香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因倚賴該等內容而引致的任何損失承擔任何責任。 茲提述(1)藥明合聯招股章程；及(2)本公司日期為二零二四年三月三十一日的 公告，內容有關（其中包括）日期為二零二三年十一月三日的二零二三年連接 子及有效載荷主服務協議，就連接子及有效載荷向藥明合聯集團提供研發及 製造服務，並向藥明合聯集團供應其ADC CRDMO服務使用的相關中間產品。 在行業快速擴張的推動下，市場對本集團ADC CRDMO服務的需求持續大幅 增長。預計對藥明合聯集團服務的需求將進一步增長，因其業務於二零二五 年繼續呈上升態勢。考慮到藥明合聯的強勁表現及藥明合聯集團於截至二零 二五年六月三十日止六個月的最近期未經審核簡明綜合中期業績，預計二零 二三年連接子及有效載荷主服務協議的交易金額於二零二五年將超過其原 定年度上限，因此，建議就二零二三年連接子及有效載荷主服務協議採納經 修訂年度上限。此外，由於二零二三年連接子及有效載荷主服務協議將於二 零二五年十二月三十一日到期，藥明合聯建議訂立 ...

Group 1: ETF Performance - The leading ETF in terms of growth is the Robot ETF Penghua (159278), which increased by 2.30% [1] - Other notable performers include the Robot ETF E Fund (159530) with a 2.22% increase and the Robot 50 ETF (159559) with a 2.10% increase [1] - The banking sector ETFs also showed positive performance, with the Bank ETF Tianhong (515290) rising by 1.96% [1] Group 2: Robotics Sector Performance - In the first half of 2025, the robotics sector achieved a total revenue of 288.83 billion yuan, reflecting a year-on-year growth of 13.81% [2] - Out of 120 companies in the robotics sector, 106 reported profits, resulting in a net profit of 21.62 billion yuan, which is a 13.72% increase year-on-year [2] - In Q2 2025, the sector's revenue reached 153.24 billion yuan, with a year-on-year growth of 14.65% [2] Group 3: Banking Sector Outlook - The banking sector is expected to see a resurgence in excess returns as macro liquidity approaches its peak [2] - Long-term fiscal spending is gradually optimizing towards subsidies in areas such as education and child-rearing, which is expected to benefit both demand and supply in the banking sector [2] Group 4: ETF Trading Activity - The China-Korea Semiconductor ETF (513310) had the highest turnover rate at 289.93% [4] - Other ETFs with significant turnover rates include the S&P Consumer ETF (159529) at 194.12% and the 5-Year Local Bond ETF (511060) at 186.18% [4][5] Group 5: New ETF Launches - Upcoming ETFs include the Southbound Hong Kong Innovation Drug ETF (159297) and the Guotai Hong Kong Automotive ETF (520720), focusing on innovative drug development and the automotive industry, respectively [6] - The Hong Kong Stock Connect Technology ETF (159101) targets major tech companies and is suitable for investors looking to capture growth in the tech sector [7] Group 6: Hong Kong Market Performance - The Hong Kong market has shown strong performance, with the Hang Seng Index and Hang Seng Tech Index rising by 27.70% and 29.79% year-to-date, respectively [8] - Significant inflows from foreign institutions have been noted, with approximately 67.7 billion HKD entering the market from May to July [8]

Core Viewpoint - The Hang Seng Index experienced a significant increase, closing at 25,617.42 points with a rise of 2.15%, driven by strong performances from major constituents like Alibaba, WuXi Biologics, and Zijin Mining, indicating a positive outlook for Hong Kong stocks amid easing external conditions [1] Market Performance - The Hang Seng Index opened high on September 1 and maintained strong performance throughout the day, with notable gains in technology, pharmaceuticals, and materials sectors [1] - Alibaba's mid-term earnings report exceeded market expectations, with cloud intelligence service revenue growing by 26% year-on-year, reinforcing the growth narrative driven by AI [1] Valuation and Comparison - The Hang Seng Technology Index currently has a price-to-earnings ratio of 21.23, which is below the historical 20% percentile, suggesting a more reasonable valuation compared to A-shares [1] - Historically, during periods of RMB appreciation, the median annualized return of the Hang Seng Index reached 36.5%, outperforming the 29.8% of the CSI 300 [1] Sector Strength - The composition of Hong Kong stocks, particularly in technology and pharmaceuticals, is seen as advantageous compared to A-shares, with a higher concentration of growth stocks [1] - The improving sentiment in AI internet and innovative pharmaceuticals sectors is expected to support further upward movement in Hong Kong stocks, with potential for valuation increases [1] Investment Recommendation - Investors are encouraged to maintain focus on Hong Kong technology ETFs, particularly those encompassing internet, semiconductors, innovative pharmaceuticals, and new energy vehicles [2]

Core Viewpoint - The Hong Kong stock market showed volatility on September 2, with the pharmaceutical sector leading gains, particularly the Hong Kong Stock Connect Medical ETF, which reached a new historical high [1] Group 1: Market Performance - The Hong Kong Stock Connect Medical ETF (159506) rose nearly 2%, achieving a new historical high [1] - Key constituent stocks such as BeiGene and 3SBio increased by over 4%, while WuXi AppTec and Kelun-Bio rose by over 2% [1] Group 2: Company Developments - Heng Rui Medicine announced that it received conditional approval from the National Medical Products Administration for its self-developed innovative drug, SHR2554, which is the first EZH2 inhibitor developed in China [2][3] - The drug targets peripheral T-cell lymphoma (PTCL), which accounts for approximately 25%-30% of non-Hodgkin lymphoma patients in China, with a median onset age of 52 years [3] - Heng Rui's total R&D investment for SHR2554 has reached approximately 21.3 million yuan [3] Group 3: Future Outlook - The first half of 2025 is expected to see explosive growth in the export of Chinese innovative drugs, with significant increases in licensing-out transaction amounts [4] - The Chinese pharmaceutical industry is becoming a major source of global innovative drugs, contributing 50% of new drug molecules entering human clinical trials globally [4] - The Hong Kong Stock Connect Medical ETF focuses on capturing investment opportunities in the pharmaceutical sector, including medical devices, drugs, biotechnology, and medical services [4]

Market Performance - The Hang Seng Index closed at 25,617, up 2.15% year-to-date, with a 27.70% increase since the beginning of the year[4] - The Hang Seng Tech Index rose by 2.20%, with a year-to-date increase of 29.79%[4] - The Shanghai Composite Index increased by 0.46%, with a year-to-date growth of 15.63%[4] - The Nikkei 225 Index fell by 1.24%, with a year-to-date increase of 5.75%[4] Sector Highlights - Alibaba's stock surged by 18.5% following strong earnings, driven by growth in cloud services and AI initiatives[10] - Gold prices approached historical highs, with a significant increase in gold and silver stocks, including a 16% rise in Tongguan Gold[10] - The semiconductor sector showed strong performance, with InnoTek rising over 12%, supported by projected revenue growth in the global semiconductor industry[10] Investment Trends - Net inflow of southbound funds reached HKD 11.9 billion on September 1[10] - Pharmaceutical outsourcing and innovative drug concepts saw gains, with WuXi Biologics up over 8%[10] - Automotive stocks generally declined, but NIO rose over 4% amid strong delivery numbers from various electric vehicle manufacturers[10]

Core Viewpoint - The innovative drug sector is experiencing strong performance due to favorable policies and positive earnings reports, with significant gains in Hong Kong-listed innovative drug stocks [1][2]. Policy Aspects - The National Healthcare Security Administration has introduced a "newly listed drug initial pricing mechanism" to encourage drug research and innovation, marking the first public announcement of this mechanism since last year's consultation [1]. - The mechanism aims to ensure that high-level innovative drugs can achieve returns that correspond to their high investment and risk during the initial listing period [1]. Performance Aspects - In the first half of this year, among 80 listed companies in the innovative drug sector, 34 companies reported year-on-year growth in net profit attributable to shareholders, excluding companies that turned losses into profits or reduced losses [2]. - For instance, Heng Rui Medicine achieved revenue of 15.76 billion yuan, a year-on-year increase of 15.88%, and a net profit of 4.45 billion yuan, up 29.67% [2]. - In the medical device sector, United Imaging Healthcare reported revenue of 6.02 billion yuan, a 12.79% increase, and a net profit of 998 million yuan, up 5.03% [2]. - The continuous optimization of the medical insurance catalog adjustment mechanism by the government has stimulated companies' enthusiasm for innovation, as they see increased chances of their products entering insurance and commercial insurance catalogs [2].

Core Viewpoint - The Hong Kong innovative drug sector is experiencing significant growth, with the Hong Kong Innovative Drug 50 ETF (513780) leading the market with a year-to-date increase of over 112% [2] Group 1: Market Performance - The Hong Kong Innovative Drug 50 ETF (513780) has seen a net inflow of 800 million yuan in the last 20 days, with a total net inflow exceeding 2 billion yuan this year, bringing its latest scale to 2.712 billion yuan [2] - The ETF is noted for having the largest scale and best liquidity among its peers, allowing for T+0 trading [2] Group 2: Composition and Holdings - The index tracked by the Hong Kong Innovative Drug 50 ETF consists solely of innovative drug companies, with major holdings including industry leaders such as CanSino Biologics, Innovent Biologics, WuXi Biologics, BeiGene, China National Pharmaceutical Group, CSPC Pharmaceutical Group, Hansoh Pharmaceutical, WuXi AppTec, and 3SBio [2] Group 3: Future Outlook - CITIC Securities anticipates an increase in innovative drug catalyst events in September, suggesting that the recent technology switch has cleared out short-term speculative money from the sector, which may allow innovative drugs to continue their upward trend after recent adjustments [2]

Group 1 - The Hong Kong stock market for innovative drug concept stocks is showing strength, with companies like BeiGene rising over 6%, 3SBio increasing over 3%, and WuXi Biologics up over 2% [1] - Several Hong Kong innovative drug-related ETFs have also increased by over 2% due to market influences [2] - Specific ETFs such as the Hong Kong Innovative Drug ETF T+0 and the Hong Kong Innovative Drug Selected ETF have reported gains of 3.24% and 2.47% respectively [3] Group 2 - Upcoming global conferences, including the World Conference on Lung Cancer (WCLC) in September and the European Society for Medical Oncology (ESMO) in October, will showcase research results from domestic innovative drugs [3] - Notable products to be presented include AK112 from CanSino Biologics and DB-1311 from InnoCare Pharma, highlighting the increasing competitiveness of domestic innovative drugs in clinical data and progress [3] - The trend of innovative drugs going global is strengthening as domestic companies enhance their clinical capabilities [3]

Market Performance - The Hang Seng Hong Kong Stock Connect Innovative Drug Select Index (HSSCPB) rose by 1.13% as of September 2, 2025, with notable increases in stocks such as 3SBio (01530) up 4.34% and BeiGene (06160) up 3.65% [3] - The Hong Kong Innovative Drug Select ETF (520690) increased by 1.90%, marking its third consecutive rise, with a latest price of 1.07 yuan [3] - The Hang Seng Healthcare Index (HSHCI) saw a 0.77% increase, with stocks like 1Life Healthcare (02522) rising by 5.13% [6] - The Hang Seng Healthcare ETF (513060) also rose by 0.96%, achieving a three-day consecutive increase, with a latest price of 0.74 yuan [6] Policy and Regulatory Developments - During the "National Drug Safety Publicity Week" in 2025, it was announced that 210 innovative drugs and 269 innovative medical devices were approved during the 14th Five-Year Plan period, indicating accelerated growth [7] - The approval of 28 innovative traditional Chinese medicine drugs has also been noted, with significant increases in clinical and market applications [7] Company Developments - On September 1, 2025, Hengrui Medicine's innovative drug "Zemiglo" was approved for market, becoming the first domestically developed EZH2 inhibitor for treating relapsed or refractory peripheral T-cell lymphoma [7] - Junshi Biosciences received FDA approval for its self-developed biosimilar HLX14, covering eight indications, marking a significant step in its international expansion [7] Institutional Insights - The approval of innovative drugs and devices, along with the advancements in traditional Chinese medicine, is expected to enhance the valuation of the pharmaceutical sector [8] - Hengrui's approval of the first domestic EZH2 inhibitor fills a treatment gap in relapsed/refractory peripheral T-cell lymphoma, adding a new commercial example for innovative drugs [8] - Junshi's FDA approval for multiple indications validates the pathway of "product internationalization leading to revenue and valuation enhancement" [8] ETF Performance and Metrics - The Hong Kong Innovative Drug Select ETF (520690) saw a significant scale increase of 54.91 million yuan over the past week, ranking in the top half among comparable funds [9] - The ETF experienced a net outflow of 5.19 million yuan recently, but had three days of net inflow totaling 41.35 million yuan over the past five trading days [9] - The ETF's highest monthly return since inception was 1.42%, with a maximum drawdown of 7.61% [10] Valuation Metrics - The Hang Seng Healthcare ETF's latest price-to-earnings ratio (PE-TTM) is 30.84, indicating it is at a historical low compared to the past three years [12] - The top ten weighted stocks in the Hang Seng Healthcare Index account for 62.89% of the index, with companies like BeiGene (06160) and Innovent Biologics (01801) among the leaders [12]

Core Viewpoint - The Hong Kong stock market for innovative drugs continues to rise, with the Hong Kong Stock Connect Innovative Drug ETF (520880) increasing by 3.24%, marking three consecutive days of gains [1]. Group 1: Market Performance - The Hong Kong Stock Connect Innovative Drug ETF (520880) has shown a remarkable year-to-date increase of 115.29%, leading the performance among various innovative drug indices [3]. - Major innovative drug companies such as BeiGene and Innovent Biologics have seen significant stock price increases, with BeiGene rising nearly 5% and Innovent Biologics over 3% [4]. Group 2: Policy and Industry Trends - On August 28, the National Healthcare Security Administration announced the preliminary review of the 2025 medical insurance and commercial insurance innovative drug directory, which includes new drugs and notable CAR-T products [2]. - The innovative drug sector is transitioning from capital-driven growth to profit-driven growth, with a positive trend in profitability across the industry [6]. Group 3: Index Adjustments - The Hang Seng Index has announced a revision to the Hang Seng Stock Connect Innovative Drug Select Index, removing companies primarily engaged in CXO services to focus on innovative drug research and development firms [8][9]. - This adjustment is expected to enhance the index's performance by eliminating disturbances from CXO companies, reflecting the maturation of China's innovative drug development [9].