司美格鲁肽 作为一种治疗2型糖尿病和长期体重管理的药物， 凭借优秀的 降糖功能和快速的减重效果 这两大标签 ， 它很快就火遍全 球， 被广泛视为"减肥神药 " 。 整理 | GLP1减重宝典内容团队 美国华盛顿大学的胃肠病专家指出，事实上，人体本身就能产生这些药物的 天然版本 ——GLP-1。那究竟 如何促进天然司美格鲁肽生 成，一篇SCI论文给出了答案。 ▍ 天然司美格鲁肽由下肠道产生，可以抑制食欲，减缓胃排空 下肠道中的特殊细菌会吸收你无法消化的食物成分，如纤维和多酚（许多加工食品中去除的植物成分），并将其转化为降低食欲和新陈 代谢的激素分子。这些细菌包括 GLP-1， 这是 Wegovy 和 Ozempic 的天然版本。 GLP-1 和其他激素（如 PYY） 有助于通过胰腺调节血糖。它们还会调节下丘脑神经元告诉您的大脑您已经吃饱了，并让您的胃和肠道 放慢食物沿消化道的移动速度，以便消化。这个系统甚至有一个名字： 结肠制动器。 既然人体能生成天然司美格鲁肽 ， 为什么我们还需要司美格鲁肽等GLP-1类药物？ 这和GLP-1类药物本身的结构不容易降解有关， 且天然司美格鲁肽 是一种由30个氨基酸组成的多肽， ...

但局面从2021年起悄悄起了变化。最明显的转折点在于，中国开始用实际动作介入合作，不是喊口号那 种，而是实打实地从能源基础重建入手。老旧油田很多都停产多年了，设备老化根本采不出油，中方企 业带去技术升级，逐步恢复生产；港口运输以前几乎瘫痪，现在也疏通了出口通道。这些动作没太多媒 体报道，但效果一点点积累起来了。 说起来，最近国际新闻里有个挺有意思的转变——委内瑞拉这个国家，大伙儿可能还记得前几年它过得 那叫一个艰难。地下明明躺着全球最丰富的石油资源，探明储量直接冲到3000亿桶以上，可老百姓连吃 饱饭都成问题，纸币贬值速度夸张到提一麻袋钱买不了一袋米，这反差也太戏剧了。 回头看看美国那边，从2017年开始施加的制裁确实挺狠的——冻结海外资产、限制金融交易、切断石油 出口渠道，到2019年甚至不承认合法政府，转而支持反对派代表。初衷可能是想施压促变，但结果呢？ 普通民众生活反而更惨了，缺电缺药缺食品，国家运作几乎停摆。越来越多人开始质疑，单边制裁到底 能不能解决问题？ 美国稳步出手？中国发力， 委内瑞拉天渐亮！ 全球第一石油储量国复苏 当然，现在说完全复苏还为时过早，经济恢复是个漫长过程，外部压力也没完全解除。 ...

园艺（花卉和水果）业成为农业增长新引擎，在国际融资和政府项目推动下快速发展，蓝莓和鳄梨 等作物出口强劲。鳄梨产量较2017年增长164%，津已成为非洲第五大鳄梨生产国。蓝莓出口收入2020 至2024年增长351%。预计至2030年，园艺出口市场规模可达20亿美元，有望推动农业出口多元化，减 少对传统作物和国内消费的依赖，增强经济韧性。 《先驱报》9月25日报道，IH证券发布的2025年津巴布韦农业部门报告显示，津农业正持续复苏并 实现增长，政府预计该行业产值将在2025年达到137.5亿美元，较2021年的82亿美元显著提升。这一增 长得益于降雨改善、水利基础设施投资以及对高价值作物的政策倾斜。糖业产量超过国内需求，但由于 售价高于进口糖、加之糖税及其他成本压力，国内消费低迷。 （原标题：糖业和园艺业推动津巴布韦农业发展） ...

Core Viewpoint - The article discusses the recent tariff increases announced by President Trump on imports from Mexico and Canada, citing drug control issues as the primary reason, while also indicating that the actual impact on trade may be limited due to existing trade agreements [1][6]. Group 1: Tariff Increases - On August 1, a 30% tariff will be imposed on goods imported from Mexico, and a 35% tariff on goods from Canada [1]. - The tariffs are justified by Trump's claims of insufficient action by both countries in controlling drug trafficking, particularly fentanyl [1][6]. - The increase in tariffs is seen as a strategy to pressure Canada and Mexico into further concessions during ongoing trade negotiations [3][12]. Group 2: Trade Relations and Agreements - The USMCA (United States-Mexico-Canada Agreement) provides exemptions for many products, which may limit the actual impact of the new tariffs [4][13]. - Most goods imported from Canada and Mexico currently enjoy low average tariff rates, often below 1% [4]. - The article notes that the trade relationship is heavily interdependent, with Canada and Mexico relying significantly on the US market for exports [12]. Group 3: Economic Implications - If comprehensive tariffs are applied, it could raise US prices by approximately 1.2%, affecting consumer goods and potentially leading to public dissatisfaction [5]. - The tariffs may also influence the automotive industry by increasing local sourcing requirements, although evidence of effective re-industrialization through tariffs is lacking [7]. - The potential for retaliatory tariffs from Canada and Mexico exists, but both countries seem inclined to negotiate rather than escalate tensions [10][12].

Core Viewpoint - The recent tariff policy implemented by the Trump administration, imposing a 25% tariff on imports from Canada and Mexico and an additional 10% on Chinese goods, has led to a significant decline in the U.S. stock market, erasing all gains since the last presidential election [1][3]. Economic Impact - The overall earnings of S&P 500 companies may decline by 2.8% due to the tariff policy, with Barclays analysts indicating that the market had not fully assessed the potential risks associated with import tariffs [3]. - Goldman Sachs economists predict that the implementation of tariffs on Canada and Mexico could lead to a 0.7% increase in core inflation and a 0.4% contraction in GDP [3]. - Nomura Securities forecasts that the U.S. GDP growth rate could drop to 0.6% by 2025, while Barclays' model suggests a potential negative growth of 0.1% [3]. Trade Relations - Canada and Mexico are crucial suppliers of agricultural products to the U.S., with significant reliance on U.S. markets for their exports (80% for Canada and 84% for Mexico) [3]. - The Midwest U.S. refineries heavily depend on Canadian crude oil, and the tariffs could lead to a rapid increase in gasoline prices in that region [3]. - Mexico, as the largest buyer of U.S. diesel and gasoline, may seek alternative suppliers from Europe and Asia, potentially disrupting the North American energy system [3]. Consumer Confidence and Market Reactions - Consumer confidence has sharply declined, with the index dropping to 98.3 in February, marking the largest monthly decline since August 2021 [5]. - A survey indicates that 57.1% of U.S. investors hold a pessimistic view of the stock market for the next six months, with bearish sentiment at historical highs [5]. - Job creation in the non-farm sector has slowed significantly, with only 151,000 new jobs added in February, falling short of market expectations [5]. Policy Instability - The Trump administration's tariff policy has faced rapid changes, including exemptions for major automakers and delays in implementation, highlighting the uncertainty in policy-making [7]. - The tariffs are harming U.S. manufacturers that produce in Canada and Mexico, affecting their ability to sell goods to American consumers [7]. - The overall economic environment is described as a "perfect storm," making it difficult for businesses to plan long-term strategies [5][7].

Core Viewpoint - Semaglutide and Tirzepatide are breakthrough drugs for weight loss and diabetes management, targeting the underlying pathways of obesity and diabetes [1] Group 1: Mechanism of Action - The body produces natural versions of these drugs, known as incretin hormones, in the gut, which are regulated by nutrients and gut microbiota [2] - Specific bacteria in the lower gut convert indigestible food components into molecules that stimulate appetite and metabolism-controlling hormones like GLP-1, the natural version of Semaglutide [3] - GLP-1 and other hormones help regulate blood sugar through the pancreas and signal the brain about satiety, slowing down food movement in the digestive tract [3][4] Group 2: Impact of Processed Foods - The rise of processed foods has led to the removal of bioactive molecules like fiber and polyphenols, which are essential for regulating metabolic pathways [3] - The loss of these key food components and the resulting decline in gut microbiota diversity may significantly contribute to the increase in obesity and diabetes [6] Group 3: Dietary Recommendations - A healthy lifestyle, including regular exercise, stress management, sleep, outdoor activities, and a balanced diet, is crucial for managing metabolic diseases [5] - Introducing minimally processed foods rich in fiber and polyphenols can enhance GLP-1 levels and address the obesity and metabolic disease epidemic [5] Group 4: Foods that Stimulate GLP-1 Production - Eggs are rich in protein and monounsaturated fats, which can enhance GLP-1 secretion [8] - Nuts like almonds, pistachios, and peanuts may increase GLP-1 levels due to their protein, fiber, and healthy fat content [8] - High-fiber grains such as oats, barley, and whole wheat can stimulate GLP-1 release through soluble fiber and short-chain fatty acids produced during fermentation [9] - Avocados can increase GLP-1 levels due to their high fiber and monounsaturated fat content [9] - Olive oil, rich in unsaturated fats, has been shown to stimulate GLP-1 release more effectively than saturated fats [10] - Vegetables like Brussels sprouts, broccoli, and carrots are beneficial for regulating blood sugar and may influence GLP-1 levels [10]

Core Viewpoint - The article discusses the challenges faced by Walmart and other U.S. retailers due to increased tariffs, leading to layoffs and potential price hikes for consumers as they navigate cost pressures and competition in the retail sector [1][2][3]. Group 1: Walmart's Response to Tariffs - Walmart plans to lay off approximately 1,500 employees as part of a restructuring effort to reduce costs amid rising tariff pressures [3]. - The company has already made cuts earlier in the year and is adjusting its organizational structure to better compete with e-commerce rivals like Amazon [3][4]. - Walmart's CEO indicated that while the company and its suppliers are absorbing some tariff costs, the scale of the tariffs makes it impossible to fully offset them [4]. Group 2: Impact on Consumer Prices - Consumers in the U.S. are likely to see price increases starting from late May, with some items already experiencing price hikes of over 20% since February [5]. - The article highlights that a significant portion of Walmart's imported goods comes from China, which exacerbates the cost pressures due to tariffs [4][5]. - Analysts predict that overall food prices in the U.S. will rise by 2.6% over the next three years due to increased tariffs, with grocery prices expected to increase by 2.7% this year [7][8]. Group 3: Consumer Sentiment and Economic Outlook - Consumer confidence in the U.S. has dropped to its lowest level since June 2022, indicating growing concerns about the economy [8]. - The article notes that high inflation and interest rates could dampen consumer spending, which is crucial for the U.S. economy [7][8]. - Retail giants are attempting to mitigate the impact of tariffs by negotiating with suppliers and adjusting product offerings, but the pressure on prices remains significant [6][7].

Core Viewpoint - The article discusses the impact of tariffs on major U.S. retailers, particularly Walmart, which is facing pressure to cut costs and potentially raise prices due to increased tariffs on imports from countries like China [2][4][5]. Group 1: Walmart's Restructuring and Layoffs - Walmart plans to lay off approximately 1,500 employees as part of a restructuring effort to reduce costs [2][4]. - This is the second round of layoffs for Walmart in 2023, following earlier job cuts and office closures [4]. - The layoffs will affect various sectors, including the global technology operations team and e-commerce fulfillment in the U.S. [4]. Group 2: Tariff Impact on Pricing - Walmart's CEO indicated that the company and its suppliers have been absorbing some tariff costs, but cannot fully offset them due to their scale [6]. - Consumers may start seeing price increases as early as the end of May, with some products already experiencing price hikes of over 20% since February [6][8]. - The article highlights that over 60% of Walmart's imported goods come from China, particularly in categories like clothing and electronics [5][6]. Group 3: Consumer Sentiment and Economic Outlook - U.S. consumer confidence has dropped to its lowest level since June 2022, raising concerns about potential economic recession [2][11]. - Retail giants are attempting to mitigate tariff impacts without significant price increases, with some companies adjusting product sourcing and negotiating with suppliers [8][9]. - Analysts predict that inflation may rise significantly in the coming months, with food prices expected to increase by 2.6% over the next three years due to tariffs [9][10].

Core Viewpoint - The article discusses the challenges faced by Walmart and other U.S. retailers due to tariffs, leading to layoffs and potential price increases for consumers. Group 1: Company Actions - Walmart plans to lay off approximately 1,500 employees as part of a restructuring effort to reduce costs [2][3] - This is the second round of layoffs for Walmart in 2023, following earlier job cuts and office closures [3] - The layoffs will impact Walmart's global technology operations, e-commerce fulfillment in U.S. stores, and advertising business [3] Group 2: Tariff Impact - Tariffs on imports from countries like Costa Rica, Peru, Colombia, and especially China have significantly increased costs for Walmart [1][4] - Approximately one-third of Walmart's imported goods come from China, with a large portion being clothing, electronics, and toys [4] - Walmart's CFO indicated that while some tariff costs are being absorbed, the scale of the tariffs makes it impossible to fully mitigate their impact [4] Group 3: Consumer Price Trends - Consumers may start seeing price increases as early as the end of May, with some items already experiencing price hikes of over 20% since February [5] - The overall inflation rate in the U.S. is expected to rise, with predictions of a 3.0-3.5% annual inflation rate [8] - The USDA forecasts a 3.2% increase in overall food prices this year, with grocery store prices expected to rise by 2.7% [8] Group 4: Consumer Sentiment - Consumer confidence in the U.S. has dropped to its lowest level since June 2022, indicating potential challenges for retail sales [9] - The Michigan Consumer Sentiment Index reflects a significant decline, suggesting that consumers are tightening their spending [9] - Economic analysts express concerns that rising prices and high inflation could dampen consumer purchasing power and overall economic activity [8][10]

Group 1 - The core issue revolves around the conflict between Walmart and the Trump administration regarding the impact of government tariffs on retail prices [1][4] - Walmart announced that it may need to raise prices on certain products due to increased tariffs, which has led to criticism from President Trump [1][4] - Despite exceeding sales expectations in the first quarter, Walmart is facing pressure to increase prices on imported goods due to higher tariffs imposed by the government [4][5] Group 2 - Walmart has chosen not to release its second-quarter profit forecast due to uncertainties stemming from tariff policies, along with issuing a price increase warning [5] - Economists note that U.S. companies importing foreign goods typically pass on tariff costs to consumers to maintain profit margins, a point of contention with Trump's stance that other countries should bear these costs [5] - Walmart's president indicated that tariffs on imports from countries like Costa Rica, Peru, and Colombia are putting pressure on prices for items such as bananas, avocados, coffee, and roses [5]