来源：温州晚报 几颗贡丸、两勺汤，再加上点芹菜末……冬日街头，来上一碗热乎乎的贡丸汤，是一代浙江人儿时的记 忆。40岁的林先生（化名）就是其中之一，近期他突然想回味童年时的味道，没想到连喝了一周，竟然 进了医院。 到医院看痛风 却被确诊尿毒症 "黄医生，我左膝盖疼痛又发作了，走不了路，没扭着，也没伤着，就这周喝了点贡丸汤，又疼了，上 次是2年前疼痛来就诊过……"浙江医院风湿免疫科黄艳医师介绍，林先生是坐着轮椅被推进诊室的。 作为一位痛风"老"患者，林先生两年前开始接受降尿酸治疗，但复查并不规律。黄艳发现他同时患有高 血压、糖尿病、肥胖等合并症。此次进食一周贡丸汤后就医，左膝盖肿胀明显，尿酸超过421umol/L （痛风患者的尿酸应控制在300~360umol/L）。但更让人揪心的是，他的肌酐高达717μmol/L（正常成人 全血中的肌酐参考值为88.4~176.8μmoI/L），肾小球滤过率只有7.5mL/min/1.73m²（正常成年男性在 110~140mL/min/1.73m²）…… 这意味着患者确诊终末期肾病（尿毒症期），此阶段的大部分老年患者都要靠血液透析、腹膜透析或肾 移植维持生命。这让黄艳非常感 ...

转自：河北新闻网 【#每天2杯奶茶男子痛风到无法走路#】#40岁男子痛风直呼痛得像生孩子# 近日报道，据杭州市中医 院： 1月25日，浙江杭州。今年40岁的王先生是一名教师，平日里非常注重健康，严格忌口，不喝酒、 不吃海鲜、不吃动物内脏，体重也控制得不错。然而，他却频繁遭受痛风折磨，发作时疼痛难忍，大脚 趾关节红肿热痛，严重影响行走。直呼"痛得像生孩子一样"，被妻子质疑"夸张"。医生在详细询问王先 生的生活习惯后，发现为了提神和缓解工作压力，他养成了每天喝一到两杯奶茶的习惯。奶茶中隐藏的 果糖，是诱发痛风的"隐形杀手"。虽然王先生避开了肉、酒等常见诱因，但每天两杯奶茶的习惯，恰恰 是诱发他痛风急性发作的重要因素。#躲过了啤酒海鲜没躲过奶茶# 医生表示，"在门诊中，有些年轻患 者并没有饮酒习惯，生活作息看似也规律，却莫名其妙地痛风发作。在详细询问病史后，我们发现他们 有一个共同点：长期大量饮用含糖饮料，尤其是奶茶。"奶茶中通常含有大量的果糖。果糖与葡萄糖不 同，它会直接参与嘌呤代谢，导致尿酸生成增多，同时抑制尿酸的排泄。这种"双向打击"使得血液中的 尿酸水平迅速升高，从而诱发痛风。其次，奶茶往往伴随着高热量，也 ...

尿酸超标，就像多米诺骨牌：不仅容易引起痛风，还会损伤肾脏和全身血管…… 如今，我国高尿酸血症患者已超过1.5亿人，痛风患者已达1500余万。 不少人体检发现尿酸超标后，就想把尿酸水平快速降下去。但在医生看来，降尿酸千万不能太快了。 尿酸降得太快有什么后果？《生命时报》邀请专家告诉你答案，并教你如何科学应对。 尿酸降太快，反而加重关节肿痛 首都医科大学附属北京友谊医院风湿内科副主任医师周航表示，临床上经常遇到这样的患者，为了缓解 关节疼痛，或者希望尽快将尿酸水平降下去，自行用药或自行加大用药剂量，反而出现疼痛不缓解、关 节肿胀加重的情况。 这是因为服用药物后，血液中的尿酸经过代谢很快排出体外，导致血尿酸水平迅速下降。 然而，关节液中的大量高浓度尿酸来不及向血液中转移，从而使关节和血液中尿酸浓度相差悬殊，致使 已经沉积在关节表面的尿酸盐结晶不稳定，骤然脱落释放。 脱落的结晶被免疫系统（如中性粒细胞）识别为"外来异物"，触发剧烈的炎症反应，引起关节红、肿、 热、痛急性发作。 降尿酸不在快，而在"稳" 尿酸降得太快，就好比冬天快速融化冰雪，很有可能导致冰凌坠落或洪水，是一个"欲速则不达"的过 程。 除了可能诱发急性痛 ...

Core Viewpoint - The rising incidence of gout among younger populations is linked to various factors, and the claim that disodium inosinate is a primary cause lacks sufficient evidence [1][2]. Group 1: Disodium Inosinate and Gout - Disodium inosinate is a food additive found in many condiments, but there is no substantial research indicating that its normal use in food significantly increases the risk of gout [1]. - The amount of purine in commonly used condiments, such as oyster sauce, is very low, and its impact on uric acid levels is minimal compared to high-purine foods [1]. Group 2: Factors Contributing to Gout in Young People - The increase in gout cases among young individuals is attributed to genetics, poor dietary habits (high purine food intake), obesity, and alcohol consumption, particularly beer [2]. - Establishing a scientific lifestyle is crucial for preventing high uric acid levels and gout, rather than fearing specific food components [2]. Group 3: Recommendations for Gout Prevention - Dietary adjustments should include strict limitations on high-purine foods such as organ meats, certain shellfish, and rich broths, along with reduced alcohol intake [2]. - Weight control is essential, but rapid weight loss should be avoided as it may lead to increased ketone bodies, which can inhibit uric acid excretion and trigger acute gout attacks [2]. - Adequate hydration is recommended, with a daily intake of over 2000 milliliters for individuals with normal heart and kidney function to promote uric acid excretion [2][3]. - Regular physical activity, such as aerobic exercises, is beneficial for weight management and metabolic improvement [3]. - High-risk individuals, including those with a family history of gout, obesity, or poor dietary habits, should regularly monitor their blood uric acid levels [4].

Group 1 - The core issue of hyperuricemia is a metabolic disorder caused by purine metabolism, with an increasing prevalence of gout among younger populations, indicating a need for attention to abnormal uric acid levels in adolescents [1] - A case study highlights a 19-year-old diagnosed with gout due to a uric acid level of 589 μmol/L, attributed to poor lifestyle choices such as lack of exercise and excessive consumption of sugary drinks [2][3] - Medical professionals indicate that the rise in gout cases among young people is linked to unhealthy dietary habits, lack of physical activity, and other negative lifestyle factors [3][5] Group 2 - The normal fasting blood uric acid levels are defined as above 420 μmol/L for males and above 360 μmol/L for females, categorizing levels above these thresholds as hyperuricemia [7] - For children under 15 years, a blood uric acid level exceeding 357 μmol/L is typically classified as hyperuricemia [9]

Core Insights - The prevalence of gout is increasing, with younger populations, including adolescents, showing abnormal uric acid levels, indicating a growing health concern [1][3] Group 1: Disease Overview - Hyperuricemia is a metabolic disorder caused by purine metabolism disruption, often preceding gout in patients [1] - A case study highlighted a 19-year-old diagnosed with gout due to a uric acid level of 589 μmol/L, attributed to poor lifestyle choices such as lack of exercise and high consumption of sugary drinks [1] Group 2: Contributing Factors - Key factors contributing to gout in adolescents include poor dietary habits, lack of physical activity, and unhealthy lifestyle choices [3] - Consumption of fructose-rich beverages, high-purine foods, and alcohol significantly increases uric acid production [5] Group 3: Health Risks - Hyperuricemia does not equate to gout but poses significant health risks, including the potential for joint inflammation and kidney issues [9] - Elevated uric acid can lead to deposits in organs, causing conditions like kidney stones, uric acid nephropathy, and increased cardiovascular risks due to arterial damage [9] Group 4: Management and Prevention - Management strategies for high uric acid levels include dietary modifications, lifestyle changes, and regular monitoring [11] - Recommendations include reducing intake of high-purine foods, increasing water consumption, maintaining a healthy weight, and ensuring adequate hydration to facilitate uric acid excretion [11]

Core Viewpoint - Gout, known as the "disease of kings," has become the second most prevalent metabolic disease in China, following diabetes, and is characterized by elevated uric acid levels leading to severe pain and potential long-term health risks [1] Group 1: Disease Overview - Gout is fundamentally a disorder of purine metabolism, resulting in the accumulation of uric acid crystals in joints and tissues, causing intense pain [1] - Misconceptions about the disease lead many patients to only seek treatment during painful episodes, contributing to the worsening of their condition [1] Group 2: Expert Engagement - Professor Ye Hua from Peking University People's Hospital will provide a live session on accurate diagnosis, staged treatment, and long-term management strategies for gout [1][5] Group 3: Live Broadcast Information - The live session can be accessed through the People's Good Doctor App, under the "Famous Doctor Live" section [6] - Viewers can also follow the People's Health public WeChat account for additional health resources and to download the app [8]

Core Viewpoint - The article discusses the consumption of crabs for individuals with high uric acid levels or a history of gout, emphasizing that with proper timing and control methods, they can safely enjoy this seasonal delicacy [1]. Group 1: Situations to Avoid Crab Consumption - Individuals experiencing an acute gout attack, even with mild joint redness or pain, should avoid crab as it can increase purine intake and exacerbate inflammation [2]. - Those with uncontrolled blood uric acid levels, such as fasting levels exceeding 480 μmol/L, or frequent joint discomfort, should also refrain from eating crab to prevent triggering gout [2]. Group 2: Situations Where Crab Can Be Consumed in Moderation - Patients with stable high uric acid levels (e.g., fasting uric acid < 420 μmol/L) and no history of gout attacks can consume crab in moderation [3]. - Gout patients in remission (more than two weeks since the last attack) with controlled uric acid levels (generally recommended < 360 μmol/L, < 300 μmol/L for those with a history of gout) may also eat crab [3]. - Individuals without severe complications such as significant renal dysfunction, hypertension, or acute diabetes complications can safely consume crab [3]. Group 3: Key Consumption Guidelines - Avoid dangerous combinations by not drinking beer (which inhibits uric acid excretion) and limiting sugary drinks (as fructose may promote uric acid production) while consuming crab [5]. - Choose fresh crabs to prevent bacterial growth and avoid harmful substances that could worsen metabolic burdens [5]. - Limit consumption to one medium-sized crab (approximately 100-150 grams) per serving, prioritizing crab meat over crab roe or fat due to higher purine and fat content [5]. - Opt for boiling as a cooking method, avoiding the broth as it contains higher purine levels than the crab meat itself [5]. - Monitor bodily reactions for 1-2 days post-consumption, watching for any joint discomfort or swelling, and take appropriate measures if adverse effects occur [5].

Group 1 - The article highlights the increasing trend of young people adopting extreme health practices, leading to chronic diseases such as gout, fatty liver, and diabetes [1][2][3] - It emphasizes the importance of balanced diets, moderate exercise, and regular routines as the foundation of true health [1][3] - Medical professionals warn that excessive exercise can lead to acute gout attacks due to elevated uric acid levels, with studies indicating that a single high-intensity workout can increase blood uric acid by over 30% [2][3] Group 2 - The phenomenon of "skinny fatty liver" is becoming more common, particularly among young women who engage in extreme dieting, leading to health issues despite weight loss [4][5] - The article discusses the mechanisms behind fatty liver development due to extreme weight loss, including insulin resistance and hormonal imbalances [4][5] - It advises that weight management should focus on balanced diets and gradual weight loss, recommending a maximum of 5% weight loss per month for safety [5] Group 3 - The article addresses the misconception that "sugar-free" drinks are entirely safe, as excessive consumption can still lead to health issues like diabetes [6][7] - It notes that the proportion of diabetes patients under 40 is increasing, linked to unhealthy lifestyles, including irregular eating and lack of exercise [7] - The article stresses the importance of early intervention during the "prediabetes" stage to prevent the progression to full diabetes [7] Group 4 - The "Three Reductions and Three Healths" initiative by the National Health Commission aims to lower chronic disease risks through scientific lifestyle interventions [8][11] - Recommendations include reducing salt intake to no more than 5 grams per day, oil intake to 25-30 grams, and added sugar to no more than 25 grams [8][10][11] - The initiative also emphasizes maintaining oral health, healthy weight, and bone health through proper nutrition and regular physical activity [12][13][14]

Core Viewpoint - The rising popularity of milk tea among young people has been linked to health risks, particularly concerning elevated uric acid levels and related conditions like gout [1][2]. Group 1: Health Risks Associated with Milk Tea - A case of a 23-year-old male who developed acute gout due to high uric acid levels from daily milk tea consumption highlights the potential health risks [2]. - High fructose content in milk tea and other sugary beverages is identified as a significant contributor to increased uric acid levels, overshadowing the low purine content of these drinks [3][4]. Group 2: Mechanism of Uric Acid Increase - Fructose metabolism occurs primarily in the liver and is not regulated by insulin, leading to direct production of uric acid [5][6]. - Unlike sucrose and glucose, fructose can inhibit the kidneys' ability to excrete uric acid, further exacerbating the issue [7]. Group 3: Associated Health Conditions - Chronic high uric acid levels can lead to various health issues, including gout, kidney damage, and metabolic syndrome, which increases the risk of cardiovascular diseases and type 2 diabetes [11][13][14]. - A study indicates that consuming sugary drinks more than four times a week is significantly associated with early onset of gout in men under 40 [10]. Group 4: Dietary Recommendations - To manage uric acid levels, individuals are advised to maintain a balanced diet, control caloric intake, limit alcohol consumption, and engage in regular physical activity [15]. - Specific food recommendations include choosing whole grains, lean meats, and low-fat dairy while avoiding high-fructose and high-purine foods [16][18].