Investment Rating - The report does not explicitly state an investment rating for the GLP-1RA drug industry Core Insights - The GLP-1 receptor agonists (GLP-1RA) are a class of drugs that mimic the action of GLP-1, promoting insulin secretion and reducing appetite, leading to blood sugar control and weight loss [2][3] - The global market for GLP-1 drugs is dominated by semaglutide and tirzepatide, with semaglutide achieving sales of $16.6 billion in the first half of 2025, making it the top-selling drug globally [8] - The expiration of patents for major drugs is expected to lead to a surge in generic versions, increasing market competition and reducing treatment costs [11] Summary by Sections GLP-1 Drug Classification and Mechanism - GLP-1RA drugs are categorized into short-acting, long-acting, and ultra-long-acting formulations, each with different pharmacokinetic profiles [2][3] - These drugs are effective in treating conditions such as obesity, type 2 diabetes, and metabolic disorders [4] Market Performance and Patent Expiration - The sales of GLP-1 drugs have shown significant growth, with semaglutide's weight management product Wegovy achieving $5.441 billion in sales, a 78% increase year-over-year [8] - Key patents for drugs like liraglutide have expired, while others like semaglutide will expire in 2026, paving the way for biosimilars [9][11] R&D Progress in China - Chinese companies are advancing in the development of dual-target and multi-target GLP-1 drugs, with significant progress in clinical trials [13][14] - The focus is shifting towards expanding indications for GLP-1 drugs beyond diabetes and obesity to include conditions like Alzheimer's and cardiovascular diseases [15] Future Market Potential - The Chinese GLP-1 market is projected to grow from 9.62 billion yuan in 2020 to 71.7 billion yuan by 2029, with a compound annual growth rate (CAGR) of 22.1% [22] - The inclusion of GLP-1 drugs in national health insurance is expected to enhance market penetration and accessibility [22] Innovation Trends - The industry is witnessing a trend towards multi-target drug development and the introduction of oral formulations to improve patient compliance [28][29] - The competitive landscape is intensifying as both original and generic drug manufacturers seek to establish a foothold in the market [30][31]

Group 1 - The hepatitis concept sector declined by 0.31%, ranking among the top declines in concept sectors, with companies like Zhongsheng Pharmaceutical and Guangji Pharmaceutical hitting the limit down [1][2] - Major stocks in the hepatitis sector that saw significant outflows include Zhongsheng Pharmaceutical with a net outflow of 684 million yuan, followed by Te Yi Pharmaceutical and Pian Zai Huang with net outflows of 112 million yuan and 81 million yuan respectively [2][3] - Conversely, stocks that experienced net inflows include Baihua Pharmaceutical, Huadong Medicine, and Kangzhi Pharmaceutical, with inflows of 97.75 million yuan, 43.11 million yuan, and 21.20 million yuan respectively [6] Group 2 - The top gainers in the hepatitis sector included Baihua Pharmaceutical, which rose by 10.01%, followed by Chengda Pharmaceutical and Kangzhi Pharmaceutical with increases of 4.79% and 3.00% respectively [1][6] - The overall market sentiment for the hepatitis sector appears negative, as evidenced by the significant net outflows and the number of stocks declining in value [2][3] - The trading volume for Zhongsheng Pharmaceutical was notably high, with a turnover rate of 18.78%, indicating active trading despite the price drop [2][3]

Market Overview - The chemical pharmaceutical sector increased by 0.02% on November 28, with Yifang Bio leading the gains [1] - The Shanghai Composite Index closed at 3888.6, up 0.34%, while the Shenzhen Component Index closed at 12984.08, up 0.85% [1] Top Gainers in Chemical Pharmaceutical Sector - Yifang Bio (688382) closed at 29.48, up 5.93% with a trading volume of 206,700 shares and a transaction value of 590 million [1] - Bibet (688759) closed at 34.88, up 5.47% with a trading volume of 115,300 shares [1] - Weier Pharmaceutical (603351) closed at 28.83, up 5.45% with a trading volume of 19,400 shares and a transaction value of 54.88 million [1] - Other notable gainers include Tingjian (002653) up 4.43% and Dongcheng Pharmaceutical (002675) up 3.53% [1] Top Losers in Chemical Pharmaceutical Sector - Guangji Pharmaceutical (000952) saw a significant decline of 9.98%, closing at 9.38 with a trading volume of 1,153,700 shares [2] - New Ganjing (920367) decreased by 5.73%, closing at 21.57 with a trading volume of 37,700 shares [2] - Hendi Pharmaceutical (301211) fell by 5.24%, closing at 15.19 with a trading volume of 310,700 shares [2] - Other notable losers include Beida Pharmaceutical (000788) down 3.80% and Fuyuan Pharmaceutical (6801089) down 3.71% [2] Fund Flow Analysis - The chemical pharmaceutical sector experienced a net outflow of 599 million from institutional investors, while retail investors saw a net inflow of 377 million [2] - Notable net inflows from retail investors were observed in stocks like Yifang Bio and Bibet, despite overall net outflows from institutional and speculative funds [3] Individual Stock Fund Flow - Yifang Bio had a net inflow of 57.86 million from institutional investors, but a net outflow from speculative and retail investors [3] - Huadong Pharmaceutical (000963) also saw a significant net inflow of 56.40 million from institutional investors, with outflows from speculative and retail investors [3] - Other stocks like Bibet and Dongcheng Pharmaceutical showed mixed fund flows, indicating varied investor sentiment [3]

Summary of Key Points from China Healthcare Conference and Tour Industry Overview - **Industry**: China Healthcare - **Focus**: Innovation, Globalization, and Recovery in Medical Technology (Medtech) Core Insights 1. **Innovation Hub**: China is establishing itself as a global innovation hub, particularly in novel modalities such as IO bispecific, ADC, and siRNA [1][2] 2. **Medtech Globalization**: Leading Chinese medical equipment companies are moving beyond simple exports to establish localized production and direct sales networks [1][3] 3. **IVD Market Recovery**: The domestic In-Vitro Diagnostics (IVD) market is showing signs of bottoming out, with hospitals incentivized to switch to cost-effective domestic solutions due to pricing pressures [1][4] 4. **CXO Sector Performance**: Strong orders in the CXO sector are sustained, with potential price recovery in domestic clinical CROs expected to improve gross margins in 2026 [1][5] Company-Specific Highlights 1. **Abbisko (2256.HK)** - Focus on clinical progress of irpagratinib and ABSK043, with a strong pipeline that remains undervalued in the market [15] - Irpagratinib's Phase 3 study for HCC is on track, and ABSK043 shows promise in combination therapies [16][17] 2. **Huadong Medicine (000963.SZ)** - Innovative drugs contributed Rmb1,675 million in sales for 9M25, up 62% YoY, with a focus on oncology and metabolic diseases [19] - Ongoing discussions for potential out-licensing of GLP-1 candidates and ADC [20] 3. **MicroPort MedBot (2252.HK)** - YTD overseas orders exceeded 70, indicating rapid commercialization in international markets [23] - Targeting cash flow breakeven in 2026, with a focus on increasing revenue from high-margin consumables [24][25] 4. **Shanghai Fosun Pharma (2196.HK)** - Optimistic about the inclusion of CAR-T therapy Yescarta in the innovative drug catalog of commercial insurance, expected to accelerate coverage [28] - Increasing R&D investment by 20% YoY, focusing on new modalities like radiopharmaceuticals [30] 5. **Henlius (2696.HK)** - HLX43 shows promising data in NSCLC, with plans for multiple registrational trials [31][33] - Developing a new platform for radiopharmaceuticals and small nucleic acids [32] 6. **Shenzhen Mindray (300760.SZ)** - Aiming to double its current 10% market share in IVD within three years, leveraging comprehensive lab solutions [37] - Global strategy focuses on localization and diversification of manufacturing [38] 7. **Tigermed (3347.HK)** - Positive revenue growth guidance for 2025, with strong orders in Phase 1/2 trials [40][42] - Expanding overseas operations, with significant growth in the US and Japan [43] 8. **United Imaging (688271.SS)** - Achieving robust growth in developed markets, with a CAGR of 50% for overseas markets expected [44][48] - Strong positioning in high-end MRI and molecular imaging sectors [47] Additional Insights - **siRNA Modality**: The siRNA field is at an inflection point, attracting significant interest from multinational corporations due to its long-dosing interval potential [2][9] - **Market Dynamics**: The domestic IVD market is experiencing a structural shift favoring domestic leaders, with hospitals seeking cost-effective solutions [4][14] - **Globalization Trends**: Chinese medtech firms are successfully executing globalization strategies, with significant growth in emerging markets [3][13] This summary encapsulates the key takeaways from the China Healthcare Conference and Tour, highlighting the industry's focus on innovation, globalization, and recovery, along with specific insights into leading companies within the sector.

（文章来源：证券日报） 证券日报网讯华东医药11月27日在互动平台回答投资者提问时表示，目前刘东舟博士为公司首席科学官 （CSO），同时兼任参股公司HeidelbergPharmaAG的首席执行官（CEO）。 ...

（PDL1/VEGF/TGFβ）正在推进I 期临床；HDM1002（GLP-1 小分子）减重III 期临床加速推进。根据 分部估值计算，公司2026 年医药工业对应估值658亿元，医美业务对应估值151亿元，医药商业对应估 值51亿元，2026年公司合理估值为859亿元，对应股价为49.0元，维持"推荐"评级。 格隆汇11月24日｜华创证券日前研报指出，华东医药发布2025年三季度归母净利润9.33亿元，同比增长 7.71%；业绩稳健增长，看好后续创新药弹性释放。目前公司创新药研发中心正在推进90余项创新药管 线项目，多款重磅产品数据读出值得关注，HDM2005（ROR1 ADC）已于Q3读出I期数据；根据医药魔 方数据显示，DR10624（GLP-1/GIP/GCGR）正在推进MASH II 期临床；DR30206 ...

Core Viewpoint - Huadong Medicine's stock price has shown a mixed performance in recent trading sessions, with a year-to-date increase of 22.30% but a decline of 2.39% over the last five trading days [1] Financial Performance - For the period from January to September 2025, Huadong Medicine achieved a revenue of 32.664 billion yuan, representing a year-on-year growth of 3.77% [2] - The net profit attributable to shareholders for the same period was 2.748 billion yuan, reflecting a year-on-year increase of 7.24% [2] Shareholder Information - As of September 30, 2025, the number of Huadong Medicine's shareholders decreased by 1.50% to 68,800, while the average number of circulating shares per person increased by 1.53% to 25,466 shares [2] - The company has cumulatively distributed 8.873 billion yuan in dividends since its A-share listing, with 3.771 billion yuan distributed over the last three years [3] Institutional Holdings - As of September 30, 2025, Hong Kong Central Clearing Limited is the third-largest circulating shareholder, holding 52.004 million shares, an increase of 12.1653 million shares from the previous period [3] - China Securities Finance Corporation remains the fourth-largest shareholder with 22.1868 million shares, unchanged from the previous period [3] - Notable changes in holdings include a decrease of 4.3243 million shares for the fifth-largest shareholder, China Universal Healthcare Mixed A [3]

证券代码：000963 证券简称：华东医药 公告编号：2025-106 华东医药股份有限公司 关于拟回购注销部分限制性股票的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 特别提示： 华东医药股份有限公司（以下简称"公司"）于2025年11月20日召 开的第十一届董事会第五次会议，审议通过了《关于回购注销部分限 制性股票的议案》，根据公司《2022年限制性股票激励计划》（以下 简称"本激励计划"、"《激励计划》"）《上市公司股权激励管理办法》 （以下简称"《管理办法》"）的相关规定，董事会同意对首次授予激 励对象中6名因离职不再具备激励资格的激励对象、16名因第三个解 除限售期个人层面绩效考核结果为不合格的激励对象、3名因第三个 解除限售期个人层面绩效考核结果为合格的激励对象及预留授予激 励对象中1名因离职不再具备激励资格的激励对象、2名因第二个解除 限售期个人层面绩效考核结果为不合格的激励对象，对应的已获授但 尚未解除限售的限制性股票合计28.42万股进行回购注销。本次回购 注销事项尚需提交股东会审议，审议通过后施行。现将具体情况公告 如下： 一、本次 ...

证券代码：000963 证券简称：华东医药 公告编号：2025-105 华东医药股份有限公司 关于调整 2022 年限制性股票激励计划回购价格的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 的授予条件已成就，监事会对首次授予日的激励对象名单再次进行了 核查并对本次调整及授予事项发表了意见。公司独立董事对前述议案 发表了同意的独立意见，律师及独立财务顾问出具了相应的报告。 2022年10月28日，公司于巨潮资讯网披露了相关公告。 6、2022年11月9日，公司披露了《关于2022年限制性股票激励计 划首次授予登记完成的公告》，公司完成了2022年限制性股票激励计 划首次授予的限制性股票登记工作，授予的限制性股票上市日为2022 年11月15日。 7、2023年7月12日，公司召开第十届董事会第十二次会议和第十 届监事会第八次会议，审议通过了《关于调整2022年限制性股票激励 计划预留授予价格的议案》、《关于向2022年限制性股票激励计划激励 对象授予预留限制性股票的议案》。公司董事会认为本激励计划规定 的预留授予条件已经成就，监事会对预留授予日的激励对象 ...

华东医药股份有限公司 关于2022年限制性股票激励计划首次授予限制性股票第三 个解除限售期解除限售条件成就的公告 证券代码：000963 证券简称：华东医药 公告编号：2025-104 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 特别提示： 1、公司 2022 年限制性股票激励计划首次授予限制性股票第三个 解除限售期解除限售条件成就，本次符合解除限售条件的激励对象共 计 77 人，可解除限售的限制性股票数量为 127.512 万股，占目前公 司总股本的 0.07%。 2、本次限制性股票解除限售尚需在相关部门办理解除限售手续， 上市流通前，公司将发布相关提示性公告，敬请投资者注意。 华东医药股份有限公司（以下简称"华东医药"、"公司"）于 2025 年 11 月 20 日召开第十一届董事会第五次会议，审议通过了《关于 2022 年限制性股票激励计划首次授予限制性股票第三个解除限售期 解除限售条件成就的议案》，根据公司《2022 年限制性股票激励计划》 （以下简称"《激励计划》"）的相关规定，董事会认为公司 2022 年 限制性股票激励计划首次授予限制性股票第 ...