证券代码：000963 证券简称：华东医药 公告编号：2025-070 华东医药股份有限公司 第十一届董事会第一次会议决议公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 一、董事会会议召开情况 华东医药股份有限公司（以下简称"公司"）第十一届董事会第 一次会议的通知于2025年07月16日以电话、口头等方式送达各位董事， 于2025年07月16日（星期三）在公司会议室以现场结合通讯方式召开。 经公司全体董事一致同意，豁免本次董事会会议提前通知时限的要求。 会议应参加董事11名，实际参加董事11名。会议由公司董事长主持。 会议的召开和表决程序符合《公司法》《公司章程》的有关规定，会 议合法有效。 二、董事会会议审议情况 董事会就以下议案进行了审议，经书面和通讯方式表决，通过决 议如下： （一）审议通过《关于选举第十一届董事会董事长、代表公司执 行公司事务的董事的议案》 经本次董事会与会董事表决，一致同意选举吕梁先生为公司第十 一届董事会董事长、代表公司执行公司事务的董事，为公司法定代表 人，任期自董事会审议通过之日起，至公司第十一届董事会任期届满 之日止（ ...

Market Overview - A-shares maintained a narrow fluctuation on July 16, with the Shanghai Composite Index closing at 3503.78 points, down 0.03% [1] - The Shenzhen Component Index and the ChiNext Index both fell by 0.22% to 10720.81 points and 2230.19 points, respectively [1] - The total trading volume in the Shanghai and Shenzhen markets was 146.19 billion yuan, a decrease of over 170 billion yuan from the previous day [1] Sector Performance - Financial stocks collectively declined, while the steel, non-ferrous metals, and coal sectors showed weakness [1] - The automotive supply chain stocks surged, with companies like Rongtai Co., Fuda Co., and Zhejiang Rongtai hitting the daily limit [1] - The innovative drug concept saw significant activity, with stocks like Guosheng Tang and Iwu Biotech rising approximately 16% [5][6] - The humanoid robot concept remained hot, with companies like Shangwei New Materials achieving a six-day limit increase [2][4] Notable Company Movements - Huadian New Energy, which debuted on the Shanghai main board, closed up 125.8%, reaching a market value of over 300 billion yuan at one point [1] - Weiyali, a Hong Kong-based electronic component distributor, saw its stock surge by 288% upon resuming trading, with an intraday increase exceeding 900% [1] Humanoid Robot Sector Insights - The humanoid robot industry is in its early stages, with significant growth expected in the next 3 to 5 years across various applications [4] - The current phase is described as the "dawn" of humanoid robot industrialization, with mass production and large-scale application becoming feasible [4] - Cost reduction is crucial for the widespread adoption of humanoid robots, and companies that master core component technologies are recommended for investment [4] Innovative Drug Sector Insights - The innovative drug sector experienced strong gains, with several companies hitting the daily limit [5][6] - The recent launch of the 11th batch of national drug centralized procurement is expected to impact the market, focusing on mature "old drugs" rather than innovative drugs [7] - The introduction of measures to support the high-quality development of innovative drugs indicates a growing role for commercial insurance in the healthcare system [7] Pet Economy Sector Insights - The pet economy concept gained traction, with companies like Weike Technology rising over 10% [8] - The pet food sector is viewed as a growing market with significant long-term growth potential, particularly for domestic brands [8]

Core Viewpoint - The patent battle over the antithrombotic drug Indobufen tablets is intensifying, with multiple companies facing procurement qualification suspensions due to patent disputes [1][2][3]. Patent Dispute Overview - The Zhejiang Provincial Hangzhou Intermediate People's Court has suspended the procurement qualifications of several companies producing Indobufen tablets, including Hunan Shangzhonghe Biological Pharmaceutical Co., Ltd. and Zhejiang Saime Pharmaceutical Co., Ltd. [1][2] - A total of five companies have had their sales of Indobufen tablets suspended, indicating a significant impact on the market [1][8]. Market Potential - Indobufen tablets are becoming a "billion-level" product in the cardiovascular medication sector, with sales in hospitals increasing from 745 million yuan in 2021 to 1.408 billion yuan in 2023, reflecting a compound annual growth rate of 37.4% [3]. - Retail sales also exceeded 100 million yuan in 2023, showcasing strong market demand [3]. Patent Strategy and Challenges - The core of the patent dispute revolves around crystal form patents, which are often used by original drug companies to extend their market exclusivity after the expiration of the basic compound patent [4][5]. - Companies like Huadong Medicine have filed administrative decisions or lawsuits against 15 enterprises for alleged patent infringements, indicating a proactive approach to protect their intellectual property [2][5]. Regulatory Environment - The introduction of the "drug patent linkage system" in 2021 has changed the landscape of pharmaceutical patent protection in China, balancing the needs of original drug innovation and market access for generic drugs [9]. - Companies must ensure they do not infringe on patents to participate in drug procurement, as seen with Guangdong Dongyangguang's suspension due to patent issues [7]. Competitive Landscape - The competition among generic drug companies has shifted from breaking through barriers to building their own barriers through secondary patents, resembling the strategies of original drug companies [9][11]. - The ongoing patent disputes are not limited to Indobufen; other drugs like Benazepril have also faced similar challenges, indicating a broader trend in the industry [10]. Implications for Innovation - The focus on patent strategies may lead to increased investment in research and development among generic drug companies, pushing for innovation in crystal forms and formulation processes [10][11]. - However, the reliance on patent battles could hinder overall industry innovation and delay the reduction of drug prices, contradicting the goals of drug procurement policies aimed at improving accessibility [11].

Summary of Conference Call Notes Industry or Company Involved - The discussion primarily revolves around the pharmaceutical industry, particularly focusing on the implications of U.S. drug pricing policies and U.S.-China trade negotiations on Chinese pharmaceutical companies and their market opportunities. Core Points and Arguments 1. **Positive Impact of U.S.-China Negotiations on Pharmaceuticals** The recent U.S.-China negotiations are viewed as a significant positive for the pharmaceutical sector, alleviating previous concerns regarding trade impacts on drug pricing and exports of innovative drugs and raw materials [1] 2. **U.S. Drug Pricing Policy Changes** Trump's announcement of an executive order to reduce prescription drug prices by 30% to 80% is highlighted. The U.S. drug pricing system, characterized by high list prices, is under scrutiny, with the potential for significant price reductions impacting the market [2][3] 3. **Global Drug Pricing Context** U.S. drug prices are noted to be among the highest globally, particularly for innovative drugs, which are approximately 300% higher than prices in countries like Japan and Germany. This pricing structure encourages innovation but also raises concerns about affordability [3] 4. **Encouragement of Competition** The U.S. policy aims to accelerate competition among high-priced drugs, encouraging the entry of biosimilars and generic drugs, which could benefit Chinese pharmaceutical companies that can offer lower-cost alternatives [4][6] 5. **Opportunities for Chinese Pharmaceutical Companies** The reduction in U.S. drug prices is expected to create opportunities for Chinese companies, particularly in the fast-follow and biosimilar segments, as they can provide high-quality, cost-effective alternatives [6][8] 6. **Long-term Trends Favoring Chinese Innovation** The inefficiencies in innovation among multinational pharmaceutical companies may lead to increased reliance on Chinese innovation and manufacturing capabilities, especially if U.S. companies face cost pressures [7][8] 7. **Market Dynamics and Export Opportunities** The easing of trade tensions is anticipated to enhance the macroeconomic environment in China, leading to improved domestic demand and potential export opportunities for medical devices and raw materials [10][9] 8. **Impact of Drug Price Reductions on Market Dynamics** The anticipated drug price reductions in the U.S. are not expected to significantly diminish the addressable market for Chinese companies, as their market share in the U.S. remains relatively small [11][12] 9. **Long-term Supply Chain Considerations** U.S. concerns regarding supply chain security may lead to a push for domestic manufacturing, which could have long-term implications for Chinese companies seeking to penetrate the U.S. market [14][15] 10. **Investment Recommendations** The call suggests focusing on three categories of companies: innovative leaders, those with strong business development (BD) expectations, and upstream suppliers with global advantages, as the market enters a new growth cycle [16][18] Other Important but Possibly Overlooked Content 1. **Sector-Specific Insights** The discussion includes insights into specific companies and their competitive advantages, such as the potential for certain drugs to achieve significant market penetration despite pricing pressures [31][33] 2. **Emerging Trends in Medical Devices** The call also touches on the medical device sector, emphasizing the importance of high-end equipment and the potential for growth in home healthcare products, which may offer higher profit margins compared to domestic markets [25][26] 3. **Long-term Growth Projections** There is an optimistic outlook for the pharmaceutical sector, with expectations of a gradual recovery in demand and performance improvements in the coming years, driven by policy support and market dynamics [29][40] 4. **Focus on Innovation and R&D** The emphasis on innovation and the need for companies to adapt to changing market conditions is reiterated, highlighting the importance of R&D in maintaining competitive advantages [19][20] 5. **Market Sentiment and Future Outlook** The overall sentiment is cautiously optimistic, with a belief that the current market conditions present opportunities for growth and investment in the pharmaceutical and medical device sectors [46][47]

Core Viewpoint - The innovative drug market is experiencing a surge in interest and investment, with significant inflows of capital and strong performance in related stocks [1][5]. Group 1: Market Performance - On July 15, the pharmaceutical ETF (562050) experienced a sharp increase during the opening auction, indicating heightened investor enthusiasm for innovative drugs [2][3]. - The ETF closed up 0.59% at 1.017 yuan per share, with a total trading volume of approximately 26.34 million yuan and a turnover rate of 22.94% [4]. - A-shares in innovative drugs have shown notable gains, with companies like ShenZhou Cell rising nearly 50% in the past month, and others like BoRui Medicine and Jilin AoDong increasing over 10% [5]. Group 2: Fund Performance and Strategy - The latest public fund reports reveal a significant shift towards innovative drugs, with the Changcheng Pharmaceutical Industry Selected Fund achieving over 90% returns, increasing its scale nearly 30 times in the second quarter [6][9]. - The fund manager of Yongying Medical Health Fund indicated a complete portfolio overhaul towards innovative drugs, with top holdings including ShuTaiShen and Rejing Biology, the latter seeing a staggering 443.59% increase this year [6][7]. - The Changcheng fund plans to continue focusing on innovative drugs in the third quarter, emphasizing clinical data, overseas licensing, and domestic sales growth [8]. Group 3: Policy and Market Trends - The innovative drug sector is benefiting from favorable policy developments, with the National Medical Insurance Bureau initiating adjustments to the drug catalog for 2025 [10]. - Data shows that the total amount for Chinese innovative drug licenses reached nearly 66 billion USD in the first half of 2025, surpassing the total for 2024, indicating a rapid rise in global competitiveness [11]. - The current market rally is primarily driven by clinical results and expectations for overseas licensing, with a focus on companies that have the potential for international expansion and those that have successfully transformed [11].

从中证钱江30指数持仓的市场板块来看，深圳证券交易所占比56.60%、上海证券交易所占比43.40%。 从中证钱江30指数持仓样本的行业来看，信息技术占比22.09%、金融占比22.01%、工业占比16.91%、 可选消费占比15.96%、原材料占比13.62%、医药卫生占比7.24%、公用事业占比2.16%。 资料显示，指数样本每半年调整一次，样本调整实施时间分别为每年6月和12月的第二个星期五的下一 交易日。特殊情况下将对指数进行临时调整。当样本退市时，将其从指数样本中剔除。样本公司发生收 购、合并、分拆等情形的处理，参照计算与维护细则处理。 据了解，中证钱江30指数从注册地在浙江省的上市公司中，根据总市值、营业收入以及净资产收益率三 个指标选取30只上市公司证券作为指数样本，以反映具备浙江经济代表性的上市公司证券的整体表现。 该指数以2009年12月31日为基日，以1000.0点为基点。 从指数持仓来看，中证钱江30指数十大权重分别为：海康威视（10.89%）、宁波银行（9.72%）、杭州 银行（9.06%）、三花智控（6.31%）、同花顺（6.25%）、小商品城（5.46%）、拓普集团（4.28%）、 ...

Group 1 - Bailitianheng's innovative biopharmaceutical izabren (EGFR×HER3 dual-target ADC) has received approval for a Phase II clinical trial to treat advanced kidney cancer in combination with lenvatinib and pembrolizumab, potentially enhancing anti-tumor effects and addressing unmet needs in kidney cancer treatment [1] - Kanghui Pharmaceutical is involved in a legal dispute with Hubei Kelaivi regarding equity repurchase payments, with the latter appealing a first-instance ruling that ordered payment of 2 million yuan and 35.994 million yuan, highlighting risks in performance guarantees and repurchase clauses in pharmaceutical mergers [2] - *ST Suwu has announced an expected net loss of 60 million to 40 million yuan for the first half of 2025, primarily due to significant impairment provisions for trade receivables, indicating potential delisting risks if the company cannot return to profitability [3] - East China Pharmaceutical is exploring early projects targeting fat reduction and muscle health, aiming to capitalize on the global trend of GLP-1 drugs, although the projects are still in early exploration stages with significant uncertainties [4] - XW003 injection by Xianweida has initiated a new Phase II clinical trial comparing its efficacy and safety against semaglutide in obese patients, which could validate its unique cAMP-biased GLP-1 mechanism and accelerate entry into the weight loss market [5]

证券代码：000963 证券简称：华东医药 公告编号：2025-067 华东医药股份有限公司 关于全资子公司获得美国FDA新药临床试验批准通知的公 告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 IND 编号：175685 适应症：晚期实体瘤 申请事项：临床试验 申请人：杭州中美华东制药有限公司 二、该药物研发及注册情况 注射用 HDM2020 是由中美华东研发并拥有全球知识产权的 1 类 生物新药，是一款靶向成纤维细胞生长因子受体 2b（Fibroblast Growth Factor Receptor 2b，FGFR2b）的新型抗体药物偶联物（Antibody-drug conjugate，ADC），可特异性结合表达人 FGFR2b 的肿瘤细胞并通过 向胞内释放毒素载荷，发挥肿瘤杀伤作用。临床前研究已证明 HDM2020 在靶点阳性的胃癌、鳞状非小细胞肺癌等药效模型中显示 出强大的抗肿瘤活性，具有良好的成药性和安全性。 2025 年 6 月，中美华东完成向美国 FDA 递交注射用 HDM2020 的临床试验申请，并于近日获得 FDA 批准。此外，注射用 ...

Core Viewpoint - The approval of the clinical trial application for injectable HDM2020 by the FDA marks a significant advancement in the product's development, enhancing the company's competitiveness in the oncology treatment sector [1] Group 1: Company Developments - The company's wholly-owned subsidiary, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., has received FDA approval to conduct Phase I clinical trials for injectable HDM2020 in the United States [1] - Injectable HDM2020 is a first-class biopharmaceutical developed by the company, targeting fibroblast growth factor receptor 2b (FGFR2b) as a novel antibody-drug conjugate (ADC) [1] - The product is noted for its favorable druggability and safety profile, indicating strong potential for successful development [1] Group 2: Industry Implications - The approval is a crucial step in the research and development process of HDM2020, which is aimed at treating advanced solid tumors [1] - This development is expected to further strengthen the company's core competitiveness in the oncology treatment field [1]

Group 1 - The core viewpoint of the articles highlights the performance of the CSI 300 Pharmaceutical Index, which closed at 11,931.35 points, showing a decline of 1.18% over the past month, an increase of 7.25% over the past three months, and a year-to-date increase of 9.53% [1][2] - The CSI 300 Pharmaceutical Index is composed of listed companies in the pharmaceutical sector selected from the CSI 300 Index, reflecting the overall performance of these companies [1] - The top ten weighted companies in the CSI 300 Pharmaceutical Index include: Heng Rui Medicine (43.14%), Pian Zai Huang (10.14%), Yunnan Baiyao (8.49%), Kelun Pharmaceutical (6.31%), East China Pharmaceutical (5.98%), New Harmony (5.69%), Fosun Pharmaceutical (5.53%), Tong Ren Tang (4.16%), Bai Li Tian Heng (3.83%), and China Resources Sanjiu (3.54%) [1] Group 2 - The market share of the CSI 300 Pharmaceutical Index is dominated by the Shanghai Stock Exchange at 69.99%, while the Shenzhen Stock Exchange accounts for 30.01% [2] - In terms of industry composition, the index is primarily made up of drug formulations at 64.78%, traditional Chinese medicine at 29.52%, and raw materials at 5.69% [2] - The index samples are adjusted semi-annually, with adjustments occurring on the next trading day after the second Friday of June and December each year, and weights are fixed until the next scheduled adjustment [2]