证券研究报告：医药生物|行业周报 发布时间：2025-06-16 行业投资评级 强于大市 |维持 行业基本情况 | 收盘点位 | | 7895.79 | | --- | --- | --- | | 52 | 周最高 | 8490.25 | | 52 周最低 | | 6070.89 | 行业相对指数表现 2024-06 2024-08 2024-11 2025-01 2025-04 2025-06 -14% -11% -8% -5% -2% 1% 4% 7% 10% 13% 16% 19% 医药生物 沪深300 资料来源：聚源，中邮证券研究所 研究所 分析师:蔡明子 SAC 登记编号:S1340523110001 Email:caimingzi@cnpsec.com 分析师:龙永茂 SAC 登记编号:S1340523110002 Email:longyongmao@cnpsec.com 近期研究报告 推荐标的：英科医疗、迈普医学、怡和嘉业、微电生理、 拱东医疗、派林生物、益丰药房、大参林、康臣药业、佐力药 业、桂林三金、天士力、新里程、美年健康、国际医学。 《政策支持上市公司通过并购重组高 质量发展，行业整合持 ...

Group 1 - A-shares experienced a decline on June 6, with the Sci-Tech Medicine Index ETF (588700) showing a fluctuation, down 0.45% and with a turnover rate exceeding 8%, and a trading volume over 18 million [1] - The Sci-Tech Medicine Index ETF closely tracks the Shanghai Stock Exchange Sci-Tech Board Biomedicine Index, which selects 50 large-cap companies in biomedicine and related fields, reflecting the overall performance of representative biomedicine companies listed on the Sci-Tech Board [1] - Notable stocks within the ETF include Maiwei Biotech-U, which rose over 3%, along with several others such as Dongfang Bio, Borui Pharma, and Shenzhou Cell, indicating active trading in the sector [1] Group 2 - The National Healthcare Security Administration has revised the medical price and procurement credit evaluation system to combat improper trading behaviors like commercial bribery, aiming to enhance market integrity and resource allocation [2] - Longcheng Securities suggests that the frequent favorable policies for the pharmaceutical sector may lead to a steady recovery in industry sentiment, particularly in the hospital market, which has been affected by previous anti-corruption measures [2] - The focus on innovative therapies is expected to drive significant growth, with domestic BIC/FIC innovative drugs improving in quantity and quality, indicating a broad space for domestic innovation and international expansion [2] Group 3 - Zhongtai Securities emphasizes the importance of embracing innovation, highlighting record-breaking BD transaction amounts and strong performances of Chinese pharmaceutical companies at ASCO, suggesting a potential revaluation of the sector [3] - The recommendation includes actively investing in segments expected to recover, such as CRO&CDMO, upstream research, specialty raw materials, chain pharmacies, and branded OTC products [3] - The overall business situation for Q2 is anticipated to become clearer, providing opportunities for strategic investments in the pharmaceutical industry [3]

Summary of Aibo Medical Conference Call Company Overview - Aibo Medical started with artificial lens business and expanded into orthokeratology lenses and contact lenses, creating a diversified product matrix [2][4] - The company has achieved a compound annual growth rate (CAGR) of 49% in revenue and 64% in net profit from 2018 to 2024 [2][5] Revenue Structure - Artificial lenses remain the main source of revenue but are declining in proportion, expected to account for 42% of revenue in 2024 [2][6] - Orthokeratology lenses are projected to increase to 17% of revenue by 2024 [2][6] - Contact lenses have rapidly increased their revenue share to 30% by 2024 [2][6] Market Expansion - Aibo Medical is actively expanding its overseas market, with current overseas revenue accounting for about 3%-4% [2][7] - The company has established sales networks in Europe, Asia, and Oceania, with plans to further expand into South America [2][7] Industry Potential - The domestic cataract surgery penetration rate is significantly lower than that of developed countries, indicating substantial market potential for artificial lenses [2][8] - The domestic market for artificial lenses is expected to exceed 10 billion yuan by 2030 [2][8] Competitive Landscape - Aibo Medical is positioned as a leading domestic player in the artificial lens market, benefiting from the trend of domestic substitution due to centralized procurement [2][9] - The average price reduction from centralized procurement is around 60%, which is considered moderate [2][9] Innovation and Development - Aibo Medical has made significant technological breakthroughs in multi-focal artificial lenses, breaking the import monopoly [3][4] - The company has developed a strong product pipeline in the field of myopia prevention, with orthokeratology lenses becoming a key growth driver [10][12] Future Growth Expectations - Aibo Medical is expected to maintain steady growth, with profit growth projected to exceed 20% from 2025 to 2027 [2][15] - The company is anticipated to achieve revenues of approximately 4.7 billion yuan in 2025, 5.9 billion yuan in 2026, and 7.1 billion yuan in 2027 [2][15] Key Milestones in Myopia Prevention - The commercialization of orthokeratology lenses has progressed significantly since 2018, supported by policy, technological breakthroughs, and market promotion [10][11] Conclusion - Aibo Medical's diversified product offerings, strong market position, and innovative capabilities position it well for future growth in the ophthalmic medical device industry [2][15]

Core Viewpoint - The company is facing significant pressure from centralized procurement and medical insurance cost control in Q1 2025, but is expected to see gradual improvement starting from Q2 2025, with projections of achieving three major BD licensing deals exceeding $5 billion each in 2025 [1][2] Group 1: Q1 2025 Performance - In Q1 2025, the company's revenue decreased by 30% year-on-year, excluding BD income, with the prescription drug segment declining by 37% [1] - Key therapeutic areas experienced declines: CNS down 30% due to medical insurance cost control and a 13% price reduction from negotiations; oncology core products saw a 66% drop in sales due to centralized procurement and channel price adjustments [1] - The company recorded 720 million RMB in licensing fee income, primarily from collaborations with AstraZeneca and BeiGene [1] - Revenue from raw materials increased by 15% year-on-year, driven by demand in the VC market and rising product prices, while functional foods and other business revenues fell by 9% due to declining demand and prices for caffeine [1] - The net profit margin improved by 3.1 percentage points to 21.1% due to high-margin licensing income and cost control efforts [1] Group 2: Future Outlook and BD Transactions - The company anticipates gradual improvement in performance starting Q2 2025, driven by increased promotion of Enbip, stabilization from procurement and inventory adjustments, rapid market entry of new products, and additional BD income recognition [2] - Management expects to achieve three large overseas licensing deals in 2025, each exceeding $5 billion, including a comprehensive technology platform licensing deal [2] - The company is advancing a Phase III study for EGFR ADC in second-line EGFR+ NSCLC in China and has initiated studies for third-line EGFR classic mutation NSCLC overseas, with further discussions with the FDA planned for June [2] - Based on optimistic BD income and operating expense forecasts, the company has raised its revenue projections for 2025-2027 by 1.5-7.5% and net profit forecasts by 8-13% [2] - The DCF target price has been adjusted to 7.2 HKD, corresponding to a 14.7x P/E ratio and 1.1x PEG for 2025, indicating that the current stock price reflects the anticipated pressure on 2025 performance and future BD transactions, with limited upside potential [2]

Group 1: Company Performance and Market Position - The revenue of traditional Chinese medicine (TCM) increased by 24.49% year-on-year, with the five key TCM products growing by 31.44% year-to-date [3] - Sales revenue of Ganqi Bingmei Tablets rose by 38.84% during the reporting period, and by 54.36% year-to-date [3] - The company has received 32 recommendations from authoritative textbooks, clinical guidelines, and expert consensus for its five key TCM products, indicating strong market and clinical recognition [3] Group 2: Sales Strategy and Market Development - The current sales strategy focuses primarily on public hospitals, which account for approximately 70% of the market, while also developing grassroots hospitals, private hospitals, retail pharmacies, and e-commerce platforms [4] - The company aims to increase its market share in existing markets while exploring new growth opportunities through a multi-channel approach [4][7] Group 3: Research and Development Progress - As of May 2025, the company has integrated its R&D pipeline with Chengdu Aorui Pharmaceutical Co., gaining control over 7 innovative drug projects targeting various cancers and autoimmune diseases [5] - The lead project, ORIC-1940, is currently in clinical phases Ia/Ib, with plans to submit IND applications for two additional projects by the end of this year and the first quarter of next year [5][6] Group 4: Response to Market Challenges - The company acknowledges that centralized procurement has a significant impact on existing products but limited effect on new varieties, and it is exploring diversified development strategies to mitigate price reduction risks [6][7] - The company is actively expanding its product line to include special medical foods and nutrition products, enhancing its market competitiveness [7]

Core Viewpoint - The company held an online performance briefing on May 27, 2025, to discuss its 2024 annual and 2025 Q1 performance, addressing investor concerns and highlighting operational and financial conditions [1]. Group 1: Financial Performance - The company's gross margin for 2024 increased by 2.86 percentage points to 69.23%, attributed to supply chain management optimization and product structure adjustments, despite a decline in operating revenue [2]. - In Q1 2025, the company achieved operating revenue of 244 million yuan, with overseas conventional product revenue reaching 47 million yuan, a year-on-year increase of 66.51% [2]. Group 2: Business Strategy and Market Position - The company is responding to industry challenges such as centralized procurement and DRG policies by optimizing sales strategies and enhancing service systems to maintain stable business development [4]. - The Metis6000 fully automated biochemical immunoassay line targets secondary and lower-tier hospitals, with over 70% of installations in these facilities, indicating a clear market positioning strategy [4][5]. Group 3: Product Development and Innovation - The Metis7000 fully automated biochemical immunoassay line is in the trial production phase, aiming to enhance performance and cost-effectiveness, with a broad testing menu covering nearly 400 items [5]. - The company plans to further increase the proportion of its chemiluminescence business, which accounted for 26.72% of self-produced product revenue in 2024, growing by 31.14% year-on-year [4]. Group 4: International Expansion - The company has established a presence in 66 countries and regions, holding over 2,500 overseas registration certificates and product import permits, with a focus on expanding its market share in Europe, Asia, and Latin America [5].

Core Viewpoint - Heng Rui Pharmaceutical's recent IPO in Hong Kong marks a significant step towards internationalization, raising approximately 9.89 billion HKD, making it the largest domestic pharmaceutical IPO of the year [3][4]. Group 1: Company Overview - Heng Rui Pharmaceutical has been a leader in China's innovative drug sector, with a strong focus on international operations through licensing agreements, contributing significantly to its revenue [3][4]. - The company has completed 14 licensing agreements for innovative drugs, with 9 of these occurring in the last three years, indicating a rapid acceleration in its international expansion efforts [3][10]. Group 2: Market Challenges - The implementation of national drug procurement policies since 2016 has significantly impacted Heng Rui's revenue, particularly affecting its generics business, which accounted for 82% of its revenue in 2019 [8][9]. - The average price drop for drugs that entered procurement has exceeded 50%, leading to substantial revenue declines for Heng Rui, which saw its revenue peak at 27.735 billion CNY in 2020 before experiencing consecutive declines [9][16]. Group 3: Strategic Transformation - In response to market pressures, Heng Rui has shifted its focus towards innovative drugs, with the proportion of innovative drug revenue rising to 46.6% in 2023, surpassing 10 billion CNY for the first time [10][24]. - The company has significantly reduced its generics R&D projects, focusing instead on innovative drugs, with 57 clinical approvals for innovative drugs compared to only 1 for generics in 2024 [24][25]. Group 4: Financial Performance - Heng Rui's revenue dropped by 6.59% in 2021, marking its first decline post-IPO, largely due to the impact of procurement policies [16][18]. - The company's net profit increased by 32.98% in 2024, attributed to recognizing a 1.6 billion EUR upfront payment from Merck for licensing agreements [59]. Group 5: Internationalization Strategy - Heng Rui's internationalization strategy includes various approaches such as direct licensing and joint development with foreign companies, aiming to enhance its global market presence [57][58]. - The company has engaged in several business development (BD) transactions, including a notable partnership with Merck, which could yield significant future revenues [59][60]. Group 6: Competitive Landscape - The competitive landscape for innovative drugs is intensifying, with rivals like BeiGene achieving significant sales milestones, highlighting the need for Heng Rui to innovate and differentiate its product offerings [28][31]. - Heng Rui's leading product, the PD-1 inhibitor, has faced pricing pressures due to increased competition, necessitating ongoing investment in marketing and physician education to maintain market share [35][36].

Core Viewpoint - Heng Rui Medicine has successfully listed on the Hong Kong Stock Exchange, raising approximately HKD 98.9 billion, marking the largest pharmaceutical IPO in China this year. This move is seen as a significant step towards internationalization for the company [2]. Group 1: Company Overview - Heng Rui Medicine is recognized as a leading company in China's innovative drug sector, with a strong pipeline of products. The company has primarily relied on licensing agreements for international expansion, with 14 licensing deals completed, 9 of which occurred in the last three years [2][3]. - The company has not engaged in any financing activities since its A-share IPO in 2000, making this recent listing a notable event in its history [3]. Group 2: Impact of Policy Changes - The implementation of national drug procurement policies since 2016 has significantly impacted Heng Rui's operations, particularly affecting its revenue from generic drugs, which constituted 82% of its income in 2019 [7][8]. - The average price drop for drugs that have undergone procurement has exceeded 50%, creating substantial pressure on the company's profitability [7][21]. Group 3: Financial Performance - Following a peak revenue of CNY 27.735 billion in 2020, Heng Rui's income has declined for two consecutive years due to procurement policies, but it began to stabilize in 2023 [8]. - The company's revenue from innovative drugs has increased to 46.6% of total revenue in 2023, surpassing CNY 10 billion for the first time [8][27]. Group 4: Strategic Transformation - Heng Rui has shifted its focus from generic drugs to innovative drug development, significantly reducing its generic drug projects and increasing its innovative drug pipeline [27][29]. - The company has established research centers globally to monitor trends and gather patent information, although it lacks a standout blockbuster product [36]. Group 5: International Expansion Strategies - Heng Rui's international strategy includes three main approaches: self-expansion, direct licensing, and joint ventures. The company has increasingly opted for direct licensing to reduce costs and risks [57][65]. - Recent licensing agreements have generated significant upfront payments, such as a EUR 160 million deal with Merck, contributing to a 32.98% increase in net profit in 2024 [66]. Group 6: Challenges and Future Outlook - The company faces challenges in the competitive landscape of innovative drugs, particularly in the PD-1 market, where it must navigate pricing pressures and market acceptance [40][43]. - Heng Rui's recent foray into NewCo transactions, which involve complex asset and equity financing, indicates a strategic pivot towards leveraging external capital for growth [68][69].

证 券 研 究 报 告 春立医疗（688236）2025 年一季报点评 推荐（维持） [ReportFinancialIndex] 主要财务指标 | | 2024A | 2025E | 2026E | 2027E | | --- | --- | --- | --- | --- | | 营业总收入(百万) | 806 | 1,051 | 1,318 | 1,604 | | 同比增速(%) | -33.3% | 30.5% | 25.4% | 21.7% | | 归母净利润(百万) | 125 | 219 | 279 | 348 | | 同比增速(%) | -55.0% | 74.5% | 27.9% | 24.9% | | 每股盈利(元) | 0.33 | 0.57 | 0.73 | 0.91 | | 市盈率(倍) | 47 | 27 | 21 | 17 | | 市净率(倍) | 2.1 | 2.0 | 1.9 | 1.8 | 资料来源：公司公告，华创证券预测 注：股价为 2025 年 5 月 16 日收盘价 公司研究 医疗器械 2025 年 05 月 18 日 当前价：15.15 元 集采影响逐渐出清，持续拓 ...

Core Viewpoint - On its 30th anniversary, Shuanglu Pharmaceutical is facing a historic turning point, reporting a net loss of approximately 74.07 million yuan for 2024, marking its first annual loss since its listing in 2004 [1][4]. Financial Performance - In 2024, Shuanglu Pharmaceutical achieved an operating revenue of approximately 660 million yuan, a year-on-year decline of 35.15%, with a corresponding net profit of -74.07 million yuan, transitioning from profit to loss [4]. - The company had previously seen net profits exceeding 100 million yuan since 2007, peaking at 695 million yuan in 2014, and fluctuating between 200 million and 500 million yuan from 2020 to 2023 [4]. - In the first quarter of 2024, the company reported an operating revenue of approximately 169 million yuan, down 31.1%, and a net profit of approximately 45.97 million yuan, down 34.46% [4]. Product Sales Decline - Multiple key products experienced significant sales declines in 2024, with the oncology and immune regulation products generating sales of 276 million yuan, accounting for 42.69% of total sales, down 27.69% year-on-year [6]. - The sales of the previously promising product, Lenalidomide, accounted for only 4.89% of the oncology product category, with a staggering year-on-year decline of 77.22% [6][7]. - Other product categories, including anti-infection, trauma repair, and cardiovascular products, also saw sales declines of 48.42%, 30.95%, and 33.92% respectively [7]. Financial Asset Impact - The decline in financial assets, particularly the fair value changes in securities investments, significantly impacted the company's performance, with a total loss of approximately 178 million yuan from its holdings in Fosun Pharma, Shouyao Holdings, and Xinghao Pharma [9]. - The fair value changes for these stocks were -22.94 thousand yuan, -161 million yuan, and -16.14 million yuan respectively, contributing to the overall financial downturn [9]. Future Outlook - The company plans to increase R&D investment and has developed a strong product pipeline in oncology, liver disease, antiviral, metabolic regulation, and cardiovascular fields, while also exploring new areas such as diabetes and ophthalmology [5]. - The chairman expressed optimism that the company will recover its performance, viewing 2025 as a year of both challenges and opportunities [5][10].