睿智医药科技股份有限公司 简式权益变动报告书 上市公司名称：睿智医药科技股份有限公司 股票上市地点：深圳证券交易所 睿智医药科技股份有限公司 简式权益变动报告书 股票简称：睿智医药 信息披露义务人：上海睿昀企业管理中心（有限合伙） 住所/通讯地址：中国（上海）自由贸易试验区临港新片区云汉路 979 号 2 楼 信息披露义务人之一致行动人：上海睿钊企业管理中心（有限合伙） 住所/通讯地址：上海市奉贤区联合北路 215 号第 1 幢 4808 室 股权变动性质：股份减少（持股比例降至 5%以下） 本报告书签署日期：2025 年 6 月 9 日 1 睿智医药科技股份有限公司 简式权益变动报告书 信息披露义务人声明 股票代码：300149 一、信息披露义务人及其一致行动人根据《中华人民共和国公司法》《中 华人民共和国证券法》《上市公司收购管理办法》《公开发行证券的公司信息 披露内容与格式准则第15号—权益变动报告书》及相关法律、法规编写本报告 书。 二、信息披露义务人及其一致行动人签署本报告书已获得必要的授权和批 准，其履行亦不违反信息披露义务人章程或内部规则的任何条款，或与之相冲 突。 三、依据《中华人民共和国证券 ...

Group 1 - The CRO concept sector has seen a significant rise, with companies like Lianhua Technology (002250) hitting the daily limit up, indicating strong investor interest [1] - Ruizhi Pharmaceutical (300149) has increased by over 10%, reflecting positive market sentiment towards the CRO sector [1] - Other companies such as Meinuohua (603538), Jinkai Biotechnology (301509), Shengnuo Biotech, Wanbang Pharmaceutical (301520), and Haoyuan Pharmaceutical have also experienced gains, showcasing a broader trend in the industry [1]

Core Viewpoint - The company, Ruizhi Pharmaceutical, is experiencing a decline in stock price and net capital outflow, despite showing positive revenue and profit growth in its latest quarterly report [1][2]. Company Summary - Ruizhi Pharmaceutical's stock closed at 10.16 yuan on June 5, down 3.05%, with a latest price-to-book ratio of 4.15 and a total market capitalization of 5.059 billion yuan [1]. - The company reported a net capital outflow of 83.8388 million yuan on June 5, with a total outflow of 156.9818 million yuan over the past five days [1]. - The main business of Ruizhi Pharmaceutical includes providing drug discovery, development, and production services to global pharmaceutical companies, biotechnology firms, and research institutions [1]. - The company's primary products consist of chemical business, pharmacodynamics and pharmacokinetics, and macromolecule business [1]. - In the first quarter of 2025, the company achieved a revenue of 261 million yuan, representing a year-on-year increase of 11.37%, and a net profit of 6.6421 million yuan, reflecting a year-on-year growth of 126.09%, with a sales gross margin of 27.44% [1]. Industry Summary - The average price-to-earnings (PE) ratio for the industry is 40.82 (TTM) and 46.97 (static), with an average price-to-book ratio of 3.46 [2]. - The median PE ratio for the industry is 45.93 (TTM) and 53.09 (static), with a median price-to-book ratio of 2.73 [2].

Core Insights - The Shanghai Composite Index rose by 0.43% on June 3, with 20 out of 28 sectors experiencing gains, particularly in the beauty care and textile sectors, which increased by 3.86% and 2.53% respectively [1] - The pharmaceutical and biotechnology sector saw a rise of 1.78%, with a net inflow of 9.17 billion yuan in capital [1] - Among the 475 stocks in the pharmaceutical sector, 416 stocks increased, with 14 hitting the daily limit up, while 54 stocks declined [1] Capital Flow Analysis - The pharmaceutical sector had 221 stocks with net capital inflows, with 6 stocks receiving over 100 million yuan in net inflows. Leading the inflow was Huahai Pharmaceutical with 266.1 million yuan, followed by Qianhong Pharmaceutical and Hehua Co., which received 201.5 million yuan and 168 million yuan respectively [1] - The outflow list included 6 stocks with net outflows exceeding 50 million yuan, with the highest outflows from Ruizhi Pharmaceutical, Hengrui Medicine, and Mindray Medical, which saw outflows of 237 million yuan, 110 million yuan, and 109 million yuan respectively [2] Pharmaceutical Sector Performance - The top gainers in the pharmaceutical sector included: - Huahai Pharmaceutical: +7.63%, turnover rate 7.71%, capital flow 266.1 million yuan - Qianhong Pharmaceutical: +10.05%, turnover rate 17.02%, capital flow 201.5 million yuan - Hehua Co.: +9.95%, turnover rate 18.47%, capital flow 167.7 million yuan [1] - The top decliners included: - Ruizhi Pharmaceutical: -13.15%, turnover rate 34.15%, capital flow -236.7 million yuan - Hengrui Medicine: -0.26%, turnover rate 0.68%, capital flow -109.7 million yuan - Mindray Medical: -3.02%, turnover rate 0.58%, capital flow -108.9 million yuan [2] ETF Insights - The Hang Seng Medical ETF, which tracks the Hang Seng Hong Kong-listed biotechnology index, experienced a 5-day increase of 3.59% with a net inflow of 9.86 million yuan [5]

Core Viewpoint - The stock price of Ruizhi Pharmaceutical (300149.SZ) surged significantly before the Dragon Boat Festival, drawing attention from the capital market due to a combination of favorable news and improved financial performance [1][2][3]. Company Summary - Ruizhi Pharmaceutical's stock experienced a consecutive two-day "20cm" limit up on May 29 and 30, resulting in a cumulative increase of 44% [2]. - The company has seen a turnaround in its financial performance, achieving a net profit for the first quarter of 2025 after two years of substantial losses, with a reported net profit of 6.64 million yuan, a significant recovery compared to previous losses [3][8]. - The company has eliminated its goodwill burden, which had previously impacted profitability, and reported a revenue of 261 million yuan for Q1 2025, reflecting an 11.4% year-on-year increase [8]. - Ruizhi Pharmaceutical specializes in the CXO (Contract Research Organization) sector, providing comprehensive services from drug discovery to commercial production for global biopharmaceutical clients [4]. Industry Summary - The Chinese pharmaceutical industry is experiencing a "approval wave" for new drugs, which has acted as a catalyst for the current market rally [3]. - The global biopharmaceutical investment and financing environment is showing signs of recovery, with a projected increase from 71 billion USD in 2023 to 102 billion USD in 2024, marking a 43.7% year-on-year growth [8]. - The recent approval of 11 new drugs by the National Medical Products Administration of China has broadened the scope of innovative drug development, covering various therapeutic areas including oncology and autoimmune diseases [4].

3、现场会议召开时间：2025 年 5 月 30 日下午 14:00 证券代码：300149 证券简称：睿智医药 公告编号：2025-44 睿智医药科技股份有限公司 2024 年年度股东会决议公告 本公司及董事会全体成员保证公告内容真实、准确和完整，没有虚假记载、误导 性陈述或重大遗漏。 特别提示： 1、本次股东会未出现否决提案的情形。 2、本次股东会无变更提案的情况。 一、会议召开和出席情况 1、召开方式：本次会议采取现场投票与网络投票相结合的方式。 2、现场会议地点：上海市浦东新区张江高科技园区金科路 2829 号金科中心 A 栋 4、网络投票时间：2025 年 5 月 30 日。其中，通过深圳证券交易系统进行网络投 票的具体时间为 2025 年 5 月 30 日上午 9:15-9:25，9:30-11:30，下午 13:00-15:00；通 过深圳证券交易所互联网投票的具体时间为 2025 年 5 月 30 日上午 9:15 至下午 15:00 期间的任意时间。 5、召集人：公司董事会 6、出席现场会议和参加网络投票的股东及股东代表共 245 人，所持（代理）有 表决权的股份总数 167,298,555 ...

证券代码：300149 证券简称：睿智医药 公告编号：2025-45 一、核查的范围与程序 1、核查对象为本次激励计划的内幕信息知情人及激励对象。 2、本次激励计划的内幕信息知情人均填报了《内幕信息知情人登记表》。 睿智医药科技股份有限公司 关于公司 2025 年限制性股票激励计划内幕信息知情人及激励对象 买卖公司股票情况的自查报告 本公司及董事会全体成员保证公告内容真实、准确和完整，没有虚假记载、 误导性陈述或重大遗漏。 睿智医药科技股份有限公司（以下简称"公司"）于 2025 年 4 月 27 日召开 了第六届董事会第六次会议、第六届监事会第六次会议，审议通过了《关于<公 司 2025 年限制性股票激励计划（草案）>及其摘要的议案》等相关议案。具体内 容详见公司于 2025 年 4 月 29 日在巨潮资讯网（www.cninfo.com.cn）上披露的相 关公告。 根据《上市公司股权激励管理办法》（以下简称"《管理办法》"）《深圳 证券交易所创业板股票上市规则》《深圳证券交易所创业板上市公司自律监管指 南第 1 号——业务办理》等有关法律法规、规章及规范性文件和《公司章程》的 相关规定，通过向中国证券登记 ...

上海市徐汇区淮海中路 1010 号嘉华中心 45 层 邮编：200031 电话：(86-21) 5404 9930 传真：(86-21) 5404 9931 北京市竞天公诚律师事务所上海分所 关于睿智医药科技股份有限公司 2024 年年度股东会的 法律意见书 致：睿智医药科技股份有限公司（贵公司） 北京市竞天公诚律师事务所上海分所（以下简称"本所"）接受贵公司的委 托，指派律师出席并见证贵公司 2024 年年度股东会（以下简称"本次会议"）。 本所律师根据《中华人民共和国公司法》（以下简称《公司法》）、《中华 人民共和国证券法》（以下简称《证券法》）、《上市公司股东会规则》（以下 简称《股东会规则》）、《律师事务所从事证券法律业务管理办法》（以下简称 《证券法律业务管理办法》）、《律师事务所证券法律业务执业规则（试行）》 （以下简称《证券法律业务执业规则》）等相关法律、行政法规、规章、规范性 文件及《睿智医药科技股份有限公司章程》（以下简称《公司章程》）的规定， 就本次会议的召集与召开程序、召集人资格、出席会议人员资格、会议表决程序 及表决结果等事宜，出具本法律意见书。 对本法律意见书的出具，本所律师特作如下 ...

证券代码：300149 证券简称：睿智医药 公告编号：2025-46 睿智医药科技股份有限公司 股票交易异常波动公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 一、股票交易异常波动的具体情况 针对公司股票交易异常波动的情况，公司董事会通过自查及通讯、书面问询 等方式，对公司、公司控股股东、实际控制人就相关问题进行了核实，现将有关 核实情况说明如下： 1、公司前期披露的信息不存在需要更正、补充之处。 2、公司未发现近期公共传媒报道了可能或已经对公司股票交易价格产生较 大影响的未公开重大信息。 3、公司近期生产经营情况及内外部经营环境未发生重大变化，公司生产经 营正常。 4、公司、控股股东和实际控制人不存在关于公司的应披露而未披露的重大 事项或处于筹划阶段的重大事项。 5、控股股东、实际控制人在股票交易异常波动期间不存在买卖公司股票的 情形。 三、是否存在应披露而未披露信息的说明 公司董事会确认，公司目前没有任何根据《深圳证券交易所创业板股票上市 规则》等有关规定应予以披露而未披露的事项或与该事项有关的筹划、商谈、意 向、协议等；董事会也未获悉公司有根据《深 ...

Group 1 - The cell immunotherapy concept index rose by 1.25%, ranking 6th among concept sectors, with 29 stocks increasing in value [1][2] - Notable gainers included Ruizhi Pharmaceutical with a 20% limit up, Hainan Haiyao at limit up, and Shutaishen, Guanhao Biological, and Fosun Pharma with increases of 15.02%, 8.88%, and 5.23% respectively [1][6] - The sector experienced a net outflow of 266 million yuan, with 20 stocks seeing net inflows, and 8 stocks receiving over 10 million yuan in net inflows, led by Hainan Haiyao with a net inflow of 144 million yuan [2][3] Group 2 - Hainan Haiyao, Anke Bio, and Dongcheng Pharmaceutical had the highest net inflow ratios at 35.56%, 5.52%, and 5.27% respectively [3][4] - The top stocks by net inflow included Hainan Haiyao, Fosun Pharma, Ruizhi Pharmaceutical, and Zhaoyan New Drug, with net inflows of 144 million yuan, 54.52 million yuan, 34.78 million yuan, and 31.86 million yuan respectively [2][3] - Stocks with significant declines included Xue Rong Biological, Saifutian, and Jinchang Protein, with decreases of 4.23%, 2.74%, and 2.61% respectively [1][5]