"运输车"，搭载基因编辑工具进入细胞。他们先用临床批准 的激光，在皮肤表层制造无痛的微米级小孔，帮助纳米颗粒顺利穿越屏障，抵达深层皮肤干细胞。一旦 到位，基因编辑器便精准修正错误DNA，唤醒皮肤自我修复能力。 团队表示，这一平台技术具有广泛适用性，可快速适配于其他遗传性皮肤病。 （文章来源：科技日报） 研究显示，新方法能在由真实人类皮肤构建的模型中，成功修复导致ARCI最常见的基因缺陷，并恢复 高达30%的正常皮肤功能。此前研究表明，这一水平足以实现临床意义上的显著改善。尤为关键的是， 它直击病因根源，一次治疗或可带来持久疗效。 CRISPR等基因编辑技术正为许多曾被视为"无解"的疾病带来新希望。尽管发展迅速，将其应用于皮肤 却长期面临挑战：皮肤作为身体的第一道屏障，天然阻隔外来物质，较大的生物药物难以穿透。 加拿大不列颠哥伦比亚大学与德国夏里特柏林卫生研究所科学家合作，开发出一种可直接用于修复人体 皮肤的基因编辑新疗法——利用CRISPR技术结合纳米颗粒"运输车"，精准纠正致病基因突变。这项成 果有望为多种遗传性皮肤病——从罕见病到湿疹等常见病，开辟全新治疗路径。相关研 ...

生命科学和医学，正在经历一次深刻而复杂的转变（transformation）：人工智能开始介入生命研究和药 物研发的关键环节；基因编辑正在重新定义我们对生物机制与进化边界的理解；在结束不久的新冠疫情 之后，社会重新思考如何应对突发性人类灾难。 与此同时，PD-1，CAR-T等革命性治疗方法，将在未来十年内令癌症变成一个完全可治的慢性病； GLP-1药物所带来的糖尿病和减肥的神奇疗效，有可能真正实现"治未病"，将预防和"消费医疗"，改善 身体健康状况，变成人们对生活品质的追求；Aβ抗体药的获批，人类对阿尔茨海默病的治疗终于获得 突破。 这一系列的科学进展，加上抗衰老与再生医学的发展，正在改变我们对生命边界的认知。人类开始严肃 地思考：生命可以被延展到什么程度？ 近日，由高山书院主办的"AI生万物"论坛中，几位重量级嘉宾围绕"生命、未来与伦理选择"主题，展开 了一场深度对话。以下是对话内容（经编辑）: 嘉宾信息 鲁白，高山书院学术管理委员会委员、上海尚思自然科学研究院院长 丁胜，清华大学药学院原院长、全球健康药物研发中心主任、拜耳特聘教授 何大一，美国国家医学院院士、哥伦比亚大学医学院艾伦·戴蒙德艾滋病研究中心主 ...

该研究 通过系统性功能筛选，开发了一种基于 微生物来源 EcRecE 核酸外切酶 的精准基因编辑工具—— Cas9-EcRecE ， 该编辑系统 在哺乳动物细胞中 显著 提 高 长片段 DNA （ 千碱基级 ） 的精准插入效率 。同时，基于 dCas9 ，该研究进一步构建了 无 需依赖 DNA 双链断裂 （DSB） 的安全 基因组编辑工具 —— dCas9-EcRecTE ，为实现安全高效的基因编辑提供新的技术支持 。 编辑丨王多鱼 排版丨水成文 CRISPR/Cas9 基因编辑 技术 已成为 21 世纪生物医学领域最具突破性的 基因编辑工具， 在基础研究和转化医学方面展现巨大潜力。然而， CRISPR/Cas9 技 术仍面临许多亟须解决的技术挑战。其一，精准且安全编辑挑战。 CRISPR/Cas9 技术依赖基因组 DNA 双链断裂 （ DSB ） 或单链断裂 （ SSB ） 来介导基因 编辑事件发生。断裂的 DNA 极易 诱发非同源末端连接 （ NHEJ） 修复通路 ，进一步 引发潜在的基因组不稳定性和细胞毒性效应。 其二，长片段高效插入挑 战。 现有基因编辑工具大多用于短序列 DNA 片段的插入或编辑 ， ...

Core Insights - The article emphasizes the rapid transition of molecular biology technologies from "basic research breakthroughs" to "precision medicine and biotechnology industry" [1] - Key technologies such as gene editing, high-sensitivity nucleic acid testing, and epigenetic regulation are highlighted as essential tools for understanding disease mechanisms, advancing biological breeding, and enhancing clinical diagnostics [1] Event Details - The series of webinars titled "Frontier Technologies and Translational Applications in Molecular Biology" is organized by Instrument Information Network, focusing on the latest advancements in molecular biology [1] - The event will take place from January 23 to April 17, 2026, featuring various sessions on gene editing and epigenetic regulation [2] Conference Agenda - The first session on January 23 will cover topics such as high-precision mitochondrial DNA base editors and advancements in gene editing research [2] - Notable speakers include researchers from West Lake University and Fudan University, as well as application experts from Bio-Rad Laboratories [2]

Core Insights - Yunnan Province has issued an action plan to accelerate the construction of a modern industrial system, focusing on the biopharmaceutical industry as a key strategic emerging industry, aiming for an industry revenue of 350 billion yuan by 2027 [1] Group 1: Industry Growth and Revenue - During the 14th Five-Year Plan, Yunnan's biopharmaceutical industry has seen steady revenue growth, increasing from 275.1 billion yuan in 2021 to 323.2 billion yuan in 2024, with an average annual growth rate exceeding 6.5% [1] - The industry has established a complete industrial chain for natural medicines and a biopharmaceutical research and production system focused on vaccines [1] Group 2: Technological Advancements and Innovations - Significant technological breakthroughs include the successful development and mass production of genetically edited donor pigs for organ transplantation, and the approval of two Class I new drugs for clinical trials [2] - Research on dengue virus isolation has been recognized as one of the "Top Ten Advances in Life Sciences in China" for 2024, and ultrasound-guided interventional therapy has been designated as a global promotion project by the United Nations [2] Group 3: Future Development Strategies - The 15th Five-Year Plan will focus on advancing core technologies in biopharmaceuticals, including new vaccines, antibody drugs, and gene therapy, while accelerating new product development [2] - Yunnan aims to integrate healthcare with biopharmaceuticals, exploring active components from highland plants and animals to develop new raw materials and products [2] - The province is also planning to promote the industrialization of biomanufacturing, cell therapy, and xenogeneic organ transplantation, expanding the application of biotechnology across various fields [2]

Group 1 - The World Top Scientists Summit will be held from February 1 to 3 in Dubai, featuring 71 leading scientists, including 39 Nobel laureates, 6 Turing Award winners, and 7 Wolf Prize winners, discussing the theme "Basic Science: Addressing Future Challenges for Humanity" [1][3] - The summit will focus on four key topics: the integration of artificial intelligence and basic science, the collaborative evolution of scientific progress and social development, global collaboration pathways for open science, and the future construction of scientific cooperation systems [3] - The 2026 World Government Summit is scheduled for February 3 to 5 in Dubai, with the theme "Shaping Future Governments," and it is expected to be the largest since its inception in 2013, with over 30 foreign heads of state and government leaders in attendance [3]

Group 1 - The World Leading Scientists Summit (WLS) and the World Government Summit (WGS) will hold a joint summit in Dubai from February 1 to 3, featuring 71 top scientists, including 39 Nobel laureates [1][2] - The theme of the summit is "Fundamental Science: Addressing the Challenges of Humanity's Future," focusing on four key topics: the integration of artificial intelligence and fundamental science, the co-evolution of scientific progress and social development, global collaboration in open science, and the future of scientific cooperation systems [1] - The summit aims to enhance the UAE's position as a "global scientific hub" through extensive scientific collaboration [1] Group 2 - The World Government Summit, held annually in Dubai since 2013, aims to drive global governance transformation through innovation and technology, with over 6,000 participants last year and an expected attendance of 40 heads of state and over 500 government ministers this year [2] - The joint summit model is expected to create new opportunities for resource linkage and collaboration, enhancing the depth and breadth of engagement between the two events [2]