Group 1 - The company signed an exclusive agreement with Pfizer for the global development, production, and commercialization rights of its PD-1/VEGF bispecific antibody SSGJ-707, excluding mainland China, with an upfront payment of $1.25 billion and potential milestone payments of up to $4.8 billion [1] - The agreement also includes a tiered sales revenue sharing based on product sales in the licensed regions, and Pfizer will purchase $100 million worth of common stock in the company upon the agreement's effective date [1] - The company maintains its profit forecast, expecting net profits of 2.328 billion, 2.612 billion, and 2.938 billion yuan for 2025-2027, with corresponding EPS of 0.97, 1.09, and 1.23 yuan per share, resulting in a current PE of 9.3, 8.3, and 7.4 times [1] Group 2 - SSGJ-707 has shown excellent ORR and DCR in the treatment of NSCLC patients, indicating its best-in-class potential, and has received breakthrough therapy designation from the National Medical Products Administration for first-line treatment of PD-L1 positive locally advanced or metastatic NSCLC [2] - The company is advancing clinical research for SSGJ-707 in other areas, including colorectal cancer and gynecological tumors, and has received FDA IND approval [2] - The company’s existing products, such as Tebentafusp, are expected to see growth due to successful negotiations for zero price reduction in 2024 and the addition of new indications, contributing to cash flow [2]

相关研究报告 医药生物/生物制品 三生制药（01530.HK） 2025 年 05 月 22 日 投资评级：买入（维持） | 日期 | 2025/5/21 | | --- | --- | | 当前股价(港元) | 20.850 | | 一年最高最低(港元) | 22.000/5.470 | | 总市值(亿港元) | 500.10 | | 流通市值(亿港元) | 500.10 | | 总股本(亿股) | 23.99 | | 流通港股(亿股) | 23.99 | | 近 3 个月换手率(%) | 134.69 | 股价走势图 数据来源：聚源 -80% 0% 80% 160% 240% 320% 2024-05 2024-09 2025-01 三生制药 恒生指数 《核心品种持续发力，多款创新药进 入收获期—港股公司首次覆盖报告》 -2025.3.27 与辉瑞就 SSGJ-707 达成授权，创新价值弹性兑现 ——港股公司信息更新报告 | 余汝意（分析师） | 余克清（分析师） | 刘艺（联系人） | | --- | --- | --- | | yuruyi@kysec.cn | yukeqing@kysec.cn | ...

三生制药（01530.HK） 2025 年 05 月 22 日 投资评级：买入（维持） 医药生物/生物制品 | 日期 | 2025/5/21 | | --- | --- | | 当前股价(港元) | 20.850 | | 一年最高最低(港元) | 22.000/5.470 | | 总市值(亿港元) | 500.10 | | 流通市值(亿港元) | 500.10 | | 总股本(亿股) | 23.99 | | 流通港股(亿股) | 23.99 | | 近 3 个月换手率(%) | 134.69 | 股价走势图 数据来源：聚源 -80% 0% 80% 160% 240% 320% 2024-05 2024-09 2025-01 三生制药 恒生指数 相关研究报告 《核心品种持续发力，多款创新药进 入收获期—港股公司首次覆盖报告》 -2025.3.27 与辉瑞就 SSGJ-707 达成授权，创新价值弹性兑现 ——港股公司信息更新报告 | 余汝意（分析师） | 余克清（分析师） | 刘艺（联系人） | | --- | --- | --- | | yuruyi@kysec.cn | yukeqing@kysec.cn | ...

Core Viewpoint - The company is preparing for its 2024 annual general meeting, outlining the procedures and agenda for the meeting, including various proposals for shareholder approval [1][2][3]. Meeting Procedures - The meeting will ensure the presence of relevant stakeholders, including shareholders, directors, supervisors, and invited guests, while excluding unrelated personnel [1][2]. - Shareholders must register and present necessary documentation to participate in the voting process, with late arrivals not permitted to vote [2][3]. - The meeting will follow a predetermined agenda for discussing and voting on proposals [2][3]. Proposals for Approval - Proposal 1: The board's work report for 2024 has been prepared and submitted for shareholder review [5]. - Proposal 2: The financial settlement report for 2024 has been created and is ready for approval [5]. - Proposal 3: The financial budget report for 2025 has been prepared for shareholder consideration [6]. - Proposal 4: The annual report for 2024 is submitted for approval [6]. - Proposal 5: The reappointment of Ernst & Young Hua Ming as the auditing firm for 2025 is proposed [7]. - Proposal 6: A profit distribution plan for 2024 is proposed, with a cash dividend of RMB 0.90 per share [8][9]. - Proposal 7: The remuneration plan for directors in 2025 is outlined, with independent directors receiving RMB 100,000 annually [10]. - Proposal 8: The execution of related party transactions for 2024 and projections for 2025 are presented, ensuring compliance with regulations and fair pricing [11][21]. Financial Performance - The company reported a net profit of RMB 704.58 million for 2024, with an unallocated profit of RMB 2.28 billion as of December 31, 2024 [25]. - The total revenue for 2024 was RMB 1.19 billion, reflecting a stable growth trajectory [25]. - The company’s operating costs increased to RMB 304.34 million, a rise of 35.80% compared to the previous year, primarily due to increased sales volumes [25]. Governance and Compliance - The board of directors has adhered to legal requirements and company regulations in conducting meetings and decision-making processes [27][28]. - The company has established a robust internal control system to enhance governance and risk management [31].

Core Viewpoint - Sanofi's strategic shift towards focusing on the autoimmune sector has led to significant revenue and profit growth, despite challenges in the competitive landscape and pricing pressures from centralized procurement policies [1][4][7]. Financial Performance - In 2024, Sanofi achieved revenue of 1.194 billion yuan, a year-on-year increase of 17.70%, and a net profit attributable to shareholders of 705 million yuan, up 139.15% [1]. - The company reported a non-recurring net profit of 246 million yuan, reflecting an 18.99% increase year-on-year [1]. - Cash flow from operating activities showed a net inflow of 281 million yuan, a decrease of 32.48% compared to the previous year [2]. Product Portfolio and Market Position - Sanofi currently has three therapeutic antibody drugs on the market, with Yisaipu being the core product, alongside Jianipai and Saiputing [3]. - The market share of Yisaipu has declined from 40.14% in 2016 to 27.00% in 2022 due to increased competition [3]. - The company has faced pricing pressures due to the expansion of centralized procurement policies, with Yisaipu's average price decreasing as it entered over 20 provincial procurement programs in 2024 [3][4]. Strategic Focus and Business Model - Sanofi has divested its oncology pipeline to concentrate on the autoimmune sector, which is seen as a strategic move to enhance its core competencies and improve financial performance [5][6][7]. - The company has signed multiple agreements to transfer oncology and ophthalmology projects to its affiliate, Shenyang Sanofi, to reduce R&D costs and focus on autoimmune drug development [6][7]. - The autoimmune disease market is projected to reach $6.1 billion by 2025, with a compound annual growth rate (CAGR) of over 20% [9]. Industry Trends and Opportunities - The autoimmune disease market is characterized by a growing patient population and a significant unmet clinical need, with only about 30 treatment options currently available globally [8][9]. - The market for biological agents in autoimmune diseases is expected to grow from 12 billion dollars in 2022 to 138 billion dollars by 2030, indicating a robust opportunity for innovation and development in this sector [9].