Group 1: Policy Release - The report includes three domestic policies related to the bio-based industry [7][18]. - Key projects in the policies focus on carbon reduction and include initiatives for biodegradable polyester rubber, high-performance bio-based materials, and sustainable aviation fuel [8][19]. Group 2: Industry Dynamics - The report highlights two domestic developments in the bio-based chemicals sector, including a project for lactic acid production and the establishment of a new company for food additives [9][20]. - A total of 13 domestic developments in the bio-manufacturing sector are reported, including strategic collaborations and new project announcements [20][21]. Group 3: Capital Events - Several financing events in the bio-based sector are noted, with companies raising millions in funding for various bio-manufacturing projects [11][22]. - Notable investments include over 100 million yuan for recombinant collagen and nearly 100 million yuan for bioactive ingredients [22]. Group 4: Scientific Research Progress - Significant breakthroughs in scientific research related to bio-based materials and manufacturing are reported, including advancements in bioremediation and the synthesis of high-order carbohydrates [12][23]. - Research highlights include the development of engineered bacteria for pollutant degradation and innovative methods for synthesizing sugars from low-carbon molecules [23]. Group 5: Upcoming Events - The fourth Synthetic Biology and Green Bio-Manufacturing Conference is scheduled for August 20-22, 2025, in Jinan, Shandong, focusing on industry trends and technological innovations [25][26].

Core Viewpoint - The article discusses the evolution of sugar consumption, the rise of high-fructose corn syrup (HFCS), and the emerging trend towards healthier sweeteners like allulose in response to health concerns related to sugar and artificial sweeteners [3][5][7][11][14]. Historical Context - Sugar transitioned from a rare commodity to a staple in modern diets, with its history marked by the cultivation of sugarcane and the establishment of a plantation economy reliant on slave labor [3]. - The "sugar revolution" began in the 16th century as European colonizers introduced sugarcane to the Americas, leading to significant economic impacts and the development of capitalism [3]. Sugar Consumption Trends - In the 17th and 18th centuries, sugar consumption in countries like England increased nearly 20 times over a century, with global consumption reaching approximately 180 million tons annually [5]. - The introduction of HFCS in the 1960s, particularly in the U.S., led to its dominance as a sweetener, with annual consumption around 20 million tons, including 5 million tons in China [5]. Health Concerns - The 21st century has seen rising health concerns regarding HFCS, with studies linking its excessive intake to obesity and diabetes, contributing to a stagnation or decline in demand in Western markets [7]. - Global obesity rates have surged, with over 1 billion adults classified as obese, prompting a shift in consumer preferences towards healthier alternatives [7]. Artificial Sweeteners - The development of artificial sweeteners has progressed through multiple generations, with ongoing debates about their safety and health impacts [9]. - Recent studies have raised alarms about certain artificial sweeteners, such as erythritol and sucralose, potentially increasing the risk of cardiovascular events and other health issues [10]. Shift Towards Healthier Alternatives - Growing health consciousness among consumers has led to the implementation of food health grading systems in various countries, indicating a shift towards healthier dietary choices [11]. - Allulose, a natural sugar discovered 80 years ago, is gaining attention as a promising alternative due to its favorable properties, including low caloric content and minimal impact on blood sugar levels [11][12]. Market Potential for Allulose - Allulose is viewed as a potential mainstream sweetener, with estimates suggesting a market demand of 200,000 tons per year if it achieves a 1% penetration in the global sugar market [14].

【SynBioCon】 获悉，6月3日， 虹摹生物 与 利乐公司 (Tetra Pak)正式达成全球战略合作，标志着"生物智造"与食品工业跨界融合的新阶段正式开 启。 合成生物乳蛋白赛道早已吸引了众多初 创公司、食品巨头和投资机构的目光： 国际布局企业 包括： Perfect Day (美国)、 Remilk (以色列)、 Imagindairy (以色列)、 Change Foods (美国/澳大利亚) 、 New Culture (美国) 、 TurtleTree (新加坡)、Formo / LegenDairy Foods (德国)、Better Dairy (英国)、Triton Algae Innovations (美国)等， 均利用精密发酵生产 酪蛋白，致力于功能、风味、营养价值和规模化开发 。 同时， 食品巨头与配料公司 同样注重这一产品布局： 双方将围绕 未来乳蛋白的创新路径 展开深度协作，共同探索营养升级与可持续发展的新方向，此次合作不仅是 一场强强联合的里程碑事件，更是全球 食品科技在未来营养领域的一次关键布局。 根据协议，虹摹生物与利乐将围绕未来 乳蛋白的创新研发、工艺转化与应用探索展开 ...

Core Viewpoint - The article discusses the intensifying global competition for carbon neutrality and how the bio-based industry can address three major contradictions: reliance on upstream raw materials, certification barriers in the midstream, and limitations in downstream applications [1] Group 1: Event Overview - A closed-door meeting focused on industry breakthroughs was held from May 25-27 during the 2025 Bio-based Conference and Exhibition in Shanghai [4] - The "2025 Bio-based Industry Strategic Seminar" was co-hosted by DT New Materials and the Zhoushan Investment Promotion Center [4] - 25 representatives from industry associations, well-known brands, material companies, and research institutions gathered to discuss three core topics: market reshaping, policy collaboration, and technological breakthroughs [6] Group 2: Key Insights from the Opening Report - The opening report emphasized that bio-based materials are a core pathway for the chemical industry to achieve sustainable development [8] - It highlighted that China's "dual carbon" policy is accelerating implementation, with industry associations promoting collaborative development through policy recommendations, standard setting, and technological rewards [8] Group 3: Brand User Demands - Certification and traceability have become essential prerequisites for collaboration, with international brands requiring non-food bio-based raw material certification [10] - Brands are generally willing to accept a price increase of up to 10%, but significant cost increases could hinder market promotion [11] - Performance must be contextualized, with specific demands for lightweight and decorative bio-based materials in automotive parts and integrated packaging solutions in cosmetics [11] Group 4: Strategies for Bio-based Material Companies - The industrialization of FDCA (2,5-furandicarboxylic acid) faces challenges, with current prices being 40 times that of PTA, making large-scale production crucial for cost reduction [14] - Companies need to identify unique value scenarios beyond merely replacing petroleum-based materials [14] - There is a call for policy collaboration to align with the EU's Packaging and Packaging Waste Regulation (PPWR) and to develop a bio-based materials standard system in China [14] Group 5: AI Empowerment in Bio-manufacturing - Companies shared practices of using AI to reduce R&D costs by 30% through protein modification, enhancing enzyme efficiency, and shortening development cycles [16] - Addressing purity issues is critical for high-end applications, with a need for collaboration across the entire supply chain [16] Group 6: Zhoushan's Strategic Positioning - Zhoushan aims to become a new hub for the bio-based industry by attracting projects related to PLA, PHA, FDCA-PEF, and other materials, providing comprehensive support [17] - The region has already gathered benchmark companies, indicating an initial scale of the industry chain ecosystem [17] Group 7: Consensus on Industry Collaboration - The meeting reached three core conclusions: 1. Non-food raw materials are essential for large-scale commercialization, requiring dual drivers of policy and technological innovation [20] 2. Accelerating the establishment of carbon footprint standards aligned with international norms is necessary to break down green trade barriers [20] 3. Collaboration between brands and material suppliers is needed to shift from performance substitution to value creation [20] - The meeting emphasized that bio-based materials represent a shift in competition rather than a shortcut, necessitating collective efforts across the entire industry chain to overcome the "valley of death" from laboratory to large-scale production [20]

Core Viewpoint - The successful launch of the world's first microbial green manufacturing project for trans-aconitic acid by Qingdao Energy Research Institute and Shandong Lukang Pharmaceutical Co., Ltd. marks a significant breakthrough in the accessibility of this important chemical raw material, which will effectively promote the rapid development of downstream applications such as bio-based materials and biopesticides [1][3]. Group 1: Project Overview - The project was officially launched on May 29, 2024, in Jining, Shandong, and is recognized for overcoming the challenges in microbial green manufacturing technology for trans-aconitic acid [1][3]. - The technology has been evaluated as internationally leading, with strong innovation and advanced indicators, suggesting further expansion of production and application scale [3][4]. Group 2: Technological Innovations - The project utilizes synthetic biology strategies to achieve microbial green manufacturing of trans-aconitic acid for the first time, employing high acid-resistant Aspergillus niger as the chassis cell [3][4]. - Key technological developments include enabling technology platforms, efficient cell factories, fermentation process demonstration, and separation and purification processes, leading to the establishment of the world's first demonstration line for microbial green manufacturing of trans-aconitic acid [3][4]. Group 3: Industry Impact - The collaboration between Qingdao Energy Research Institute and Lukang Pharmaceutical exemplifies interdisciplinary innovation in bio-chemical-materials integration, transforming disruptive technologies into new productive forces [4]. - The project has been recognized as a benchmark for green, low-carbon, and high-quality development, injecting new momentum into the bio-economy sector [5].

团队前期的工作围绕甲醇作为一种可再生的 C1 化合物以及与二氧化碳氢化合成技术的重大突破，通过碳氮协同耦合代谢工程与基因组扰动等多重策 略，有效提升天然甲基营养菌中甲醇向单细胞蛋白的定向转化效率，进而突破工业菌株性能极限，为利用甲醇作为碳源生物制造微生物蛋白大规模工业 化生产提供了关键技术支持；在气态非粮生物制造微生物蛋白方面，通过构建大肠杆菌中的光 - 暗反应能量适配器，实现光驱动 CO 2 同化的全细胞 催化过程；通过电催化 - 生物耦合技术，可将电化学还原 CO 2 生成的甲酸盐与微生物同化模块精准对接，为气态非粮原料的转化技术开辟了负碳生 物制造微生物蛋白的新维度；在固态非粮原料生物合成微生物蛋白技术方面，该团队通过机器学习模型，基于木质纤维素结构特性破译出降解酶系组成 的新算法，进而摆脱复杂性底物结构 - 多样性酶系构效关系的实验先验，精准定制了多种地源性木质纤维素来源的微生物蛋白，达到地源性农业废弃 物资源利用与微生物蛋白生物合成"一草双收"效果。这些创新转化模式不仅提升了农业废弃物资源化利用经济价值，更开辟了农业废弃物规模化生物 合成微生物蛋白的工业化新路径。 以下文章来源于中国科学院天津工业生 ...

Core Viewpoint - The strategic partnership between Suzhou Juweiyuan Biotechnology Co., Ltd. and Kunshan Yaxiang Flavor Co., Ltd. signifies the deep integration of synthetic biology technology and AI with the traditional flavor and fragrance industry, focusing on collaborative innovation in bio-based flavor and fragrance raw materials, green manufacturing pathways, and international market expansion [1][4]. Group 1 - The partnership aims to address the rapidly growing consumer demand for natural, safe, and green flavors and fragrances, positioning synthetic biology as a key opportunity for transforming the industry from petrochemical synthesis to sustainable manufacturing [4]. - Juweiyuan, as a leading synthetic biology enterprise, leverages its proprietary chassis cell library, high-throughput gene editing platform, and AI protein engineering system to overcome critical bottlenecks in the biomanufacturing supply chain [4]. - The collaboration is aligned with China's dual carbon goals, promoting the high-end, green, and international transformation of manufacturing, with a focus on low-carbon alternatives and high-value innovation [4]. Group 2 - The partnership will create a globally leading joint innovation platform for bio-synthetic flavors and fragrances, accelerating the transition of green products from laboratory to market [4]. - The initiative is expected to reshape the supply system and value structure of the flavor and fragrance industry, emphasizing the unique advantages of synthetic biology in raw material substitution, process innovation, and low-carbon manufacturing [4].

Core Viewpoint - Modern fermentation technology is revolutionizing various industries, including agriculture, medicine, energy, and materials, by integrating natural wisdom with technological advancements, leading to a new era of precision health science [1][3][9] Traditional Fermentation Technology - Traditional fermentation is a treasure of human wisdom, producing unique foods that reflect regional culture and history, such as Korean kimchi and Chinese soy sauce [3] - The essence of traditional fermentation lies in its naturalness and cultural heritage, but its artisanal production model struggles to meet modern demands for scalability and standardization [3][4] Modern Fermentation Technology - Modern fermentation technology emphasizes scientific and innovative approaches, utilizing synthetic biology and metabolic engineering to optimize microbial metabolic pathways, significantly enhancing production efficiency [4][6] - Techniques such as CRISPR and metabolic pathway design enable the creation of microbial cell factories that can produce high-value compounds like human milk oligosaccharides and heme for plant-based meat [5][6] Economic Impact and Sustainability - Modern fermentation technology is driving industries towards a "biomanufacturing closed loop," converting agricultural waste into energy and purifying industrial wastewater, thus forming a zero-carbon chain [6][7] - It is projected that by the end of the 21st century, biomanufacturing will account for one-third of global chemical production, potentially generating $30 trillion in economic value [7] Applications in Traditional Medicine - Modern fermentation technology offers new opportunities for the modernization of traditional Chinese medicine, such as significantly increasing the yield of artemisinin from 0.1% to 25 g/L through engineered yeast [7][8] - Fermentation can enhance the efficacy of traditional herbal medicines by converting inactive components into active ones and improving bioavailability, as seen with ginsenoside Rh2 [8] Future Prospects - The integration of artificial intelligence and big data into fermentation research is expected to accelerate development cycles and enhance production processes [5][9] - As modern fermentation technology continues to evolve, it is anticipated to transform the health industry, making concepts like "precision nutrition" and "sustainable health" a reality in daily life [9]

Core Viewpoint - The establishment of the American Bio-Manufacturing Alliance (AAB) aims to enhance the U.S. bio-manufacturing capabilities, promote domestic innovation, and increase the country's influence in the rapidly growing global bio-economy [1][2] Group 1: Alliance Formation - The AAB was formed on May 21, 2023, and includes stakeholders from the bio-manufacturing sector, such as CEOs from Manus, Pivot Bio, Novonesis North America, Kula Bio, and LanzaTech Global [1] - The formation of the alliance follows a call from the emerging biotechnology national security council (NSCEB) for a coordinated national strategy to strengthen U.S. leadership in the field [1] Group 2: Objectives of AAB - AAB has two main objectives: to increase demand for bio-based products and technologies in the U.S. and to ensure a comprehensive market for existing and emerging bio-products [2] - Founding members highlighted the economic and environmental potential of bio-manufacturing, emphasizing the development of low-cost, high-performance agricultural inputs to reduce reliance on global supply chains [2] Group 3: Industry Impact - Bio-manufacturing is applicable across various sectors, including agriculture, energy, chemicals, materials, nutrition, and pharmaceuticals, utilizing biological materials to produce sustainable products [1] - The global bio-manufacturing market is currently valued at $20 billion and is expected to experience significant growth over the next decade [1]

Core Viewpoint - The article highlights the advancements in plant-based indigo dye technology by Hehua Zhizhi Biotechnology Co., showcasing their 40% purity plant indigo product at the Bio-based 2025 conference in Shanghai [1][4]. Company Overview - Hehua Zhizhi Biotechnology Co., established in 2022 in Fenggang County, Zunyi City, Guizhou Province, has an investment of 20 million RMB and operates a 5,000-acre plantation with an annual production capacity of 80 tons and sales revenue of 48 million RMB, creating jobs for 30 local residents [4]. - The company has achieved significant milestones, including obtaining environmental assessment approvals, securing four patent technologies, and demonstrating a plant indigo purity of 40%-50% through large-scale pilot production [4]. Product Highlights - The showcased plant indigo dye has a purity of 40%, achieved through innovative patented extraction technology, which enhances dyeing processes, improves color fastness, and optimizes color performance [4][5]. - The natural plant indigo dye meets green, eco-friendly, and health standards, and aims to compete with synthetic dyes in the market due to its cost-effective and intelligent production methods [4][5]. Market Context - There is a notable increase in domestic demand for eco-friendly textile dyeing materials driven by global environmental needs, alongside a continuous growth in the international market for such products [5]. Industry Engagement - Hehua Zhizhi has joined the "bio-based link" global bio-based and bio-manufacturing industry service platform, enhancing its visibility and industry connections [7].