Group 1: Policy Release - The report includes three domestic policies related to the bio-based industry released in May 2025, focusing on carbon reduction projects [7][18]. - Key projects include a 110,000-ton biodegradable polyester rubber demonstration project and a 1 million-ton waste oil processing sustainable aviation fuel project [8][19]. Group 2: Industry Dynamics - The report highlights two domestic bio-based chemical company updates, including a 120 million yuan investment in a lactic acid production demonstration line by Heilongjiang Guoke Bio-based New Materials [9][20]. - Wanhu Chemical has established a new company focusing on food additives, with a registered capital of 200 million yuan [10]. Group 3: Capital Events - Several financing events in the bio-based sector are reported, including a multi-million yuan investment in Senqi New Materials for bio-based high barrier film materials [11][22]. - Other notable investments include a joint investment exceeding 100 million yuan in Juyuan Bio for recombinant collagen [22]. Group 4: Scientific Research Progress - Significant breakthroughs in bio-based materials research are noted, including a study on lignin-derived carbon improving catalytic performance [12][23]. - Research on a new type of printable conductive "E-skin" with antibacterial properties has been developed, mimicking slime mold characteristics [12][23]. Group 5: Upcoming Events - The Fourth Synthetic Biology and Green Bio-manufacturing Conference will be held from August 20-22, 2025, in Jinan, Shandong, focusing on the development trends of the bio-manufacturing industry [25][26].

# SynBio团队 | 中科院苏州医工所马富强 在人工生命体精准编程的"黄金时代"，合成生物学作为融合工程学、计算机科学与分子生物学的交叉学科， 正通过"设计-构建-测试"的循环模式重塑生物制造范式。这一领域不仅被列为全球科技竞争的战略高地，更在 医药研发、碳中和、农业升级等关乎国计民生的赛道上展现出颠覆性潜力。 其核心突破点聚焦 三大支柱 ： 三大支柱技术如同精密咬合的齿轮，共同决定了细胞合成工厂的效率 。 【SynBioCon】 获 悉，近日， 苏州医工所马富强研究团队 围绕上述合成生物学三大支柱技术开展了系统工 作： 图2. 利用深度学习辅助生成新型启动子的两种方法 ： 左 图 ， 通过对现有启动子引入突变或随机生成新序列 来创建新的序列。这些新生成的序列通过启动子识别模型进行筛选，以验证其功能 ；右 图 ， 使用扩散模型 或生成对抗网络（GANs）来生成新的启动子。扩散模型通过添加高斯噪声逐步生成启动子序列。GANs 由生 成器和判别器组成，生成器负责生成假样本，而判别器用于区分真实样本和生成的假样本。通过训练过程不 断优化生成器的性能，使其能够生成更逼真的启动子序列。 工作1 ： 新型酶资源 的 ...

Core Viewpoint - The article discusses the establishment of pilot testing platforms for biomanufacturing, focusing on key product areas such as food additives, biopharmaceuticals, cosmetics, chemicals, energy, and enzyme preparations, with a goal to support innovation and commercialization in the industry [1][2]. Group 1: Pilot Testing Platforms - The Ministry of Industry and Information Technology and the National Development and Reform Commission aim to cultivate over 20 pilot testing platforms by 2027, serving more than 200 enterprises and incubating over 400 products [1]. - The initiative emphasizes market-driven and demand-led approaches, encouraging national laboratories and innovation platforms to develop pilot testing capabilities [1][2]. - The platforms will focus on addressing the shortcomings and pain points in the pilot testing phase of biomanufacturing, particularly in the development of new raw materials such as lignocellulosic and one-carbon compounds [2]. Group 2: Guidelines and Events - The article includes attachments such as the "Biomanufacturing Pilot Testing Capability Construction Platform Cultivation Guidelines (2025 Edition)" and an application form for the platform [3]. - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) is scheduled for August 20-22 in Jinan, Shandong, aiming to discuss trends in biomanufacturing and promote technology transfer and commercialization [4].

Core Viewpoint - The bio-basedlink platform is officially launched to provide precise and efficient supplier matching services for the bio-based and biomanufacturing industry, featuring four main categories: industry news, research reports, new product database, and supply-demand database [1]. Group 1: Platform Features - The new product database includes eight subfields such as materials, energy and chemicals, synthetic biology, and biomanufacturing [1]. - The supply-demand database covers upstream and downstream demand, supply, technology achievements, and talent matching [1]. - Companies can join the new product database to gain a dedicated company page showcasing their logo, positioning, product keywords, and advantages, with free updates available for information changes [4]. Group 2: Accessing the Platform - Users can find the official website by following the WeChat public account "Synthetic Biology and Green Biomanufacturing" or by searching for www.bio-basedlink.net [2]. - Companies that have participated in relevant activities can join the new product database for free, and DT members receive priority recommendations for one year of platform cooperation [8]. Group 3: Supply-Demand Database - The supply-demand database allows users to publish and match their industry needs, including products, technologies, and talents [10]. - The platform will collect and publicly share information on industry "new technological achievements" and "end-user brand demands" [10]. Group 4: Research and Reports - The DT Industry Research Institute will publish monthly, quarterly, and annual reports on the bio-based and biomanufacturing industry, providing insights based on real-time information and industry surveys [14]. - The platform aims to help users maintain a competitive edge through systematic and in-depth observations and research [15]. Group 5: Marketing and Exposure - New products and related articles will be promoted across various channels, including the bio-basedlink platform website and multiple WeChat public accounts [16]. - The platform aims to facilitate exposure and networking opportunities for companies in the bio-based materials sector [17].

Core Viewpoint - The research group led by Yu Tao focuses on utilizing synthetic biology to address major issues such as sustainable manufacturing, green energy, and food security through innovative methods of converting CO2 into valuable compounds [1][2]. Group 1: CO2 Conversion and Sustainable Production - Significant progress has been made in converting CO2 into simple low-carbon compounds (C1-3) through various methods, but producing complex compounds remains challenging [1]. - The research group successfully demonstrated the conversion of CO2 into glucose and fatty acids using an electrochemical-coupled microbial cell factory, providing a viable method for sustainable production of sugar-derived food and chemicals [1]. - This achievement was recognized as one of the "Top Ten Scientific Advances in China" in 2022 [1]. Group 2: Synthetic Energy Systems - The research team constructed a synthetic energy system within yeast cells, supporting cell growth and efficient fatty acid synthesis [2]. - Low-carbon compounds such as methanol and ethanol were converted into sugars and sugar derivatives, including glucose and starch, through synthetic biology and metabolic engineering techniques [2]. Group 3: Upcycling Chemical Byproducts - The research group collaborated with other institutions to address the challenge of surplus byproducts in the chemical industry, specifically converting excess acetone into high-value natural products using a tandem electro-biosystem [3]. - The results of this work were published in Nature Sustainability, showcasing a novel approach to upcycling surplus acetone into long-chain chemicals [3][6]. Group 4: Electrochemical and Biological Catalysis - A synergistic strategy combining electrochemical and synthetic biology was proposed, where acetone is first converted into high-purity isopropanol (IPA) through electrochemical hydrogenation, followed by fermentation to produce high-value natural products [6][8]. - The research demonstrated a maximum IPA Faradaic efficiency of 95.6% and a current density of -240 mA cm-2 using a specially designed catalyst [8][10]. Group 5: Future Directions - Future research will focus on optimizing the bipolar membrane electrode reactor design, regulating metabolic pathways for fermentation, and expanding the application of electro-biosynthetic coupling systems [15].

Group 1: Core Insights - The article introduces the "Global Bio-based Industry Monthly Report," providing insights into the latest trends and opportunities in the bio-based sector [1][2][3] - The report is available for free to industry peers, highlighting the importance of collaboration and information sharing within the bio-based industry [1][3] Group 2: Policy Releases - The report includes three domestic bio-based related policies, emphasizing projects focused on carbon reduction and sustainable materials [7][19] - Key projects mentioned include a 110,000-ton biodegradable polyester rubber demonstration project and a 1 million-ton sustainable aviation fuel project [8][19] Group 3: Industry Dynamics - The report details two domestic bio-based chemical company updates, including a 120 million yuan investment in a lactic acid production demonstration line [9][10] - It also highlights the establishment of a new company focused on food additives, indicating growth in the bio-based chemicals sector [10] Group 4: Capital Events - The report outlines several financing events in the bio-based sector, including a multi-million yuan investment in a company specializing in bio-based high barrier film materials [11][22] - Notable investments include over 100 million yuan in a company focused on recombinant collagen and near 100 million yuan in a company producing bioactive ingredients [22] Group 5: Scientific Research Progress - The report presents significant research breakthroughs in the bio-based field, such as the development of a new method for synthesizing high-order carbohydrates from low-carbon molecules [12][23] - It also discusses advancements in bioremediation techniques using engineered bacteria to address environmental pollution [12][23] Group 6: Upcoming Events - The "Fourth Synthetic Biology and Green Bio-manufacturing Conference" is scheduled for August 20-22, 2025, in Jinan, Shandong, focusing on the future of bio-manufacturing [25][26] - The conference aims to foster collaboration among industry leaders, researchers, and investors to explore innovative technologies and applications in the bio-manufacturing sector [25]

Project Overview - The project is named "Baikaiseng (Jiangsu) Biotechnology Co., Ltd. New Green Biosynthesis Industrialization Project" with a total investment of 120 million yuan, including 6.13 million yuan for environmental protection [2] - The project will be located in Lianyungang City, Jiangsu Province, covering an area of 29,597 square meters (approximately 44.39 acres) [2] - Construction is planned to start in June 2025 and be completed by December 2025 [2] Production Capacity and Products - The project will establish an automated flexible fermentation production line with a total annual production capacity of: - Squalene: 180 tons - Ergothioneine: 10 tons - Rebaudioside M: 50 tons - Valencene: 20 tons - Ectoine: 40 tons [2][3] - The production lines will operate for varying hours annually, with Squalene production running for 4,728 hours and Ergothioneine for 600 hours [3] Product Applications - Squalene: Used as a dietary supplement to improve fatigue and enhance immunity, suitable for high-pressure or hypoxic environments [5] - Ergothioneine: A natural antioxidant used as a dietary supplement with anti-inflammatory and neuroprotective effects [6] - Ectoine: A natural amino acid derivative with antioxidant and anti-inflammatory properties, aiding in post-exercise recovery [6] - Rebaudioside M: A natural sweetener derived from stevia, approved as a food additive, suitable for various food and beverage applications [6][7] - Valencene: A food additive used to enhance citrus aroma in food products [7] Company Background - Baikaiseng (Jiangsu) Biotechnology Co., Ltd. is a subsidiary of Baikaiseng (Shanghai) Biotechnology Co., Ltd., established on March 15, 2024 [8] - The company focuses on the research and development of biomanufacturing technologies across pharmaceuticals, cosmetics, and food sectors [8]

【SynBioCon】 获 悉，近日， 诺泰生物 （688076.SH）与 诺唯赞生物 （688105.SH）战略签约，合作 成立合资公司，共同推进双方在 合成生物学领域 的业务发展。 这是诺泰生物在小分子技术平台，多肽技术平台和寡核苷酸技术平台的基础上，拓展建设的 合成生物学技 术平台 。公司高度重视科技平台的建设和创新，通过学科交叉推行平台战略，实现产业升级，扩大公司在 医药产品的技术和生产优势，巩固和提升在细分领域的领先地位。 此次战略合作的达成，不仅是诺泰生物（688076.SH）与诺唯赞生物（688105.SH）在业务拓展和技术创新 方面的重要一步，也为整个生物科技行业带来了新的发展机遇。期待双方未来在合成生物学领域内的探索 不仅能在生物医药领域产生重大影响力，还可以在 动物保健 与 农业 等更多领域产能较强的影响力。 合资 公司由诺泰生物控股 。 生物合成是生物学研究的前沿领域，以生物酶作为催化剂为核心。与传统化学反应相比， 生物酶催化展现 出诸多显著优势，如绿色无害、安全性高、特异性极强以及原子经济性高等。 （ Source: 《生物革命：创新改变了经济、社会和人们的生活——麦肯锡全球研究院》（ ...

【SynBioCon】 获悉，近日，世界知识产权组织（WIPO）公布了 2025年全球奖30强名单 ，黄埔本 土企业 慕恩（广州）生物科技有限公司 （以下简称"慕恩生物"）凭借其在微生物资源开发与生物制造 领域的突破性成果成功入围。包括慕恩生物在内，本次共有6家中国企业入围30强，慕恩生物是唯一一 家广东企业。 据悉，WIPO全球奖自2022年设立，是目前 全球知识产权领域的最高奖项 ，旨在表彰企业在知识产权 布局、技术创新、社会价值创造上的卓越实力。今年，共有来自95个国家的780家企业参与竞争这一 知识产权领域"奥斯卡"，脱颖而出的慕恩生物成为该奖项设立以来，首家入围30强的黄埔企业。 建立全球最大商业菌种库，引领可持续农业发展 当前，新一轮科技革命和产业变革不断加剧，企业之间的竞争愈发成为知识产权的比拼。而每年评选一 次的WIPO全球奖，便主要关注 企业能否将知识产权转化为成功的商业运营、能否通过知识产权战略 实现业务增长、能否有助于实现联合国可持续发展目标 。 据WIPO中国微信公众号消息，本次入围30强的6家中国企业，分别是慕恩生物、上海邦邦机器人有限 公司、碳一新能源（杭州）有限责任公司、成都成华 ...

天然生物基因组编码海量的功能基因，这些基因在长期进化选择过程中，占据了广泛的序列空间，并发展 出精巧多样的功能活性，为生物体在复杂环境中的生存和繁衍提供了独特优势。 随着测序获得的生物序列累计达数十亿量级，这些潜在的功能基因也为生物制造和合成生物技术提供了基 因元件的"宝库"。然而，尽管天然基因具备极为丰富的功能和应用潜力，目前只有一小部分热门的功能基因 （如基因编辑工具酶）被高质量注释并构建了序列或结构模型。因此，基于序列、结构或深度学习的基因 挖掘和蛋白质设计方法无法拓展至复杂功能基因，限制了对高价值基因元件的挖掘与开发利用。 【SynBioCon】 获悉，针对上述问题 ， 北京大学定量生物学中心钱珑 团队 于近日推出了 一款面向 合成生物学元件挖掘与生物制造应用的大语言模型 SYMPLEX ， 该模型通过融合领域大语言模型训 练、合成生物专家知识对齐和大规模生物信息分析，实现了从海量文献中自动化挖掘功能基因元件并精准 推荐其工程化应用潜力。 此外， 团队 与 中科院深圳先进技术研究院娄春波研究员 合作，将 SYMPLEX 应用于 mRNA 疫苗生物制 造关键酶—— 加帽酶的挖掘 ，成功获得多种高性能新型 ...