港股创新药板块持续拉升，昭衍新药（603127）涨超8%，绿叶制药涨超7%，泰格医药（300347）、君 实生物、中国生物制药跟涨。 ...

Market Overview - The Shanghai Composite Index rose by 0.70% on July 8, with 29 out of the 31 sectors in the Shenwan classification experiencing gains, led by the communication and power equipment sectors, which increased by 2.89% and 2.30% respectively [1] - The pharmaceutical and biological industry saw a modest increase of 0.31% [1] - The sectors that declined included public utilities and banking, with decreases of 0.37% and 0.24% respectively [1] Capital Flow Analysis - The net inflow of capital in the two markets was 15.45 billion yuan, with 14 sectors experiencing net inflows [1] - The electronics sector had the highest net inflow, totaling 7.437 billion yuan, and it rose by 2.27% [1] - The power equipment sector followed with a net inflow of 3.678 billion yuan and a daily increase of 2.30% [1] - Conversely, 17 sectors experienced net outflows, with public utilities leading at a net outflow of 2.297 billion yuan, followed by the pharmaceutical and biological sector with a net outflow of 2.285 billion yuan [1] Pharmaceutical and Biological Sector Performance - Within the pharmaceutical and biological sector, 474 stocks were tracked, with 337 stocks rising and 123 stocks falling [2] - The top gainers included Zhaoyan New Drug, which saw a net inflow of 263 million yuan and a price increase of 8.27%, followed by Ha Sanlian and Mindray Medical with net inflows of 232 million yuan and 139 million yuan respectively [2] - The sector also had 10 stocks with net outflows exceeding 100 million yuan, with Changshan Pharmaceutical leading at a net outflow of 783 million yuan, followed by Yong'an Pharmaceutical and Hanyu Pharmaceutical with outflows of 236 million yuan and 208 million yuan respectively [4] Top Gainers in Pharmaceutical Sector - The top gainers in the pharmaceutical sector included: - Zhaoyan New Drug: +8.27%, turnover rate 9.51%, net inflow 262.56 million yuan - Ha Sanlian: +10.00%, turnover rate 15.14%, net inflow 232.27 million yuan - Mindray Medical: +0.43%, turnover rate 0.44%, net inflow 138.84 million yuan [2] Top Losers in Pharmaceutical Sector - The top losers in the pharmaceutical sector included: - Changshan Pharmaceutical: -12.80%, turnover rate 8.90%, net outflow -783.11 million yuan - Yong'an Pharmaceutical: -5.88%, turnover rate 20.93%, net outflow -236.84 million yuan - Hanyu Pharmaceutical: -2.33%, turnover rate 20.52%, net outflow -207.84 million yuan [4]

Group 1 - The Hong Kong stock market's innovative drug sector continues to strengthen, with Rongchang Biologics rising over 7% [1] - Junshi Biosciences increased by more than 4% [1] - Tigermed (300347) and Zhaoyan New Drug (603127) both saw gains of over 3% [1] Group 2 - Innovent Biologics and Kanglong Chemical (300759) experienced increases of over 2% [1]

截至7月7日收盘，CRO概念下跌1.07%，位居概念板块跌幅榜前列，板块内，汇宇制药、*ST双成、睿 智医药等跌幅居前，股价上涨的有15只，涨幅居前的有诺思格、昭衍新药、翰宇药业等，分别上涨 3.03%、2.24%、2.11%。 | 002675 | 东诚药业 | -3.15 | 2.11 | -1460.10 | | --- | --- | --- | --- | --- | | 002821 | 凯莱英 | -2.94 | 1.10 | -1440.10 | | 688117 | 圣诺生物 | -0.77 | 7.83 | -1379.21 | | 603229 | 奥翔药业 | -2.05 | 1.37 | -1331.54 | | 300261 | 雅本化学 | -0.14 | 1.47 | -1240.44 | | 300363 | 博腾股份 | -1.98 | 1.86 | -1086.79 | | 301277 | 新天地 | -0.62 | 7.98 | -1072.75 | | 301509 | 金凯生科 | -0.61 | 7.64 | -985.87 | | 603538 | 美诺华 | ...

Group 1 - The Hong Kong CXO concept stocks experienced a decline, with WuXi Biologics falling over 5% [1] - Kingsoft Biotech dropped more than 3% [1] - Other companies such as Kelaiying (002821), WuXi AppTec (603259), Tigermed (300347), and Zhaoyan New Drug (603127) saw declines of over 2% [1]

Group 1 - The stock price of Zhaoyan New Drug (603127) increased by 16.95% this week, closing at 22.36 yuan, with a weekly high of 22.76 yuan and a low of 18.92 yuan [1] - Zhaoyan New Drug's current total market capitalization is 16.758 billion yuan, ranking 9th in the medical services sector and 950th among all A-shares [1] Group 2 - Zhaoyan New Drug announced its plan to invest up to 20 million yuan in the Huaxia Zhiyuan Venture Capital Fund, which has a target fundraising scale of 35 million yuan [2][4] - The fund will focus on equity investments in unlisted companies related to molecular diagnostics and targeted therapy, with a management fee of 1% per year based on the total capital contributions [2] - As of June 30, 2025, the legal registered capital of Zhaoyan New Drug's H-shares and A-shares remains unchanged at 118,995,206 shares and 630,482,128 shares, respectively [3][4]

| FF301 | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 | | | | | | | | | | 截至月份: 2025年6月30日 | | | | | | | | 狀態: 新提交 | | 致：香港交易及結算所有限公司 | | | | | | | | | | 公司名稱: 北京昭衍新藥研究中心股份有限公司 | | | | | | | | | | 呈交日期: 2025年7月4日 | | | | | | | | | | I. 法定/註冊股本變動 | | | | | | | | | | (如上市) 06127 證券代號 說明 | | | | | | | | | | 法定/註冊股份數目 | | | | 面值 | | | | 法定/ | | 註冊股本 | | | | | | | | | | 上月底結存 118,995,206 RMB | | | | | | 1 | | | | RMB 118,995,206 | | | | | | | ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年6月30日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 北京昭衍新藥研究中心股份有限公司 呈交日期: 2025年7月4日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06127 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 118,995,206 | RMB | | 1 | RMB | | 118,995,206 | | 增加 / 減少 (-) | | | 0 | | | | RMB | | 0 | | 本月底結存 | | | 118,995,206 | RMB | | 1 | RMB | | 118,995,206 | | 2. 股份分類 ...

Group 1 - The stock price of Zhaoyan New Drug (603127) reached a new high of 19.49 HKD, surpassing the previous high in March and marking the highest price since September 2023 [1] - The stock experienced significant volatility, with a nearly 30% drop in April due to market turbulence and regulatory changes, followed by a recovery of over 40% in May [1][4] - After peaking on June 17, the stock faced a three-day decline, dropping to a low of 13.89 HKD, a decrease of 28.73% from the peak [1] Group 2 - The Hang Seng Healthcare Index also rebounded after a five-day decline, indicating continued upward momentum in the Hong Kong pharmaceutical sector [2] - Investors are closely watching whether Zhaoyan New Drug can achieve new highs amid ongoing market fluctuations [2] Group 3 - Since the beginning of the year, southbound funds have accumulated a net purchase of nearly 700 billion HKD in Hong Kong stocks, with the healthcare sector showing significant gains [4] - The holding ratio of southbound funds in Zhaoyan New Drug increased from 37.58% to 40.64% in 2025, indicating a trend of increased investment [4][6] - The investment behavior of northbound funds shifted from "buying on dips" to "buying on rises" and back to "buying on dips" again, reflecting changing market dynamics [6] Group 4 - The recent surge in the Hong Kong innovative drug sector is driven by improved performance, policy optimization, and low valuations [4] - The financing environment for the domestic biopharmaceutical sector has improved, with a notable increase in investment cases and amounts in Q1 2025 [7] - The number of clinical approvals for new drugs in China has significantly increased, with 186 first-class new drugs receiving clinical approval in Q1 2025 [8][10] Group 5 - Zhaoyan New Drug reported a 115.11% year-on-year increase in net profit for Q1 2025, indicating strong financial performance despite market fluctuations [10] - The National Medical Products Administration's recent announcement aims to optimize the clinical trial review process, potentially accelerating the approval timeline for innovative drugs [10][12] - The average duration for new drug IND tasks in China is currently 71 days, with plans to reduce this to 30 working days, which could stimulate demand for Zhaoyan New Drug's services [12]

Core Viewpoint - The company, Zhaoyan New Drug, has experienced a decline in stock price and revenue, while showing significant growth in net profit, indicating mixed performance in the current market environment [1]. Company Summary - Zhaoyan New Drug's closing stock price on July 2 was 21.95 yuan, down 1.57%, with a rolling PE ratio of 42.46 times and a total market capitalization of 16.451 billion yuan [1]. - The company operates primarily in non-clinical safety evaluation services for drugs, clinical research services, and sales of experimental animals and related products [1]. - For the first quarter of 2025, Zhaoyan New Drug reported revenue of 287 million yuan, a year-on-year decrease of 11.54%, while net profit reached 41.1195 million yuan, reflecting a year-on-year increase of 115.11%, with a gross profit margin of 28.61% [1]. Industry Summary - The average PE ratio for the medical services industry is 41.66 times, with a median of 43.69 times, placing Zhaoyan New Drug at the 29th position within the industry [1]. - As of the first quarter of 2025, 22 institutions held shares in Zhaoyan New Drug, including 20 funds, with a total holding of 72.9482 million shares valued at 1.484 billion yuan [1]. - The industry comparison shows that Zhaoyan New Drug's PE ratio is higher than the industry average but lower than the median, indicating a competitive yet challenging market position [2].