Core Viewpoint - The Hong Kong stock market continues to adjust, with the pharmaceutical sector declining alongside the market, particularly affected by a short-term cooling of AI medical concepts [1][12]. Group 1: Market Performance - The Hong Kong Medical ETF Huabao (159137) fell by 0.93%, marking two consecutive days of decline, while the Hong Kong Innovation Drug ETF (520880) dropped by 1.08% [1][12]. - The medical sector saw 13 stocks rise and 37 fall, with Ark Health, a hot stock in AI medical concepts, leading the decline at 6.98%, and Alibaba Health also falling by 5.16% [2][13]. - The Hong Kong Medical Theme Index achieved a record nine consecutive days of gains before experiencing a pullback, with the Huabao ETF having a cumulative increase of 6.9% in its first week, outperforming the Hang Seng Index, which rose by 2.34% [3][14]. Group 2: Sector Analysis - The Huabao Medical ETF covers 50 leading stocks across various medical fields, including CXO, AI medical, medical devices, and innovative drugs, indicating a comprehensive approach to capturing market trends [5][16]. - The medical sector has shown significant recovery since 2026, driven by hot themes like brain-computer interfaces and AI medical, with increasing investment value [6][17]. - The CXO sector is expected to see a recovery in demand, with WuXi AppTec forecasting a net profit of 19.151 billion yuan for 2025, reflecting a year-on-year growth of approximately 102.65% [18]. Group 3: Investment Opportunities - Analysts suggest focusing on innovative overseas expansion and hard technology sectors, such as AI medical and brain-computer interfaces, while monitoring the expansion of medical insurance and essential drug directories [18]. - The Huabao Medical ETF is highlighted as a high-elasticity investment tool for capturing new opportunities in the medical field, particularly in AI medical and innovative drug supply chains [18]. - The largest medical ETF in the A-share market, focusing on medical devices and services, is also noted for its significant weight in AI medical and brain-computer interface concept stocks [18].

Core Viewpoint - The Hong Kong stock market continues to adjust, with the pharmaceutical sector declining alongside the market, particularly affected by a short-term cooling of AI medical concepts [1][12]. Group 1: Market Performance - The Hong Kong Medical ETF Huabao (159137) fell by 0.93%, marking two consecutive days of decline, while the Hong Kong Innovation Drug ETF (520880) dropped by 1.08% [1][12]. - The medical sector saw 13 stocks rise and 37 fall, with Ark Health, a hot stock in AI medical concepts, leading the decline at 6.98%, and Alibaba Health also falling by 5.16% [2][13]. - The Hong Kong Medical Theme Index achieved a record nine consecutive days of gains before experiencing a pullback, with the Medical ETF Huabao having a cumulative increase of 6.9% in its first week, outperforming the Hang Seng Index [3][14]. Group 2: Sector Analysis - The Hong Kong Medical ETF Huabao covers 50 leading stocks across various medical fields, including CXO, AI medical, medical devices, and innovative drugs, indicating a comprehensive approach to capturing market trends [5][16]. - The medical sector has shown significant recovery since 2026, driven by hot themes like brain-computer interfaces and AI medical, with increasing investment value [6][17]. - The CXO sector is expected to see a "Davis Double Play" with both profit and valuation improvements, as demand gradually recovers and supply has been cleared over the past three years [18]. Group 3: Future Outlook - Analysts predict that by 2026, key areas of growth will include innovative overseas expansion and hard technology sectors such as AI medical and brain-computer interfaces, with a focus on monitoring the expansion of medical insurance and essential drug directories [18]. - The Medical ETF Huabao is positioned as a high-elasticity tool for capturing new opportunities in the medical field, particularly in AI medical, brain-computer interfaces, and innovative drug supply chains [18]. - The total scale of the medical ETF fund reached 27 billion yuan, making it the largest in the market for medical-related ETFs [19].

Group 1 - The core focus of the news is on the performance of the ChiNext Medical ETF (159377), which rose over 2.2%, highlighting the significance of brain-computer interfaces and innovative medical devices [1] - The development of pan-RAS/KRAS inhibitors aims to cover a broader range of mutation types and potentially overcome resistance issues more effectively, with KRAS mutations being the most prevalent in human cancers at 81% [1] - The CXO and upstream sectors are experiencing slight growth in pharmaceutical financing, with factors such as BD transactions and H-share IPOs revitalizing innovation enthusiasm, leading to a recovery in order demand [1] Group 2 - The ChiNext Medical ETF tracks the Innovation Medicine Index (399275), which includes listed companies in the biopharmaceutical and medical device sectors, reflecting the overall performance of China's healthcare industry in innovation [2] - The index has a daily price fluctuation limit of 20%, and it encompasses companies involved in innovative drug development, biotechnology, and medical services [2]

Group 1: Market Overview - The A-share market experienced a collective pullback on January 13, with the Shanghai Composite Index down 0.64%, ending a 17-day winning streak, while the Shenzhen Component Index fell 1.37% and the ChiNext Index dropped 1.96% [1] - The trading volume in the Shanghai, Shenzhen, and Beijing markets exceeded 3.6 trillion yuan, marking a slight increase from the previous day and setting a new historical high [1] Group 2: AI Medical Sector - The AI medical sector continues to thrive, with significant gains; the Hong Kong medical ETF (159137) surged by 3.44% and reached a near-limit-up level, while the largest A-share medical ETF (512170) hit a three-month high with a peak increase of 3.67% [4][6] - AI medical concept stocks saw substantial increases, with Ark Health rising over 76% after announcing a collaboration with Tencent Health on an "AI + chronic disease management" plan [4][8] Group 3: Banking Sector - The banking sector showed resilience, with several banks like Ningbo Bank and Hangzhou Bank seeing gains of over 4% and 3% respectively, while the top banking ETF (512800) rose by 0.37% [11][13] - The first bank executive buyback announcement of 2026 was made by Chongqing Rural Commercial Bank, indicating confidence in the company's fundamentals [13] - Historical data suggests that the banking sector tends to perform well before the Spring Festival, with an average absolute return of 4.4% [16] Group 4: Commercial Aerospace Sector - The commercial aerospace sector faced volatility, with the general aviation ETF (159231) experiencing a significant drop of 7.27%, despite a net inflow of 46 million yuan on the same day [18][19] - The sector's performance has been mixed, with 44 out of 50 component stocks declining, while some stocks like Tianyin Electromechanical and Haige Communication saw gains [18] Group 5: Future Outlook - Analysts suggest that the current market liquidity is ample, and thematic trading is expected to continue, with a focus on the "Musk Chain" and non-bank financial investment opportunities [3] - The market is anticipated to exhibit structural opportunities, with a theme-driven approach and rapid capital rotation among different industry lines [3]

Market Overview - The A-share market has experienced a correction after continuous growth, while the Hong Kong stock market showed signs of catching up, opening with a gap and closing up 0.90% with a trading volume of HKD 315.2 billion [1] - The AI sector is gaining significant attention, with Alibaba's Tongyi Qianwen series models achieving over 700 million downloads, making it the highest downloaded open-source AI series on the Hugging Face platform [1] - Concerns remain in the market due to geopolitical tensions, particularly with the U.S. urging citizens to leave Iran, which has affected investor sentiment [1] AI Sector - Several domestic AI companies, including MiniMax and Zhipu AI, have recently gone public in Hong Kong, attracting market interest, with the latest listing of Zhaoyi Innovation seeing a rise of over 40% [2] - Despite recent adjustments in the AI sector, the overall interest in high-tech companies remains strong [2] Pharmaceutical and Biotechnology - Merck's CEO indicated plans for aggressive acquisitions to strengthen its innovative drug pipeline before the expiration of the patent for Keytruda in 2028, which is positive news for Chinese innovative drug companies [3] - WuXi Biologics reported record high upfront and total payment amounts for research services, with potential milestone payments exceeding USD 4 billion, leading to a positive outlook for CXO companies [3] Commercial Aerospace - A number of companies in the commercial aerospace sector issued risk warnings, indicating that their aerospace business constitutes a minimal portion of their operations, with most being less than 1% [2] - Regulatory efforts appear to be aimed at cooling down the commercial aerospace hype, as evidenced by a nearly 10% drop in shares of Goldwind Technology [2] Renewable Energy and Storage - The domestic energy storage market saw a significant increase in bidding volume, with a year-on-year growth of 61% in new bidding capacity [5] - Companies like Guofeng Lithium and Tianqi Lithium have performed well, driven by market expectations for increased demand in the short term due to policy changes regarding export tax rebates for photovoltaic and battery products [4] Gold and Mining - Zijin Mining International's stock rose over 7% as gold prices reached new highs, supported by rising risk aversion among investors [7] - The company has a significant amount of gold resources and a low average acquisition cost for gold mines, which positions it favorably for future growth [8] - The company’s gold production is expected to maintain a compound annual growth rate (CAGR) of over 15% through 2025-2027, driven by both internal growth and acquisitions [8]

Group 1 - The CRO and innovative drug sectors are experiencing strong gains, with stocks like Rongchang Biopharma A-shares and H-shares, WuXi AppTec, and Sanofi rising by 17%, 9%, 7.9%, and 7.2% respectively, leading to a 3.5% increase in the Tianhong Innovative Drug ETF [1] - The Tianhong Innovative Drug ETF (517380) is the only ETF tracking the Hang Seng Shanghai-Shenzhen Hong Kong Innovative Drug Selected 50 Index, focusing on 50 actively traded innovative drug and CXO companies with high R&D investment [1] - The ETF has seen a net inflow of 207 million yuan over the past five days, indicating strong investor interest [1] Group 2 - The 44th JPMorgan Global Healthcare Conference is set to take place, with over 20 domestic innovative drug companies confirmed to participate, including WuXi AppTec and several others [1] - WuXi AppTec is projected to achieve a profit of 19.151 billion yuan in 2025, representing a year-on-year increase of 103%, with Q4 net profit expected to reach 7.075 billion yuan, a quarter-on-quarter increase of 101% [1] - The sixth batch of national centralized procurement for high-value medical consumables is about to open for bidding, including 12 types of medical consumables [2] Group 3 - The medical device ETF (159873) has a significant focus on brain-machine interfaces, accounting for over 19% of its composition, indicating strong technological attributes [2] - The ETF's components include a high proportion of stocks from the Sci-Tech Innovation Board and the Growth Enterprise Market, nearly 80%, suggesting a robust growth potential [2] - The industry outlook for 2026 remains positive, with a focus on innovation, international expansion, and recovery in challenging markets, particularly in the CXO and upstream supply chain sectors [2]

Group 1 - The core viewpoint of the article highlights the strong market interest in the chemical CDMO sector, particularly regarding Chinese companies' advantages in talent, chemical capabilities, compliance capacity, and intellectual property protection [1] - According to Guosen Securities, Chinese enterprises in the chemical CDMO field are expected to maintain a strong irreplaceable position over the next five years, especially compared to European and Indian counterparts [1] - The domestic leader WuXi AppTec is increasing its global market share in the CRDMO sector, indicating competitive dynamics among China, Europe, the US, Japan, and South Korea in the biopharmaceutical CDMO space [1] Group 2 - The "Biological Safety Act" is expected to have a mild impact in the short term, but long-term attention is needed on the restructuring of the global biopharmaceutical supply chain and the implementation of the act's details, which may affect the international business of Chinese CXO companies [1] - The Chinese innovative drug industry is projected to have a long-term positive outlook, with explosive growth in BD transactions, and external licensing being a starting point for global development [1] - The Guotai Innovation Drug ETF (517110) tracks the SHS Innovation Index (931409), which selects innovative pharmaceutical companies from the Shanghai, Shenzhen, and Hong Kong markets, focusing on those with outstanding R&D capabilities and growth potential [1]

Core Insights - The Chinese healthcare industry has undergone a significant transformation from 2020 to 2025, transitioning from a "golden era" of investment to a "bubble-clearing period" characterized by a K-shaped divergence in market performance [1][2][4]. Group 1: K-shaped Downward Trends - The collapse of previously successful business models, particularly in CXO, consumer healthcare, and internet healthcare, has led to substantial market value losses, with some companies experiencing declines of over 90% [4][7]. - The downturn is attributed to macroeconomic factors such as U.S. interest rate hikes and geopolitical tensions, as well as microeconomic issues like supply-demand imbalances and the disappearance of growth dividends [8][10]. - The CXO sector, once seen as a perpetual growth engine, has faced a 46.68% decline for WuXi Biologics and 44.47% for Tigermed, revealing the fragility of its business model reliant on continuous global financing [12][10]. - Consumer healthcare has suffered a "Davis double whammy," with companies like Yonghe Medical and Aier Eye Hospital seeing declines of 86.19% and 52.69%, respectively, as consumer spending shifts away from discretionary healthcare services [14][15]. - Internet healthcare companies, including Zhiyun Health and Dingdang Health, have also faced severe declines, with drops of 92.44% and 90.67%, as the market realizes that their revenue largely comes from online drug sales rather than innovative healthcare solutions [19][21]. Group 2: K-shaped Upward Trends - In contrast, companies with strong global rights and hard-core technology have thrived, with Keren Biotechnology and Kangfang Biopharma seeing increases of 518.33% and 166.72%, respectively, marking a shift towards biopharma and global market engagement [29][31]. - The rise of these companies signifies a new era where capital is attracted to firms that can demonstrate robust clinical data and global market potential, moving away from mere concepts [30][31]. - Even within struggling sectors, some companies like WuXi AppTec and Yuyue Medical have shown resilience, with increases of 113.36% and 28.75%, respectively, by focusing on high-tech, high-barrier services [34][35]. Group 3: Challenges Ahead - Despite the emergence of new leaders, significant challenges remain, including the risks associated with licensing agreements that may compromise long-term profitability [36][37]. - The ADC sector is experiencing a rush similar to the past PD-1 craze, raising concerns about market saturation and price competition, which could undermine future profitability [39][40]. - The ongoing "ice age" in the primary market poses a threat to innovation, as funding for early-stage companies has become increasingly scarce, potentially leading to a decline in new drug approvals in the coming years [42][43].

Group 1 - The CRO and innovative drug sectors are experiencing strong gains, with Rongchang Biopharma A-shares rising by 17%, H-shares by 9%, WuXi AppTec by 7.9%, and 3SBio by 7.2%, leading to a 3.5% increase in the Tianhong Innovative Drug ETF, outperforming the Hong Kong Stock Connect innovative drug index (2.25%) and the Hong Kong innovative drug index (0.18%) [1] - The Tianhong Innovative Drug ETF (517380) is the only ETF tracking the Hang Seng-Hushen-Hong Kong innovative drug selected 50 index, comprising 50 actively traded innovative drug and CXO companies with high R&D investment [1] - The ETF has seen a net inflow of 207 million yuan over the past five days, indicating strong investor interest [1] Group 2 - The 44th JPMorgan Global Healthcare Conference is set to take place on January 12, featuring over 20 domestic innovative drug companies, including WuXi AppTec and several others [2] - WuXi AppTec is projected to achieve a pre-tax profit of 19.151 billion yuan in 2025, representing a year-on-year increase of 103%, with Q4 net profit expected to reach 7.075 billion yuan, a quarter-on-quarter increase of 101% [2] - The sixth batch of national centralized procurement for high-value medical consumables is about to open for bidding, including 12 types of medical consumables [2] Group 3 - Guotai Junan Securities is optimistic about the pharmaceutical industry in 2026, focusing on innovation, overseas expansion, and recovery trends, with an emphasis on innovative drugs and supply chains as foundational investments [2] - The medical device ETF (159873) has a significant focus on brain-computer interfaces, accounting for over 19%, and is expected to benefit from domestic innovation, accelerated exports, and new technologies [2] - The biopharmaceutical ETF (159859) is recommended for its higher concentration and focus on 30 industry leaders, offering greater sharpness and elasticity in the market [2]

Macro and Strategy Research - The US manufacturing PMI has further declined in December 2025, marking the largest month-on-month drop since 2024, indicating a prolonged downturn for 10 months, while the service sector PMI remains strong, highlighting structural divergence in the US economy [2][3] - In China, the manufacturing PMI returned above the threshold in December 2025, with improvements in both supply and demand, while the non-manufacturing sector also showed unexpected recovery [3] Fixed Income Research - In December 2025, the central bank's liquidity net injection exceeded 800 billion, with money market rates remaining low, while the yield on 10Y government bonds rose by 1 basis point to 1.85% by the end of December [7][9] - The bond market is expected to maintain a range-bound pattern, with inflation and monetary policy acting as anchors for the upper and lower bounds of this range [9] Industry Research - The listing of Rebio Biotech on the Hong Kong Stock Exchange has increased attention on the small nucleic acid sector, with significant developments in the industry including the approval of new drugs and strategic partnerships [10][12][13] - The SW pharmaceutical index rose by 6.13% in the week of January 5-8, 2026, with all sub-sectors experiencing gains, indicating a strong market performance [13]