Group 1 - The event held in Nanning, Guangxi, focused on the transformation of significant scientific achievements from the Chinese Academy of Sciences, with 21 key projects signed to enhance the high-quality development of Guangxi's industries [1][3] - The theme "Chinese Academy of Sciences Enters Guangxi, Creating a Future" highlights the collaboration between the Guangxi Science and Technology Department and the Guangzhou Branch of the Chinese Academy of Sciences, addressing urgent needs in artificial intelligence, high-end equipment manufacturing, and advanced new materials [3][5] - A total of 65 cutting-edge technological achievements were showcased at the event, with an additional 240 achievements released online, demonstrating the strong momentum technology provides for industrial upgrades in Guangxi [3][5] Group 2 - Four Guangxi enterprises and four research institutes from the Chinese Academy of Sciences presented their major technological achievements in fields such as artificial intelligence, biomanufacturing, new materials, and marine medicine, fostering deeper industry-academia-research collaboration [5] - The Guangxi Technology Achievement Transformation Fund was promoted at the event, aiming to provide financial support for the transformation of scientific achievements into production, thereby injecting momentum into Guangxi's industrial development [5]

Core Viewpoint - The article discusses the announcement of a project by Ningxia Zhongke Biological New Materials Co., Ltd. to produce 110,900 tons of bio-fermentation products annually, highlighting the company's technological upgrades and production capabilities in the bio-manufacturing sector [1]. Project Overview - Project Name: Annual production of 110,900 tons of bio-fermentation products - Construction Unit: Ningxia Zhongke Biological New Materials Co., Ltd. - Nature of Construction: Technological upgrade - Industry Category: C2710 Chemical raw materials and pharmaceutical manufacturing - Investment: 100.89 million yuan - Location: Shizuishan Economic and Technological Development Zone - Land Area: 387,309.18 m², utilizing existing facilities without new land acquisition [2]. Construction Scale - The project includes four flexible production lines: 1. **Long-chain dicarboxylic acid production line**: Annual capacity of 18,000 tons, producing various dicarboxylic acids [3]. 2. **Bio-fermentation functional products production line**: Annual capacity of 5,100 tons, including D-chiro-inositol, coenzyme Q10, and DHA algae oil [4]. 3. **Bio-food production line**: Annual capacity of 63,000 tons, producing calcium propionate and L-malic acid [5]. 4. **Amino acid products production line**: Annual capacity of 24,800 tons, producing various amino acids [6]. Technological Upgrade Scope - The upgrade encompasses fermentation workshops, extraction workshops, refining workshops, drying workshops, liquid bio-fertilizer workshops, tank areas, and power centers [7]. Company Background - Ningxia Zhongke Biological New Materials Co., Ltd. was established on June 2, 2017, with a registered capital of 1.3 billion yuan. The company is involved in the production of feed additives, food additives, fertilizers, and bio-based materials [8]. Financial Performance - The company reported revenue of 345 million yuan and a net loss of 539 million yuan during the reporting period. To address its debt crisis, the company entered pre-restructuring in May 2024, with government support extended until the end of 2024 [9]. - In the first quarter of 2025, the company achieved total revenue of 93.82 million yuan, a year-on-year increase of 74.08%, but still reported a net loss of 64.08 million yuan [11].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the "14th Five-Year Plan" period, discussing innovative technologies and products that can sustain the industry's vitality [1]. Group 2: Organizers and Highlights - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. - Key highlights include forums on biomanufacturing trends, youth innovation sharing, project roadshows, and participation from leading enterprises, top universities, and investment institutions [4]. Group 3: Agenda and Special Activities - The first day features a closed-door high-level seminar focusing on biomanufacturing development trends and growth points, inviting 30 industry leaders and experts [7]. - The second and third days will include a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. Group 4: Focus Areas in Sub-Forums - Sub-forum topics include the development of bio-based chemicals, green manufacturing technologies for fine chemicals, and the use of non-food raw materials for high-value product development [11]. - AI applications in biomanufacturing will also be discussed, including the use of AI for enzyme discovery and industrial fermentation process control [11].

特色专场 生物制造青年论坛 8月20日，浙江·宁波 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 SynBioCon 大会 | 生物制造青年论坛 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （ ...

Core Viewpoint - The article discusses the innovative approach of Ecopha Biotech, founded by Dr. Wilson Ling, to significantly reduce the cost of PHA (polyhydroxyalkanoates) production by utilizing non-food plant oils, specifically Pongamia oil, as a raw material, aiming to compete with traditional petroleum-based plastics [2][9][31]. Group 1: Industry Background - The biodegradable materials market, including PLA and PBAT, has faced challenges such as oversupply and performance limitations, leading to a decline in production rates [6][7]. - PHA stands out due to its advantages like "biomanufacturing," "marine biodegradability," and high thermal resistance (up to 100°C), with the global market expected to reach $367 million by 2030 [6][9]. - The current cost of PHA exceeds 40,000 yuan per ton, making it difficult to compete with petroleum-based plastics priced below 10,000 yuan per ton [7][9]. Group 2: Company Background - Ecopha Biotech was established in June 2025, with Dr. Wilson Ling returning to China after years of research and entrepreneurship abroad, driven by the desire to overcome the cost barriers of PHA production [9][19]. - The company aims to leverage a patented strain of bacteria and non-food oils to achieve a significant reduction in production costs [9][22]. Group 3: Raw Material Cost Reduction - The primary focus for cost reduction is on raw materials, which account for over 50% of PHA production costs. Traditional sugar-based routes have a conversion rate capped at 30%, leading to high costs [22][23]. - Dr. Ling's research determined that using plant oils, particularly Pongamia oil, could achieve a conversion rate of over 80%, significantly lowering production costs [22][31]. - Pongamia oil is non-food, cost-effective (half the price of palm oil), and has a high yield, making it suitable for sustainable production [25][30][31]. Group 4: Technological Advancements - Ecopha Biotech has completed laboratory and pilot-scale validations for using Pongamia oil and has designed a process package for a large-scale production line [32]. - The company plans to focus on medical products initially, targeting the Australian market, where there is a high demand for biodegradable medical supplies [33]. - The first production line in China is expected to replace 15,000 to 20,000 tons of petroleum-based plastics annually once operational [33]. Group 5: Future Outlook - Dr. Ling envisions that the real competition for PHA is not other bioplastics but the vast quantities of petroleum-based plastics that contribute to environmental pollution [34]. - The company aims to collaborate with domestic peers to promote the large-scale industrialization of PHA, potentially alleviating plastic pollution issues as production scales up [34].

SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （ ...

Project Overview - The project is named "Jinan Baijie High-Performance New Enzyme Preparation R&D and Industrialization Construction Project" [2] - The construction unit is Jinan Baijie Biological Engineering Co., Ltd., located in the Shanghe Chemical Industry Park, Jinan, covering an area of 70,067.81 m² (approximately 105.1 acres) [2] Investment and Construction Details - The total investment for the project is 775.49 million yuan, with phase one investment at 562.24 million yuan and phase two at 213.25 million yuan [3] - Environmental investment for phase one is 41.59 million yuan (7.39% of total investment), and for phase two is 6.21 million yuan (2.91% of total investment), all funded by the company [3] - The construction period for both phases is 21 months each [4] Production Capacity and Facilities - The project includes the construction of a fermentation workshop with a total of 12 fermentation tanks (6 in each phase), and two extraction and blending workshops [4] - The total production capacity for high-performance new enzyme preparations will be 45,000 tons per annum (t/a), with each phase contributing 22,500 t/a [4] Existing Product Situation - The northern fermentation workshop has been out of production for several years, while the southern workshop is operational [6] - The northern workshop has an annual production capacity of 1,500 tons for α-galactosidase, while the southern workshop has capacities of 5,200 t/a for liquid single enzyme products, 3,000 t/a for liquid proteases, and 8,000 t/a for liquid glucose oxidase and liquid fat enzymes, totaling 17,700 t/a for the entire plant [7] Company Background - Jinan Baijie Biological Engineering Co., Ltd. was formerly known as Jinan Nuoneng Biological Engineering Co., Ltd. and is a wholly-owned subsidiary of Kingsoft Bio-Technology (HK01548), established in 2009 [9] - The company specializes in the R&D, production, and sales of biological enzyme preparations, focusing on feed and industrial enzyme preparations, with core products including glucose oxidase, phytase, and compound enzymes [10]

Group 1 - The research team led by He Wei focused on developing new productive forces tailored to local conditions to promote the rapid rise of the central region during their visit to Henan [1][2] - He Wei emphasized the strategic importance of Henan as a major population, economic, and agricultural province, highlighting the need for the central region to accelerate its rise as part of a national strategy [2] - The team conducted field research at various institutions, including medical colleges and emergency rescue practice stations, to assess the implementation of Red Cross work and gather insights on local governance and development [1][2] Group 2 - The central government's strategy for the rise of the central region is a significant decision based on the overall modernization of the country, requiring adherence to key political principles and the implementation of relevant policies [2] - There is a focus on upgrading traditional industries and developing new productive forces, with an emphasis on strategic emerging industries such as artificial intelligence, new materials, and biomanufacturing [2]

Core Viewpoint - Lignin valorization is crucial for achieving economically viable and sustainable lignocellulosic biorefineries, with a focus on overcoming the challenges posed by expensive cofactors and enzyme activity imbalance [1][3][14] Group 1: Lignin Valorization Challenges - The continuous demand for expensive cofactors like ATP, NADPH, and CoA significantly hinders the sustainable conversion of lignin into valuable products [1] - The production rates of valuable molecules derived from lignin, such as raspberry ketone (RK) and curcumin, are extremely low, highlighting the inefficiencies in current conversion processes [1][3] Group 2: iMECS Strategy Development - The iMECS (in vitro multi-enzyme coordinated expression with cofactor self-circulation) strategy integrates cofactor regeneration and cell-free expression into the lignin upgrading process [3][4] - The iMECS platform demonstrated a 48-fold increase in overall catalytic efficiency without the addition of external cofactors, achieving a curcumin production rate of 0.175 g/L/h and a molar yield of 95.31% [3][6] Group 3: Multi-Enzyme Optimization - The study optimized the production of curcumin by establishing a biocatalytic module and introducing an in situ multi-cofactor recovery module, resulting in a curcumin yield of 126.4 mg/L [5][6] - The iMECS system achieved a curcumin production rate that was over 1455% higher than traditional whole-cell bioconversion methods [6] Group 4: Application to Vanillin Synthesis - The iMECS system was further evaluated for the conversion of ferulic acid to vanillin, achieving a vanillin yield of 94.4 mg/L with a 67% reduction in ATP demand [7][8] - The system's efficiency was enhanced by employing a temperature-guided biocatalytic process, which maintained enzyme activity while inactivating undesirable endogenous enzymes [9] Group 5: RK Biosynthesis - The iMECS strategy was applied to the more complex pathway of converting p-coumaric acid (pCA) to RK, achieving a production rate of 0.15 g/L/h and a conversion rate of 91.56% [10][13] - The integration of upstream and downstream modules within the iMECS system demonstrated significant potential for synthesizing more complex products from lignin-derived substrates [12][13] Group 6: Environmental and Economic Implications - The iMECS strategy promotes the use of lignin-rich agricultural waste as a feedstock, decoupling biomanufacturing from sugar prices and reducing greenhouse gas emissions compared to traditional petroleum-based synthesis [14]

精英计划-人才需求 | 天津工生所 中国科学院天津工业生物技术研究所是由中国科学院与天津市人民政府共建、整建制从事生物制造和 工业生物技术研究的国立科研机构，是我国工业生物领域的战略科技力量，肩负着创新生物产业关键 核心技术、发展生物制造重大颠覆性技术、支撑我国生物经济高质量可持续发展的历史使命，围 绕"以可再生碳资源替代化石资源、以清洁生物加工方式替代传统化学加工方式、以现代生物技术提 升产业水平"三大战略主题，重点开展"工业蛋白质科学与生物催化工程、合成生物学与微生物制造 工程、生物系统与生物工艺工程"三个领域方向的基础研究和应用基础研究。 招 聘部门 简介 01 邓子新大师工作室以活性天然产物的创新与绿色制造为目标，遵循"师从于自然、认知于自然，创新 于自然"的学术思路，运用合成生物学理念，聚焦交叉学科前沿，建立和完善天然药物精准发掘、结 构创新和优产新模式，实现微生物天然药物的高效生产。 团队由 徐敏研究员 与 侯安伟研究员 领衔，重点关注全新作用机制抗生素（糖肽抗生素）与萜类天 然产物的高效精准挖掘、生物合成机制与作用机制解析以及相关新分子的高效创制。 徐敏研究员主要从事微生物天然产物合成生物学以及 ...