每经记者｜许立波 每经编辑｜文多 丨 2025年5月8日 星期四 丨 5月7日上午，常山药业盘中一度涨停，股价创历史新高。7日上午，《每日经济新闻》记者致电公司证 券部，对方表示公司生产经营一切正常。同日晚间，常山药业公告称，公司艾本那肽注射液尚未上市销 售，该注射液用于治疗2型糖尿病的上市许可申请已经获得国家药监局受理，目前处于专业审评阶段， 艾本那肽最终能否获批上市及获批时间仍存在不确定性。即使未来艾本那肽上市，也面临较高的市场竞 争风险。 点评：公司公告已明确，核心产品艾本那肽尚处于审评阶段，且未来面临较高竞争压力和不确定性。短 期内，公司股价已明显脱离基本面，存在情绪炒作迹象。 NO.1 将减肥药纳入基本药物目录？世卫组织回应 免责声明：本文内容与数据仅供参考，不构成投资建议，使用前请核实。据此操作，风险自 担。 5月7日，昊海生科公告称，公司收到控股股东、实际控制人之一蒋伟通知，其于近日收到中国证监会出 具的《立案告知书》：因涉嫌内幕交易，决定对其立案。据昊海生科了解，该事项与公司股票无关。本 次事项系对蒋伟个人的调查，其不参与公司日常经营管理，该事项不会对公司日常经营活动产生重大影 响。 点评：尽 ...

Macro News - The People's Bank of China announced a reduction in the reserve requirement ratio by 0.5 percentage points and a decrease in policy interest rates by 0.1 percentage points, along with adjustments to structural monetary policy tools [3] - The National Financial Regulatory Administration plans to enhance the role of insurance funds as patient and long-term capital, introducing measures to support capital market stability and activity [3] - The China Securities Regulatory Commission (CSRC) is set to implement reforms for the Sci-Tech Innovation Board and the Growth Enterprise Market, and will revise the management measures for major asset restructuring of listed companies [3] Industry News - China's gold reserves reached 73.77 million ounces at the end of April, marking an increase of 70,000 ounces and continuing a six-month trend of gold accumulation [6] - The CSRC has issued an action plan to promote the high-quality development of public funds, which includes adjusting management fees and establishing a performance-based assessment system for fund managers [6] - Shanghai announced a reduction in personal housing provident fund loan rates, effective from May 8, 2025, with rates for first-time homebuyers set at 2.1% for loans under five years and 2.6% for loans over five years [6] Company News - Geely Automobile announced a proposal to privatize Zeekr at a price of $2.57 per share [9] - Kweichow Moutai reported a share buyback of 934,800 shares in April, with a total expenditure of 1.44 billion yuan [10] - BeiGene reported a net loss of 94.5 million yuan in the first quarter [10] - Qingdao Beer plans to acquire 100% equity of Jimo Huangjiu [10] - Hive Storage confirmed that its LPDDR4X and eMMC storage products are being used in the Go2 intelligent robotic dog developed by Yushu Technology [10]

Group 1 - Geely Auto proposed to privatize Zeekr with an offer of $2.57 per share, representing a 13.6% premium over the last trading price [1] - The offer also includes a premium of 20.0% over the volume-weighted average price of the last 30 trading days [1] - Geely currently holds approximately 65.7% of Zeekr's issued share capital [1] Group 2 - Sun Group announced the U.S. Department of Commerce has revoked its investigation into steel wheels made in Vietnam using Chinese components [2] - The revocation is expected to positively impact the company's export orders and future overseas business layout [2] Group 3 - Qingdao Beer plans to acquire 100% equity of Jimo Yellow Wine for a total consideration of RMB 665 million [3] - The acquisition aims to enhance industry synergy, competitiveness, and expand product lines and market channels [3] Group 4 - BeiGene reported a net loss of 94.503 million yuan in Q1 2025, a reduction in loss compared to the previous year [4] - The company achieved total revenue of 8.048 billion yuan, a year-on-year increase of 50.2%, driven by sales growth of its self-developed products [4] Group 5 - Daqin Railway reported a 0.99% year-on-year increase in cargo transportation volume for April [5] - Shaanxi Coal's self-produced coal sales reached 13.1033 million tons in April, up 0.76% year-on-year [5] Group 6 - Shennong Group sold 227,300 pigs in April, marking a 32.85% year-on-year increase [6] - Poly Developments reported a 25.44% year-on-year decrease in contracted sales amounting to 24.622 billion yuan in April [6] Group 7 - Hainan Development plans to acquire 51% equity of Wangying Technology [7] - Huafeng Measurement Control's shareholders plan to transfer 2.9% of shares at an initial price of 121.42 yuan per share [7] Group 8 - Various companies reported significant stock price fluctuations, with Changshan Pharmaceutical's injection not yet on the market and facing regulatory uncertainties [8] - The company is in the professional review stage for its diabetes treatment application [8]

Market Performance - On May 7, the Shanghai Composite Index rose by 0.80%, with institutional investors appearing on the trading lists of 18 stocks, net buying 6 and net selling 12 [1] - The average increase of stocks with net institutional purchases was 8.24%, outperforming the Shanghai Composite Index [3] Institutional Buying and Selling - The stock with the highest net institutional purchase was Tianyuan Dike, which closed up 8.46% with a turnover rate of 48.90%, and a total transaction amount of 4.747 billion [2] - Changshan Pharmaceutical hit the daily limit with a closing increase of 20.00% and a turnover rate of 10.63%, with net institutional purchases of 5129.86 million [2] - The stock with the highest net institutional sale was Hezhu Intelligent, with a net selling amount of 6897.78 million [3][6] Stock Flow and Performance - The stocks with significant net inflows included Tianyuan Dike and Changshan Pharmaceutical, while stocks like Hezhu Intelligent and Nanfang Precision experienced notable net outflows [3][4] - Among the stocks with institutional net purchases, only one stock provided a half-year performance forecast, with a projected net profit increase of 4.72% for Zhongjie Automobile [3] Deep and Hong Kong Stock Connect - On May 7, 12 stocks on the trading list had appearances from the Deep and Hong Kong Stock Connect, with net purchases in stocks like Zongshen Power and Tianyuan Dike [7][8] - The net purchase amounts for these stocks included 5462.66 million for Zongshen Power and 4493.94 million for Tianyuan Dike [8]

Core Viewpoint - On May 7, the Shanghai Composite Index rose by 0.8%, the Shenzhen Component Index increased by 0.22%, and the ChiNext Index gained 0.51%, indicating a positive market trend for the day [2]. Group 1: Stock Performance - Tianyu Shuke (002354.SZ) saw the highest net inflow of funds, amounting to 214 million yuan, representing 7.7% of its total trading volume, and closed with a gain of 10.05% and a turnover rate of 24.92% [2][4]. - Changshan Pharmaceutical (300255.SZ) experienced the largest net outflow of funds, totaling 192 million yuan, which accounted for 7.18% of its total trading volume, and closed up by 20.02% with a turnover rate of 10.63% [6][8]. Group 2: Institutional and Northbound Fund Activity - On May 7, 19 stocks on the Dragon and Tiger list saw institutional participation, with a total net purchase of approximately 94.99 million yuan, where institutions net bought 8 stocks and net sold 11 stocks [6][10]. - The stock with the highest net purchase by institutions was Tianyuan Dike (300047.SZ), which closed up by 8.46% with a turnover rate of 48.9% [7]. - Northbound funds participated in 12 stocks on the Dragon and Tiger list, with a total net purchase of 246 million yuan, where the highest net purchase was in Zongshen Power (001696.SZ) at 54.62 million yuan [11]. Group 3: Divergence in Fund Flows - Both institutions and northbound funds jointly net bought Tianyuan Dike and Changshan Pharmaceutical, while they jointly net sold Construction Industry and Suoao Sensor [12][13]. - In Tianyu Shuke, there was a divergence where institutions net sold 13.05 million yuan while northbound funds net bought 33.67 million yuan [12].

证券代码：300255 证券简称：常山药业 公告编号：2025-19 河北常山生化药业股份有限公司 2．公司艾本那肽注射液拟用于减重适应症的临床试验申请已经获得国家药监局 受理，目前处于审评阶段，能否获得临床试验批准通知书存在不确定性。艾本那肽 即使获批开展减重适应症临床试验研究，临床试验进度及结果、未来产品市场竞争 形势均存在诸多不确定性。 3．艾本那肽是以公司控股子公司常山凯捷健生物药物研发（河北）有限公司（以 下简称"常山凯捷健"）为主体进行的研发注册，公司持有常山凯捷健51%股份，其 净利润中由上市公司股东享有的份额为51%，由少数股东享有的份额为49%。常山凯 捷健未来实现盈利后，公司不能享有其实现的全部净利润。 4．公司 2024 年度营业收入为 103,081.05 万元，较上年下降 26.92%；归属于上 市公司股东的净利润为亏损 24,947.77 万元；基本每股收益为亏损 0.27 元/股。具体 情况详见公司 2025 年 4 月 29 日于巨潮资讯网站发布的《2024 年年度报告》（公告编 号 2025-11），并请关注其中详述公司经营所面临的风险。 5．公司股票连续两个交易日（2025 ...

Group 1 - The core point of the article is that Changshan Pharmaceutical's stock price has been experiencing significant fluctuations, with multiple instances of hitting the daily limit up, attributed to investor interest in its weight loss drug Aibennate [1] - The company reported a stock price increase of 11.89% the previous day, indicating strong market interest [1] - Aibennate is an innovative drug developed by Changshan Pharmaceutical's subsidiary, Changshan Kaijie Health, and is currently in the registration phase [1] Group 2 - The company confirmed that there is no new progress regarding Aibennate, addressing investor inquiries [1] - Regarding two other anti-tumor targeted original new drugs, CSCJC3456 and CSCJC4523, the company stated that they are in Phase I clinical trials and preclinical research stages, respectively [1]

Core Viewpoint - Changshan Pharmaceutical's stock price has reached a historical high, driven by investor interest in its weight loss drug, Aibennate, despite the company facing ongoing performance challenges [1][3]. Group 1: Company Developments - Aibennate, developed by Changshan Pharmaceutical's subsidiary, is a novel GLP-1 receptor agonist aimed at treating type 2 diabetes and potentially aiding in weight loss [2]. - The National Medical Products Administration (NMPA) has accepted the new drug application (NDA) for Aibennate, indicating progress in its regulatory pathway [2]. - The company has acknowledged the competitive landscape for GLP-1 drugs, with several already approved for weight loss, which may impact Aibennate's market potential [2]. Group 2: Financial Performance - In 2024, Changshan Pharmaceutical reported a revenue of 1.031 billion yuan, a year-on-year decline of 26.92%, and a net profit attributable to shareholders of -249 million yuan, indicating a loss reduction compared to previous periods [3]. - For Q1 2025, the company achieved a revenue of 259 million yuan, down 12.10% year-on-year, but reported a net profit of 3.78 million yuan, reflecting a significant increase of 106.13% [3]. - The decline in revenue is primarily attributed to changes in the market structure due to centralized procurement policies affecting the sales of its main product, low molecular weight heparin calcium injection [3].

Core Viewpoint - Changshan Pharmaceutical is actively implementing a development strategy focused on expanding advantages, addressing shortcomings, developing new products, innovating drugs, and pursuing external growth in response to changes in the heparin industry [1][2]. Group 1: Business and Product Structure - Changshan Pharmaceutical is one of the few domestic companies with a complete heparin product industrial chain, engaging in the research, production, and sales of heparin crude products, active pharmaceutical ingredients, and formulations [1]. - The company’s main heparin products include heparin sodium crude, heparin sodium API, low molecular weight heparin calcium API, and various heparin injection solutions [1]. - The low molecular weight heparin calcium injection has maintained a leading market share for several years but has seen a decline in sales due to the impact of centralized procurement policies [1]. Group 2: Financial Performance - In the reporting period, Changshan Pharmaceutical achieved a revenue of 1.031 billion yuan, with low molecular weight heparin API contributing 145 million yuan, a year-on-year increase of 31.82% [2]. - Revenue contributions from ordinary heparin API and low molecular weight heparin formulations were 242 million yuan and 454 million yuan, respectively, while platform heparin formulations saw an 8.33% year-on-year growth to 54 million yuan [2]. Group 3: Innovation and R&D - The company views innovative drug research and development as key to overcoming current challenges, with a focus on the GLP-1 long-acting formulation, Aibennate injection, which has received acceptance for its marketing application from NMPA [2]. - If Aibennate is approved and launched, it is expected to reduce the company's reliance on heparin business for revenue and enhance profitability and risk resilience [2]. - Changshan Pharmaceutical is also advancing the development of two anti-tumor targeted original new drugs, CSCJC3456 and CSCJC4523, with CSCJC3456 having received NMPA approval for clinical trials in late-stage solid tumors [3]. Group 4: Future Strategy - For 2025, the company plans to maintain the sales of low molecular weight heparin formulations while focusing on increasing sales of heparin crude and API products [3]. - The company aims to actively promote the clinical progress and market launch of innovative drugs like Aibennate and CSCJC3456, with the goal of enhancing overall profitability [3].

证券代码：300255 证券简称：常山药业 公告编号：2025-17 河北常山生化药业股份有限公司 关于提请股东大会授权董事会办理以简易程序 向特定对象发行股票的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 根据《上市公司证券发行注册管理办法》《深圳证券交易所上市公司证券发 行上市审核规则》《深圳证券交易所上市公司证券发行与承销业务实施细则》等 相关规定，河北常山生化药业股份有限公司（以下简称"公司"）于 2025 年 4 月 28 日召开第六届董事会第二次会议、第六届监事会第二次会议，审议通过《关 于提请股东大会授权董事会办理以简易程序向特定对象发行股票的议案》，同意 公司董事会提请股东大会授权董事会办理以简易程序向特定对象发行融资总额 不超过人民币 3 亿元且不超过最近一年末净资产 20%的股票，授权期限为自 2024 年度股东大会通过之日起至 2025 年度股东大会召开之日止。 本议案尚需提交股东大会审议，现将有关情况公告如下： 一、具体内容 （一）发行股票的种类和面值 本次发行股票的种类为境内上市人民币普通股（A 股），每股面值人民币 1.00 ...